Yorozu Akira 萬顕

Researcher Number	20792120
Other IDs	https://orcid.org/0009-0008-1837-8542
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 札幌医科大学, 医学部, 訪問研究員 2019 – 2020: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator がん関連線維芽細胞 / 腫瘍微小環境 / がん間質 / ACLP / 腫瘍免疫 / がん微小環境 / 頭頸部がん / 微小環境 / がん線維芽細胞 / 頭頸部扁平上皮がん … More / 腫瘍微小免疫環境 / 細胞外基質 / 頭頚部がん / 癌関連線維芽細胞 / 腫瘍間質 / 扁平上皮癌 / CAF / AEBP1 / 癌間質 / 頭頚部癌 Less

Elucidation of Molecular Mechanisms in the Tumor Microenvironment of Head and Neck Cancer and Its Application to Cancer Immunotherapy.Principal Investigator
- Principal Investigator
  
  萬顕
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Elucidation of ACLP function in the head and neck cancer microenvironment and development of novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  Yorozu Akira
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Identification of tumor stroma-related genes in head and neck cancerPrincipal Investigator
- Principal Investigator
  
  Yorozu Akira
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.2023
- Author(s)
  Yoshido A, Sudo G, Takasawa A, Aoki H, Kitajima H, Yamamoto E, Niinuma T, Harada T, Kubo T, Sasaki H, Ishiguro K, Yorozu A, Kai M, Katanuma A, Yamano HO, Osanai M, Nakase H, Suzuki H.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 38 Issue: 2 Pages: 301-310
- DOI
  10.1111/jgh.16055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K07964, KAKENHI-PROJECT-21K15556, KAKENHI-PROJECT-21K16846, KAKENHI-PROJECT-22K16001, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-20K07662, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-23K06445, KAKENHI-PROJECT-23K07420
[Journal Article] CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma.2023
- Author(s)
  Yorozu A, Sekiguchi S, Takasawa A, Okazaki F, Niinuma T, Kitajima H, Yamamoto E, Kai M, Toyota M, Hatanaka Y, Nishiyama K, Ogi K, Dehari H, Obata K, Kurose M, Kondo A, Osanai M, Miyazaki A, Takano K, Suzuki H.
- Journal Title
  
  Cancer Med.
  
