Niide Teppei 二井手哲平

Researcher Number	20802705
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院情報科学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院情報科学研究科, 助教 2023: 大阪大学, 情報科学研究科, 助教 2020 – 2021: 大阪大学, 情報科学研究科, 助教 2017 – 2019: 東北大学, 工学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related Except Principal Investigator Broad Section D / Medium-sized Section 62:Applied informatics and related fields / Biofunction/Bioprocess
Keywords	Principal Investigator タンパク質工学 / 計算科学 / 酵素工学 / ファージ提示法 / ナノ材料 / バイオインフォマティクス / 酵素 / 進化学 / 進化 / 合理的酵素設計 … More / ドッキングシミュレーション / 構造モデリング / シミュレーション / 耐熱化 / 機械学習 / 酵素設計 / ナノ界面 / データベース / 指向性進化 / タンパク質設計 / 分子標的薬 / 低分子医薬 / ファージディスプレイ / 抗体 / 自己組織化 / タンパク質 / 大規模セレクション / 酵母表層提示法 / ペプチド移植 / 抗体工学 … More Except Principal Investigator バイオものづくり / 育種 / 代謝解析 / 気相反応 / 微生物 / 代謝フラックス / 光合成 / 変動光 / 代謝フラックス解析 / シミュレーション / 酵素反応 / 生物・生体工学 / ナノ材料 / ナノ粒子 / 酵素 / 生体分子 Less

In-cell enzyme optimization cycle with evolutionary information and CRISPR base editorPrincipal Investigator
- Principal Investigator
  
  二井手哲平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Osaka University
A Study of Science and Process Construction of Microbial Gas-phase Reaction
- Principal Investigator
  
  堀克敏
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section D
- Research Institution
  Nagoya University
進化情報を構造シミュレーションに組み入れた合理的酵素設計とそのプロセス化Principal Investigator
- Principal Investigator
  
  二井手哲平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Osaka University
Systems analysis of photosynthesis and metabolism of cyanobacteria under fluctuation light condition
- Principal Investigator
  
  Shimizu Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  Osaka University
Requirment driven protein design for nano targeting drug productionPrincipal Investigator
- Principal Investigator
  
  Niide Teppei
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Osaka University
Bottom-up design of anti-material bispecific antibodies for the formation of hetero-nanocomposite materialsPrincipal Investigator
- Principal Investigator
  
  Niide Teppei
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Osaka University
  Tohoku University
Application of hybrid nano-assembly for in-vitro synthetic biology tool
- Principal Investigator
  
  Umetsu Mitsuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] 材料表面を認識するペプチド・タンパク質から発想するハイブリッドナノアセンブリ2022
- Author(s)
  梅津光央、中澤光、二井手哲平
- Journal Title
  
  バイオインダストリー
  
  Volume: 39 Pages: 27-34
- Data Source
  KAKENHI-PROJECT-20K15096
[Journal Article] Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties2022
- Author(s)
  Sugiki Sou、Niide Teppei、Toya Yoshihiro、Shimizu Hiroshi
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 11 Issue: 12 Pages: 3973-3985
- DOI
  10.1021/acssynbio.2c00315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04841, KAKENHI-PROJECT-19H05626
[Journal Article] Acceleration of target production in co‐culture by enhancing intermediate consumption through adaptive laboratory evolution2021
- Author(s)
  Kawai Ryutaro、Toya Yoshihiro、Miyoshi Kenta、Murakami Manami、Niide Teppei、Horinouchi Takaaki、Maeda Tomoya、Shibai Atsushi、Furusawa Chikara、Shimizu Hiroshi
- Journal Title
  
  Biotechnology and Bioengineering
  
  Volume: 119 Issue: 3 Pages: 936-945
- DOI
  10.1002/bit.28007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15096, KAKENHI-PROJECT-19H05626
[Journal Article] Association behavior and control of the quality of cancer therapeutic bispecific diabodies expressed in Escherichia coli2020
- Author(s)
  Hikaru Nakazawa, Tomoko Onodera-Sugano, Aruto Sugiyama, Yoshikazu Tanaka, Takamitsu Hattori, Teppei Niide, Hiromi Ogata, Ryutaro Asano, Izumi Kumagai, Mitsuo Umetsu
- Journal Title
  
  Biochemical Engineering Journal
  
  Volume: 160 Pages: 1-9
- DOI
  10.1016/j.bej.2020.107636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04842, KAKENHI-PROJECT-18K14059, KAKENHI-PROJECT-19H03511, KAKENHI-PROJECT-20H02534, KAKENHI-PROJECT-19H02831, KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-20H00315
[Journal Article] Complementary Design for Pairing between Two Types of Nanoparticles Mediated by a Bispecific Antibody: Bottom-Up Formation of Porous Materials from Nanoparticles2019
- Author(s)
  Niide Teppei、Manabe Noriyoshi、Nakazawa Hikaru、Akagi Kazuto、Hattori Takamitsu、Kumagai Izumi、Umetsu Mitsuo
- Journal Title
  
