Miyamoto Takaaki 宮本昂明

Researcher Number	20804040
Other IDs	https://orcid.org/0000-0002-8192-9342
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 2019 – 2021: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 28040:Nanobioscience-related
Keywords	Principal Investigator DNA送達 / ナノミセル / 細胞壁 / 双性型イオン液体 / 遺伝子導入 / 双性イオン型ペプチド / 植物バイオ / オルガネラゲノム改変 / 二重刺激応答型ナノミセル / ペプチド … More / 葉緑体 / 葉緑体移行シグナル / 葉緑体改変 / ストレス / 植物細胞壁 / 遺伝子送達 / 葉緑体ゲノム改変 / 抗酸化ペプチド / 活性酸素種 / 葉緑体移行ペプチド / ミトコンドリア移行ペプチド / 細胞膜透過ペプチド / 植物 / 二重修飾ミセル / エンドソーム脱出 / 遺伝子送達ペプチド / エンドソーム脱出ナノミセル / 植物オルガネラ / エンドソーム脱出ミセル / ペプチド提示型ミセル / エンドソーム不安定化ペプチド / 膜透過ペプチド / 植物オルガネラ改変 Less

Dual stimuli-responsive micelle complexes for organelle-targeted DNA release in plantsPrincipal Investigator
- Principal Investigator
  
  宮本昂明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Institute of Physical and Chemical Research
Cell wall-loosening agents and DNA-transporting nanomicelles for efficient gene delivery to plant chloroplastsPrincipal Investigator
- Principal Investigator
  
  Miyamoto Takaaki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Institute of Physical and Chemical Research
Micelle complexes displaying multiple functional peptides for efficient DNA delivery to plant mitochondriaPrincipal Investigator
- Principal Investigator
  
  Miyamoto Takaaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Phenylboronic Acid-Functionalized Micelles Dual-Targeting Boronic Acid Transporter and Polysaccharides for siRNA Delivery into Brown Algae2024
- Author(s)
  Yoshinaga Naoto、Miyamoto Takaaki、Goto Mami、Tanaka Atsuko、Numata Keiji
- Journal Title
  
  JACS Au
  
  Volume: 4 Issue: 4 Pages: 1385-1395
- DOI
  10.1021/jacsau.3c00767
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14575
[Journal Article] Organelle-targeted gene delivery in plants by nanomaterials2023
- Author(s)
  Law Simon Sau Yin、Miyamoto Takaaki、Numata Keiji
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 47 Pages: 7166-7181
- DOI
  10.1039/d3cc00962a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14575
[Journal Article] Advancing Biomolecule Delivery in Plants: Harnessing Synthetic Nanocarriers to Overcome Multiscale Barriers for Cutting-Edge Plant Bioengineering2023
- Author(s)
  Miyamoto Takaaki、Numata Keiji
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: 96 Issue: 9 Pages: 1026-1044
- DOI
  10.1246/bcsj.20230147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14575, KAKENHI-PROJECT-22H04975
[Journal Article] Design of an Artificial Peptide Inspired by Transmembrane Mitochondrial Protein for Escorting Exogenous DNA into the Mitochondria to Restore their Functions by Simultaneous Multiple Gene Expression2023
- Author(s)
  Yoshinaga Naoto、Miyamoto Takaaki、Odahara Masaki、Takeda‐Kamiya Noriko、Toyooka Kiminori、Nara Seia、Nishimura Haruna、Ling Feng、Su'etsugu Masayuki、Yoshida Minoru、Numata Keiji
- Journal Title
  
  Advanced Functional Materials
  
  Volume: 34 Issue: 8 Pages: 2306070-2306070
- DOI
  10.1002/adfm.202306070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14575, KAKENHI-PLANNED-23H04882, KAKENHI-PROJECT-22H04975, KAKENHI-PROJECT-23H05473
[Journal Article] Plant Mitochondrial-Targeted Gene Delivery by Peptide/DNA Micelles Quantitatively Surface-Modified with Mitochondrial Targeting and Membrane-Penetrating Peptides2023
- Author(s)
  Abe Naoya、Fujita Seiya、Miyamoto Takaaki、Tsuchiya Kousuke、Numata Keiji
- Journal Title
  
  Biomacromolecules
  
  Volume: 24 Issue: 8 Pages: 3657-3665
- DOI
  10.1021/acs.biomac.3c00391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14575
[Journal Article] Relaxation of the Plant Cell Wall Barrier via Zwitterionic Liquid Pretreatment for Micelle‐Complex‐Mediated DNA Delivery to Specific Plant Organelles2022
- Author(s)
  Miyamoto Takaaki、Tsuchiya Kousuke、Toyooka Kiminori、Goto Yumi、Tateishi Ayaka、Numata Keiji
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 32
- DOI
  10.1002/anie.202204234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14575, KAKENHI-PROJECT-20K05636
[Journal Article] A Synthetic Multidomain Peptide That Drives a Macropinocytosis-Like Mechanism for Cytosolic Transport of Exogenous Proteins into Plants2022
- Author(s)
  Miyamoto Takaaki、Toyooka Kiminori、Chuah Jo-Ann、Odahara Masaki、Higchi-Takeuchi Mieko、Goto Yumi、Motoda Yoko、Kigawa Takanori、Kodama Yutaka、Numata Keiji
- Journal Title
  
