Takahashi Sayaka 高橋さやか

… Alternative Names

Nomura Sayaka 野村さやか

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Researcher Number	20791651
Other IDs
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 薬理学, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 薬理学, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science
Keywords	Principal Investigator LXR / 高脂肪食 / 腸内細菌叢 / サルコペニア肥満 / 高脂肪高ショ糖食 / IL-1β / サルコペニア / 加齢 / コグニティブフレイル / 炎症 … More / 老化 / SAMP8 / Liver X receptor / TNF / LXRアゴニスト / 腸管分化 / 腸管幹細胞 / オルガノイド / ミクログリア / LPS / 腸管炎症 / 分子状水素 / IL-6 / インフラマソーム / 脳炎症 / 腸管再生 … More Except Principal Investigator 脳内炎症 / 神経新生障害 / 認知機能障害 / LPS / TNF / ミクログリア / 老年期うつ病 / イムノメタボリズム / 脂肪炎症 / 認知機能低下 / 抑うつ様行動 / ディスバイオシス / 高脂肪食 / サイトカイン / 神経新生 / メタボリック・シンドローム / IL-18 / IL-1beta / 神経分化 / 神経前駆細胞 / インフラマソーム Less

イムノメタボリズムに着目した老年期うつ病発症・増悪機構の解明と治療への応用
- Principal Investigator
  
  石塚俊晶
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Defense Medical College
腸内環境改善と炎症制御による新たなサルコペニア肥満治療の開発Principal Investigator
- Principal Investigator
  
  高橋さやか
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Defense Medical College
Elucidation and application to treatment of the mechanism of cognitive impairment caused by adipose tissue inflammation and dysbiosis
- Principal Investigator
  
  Ishizuka Toshiaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Defense Medical College
Elucidation and application to treatment of the mechanism of intestinal regeneration dysfunction cased by high-fat diet intake and psychological stress ical stress and its application to treatmentPrincipal Investigator
- Principal Investigator
  
  Nomura Sayaka
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Defense Medical College
Clarification and prevention of novel mechanisms of cognitive impairment in patients with metabolic syndrome
- Principal Investigator
  
  Ishizuka Toshiaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  National Defense Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] A preliminary therapeutic study of the effects of molecular hydrogen on intestinal dysbiosis and small intestinal injury in high-fat diet-loaded senescence-accelerated mice2024
- Author(s)
  Takahashi Sayaka、Nakagawa Keiichi、Nagata Wataru、Koizumi Akiho、Ishizuka Toshiaki
- Journal Title
  
  Nutrition
  
  Volume: 122 Pages: 112372-112372
- DOI
  10.1016/j.nut.2024.112372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11844, KAKENHI-PROJECT-20K11548
[Journal Article] Treatment with lysophosphatidic acid prevents microglial activation and depression-like behaviours in a murine model of neuropsychiatric systemic lupus erythematosus2023
- Author(s)
  Nagata Wataru、Koizumi Akiho、Nakagawa Keiichi、Takahashi Sayaka、Gotoh Mari、Satoh Yasushi、Ishizuka Toshiaki
- Journal Title
  
  Clinical and Experimental Immunology
  
  Volume: 212 Issue: 2 Pages: 81-92
- DOI
  10.1093/cei/uxad010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07098, KAKENHI-PROJECT-20K11548
[Journal Article] Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice2021
- Author(s)
  Matsuura Fumihiro、Satoh Yasushi、Itakura Sayako、Morohashi Toru、Kawaguchi Masanori、Takahashi Tetsuya、Iwanaga Koji、Terashima Hayato、Kobayashi Yasushi、Wang Xin、Ishizuka Toshiaki、Endo Shogo、Ikeda Takehiko
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 99 Issue: 6 Pages: 1666-1688
- DOI
  10.1002/jnr.24827
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11548, KAKENHI-PROJECT-18K08878, KAKENHI-PROJECT-19H04044, KAKENHI-PROJECT-21K19752, KAKENHI-PROJECT-21K16555
[Journal Article] Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells2020
- Author(s)
  Toshiaki Ishizuka, Nagata Wataru, Nomura Sayaka, Yasushi Satoh
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 888 Pages: 173456-173456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11120
[Journal Article] Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells2020
- Author(s)
  Ishizuka Toshiaki、Nagata Wataru、Nomura-Takahashi Sayaka、Satoh Yasushi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 888 Pages: 173456-173456
- DOI
  10.1016/j.ejphar.2020.173456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11548
[Journal Article] Effects of muscarinic acetylcholine receptor stimulation on the differentiation of mouse induced pluripotent stem cells into neural progenitor cells.2018
- Author(s)
  Ishizuka T, Ozawa A, Katsuura M, Nomura S, Satoh Y.
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 45 Issue: 11 Pages: 1198-1205
- DOI
  10.1111/1440-1681.12993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01886, KAKENHI-PROJECT-18K11120
[Journal Article] Discovery of small molecules that induce the degradation of Huntingtin.2017
- Author(s)
  Tomoshige S, Nomura S, Ohgane K, Hashimoto Y, Ishikawa M
- Journal Title
  