  Volume: 12 Issue: 5 Pages: 5953-5963
- DOI
  10.1002/cam4.5392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-21K16846, KAKENHI-PROJECT-22K17188, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-22K09687, KAKENHI-PROJECT-23K06445
[Journal Article] ACLP Activates Cancer-Associated Fibroblasts and Inhibits CD8+ T-Cell Infiltration in Oral Squamous Cell Carcinoma2023
- Author(s)
  Sekiguchi Shohei、Yorozu Akira、Okazaki Fumika、Niinuma Takeshi、Takasawa Akira、Yamamoto Eiichiro、Kitajima Hiroshi、Kubo Toshiyuki、Hatanaka Yui、Nishiyama Koyo、Ogi Kazuhiro、Kai Masahiro、Hirohashi Yoshihiko、Torigoe Toshihiko、Kojima Takashi、Osanai Makoto、Takano Kenichi、Miyazaki Akihiro、Suzuki Hiromu
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 17 Pages: 4303-4303
- DOI
  10.3390/cancers15174303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17188, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K09687, KAKENHI-PROJECT-23K06445, KAKENHI-PROJECT-21K16846, KAKENHI-PROJECT-23K24186
[Journal Article] DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes2021
- Author(s)
  Hatanaka Yui、Niinuma Takeshi、Kitajima Hiroshi、Nishiyama Koyo、Maruyama Reo、Ishiguro Kazuya、Toyota Mutsumi、Yamamoto Eiichiro、Kai Masahiro、Yorozu Akira、Sekiguchi Shohei、Ogi Kazuhiro、Dehari Hironari、Idogawa Masashi、Sasaki Yasushi、Tokino Takashi、Miyazaki Akihiro、Suzuki Hiromu
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 20438-20438
- DOI
  10.1038/s41598-021-99736-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19239, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-19K10337, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-21K07130, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-21K16846
[Journal Article] Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β‐serum amyloid A1 axis2021
- Author(s)
  Sudo Gota、Aoki Hironori、Yamamoto Eiichiro、Takasawa Akira、Niinuma Takeshi、Yoshido Ayano、Kitajima Hiroshi、Yorozu Akira、Kubo Toshiyuki、Harada Taku、Ishiguro Kazuya、Kai Masahiro、Katanuma Akio、Yamano Hiro‐o、Osanai Makoto、Nakase Hiroshi、Suzuki Hiromu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4151-4165
- DOI
  10.1111/cas.15080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08398, KAKENHI-PROJECT-20K17057, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-20K07662, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-21K16846
[Journal Article] Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer2020
- Author(s)
  Yorozu Akira、Yamamoto Eiichiro、Niinuma Takeshi、Tsuyada Akihiro、Maruyama Reo、Kitajima Hiroshi、Numata Yuto、Kai Masahiro、Sudo Gota、Kubo Toshiyuki、Nishidate Toshihiko、Okita Kenji、Takemasa Ichiro、Nakase Hiroshi、Sugai Tamotsu、Takano Kenichi、Suzuki Hiromu
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 5 Pages: 1631-1644
- DOI
  10.1111/cas.14360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-18K15325, KAKENHI-PROJECT-20K07412, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K18736
[Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells2019
- Author(s)
  Niinuma Takeshi、Kitajima Hiroshi、Kai Masahiro、Yamamoto Eiichiro、Yorozu Akira、Ishiguro Kazuya、Sasaki Hajime、Sudo Gota、Toyota Mutsumi、Hatahira Tomo、Maruyama Reo、Tokino Takashi、Nakase Hiroshi、Sugai Tamotsu、Suzuki Hiromu
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 11 Issue: 1 Pages: 70-70
- DOI
  10.1186/s13148-019-0668-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19K18736, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700
[Presentation] CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma2023
- Author(s)
  萬顕
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] AEBP1は骨格筋細胞分化の抑制因子である2022
- Author(s)
  岡崎史佳，関口翔平，萬顕，新沼猛，北嶋洋志，山本英一郎，甲斐正広，高野賢一，宮崎晃亘，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] 腫瘍間質のAEBP1は頭頚部扁平上皮がんの進展を促進する2022
- Author(s)
  関口翔平，萬顕，岡崎史佳，山本英一郎，新沼猛，高澤啓，須藤豪太，畠中柚衣，吉戸文乃，北嶋洋志，甲斐正広，小山内誠，廣橋良彦，小島隆，宮崎晃亘，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] 口腔扁平上皮がんの浸潤と腫瘍間質におけるCXCL12発現の関係について2022
- Author(s)
  萬顕，関口翔平，高澤啓，山本英一郎，新沼猛，北嶋洋志，甲斐正広，小山内誠，宮崎晃亘，高野賢一，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] 頭頸部扁平上皮がんの腫瘍微小環境におけるAEBP1の解析．2021
- Author(s)
  関口翔平，萬顕，山本英一郎，新沼猛，高澤啓，須藤豪太，小池和茂，畠中柚衣，吉戸文乃，北嶋洋志，甲斐正広，小山内誠，高野賢一，宮﨑晃亘，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] DLEU1はインターフェロン関連遺伝子の発現とヒストン修飾を制御し口腔扁平上皮癌の進行を促進する．2021
- Author(s)
  畠中柚衣，新沼猛，西山廣陽，北嶋洋志，山本英一郎，甲斐正広，萬顕，関口翔平，荻和弘，宮﨑晃亘，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] 新規頭頸部癌関連long non-coding RNAの同定と機能解析．2021
- Author(s)
  新沼猛，北嶋洋志，畠中柚衣，関口翔平，萬顕，久保俊之，佐々木基，原田拓，甲斐正広，仲瀬裕志，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16846
[Presentation] 頭頚部扁平上皮がんの微小環境におけるAEBP1の解析2020
- Author(s)
  14.萬顕，関口翔平，山本英一郎，新沼猛，高澤啓，須藤豪太，畠中柚衣，北嶋洋志，甲斐正広，小山内誠，宮崎晃亘，高野賢一，鈴木拓
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K18736
[Presentation] Analysis of AEBP1 in the microenvironment of head and neck squamous cell carcinoma.2019
- Author(s)
  2.Akira Yorozu, Makoto Kurose, Takashi Kojima, Kenichi Takano, Hiromu Suzuki.
- Organizer
  15th Japan-Taiwan Conference on Otolaryngory-Head and Neck Surgery.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18736
[Presentation] 大腸がんにおける腫瘍血管内皮関連遺伝子の同定．2019
- Author(s)
  20.萬顕，山本英一郎，須藤豪太，新沼猛，北嶋洋志，甲斐正広，高野賢一，鈴木拓．
- Organizer
  第120回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K18736
[Presentation] 頭頚部偏平上皮がんの微小環境におけるAEBP1の解析．2019
- Author(s)
  10.萬顕，山本英一郎，須藤豪太，沼田有斗，新沼猛，北嶋洋志，甲斐正広，小島隆，高野賢一，鈴木拓．
- Organizer
  第78回日本癌学会学術総会．
- Data Source
  KAKENHI-PROJECT-19K18736

1. 新沼猛 (60708113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 北嶋洋志 (90777971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 畠中柚衣

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 山本英一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 青木敬則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yorozu Akira 萬 顕

Research Projects

Research Products

Co-Researchers

Elucidation of Molecular Mechanisms in the Tumor Microenvironment of Head and Neck Cancer and Its Application to Cancer Immunotherapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of ACLP function in the head and neck cancer microenvironment and development of novel therapeutic strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of tumor stroma-related genes in head and neck cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ACLP Activates Cancer-Associated Fibroblasts and Inhibits CD8+ T-Cell Infiltration in Oral Squamous Cell Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β‐serum amyloid A1 axis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma2023

Author(s)

Organizer

Data Source

[Presentation] AEBP1は骨格筋細胞分化の抑制因子である2022

Author(s)

Organizer

Data Source

[Presentation] 腫瘍間質のAEBP1は頭頚部扁平上皮がんの進展を促進する2022

Author(s)

Organizer

Data Source

[Presentation] 口腔扁平上皮がんの浸潤と腫瘍間質におけるCXCL12発現の関係について2022

Author(s)

Organizer

Data Source

[Presentation] 頭頸部扁平上皮がんの腫瘍微小環境におけるAEBP1の解析．2021

Author(s)

Organizer

Data Source

[Presentation] DLEU1はインターフェロン関連遺伝子の発現とヒストン修飾を制御し口腔扁平上皮癌の進行を促進する．2021

Author(s)

Organizer

Yorozu Akira 萬顕