  Langmuir
  
  Volume: 35 Issue: 8 Pages: 3067-3076
- DOI
  10.1021/acs.langmuir.8b03687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04842, KAKENHI-PROJECT-18K14059, KAKENHI-PROJECT-16K18296
[Journal Article] Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins2018
- Author(s)
  Saito Yutaka、Oikawa Misaki、Nakazawa Hikaru、Niide Teppei、Kameda Tomoshi、Tsuda Koji、Umetsu Mitsuo
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 7 Issue: 9 Pages: 2014-2022
- DOI
  10.1021/acssynbio.8b00155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04842, KAKENHI-PLANNED-17H06410, KAKENHI-PROJECT-16H04570, KAKENHI-PROJECT-16K18296
[Journal Article] Compact seahorse-shaped T cell-activating antibody for cancer therapy2018
- Author(s)
  Hiroto Fujii, Yoshikazu Tanaka, Hikaru Nakazawa, Aruto Sugiyama, Noriyoshi Manabe, Akira Shinoda, Nobutaka Shimizu, Takamitsu Hattori, Katsuhiro Hosokawa, Takuma Sujino, Tomoyuki Ito, Teppei Niide, Ryutaro Asano, Izumi Kumagai, and Mitsuo Umetsu
- Journal Title
  
  Advanced Therapeutics
  
  Volume: 1700031 Issue: 3 Pages: 1-10
- DOI
  10.1002/adtp.201700031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04570, KAKENHI-PROJECT-15KK0248, KAKENHI-PUBLICLY-16H00748
[Journal Article] Photosynthesis of colloidal Ag-AgCl nanoparticles mediated by Tilia sp. leachate, evaluation of their behaviour in liquid phase and catalytic properties2018
- Author(s)
  Zuzana Konvickova, Veronika sova, Marek Kolencik, Teppei Niide, Gabriela Kratosova, Mitsuo Umetsu, and Jana Seidlerova
- Journal Title
  
  Colloid and Polymer Science
  
  Volume: 296 Issue: 4 Pages: 677-687
- DOI
  10.1007/s00396-018-4290-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04570, KAKENHI-PROJECT-16K14483
[Journal Article] High-throughput cytotoxicity and antigen-binding assay for screening small bispecific antibodies without purification2018
- Author(s)
  Sugiyama Aruto、Umetsu Mitsuo、Nakazawa Hikaru、Niide Teppei、Asano Ryutaro、Hattori Takamitsu、Kumagai Izumi
- Journal Title
  
  JBB
  
  Volume: - Issue: 2 Pages: 31237-31239
- DOI
  10.1016/j.jbiosc.2018.02.007
- NAID
  40021645320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18296, KAKENHI-PROJECT-16J04866, KAKENHI-PROJECT-16H04570, KAKENHI-PROJECT-16K14483
[Journal Article] A semi high-throughput method for screening small bispecific antibodies with high cytotoxicity2017
- Author(s)
  Sugiyama Aruto、Umetsu Mitsuo、Nakazawa Hikaru、Niide Teppei、Onodera Tomoko、Hosokawa Katsuhiro、Hattori Shuhei、Asano Ryutaro、Kumagai Izumi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 2862-2873
- DOI
  10.1038/s41598-017-03101-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18296, KAKENHI-PROJECT-16H04570, KAKENHI-PROJECT-16K14483
[Journal Article] 親和性ペプチド分子による有機結晶の構造制御と生体分子-半導体有機結晶ハイブリッド材料作製プロセスの開発2017
- Author(s)
  二井手哲平, 中澤光, 梅津光央
- Journal Title
  