  JACS Au
  
  Volume: 2 Issue: 1 Pages: 223-233
- DOI
  10.1021/jacsau.1c00504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15411
[Journal Article] Endosome-escaping micelle complexes dually equipped with cell-penetrating and endosome-disrupting peptides for efficient DNA delivery into intact plants2021
- Author(s)
  Miyamoto Takaaki、Tsuchiya Kousuke、Numata Keiji
- Journal Title
  
  Nanoscale
  
  Volume: 13 Issue: 11 Pages: 5679-5692
- DOI
  10.1039/d0nr08183c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15411, KAKENHI-PLANNED-20H05735
[Journal Article] Fusion Peptide-Based Biomacromolecule Delivery System for Plant Cells2021
- Author(s)
  Watanabe Kenta、Odahara Masaki、Miyamoto Takaaki、Numata Keiji
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 7 Issue: 6 Pages: 2246-2254
- DOI
  10.1021/acsbiomaterials.1c00227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22405, KAKENHI-PROJECT-19K15411
[Journal Article] Dual peptide-based gene delivery system for the efficient transfection of plant callus cells2020
- Author(s)
  Miyamoto Takaaki、Tsuchiya Kousuke、Numata Keiji
- Journal Title
  
  Biomacromolecules
  
  Volume: － Issue: 7 Pages: 2735-2744
- DOI
  10.1021/acs.biomac.0c00481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15411
[Journal Article] Peptide-Mediated Gene Transfer into Marine Purple Photosynthetic Bacteria2020
- Author(s)
  Higuchi-Takeuchi Mieko、Miyamoto Takaaki、Foong Choon Pin、Goto Mami、Morisaki Kumiko、Numata Keiji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 22 Pages: 8625-8625
- DOI
  10.3390/ijms21228625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15411
[Journal Article] Zwitterionic Polypeptides: Chemoenzymatic Synthesis and Loosening Function for Cellulose Crystals2020
- Author(s)
  Tsuchiya Kousuke、Yilmaz Neval、Miyamoto Takaaki、Masunaga Hiroyasu、Numata Keiji
- Journal Title
  
