KIMISHIMA Atsushi 君嶋敦

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Kimishima Atsushi 君嶋敦

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Researcher Number	20812134
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院薬学研究科, 特任助教(常勤) 2022 – 2023: 大阪大学, 大学院薬学研究科, 特任助教(常勤) 2020 – 2021: 大阪大学, 薬学研究科, 特任助教(常勤) 2018 – 2020: 大阪大学, 薬学研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Keywords	Principal Investigator 脱芳香環化 / 構造活性相関 / 天然物合成 / 酸化反応 / 連続反応 / DC1149B / 真菌 / 全合成 / がん微小環境 / 酸化的脱芳香環化 … More / 網羅的合成 / フロー合成 / 低栄養環境 / ジチオジケトピペラジン / Trichoderma lixii / 脱芳香族化 / シリルテザー / 抗菌活性 / 低酸素環境 / 酸化的環化反応 / 酸化的カップリング反応 / 天然物化学 / 潜在性結核菌 / 二量化反応 / グルコース飢餓環境選択的 / 一重項酸素 / 増殖阻害活性 / 天然物 / トリコデルマミド … More Except Principal Investigator 創薬標的 / 生物活性 / 標的分子 / 海洋天然物 Less

酸化的炭素骨格構築を基盤とする生物活性ピロロインドール類の創製Principal Investigator
- Principal Investigator
  
  君嶋敦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Osaka
酸化駆動型連続反応を基盤とした低栄養環境応答型分子の創出Principal Investigator
- Principal Investigator
  
  君嶋敦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Osaka University
Study towards development of anti-latent tuberculosis pyrroloindolesPrincipal Investigator
- Principal Investigator
  
  Kimishima Atsushi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Osaka University
Research toward the development of microenvironment-responsive epidithiodiketopiperazinesPrincipal Investigator
- Principal Investigator
  
  Kimishima Atsushi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Osaka University
Creation of new drug targets based on marine natural products
- Principal Investigator
  
  ARAI MASAYOSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.2024
- Author(s)
  Honma Sota、 Kimishima Aoi、 Kimishima Atsushi、 Honsho Masako、 Kojima Hiroki、Tokiwa Toshiyuki、Nishitomi Atsuka、Kato Satoshi、Kondo Naozumi、Araki Yasuko、TAKAHASHI Tadashi、Chinen Takumi、USUI Takeo、Fuji Shin-ichi、ITO Kotaro、Asami Yukihiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06526
[Journal Article] Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite2024
- Author(s)
  Hori Sho、Taniguchi Hikari、Yoshimura Sota、Takeda Kanako、Yamashita Ryusei、Kimishima Atsushi、Harada Kazuo
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 4 Pages: 393-398
- DOI
  10.1248/cpb.c24-00050
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-04-19
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06526, KAKENHI-PROJECT-23K21354
[Journal Article] Cytotoxic activity of cordycepin produced by marine-derived fungus Emericella sp. against HT29 human colon cancer cell lines2023
- Author(s)
  Julianti Elin、Azhari Muhammad、Singgih Marlia、Aminah Fitri Siti Dzurriyyah、Putra Masteria Yunovilsa、Lin Jianyu、Kimishima Atsushi、Arai Masayoshi
- Journal Title
  
  Archives of Microbiology
  
  Volume: 205 Issue: 12 Pages: 378-378
- DOI
  10.1007/s00203-023-03706-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06526
[Journal Article] Single-step construction of an acetoxypyrroloindole skeleton via tandem iodocyclization/acetoxylation of indoles2022
- Author(s)
  Atsushi Kimishima, Hiroki Kato, Keijin Nakaguro, Masayoshi Arai
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 27 Pages: 5397-5397
- DOI
  10.1039/d2ob01001a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06526, KAKENHI-PROJECT-23K21156
[Journal Article] Single-step construction of an acetoxypyrroloindole skeleton via a tandem iodocyclization/acetoxylation of indoles2022
- Author(s)
  Atsushi Kimishima, Hiroki Kato, Keijin Nakaguro, Masayoshi Arai
- Journal Title
  