  ケミカルエンジニヤリング
  
  Volume: 62 Pages: 23-27
- Data Source
  KAKENHI-PROJECT-16H04570
[Patent] 難水溶性薬物の複合体及びその製造方法2020
- Inventor(s)
  二井手哲平, 梅津光央, 中澤光
- Industrial Property Rights Holder
  二井手哲平, 梅津光央, 中澤光
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K14059
[Presentation] バイオモノづくりにおけるデータ駆動酵素工学2024
- Author(s)
  二井手哲平
- Organizer
  応用物理学会 M&BE未来技術研究会 2024
- Invited
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 進化と構造の情報を組み込んだ酵素の耐熱化デザイン2023
- Author(s)
  宮脇佳汰, 二井手哲平, 戸谷吉博, 清水浩
- Organizer
  第75回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 機械学習を活用した酵素の分子認識特性の変換2023
- Author(s)
  二井手哲平, 杉木創, 森聖也, 戸谷吉博, 清水浩
- Organizer
  化学工学会第54回秋季大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] Machine learning-guided cofactor specificity conversion of a malic enzyme using sequence datasets divided by catalytic properties2023
- Author(s)
  Teppei Niide, Sou Sugiki, Yoshihiro Toya, Hiroshi Shimizu
- Organizer
  Metabolic Engineering 15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 機械学習を用いた代謝酵素の基質特異性決定残基の推定と変換2023
- Author(s)
  森聖也, 二井手哲平, 戸谷吉博, 清水浩
- Organizer
  第75回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 酵素の基質特異性決定残基の同定におけるロジスティック回帰モデルの有用性2023
- Author(s)
  二井手哲平、杉木創、森聖也、戸谷吉博、清水浩
- Organizer
  第75回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 異種生物由来酵素の発現量向上を目指した酵素設計プロセス開発2022
- Author(s)
  宮脇佳汰, 二井手哲平, 戸谷吉博, 清水浩
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] タンパク質の構造保存性と合理的機能設計2022
- Author(s)
  二井手哲平
- Organizer
  酵素工学研究会第87回講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] M13ファージのライフサイクルを活用したS-Allyl-L-cysteine生合成経路の最適化2022
- Author(s)
  松本拓也, 二井手哲平, 戸谷吉博, 清水浩
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] リンゴ酸酵素の補酵素特異性変換を先導する機械学習手法の提案2022
- Author(s)
  杉木創, 二井手哲平, 戸谷吉博, 清水浩
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 補酵素特異性改変を目指した合理的酵素設計プロセスの開発2022
- Author(s)
  宮脇佳汰、二井手哲平、戸谷吉博、清水浩
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-20K15096
[Presentation] 配列保存度情報を組み入れた酵素工学2022
- Author(s)
  二井手哲平, 杉木創, 宮脇佳汰, 戸谷吉博, 清水浩
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 配列保存度情報と構造モデリングを活用した酵素の耐熱化戦略の提案2022
- Author(s)
  二井手哲平, 戸谷吉博, 清水浩
- Organizer
  化学工学会第53回秋季大会
- Data Source
  KAKENHI-PROJECT-22K04841
[Presentation] 機械学習を活用したリンゴ酸酵素の補酵素特異性変換2022
- Author(s)
  杉木創、二井手哲平、戸谷吉博、清水浩
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-20K15096
[Presentation] 免疫細胞の活性機能調節を目指したin silicoタンパク質設計2021
- Author(s)
  二井手哲平、スィーカーデイビッド、クールマンブライアン
- Organizer
  化学工学会第86年会
- Data Source
  KAKENHI-PROJECT-18K14059
[Presentation] Rationally Designing Active Ga Protein Inhibitors for Signal Transduction Regulation2020
- Author(s)
  Teppei NIide, David Thieker, Matthew Cummins, Brian Kuhlman
- Organizer
  Winter RosettaCON
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14059
[Presentation] Machine-learning-guided mutagenesis platform for desired evolution: in the case of Fluorescent protein?2018
- Author(s)
  Misaki Oikawa,　Yutaka Saito,　Tomoshi Kameda,　Hikaru Nakazawa,　Teppei Niide,　Koji Tsuda,　 Mitsuo Umetsu
- Organizer
  10th Annual PEGS Summit, Protein&Antibody Engineering Summit
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04570
[Presentation] AIはタンパク質進化を導くか？：機械学習支援によるGFPのYFP化検証2018
- Author(s)
  及川未早来, 二井手哲平, 中澤光, 亀田倫史,津田宏治,斉藤裕, 梅津光央
- Organizer
  第70回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-16H04570
[Presentation] AIを利用したスマートホットライブラリーデザイン：AIはGFPをYFP化できるか？2018
- Author(s)
  及川未早来, 二井手哲平, 中澤光, 亀田倫史,津田宏治,斉藤裕, 梅津光央
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04570
[Presentation] 機械学習へ向けた迅速な変異体群の作製と機能評価プロセスの開発2017
- Author(s)
  及川未早来、中澤光、二井手哲平、亀田倫史、斎藤裕、津田浩二、梅津光央
- Organizer
  バイオ工学シンポジウム
- Data Source
  KAKENHI-PROJECT-16H04570

1. Shimizu Hiroshi (00226250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 戸谷吉博 (70582162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Umetsu Mitsuo (70333846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 高見誠一 (40311550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 中澤光 (40584991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 堀克敏 (50302956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉本将悟 (90806291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 津川裕司 (30647235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Niide Teppei 二井手 哲平

Research Projects

Research Products

Co-Researchers

In-cell enzyme optimization cycle with evolutionary information and CRISPR base editorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A Study of Science and Process Construction of Microbial Gas-phase Reaction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

進化情報を構造シミュレーションに組み入れた合理的酵素設計とそのプロセス化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Systems analysis of photosynthesis and metabolism of cyanobacteria under fluctuation light condition

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Requirment driven protein design for nano targeting drug productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bottom-up design of anti-material bispecific antibodies for the formation of hetero-nanocomposite materialsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Application of hybrid nano-assembly for in-vitro synthetic biology tool

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 材料表面を認識するペプチド・タンパク質から発想するハイブリッドナノアセンブリ2022

Author(s)

Journal Title

Data Source

[Journal Article] Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acceleration of target production in co‐culture by enhancing intermediate consumption through adaptive laboratory evolution2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association behavior and control of the quality of cancer therapeutic bispecific diabodies expressed in Escherichia coli2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complementary Design for Pairing between Two Types of Nanoparticles Mediated by a Bispecific Antibody: Bottom-Up Formation of Porous Materials from Nanoparticles2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Compact seahorse-shaped T cell-activating antibody for cancer therapy2018

Author(s)

Journal Title

DOI

Data Source

Niide Teppei 二井手哲平