  Biomacromolecules
  
  Volume: 21 Issue: 5 Pages: 1785-1794
- DOI
  10.1021/acs.biomac.9b01700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15411, KAKENHI-PROJECT-20K05636
[Patent] バイオマス材料処理剤およびバイオマス材料の処理方法2020
- Inventor(s)
  沼田圭司，土屋康佑，宮本昂明
- Industrial Property Rights Holder
  国立研究開発法人理化学研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-049180
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K15411
[Patent] Polypeptide comprising cell-penetrating sequence and composition comprising same2020
- Inventor(s)
  沼田圭司，土屋康佑，宮本昂明
- Industrial Property Rights Holder
  国立研究開発法人理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K15411
[Patent] 標的細胞への物質の導入法2019
- Inventor(s)
  沼田圭司，宮本昂明，他4名
- Industrial Property Rights Holder
  国立研究開発法人理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] Peptide-mediated DNA delivery to target organelles in plants: Strategies to overcome plant cellular barriers2024
- Author(s)
  Takaaki Miyamoto & Keiji Numata
- Organizer
  S-FISNA~NIH~&~NSF~
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] Peptide-mediated intracellular cargo delivery for plant biomodification2023
- Author(s)
  Takaaki Miyamoto & Keiji Numata
- Organizer
  第72回高分子年次大会、日台ジョイントセッション
- Invited
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] 植物の葉緑体で活性酸素種を消去するペプチドを利用した強光ストレス下での光合成機能の保護2023
- Author(s)
  宮本昂明、沼田圭司
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] Designed antioxidant peptides with cell permeability, chloroplast targeting and ROS scavenging capabilities for plant protection under abiotic stress conditions2023
- Author(s)
  Takaaki Miyamoto, Keiji Numata.
- Organizer
  2023 Gordon Research Conference on Chloroplast Biotechnology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] 植物の形質改変を目指した高機能ペプチド材料の開発とマテリアルDXの融合に向けた展開2023
- Author(s)
  宮本昂明、沼田圭司
- Organizer
  DxMT 若手WORKSHOP OSAKA 2023
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] ペプチドによる植物への核酸導入2022
- Author(s)
  宮本昂明、沼田圭司
- Organizer
  FIBER核酸化学ユニバース13 (FIBER FUTURE COLLEGE91)
- Invited
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] 核酸を内包するペプチド提示ミセルと細胞壁を緩める双性型イオン液体を組み合わせた植物オルガネラへのDNA送達2022
- Author(s)
  宮本昂明、沼田圭司
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] 植物細胞のバリアを克服するペプチドの設計と核酸・タンパク質デリバリーへの応用2022
- Author(s)
  宮本昂明、沼田圭司
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] ペプチド提示型ミセルと細胞壁の透過性を向上させる双性型イオン液体を利用した植物葉緑体への核酸導入2022
- Author(s)
  宮本昂明、沼田圭司
- Organizer
  第32回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-22K14575
[Presentation] マクロピノサイトーシス様の取り込み機構を誘起する人工ペプチドを利用した植物へのタンパク質デリバリー2021
- Author(s)
  宮本昂明、豊岡公徳、後藤友美、児玉豊、沼田圭司
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] エンドソーム脱出能を付与したペプチド修飾ミセルによる植物への核酸導入2020
- Author(s)
  宮本昂明，土屋康佑，沼田圭司
- Organizer
  第30回バイオ・高分子シンポジウム, 2, web開催, 2020年7月
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] Micelles dually modified with cell-penetrating and endosome-disrupting peptides for efficient endosomal escape and gene delivery to plants2020
- Author(s)
  宮本昂明，土屋康佑，沼田圭司
- Organizer
  第69回高分子討論会, 1ESB09, web開催, 2020年9月
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] Micelles postmodified with cell penetrating peptides for efficient gene delivery in plants2019
- Author(s)
  Takaaki Miyamoto, Kousuke Tsuchiya, Keiji Numata
- Organizer
  258th ACS National Meeting, PMSE 509, San Diego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] 細胞膜透過ペプチドとエンドソーム不安定化ペプチドを修飾したミセルによる植物への遺伝子導入2019
- Author(s)
  宮本昂明，土屋康佑，沼田圭司
- Organizer
  第68回高分子討論会, 3N12, 福井
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] マクロピノサイトーシス誘起ペプチドと核酸運搬ペプチドを組み合わせた植物カルスへの効率的な遺伝子導入2019
- Author(s)
  宮本昂明，土屋康佑，沼田圭司
- Organizer
  第68回高分子年次大会, 3M20, 大阪
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] 細胞膜透過ペプチドから成るイオン性複合体を用いた植物への遺伝子導入およびマクロピノサイトーシス誘起ペプチドの協調効果2019
- Author(s)
  宮本昂明，土屋康佑，沼田圭司
- Organizer
  第28回バイオ・高分子シンポジウム, O4, 大岡山
- Data Source
  KAKENHI-PROJECT-19K15411
[Presentation] 複数種の機能性ペプチドを提示したイオン性複合体による植物への遺伝子導入2019
- Author(s)
  宮本昂明，土屋康佑，沼田圭司
- Organizer
  第13回バイオ関連化学シンポジウム, 2A-22, 仙台
- Data Source
  KAKENHI-PROJECT-19K15411

1. 小田原真樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyamoto Takaaki 宮本 昂明

Research Projects

Research Products

Co-Researchers

Dual stimuli-responsive micelle complexes for organelle-targeted DNA release in plantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell wall-loosening agents and DNA-transporting nanomicelles for efficient gene delivery to plant chloroplastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Micelle complexes displaying multiple functional peptides for efficient DNA delivery to plant mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Phenylboronic Acid-Functionalized Micelles Dual-Targeting Boronic Acid Transporter and Polysaccharides for siRNA Delivery into Brown Algae2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organelle-targeted gene delivery in plants by nanomaterials2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Advancing Biomolecule Delivery in Plants: Harnessing Synthetic Nanocarriers to Overcome Multiscale Barriers for Cutting-Edge Plant Bioengineering2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design of an Artificial Peptide Inspired by Transmembrane Mitochondrial Protein for Escorting Exogenous DNA into the Mitochondria to Restore their Functions by Simultaneous Multiple Gene Expression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plant Mitochondrial-Targeted Gene Delivery by Peptide/DNA Micelles Quantitatively Surface-Modified with Mitochondrial Targeting and Membrane-Penetrating Peptides2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relaxation of the Plant Cell Wall Barrier via Zwitterionic Liquid Pretreatment for Micelle‐Complex‐Mediated DNA Delivery to Specific Plant Organelles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Synthetic Multidomain Peptide That Drives a Macropinocytosis-Like Mechanism for Cytosolic Transport of Exogenous Proteins into Plants2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endosome-escaping micelle complexes dually equipped with cell-penetrating and endosome-disrupting peptides for efficient DNA delivery into intact plants2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fusion Peptide-Based Biomacromolecule Delivery System for Plant Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual peptide-based gene delivery system for the efficient transfection of plant callus cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peptide-Mediated Gene Transfer into Marine Purple Photosynthetic Bacteria2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zwitterionic Polypeptides: Chemoenzymatic Synthesis and Loosening Function for Cellulose Crystals2020

Author(s)

Journal Title

Miyamoto Takaaki 宮本昂明

[Presentation] ペプチド提示型ミセルと細胞壁の透過性を向上させる双性型イオン液体を利用した植物葉緑体への核酸導入2022