  －
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15956
[Journal Article] Asymmetric Formal Synthesis of Trichodermamides B and C2021
- Author(s)
  Atsushi Kimishima, Hayato Saito, Violeta Petrova, Masayoshi Arai
- Journal Title
  
  Synlett
  
  Volume: 32 Issue: 18 Pages: 1865-1868
- DOI
  10.1055/s-0040-1720383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15956, KAKENHI-PROJECT-23K21156
[Journal Article] Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation2020
- Author(s)
  Tang Rui、Zhou Dongyi、Kimishima Atsushi、Setiawan Andi、Arai Masayoshi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 73 Issue: 12 Pages: 873-875
- DOI
  10.1038/s41429-020-0340-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02096
[Journal Article] A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines2020
- Author(s)
  Kimishima Atsushi、Saito Hayato、Yamaguchi Ayuta、Arai Masayoshi
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 61 Issue: 4 Pages: 151412-151412
- DOI
  10.1016/j.tetlet.2019.151412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14867, KAKENHI-PROJECT-18H02096
[Journal Article] Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.2020
- Author(s)
  Abdel-Naime Waleed A、Kimishima Atsushi、Setiawan Andi、Fahim John Refaat、Fouad Mostafa A.、Kamel Mohamed Salah、Arai Masayoshi
- Journal Title
  