  Angew Chem
  
  Volume: 129 Pages: 11688-11691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Effects of molecular hydrogen to age-related changes in T cell subsets and cytokine-producing capabilities on senescence-accelerated mouse fed with high fat and high sucrose diet2023
- Author(s)
  Nakagawa K, Takayama E, Koizumi A, Nagata W, Takahashi S, Ishizuka T
- Organizer
  19th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] 腸内細菌叢および腸管組織に与える老化や高脂肪食摂取の影響とその制御2023
- Author(s)
  中川　慶一、高橋　さやか、永田　亘、石塚　俊晶
- Organizer
  第41回日本ヒト細胞学会シンポジウム
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] The ameliorating effects of molecular hydrogen on intestinal injury in high fat diet-loaded senescence-accelerated mouse2022
- Author(s)
  Nomura Sayaka, Nakagawa keiichi, Nagata Wataru, Koizumi Akiho, Ishizuka Toshiaki
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] Effects of molecular hydrogen on dysbiosis and intestinal inflammation in high fat diet-loaded senescence-accelerated mice2022
- Author(s)
  高橋　さやか
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K11844
[Presentation] リゾホスファチジン酸がSLEモデルマウスの糸球体腎炎を改善させる2022
- Author(s)
  永田　亘、小泉　明穂、中川　慶一、高橋　さやか、石塚　俊晶
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] 高脂肪食負荷老化促進マウスの腸管障害に対する分子状水素の改善作用2022
- Author(s)
  高橋　さやか、中川　慶一、永田　亘、小泉　明穂、石塚　俊晶
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] 高脂肪食負荷老化促進マウスのディスバイオシスおよび腸管炎症に対する分子状水素の効果2022
- Author(s)
  高橋　さやか、中川　慶一、永田　亘、小泉　明穂、石塚　俊晶
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] Treatment with lysophosphatidic acid(LPA)improves depressive-like behaviors in neuropsychiatric lupus erythematosus (NPSLE) model mice through LPA receptor2022
- Author(s)
  永田　亘、小泉　明穂、中川　慶一、野村　さやか、深澤　桂子、後藤真理、石塚　俊晶
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] リゾホスファチジン酸(LPA)がLPA受容体を介して精神神経ループスモデルマウスの抑うつを改善する2022
- Author(s)
  永田　亘、小泉　明穂、中川　慶一、高橋　さやか、石塚　俊晶
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] 老化促進モデルマウスにおけるT細胞分画およびサイトカイン産生能と加齢に伴う変化の検討2022
- Author(s)
  中川　慶一、高山　英次、小泉　明穂、永田　亘、高橋　さやか、石塚　俊晶
- Organizer
  第40回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] 高濃度水素ゼリーは高脂肪食負荷老化促進マウスの腸管障害を改善する2021
- Author(s)
  高橋　さやか、中川　慶一、永田　亘、小泉　明穂、石塚　俊晶
- Organizer
  第10回日本分子状水素医学生物学会大会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] 行動柔軟性を評価するための5本腕バンディットタスク2021
- Author(s)
  太田　宏之、荒毛　将史、佐鳥　玖仁朗、宝田　悠、高橋　達二、佐藤　泰司、守本　祐司、石塚　俊晶
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] Transrepression作用選択的なLiver X 受容体リガンドの創製とインフラマソーム活性化に及ぼす影響2021
- Author(s)
  高橋　さやか、梅田　香織、槇島　誠、橋本　祐一、石塚　俊晶、石川　稔
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製とインフラマソーム活性化に及ぼす影響の検討2021
- Author(s)
  石塚俊晶、野村さやか、梅田（遠藤）香織、槇島誠、橋本祐一、石川稔
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] 高脂肪食およびLPS投与が脳内炎症、神経新生および認知機能に及ぼす影響2021
- Author(s)
  石塚　俊晶、永田　亘、高橋　さやか、太田　宏之、佐藤　泰司
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製とインフラマソーム活性化に及ぼす影響の検討2021
- Author(s)
  野村　さやか
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] 高濃度水素含有ゼリーは高脂肪食負荷老化促進マウスの腸管障害を改善する2021
- Author(s)
  Nomura Sayaka, Nakagawa keiichi, Nagata Wataru, Koizumi Akiho, Ishizuka Toshiaki
- Organizer
  第10回日本分子状水素医学生物学会大会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] Cyclic phosphatidic acid improves depression in a mouse model of neuropsychiatric lupus erythematosus (NPSLE)2021
- Author(s)
  永田　亘、小泉　明穂、中川　慶一、野村　さやか、深澤　桂子、後藤真理、石塚　俊晶
- Organizer
  日本ヒト細胞学会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] 環状ホスファチジン酸が精神神経ループスモデルマウスの抑うつを改善する2021
- Author(s)
  永田　亘、小泉　明穂、中川　慶一、高橋　さやか、深澤　桂子、後藤　真里、石塚　俊晶
- Organizer
  第39回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] Effects of transrepression-selective liver X receptor ligands on inflammasome activation of microglia and neural progenitor cells.2020
- Author(s)
  Ishizuka T, Takahashi S, Goda W, Makishima M, Ishikawa M, Hashimoto Y.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Transrepression作用選択的LXRリガンドはミクログリアや神経前駆細胞のインフラマソーム活性化を抑制する2020
- Author(s)
  石塚　俊晶、高橋　さやか、合田　和香美、槇島　誠、石川　稔
- Organizer
  第38回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11548
[Presentation] Effects of inflammasome activation on proliferation and differentiation of neural progenitor cells2019
- Author(s)
  Ishizuka T, Ozawa A, Nomura S, Satoh Y.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] ミクログリアおよび神経前駆細胞のインフラマソーム活性化に対するTransrepression作用選択的なLXRリガンドの影響2019
- Author(s)
  石塚　俊晶、高橋　さやか、合田　和香美、槇島　誠、石川　稔、橋本　祐一
- Organizer
  第6回　サイコグリア研究会
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Effects of inflammasome activation on proliferation and differentiation of neural progenitor cells2019
- Author(s)
  Ishizuka T, Ozawa A, Nomura S, Satoh Y.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] 探索行動テストのための24時間型オペラント箱の開発2019
- Author(s)
  太田　宏之、荒毛　将史、宝田　悠、佐鳥　久仁朗、高橋　達二、守本　祐司、石塚　俊晶
- Organizer
  第141回　日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製と腸管新生作用の検討2018
- Author(s)
  野村さやか、梅田香織、槇島誠、橋本祐一、石塚俊晶、石川稔
- Organizer
  第36回ヒト細胞学会
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] Development of transrepression-selective liver X receptor ligands.2018
- Author(s)
  Nomura S, Umeda K, Makishima M, Hashimoto Y, Ishizuka T, Ishikawa M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] Effects of inflammasomes on differentiation of neural progenitor cells into neural cells.2018
- Author(s)
  Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
- Organizer
  ISSCR 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製と腸管新生作用の検討2018
- Author(s)
  野村さやか、梅田香織、槇島誠、橋本祐一、石塚俊晶、石川稔
- Organizer
  第36回ヒト細胞学会
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Activation of inflammasomes in neural progenitor cells inhibits differentiation into neural cells.2018
- Author(s)
  Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Activation of inflammasomes in neural progenitor cells inhibits differentiation into neural cells.2018
- Author(s)
  Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] Effects of inflammasomes on differentiation of neural progenitor cells into neural cells.2018
- Author(s)
  Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
- Organizer
  ISSCR 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11120
[Presentation] Development of transrepression-selective liver X receptor ligands.2018
- Author(s)
  Nomura S, Umeda K, Makishima M, Hashimoto Y, Ishizuka T, Ishikawa M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01886
[Presentation] Effects of oxidized low density lipoprotein on proliferation or differentiation of mouse neural progenitor cells into neural cells2017
- Author(s)
  Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
- Organizer
  ISSCR 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01886