  Marine Drugs
  
  Volume: 18 Issue: 11 Pages: 555-555
- DOI
  10.3390/md18110555
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02096
[Journal Article] Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain2020
- Author(s)
  Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 6
- DOI
  10.1172/jci.insight.133348
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05363, KAKENHI-PROJECT-18K19399, KAKENHI-PUBLICLY-18H05132, KAKENHI-PUBLICLY-19H05217, KAKENHI-PROJECT-17H02800, KAKENHI-PROJECT-17K19488, KAKENHI-PLANNED-18H05416, KAKENHI-PROJECT-17H03989, KAKENHI-PROJECT-17H05054, KAKENHI-PROJECT-20H00492, KAKENHI-PROJECT-18H02096
[Journal Article] Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation2020
- Author(s)
  Tang Rui、Kimishima Atsushi、Setiawan Andi、Arai Masayoshi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 74 Issue: 2 Pages: 495-500
- DOI
  10.1007/s11418-020-01390-0
- NAID
  40022183716
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04645, KAKENHI-PROJECT-18H02096
[Journal Article] Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation2019
- Author(s)
  Tang Rui、Kimishima Atsushi、Ishida Ryosuke、Setiawan Andi、Arai Masayoshi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 74 Issue: 1 Pages: 153-158
- DOI
  10.1007/s11418-019-01357-w
- NAID
  40022130204
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04645, KAKENHI-PROJECT-18K14867
[Presentation] Trichodermamide Eの合成と構造訂正2023
- Author(s)
  ○君嶋敦、永田怜、竹下悠仁、荒井雅吉
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06526
[Presentation] 酸化的アセトキシ環化反応を用いたprotubonine AおよびBの不斉合成2023
- Author(s)
  君嶋敦、○加藤大樹、中畔慶人、荒井雅吉
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06526
[Presentation] 脱芳香環化を駆動力とする二量体ピロロインドールの合成2023
- Author(s)
  君嶋敦
- Organizer
  第2回有機合成を基盤とした自由な天然物若手勉強会
- Data Source
  KAKENHI-PROJECT-22K06526
[Presentation] 標的分子同定を指向した3-(phenethylamino)dimethyl(oxy)aaptamineプローブ分子の合成および機能評価2023
- Author(s)
  松崎倫久、君嶋敦、嶋田裕介、堀之内里玖、中村健彦、古徳直之、荒井雅吉
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-22K06526
[Presentation] 脱芳香環化を基盤とする天然物の効率的合成2022
- Author(s)
  ○君嶋敦
- Organizer
  第9回食品薬学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06526
[Presentation] 酸化駆動型連続反応を鍵とする天然物合成2022
- Author(s)
  ○君嶋敦
- Organizer
  第23回スクリプス・バイオメディカルフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06526
[Presentation] トリコデルマミド類の合成2021
- Author(s)
  君嶋敦、永田怜、齊藤隼人、Violeta Petrova、荒井雅吉
- Organizer
  第６３回　天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-20K15956
[Presentation] Selective cytotoxicity of marine-derived fungal diketopiperazine against nutrient-starved cancer cells.2020
- Author(s)
  Rui Tang, ○Dongyi Zhou, 君嶋　敦, Andi Setiawan, 荒井雅吉
- Organizer
  第７０回　日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18H02096
[Presentation] Trichodermamide BおよびCの形式不斉合成2019
- Author(s)
  君嶋敦、齊藤隼人、荒井雅吉
- Organizer
  第69回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K14867
[Presentation] An Efficient Method for the Construction of cis-1,2-oxazadecaline Skeleton and its Application to Formal Enantioselective Synthesis of trichodermamide B and C2019
- Author(s)
  Atsushi Kimishima, Hayato Saito, Masayoshi Arai
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14867
[Presentation] Manzamine類の抗潜在性結核活性と標的分子解析2019
- Author(s)
  木下遼祐、原　康雅、君嶋　敦、 Andi Setiawan、荒井雅吉
- Organizer
  日本生薬学会第66 回年会
- Data Source
  KAKENHI-PROJECT-18H02096
[Presentation] 新規cis-1,2-オキサザデカリン骨格構築法を用いたtrichodermamide BおよびCの形式不斉合成2019
- Author(s)
  君嶋敦、齊藤隼人、荒井雅吉
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K14867
[Presentation] 海洋由来天然物DC1149Bの栄養飢餓環境選択的がん細胞増殖阻害活性と作用機序の解明2018
- Author(s)
  君嶋敦、唐睿、石田良典、山口亞由太、荒井雅吉
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K14867
[Presentation] 海洋真菌由来天然物DC1149Bの栄養飢餓環境選択的がん細胞増殖阻害活性とその作用機序解析2018
- Author(s)
  ◯君嶋敦, 唐睿, 石田良典, 山口亞由太, 荒井雅吉
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18H02096
[Presentation] DC1149Bの合成を指向した新規cis-1,2-オキサアザデカリン骨格構築法の開発2018
- Author(s)
  君嶋敦、山口亞由太、荒井雅吉
- Organizer
  第68回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-18K14867
[Presentation] Arenastatin Aの標的タンパク質結合部位解析を指向したプローブ合成2018
- Author(s)
  ◯加藤大貴, 神野佑司, 古徳直之, 君嶋　敦, 荒井雅吉
- Organizer
  第６８回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-18H02096
[Presentation] 海洋由来天然物DC1149Bの栄養飢餓環境選択的がん細胞増殖阻害活性2018
- Author(s)
  君嶋敦、唐睿、石田良典、荒井雅吉
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K14867

1. ARAI MASAYOSHI (80311231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 古徳直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMISHIMA Atsushi 君嶋 敦

Kimishima Atsushi 君嶋 敦

Research Projects

Research Products

Co-Researchers

酸化的炭素骨格構築を基盤とする生物活性ピロロインドール類の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸化駆動型連続反応を基盤とした低栄養環境応答型分子の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study towards development of anti-latent tuberculosis pyrroloindolesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research toward the development of microenvironment-responsive epidithiodiketopiperazinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of new drug targets based on marine natural products

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.2024

Author(s)

Journal Title

Data Source

[Journal Article] Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Cytotoxic activity of cordycepin produced by marine-derived fungus Emericella sp. against HT29 human colon cancer cell lines2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-step construction of an acetoxypyrroloindole skeleton via tandem iodocyclization/acetoxylation of indoles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-step construction of an acetoxypyrroloindole skeleton via a tandem iodocyclization/acetoxylation of indoles2022

Author(s)

Journal Title

Data Source

[Journal Article] Asymmetric Formal Synthesis of Trichodermamides B and C2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.2020

Author(s)

Journal Title

DOI

KIMISHIMA Atsushi 君嶋敦

Kimishima Atsushi 君嶋敦