1. Ishizuka Toshiaki (30399117)

# of Collaborated Projects: 5 results

# of Collaborated Products: 37 results
2. 佐藤泰司 (10505267)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
3. 高山英次 (70533446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. GOTOH Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Sayaka 高橋 さやか

Nomura Sayaka 野村 さやか

Research Projects

Research Products

Co-Researchers

イムノメタボリズムに着目した老年期うつ病発症・増悪機構の解明と治療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸内環境改善と炎症制御による新たなサルコペニア肥満治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation and application to treatment of the mechanism of cognitive impairment caused by adipose tissue inflammation and dysbiosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation and application to treatment of the mechanism of intestinal regeneration dysfunction cased by high-fat diet intake and psychological stress ical stress and its application to treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification and prevention of novel mechanisms of cognitive impairment in patients with metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A preliminary therapeutic study of the effects of molecular hydrogen on intestinal dysbiosis and small intestinal injury in high-fat diet-loaded senescence-accelerated mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment with lysophosphatidic acid prevents microglial activation and depression-like behaviours in a murine model of neuropsychiatric systemic lupus erythematosus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells2020

Author(s)

Journal Title

Data Source

[Journal Article] Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of muscarinic acetylcholine receptor stimulation on the differentiation of mouse induced pluripotent stem cells into neural progenitor cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of small molecules that induce the degradation of Huntingtin.2017

Author(s)

Journal Title

Data Source

[Presentation] Effects of molecular hydrogen to age-related changes in T cell subsets and cytokine-producing capabilities on senescence-accelerated mouse fed with high fat and high sucrose diet2023

Author(s)

Organizer

Data Source

[Presentation] 腸内細菌叢および腸管組織に与える老化や高脂肪食摂取の影響とその制御2023

Author(s)

Organizer

Data Source

[Presentation] The ameliorating effects of molecular hydrogen on intestinal injury in high fat diet-loaded senescence-accelerated mouse2022

Author(s)

Organizer

Data Source

Takahashi Sayaka 高橋さやか

Nomura Sayaka 野村さやか