Morita Kaoru 森田薫

Researcher Number	20813223
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2023: 自治医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator cGVHD / endothelium / GVL / GVHD / CMV / MHCクラスII / 免疫沈降 / フローサイトメトリー / H-Y蛋白質/MHC class II複合体 / 同種抗原/MHCクラスII複合体 … More / 同種移植 / H-Y抗原/MHCクラスII複合体 / 同種抗体 / ネオセルフ / HLA class II / DBY / 慢性GVHD … More Except Principal Investigator 代謝 / T細胞 / ヒストンアセチル化 / カルニチン / ヒストン / 脂肪酸 / ミトコンドリア / GVHD / アセチル化 / ヒストン修飾 / 脂肪酸代謝 / 移植片対宿主病 / 造血幹細胞移植 Less

mechanisms of vasculopathy in chronic GVHDPrincipal Investigator
- Principal Investigator
  
  Morita Kaoru
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
Lipid-derived acetyl-CoA promotes lipid-specific gene expression in alloreactive T-cells
- Principal Investigator
  
  Sato Kazuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
DBY/HLA class II complex formation on the vascular endothelium leads to cGVHD in female-to-male HSCTPrincipal Investigator
- Principal Investigator
  
  Morita Kaoru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University

All 2024 2023 2022 2021 Other

All Journal Article Presentation Patent Other

[Journal Article] Cost-Effectiveness of Anti-BCMA Chimeric Antigen Receptor T Cell Therapy in Relapsed/Refractory Multiple Myeloma2024
- Author(s)
  Yamamoto Chihiro, Morita Kaoru, Kanda Yoshinobu, et.al.
- Journal Title
  
  Transplantation and Cellular Therapy
  
  Volume: 30 Issue: 1 Pages: 118.e1-118.e15
- DOI
  10.1016/j.jtct.2023.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16309
[Journal Article] Phase 2 trial of induction with dasatinib and consolidation with hyper-CVAD plus dasatinib followed by allografting for Ph-positive acute lymphoblastic leukemia in adults2024
- Author(s)
  Oh Iekuni, Morita Kaoru, Kanda Yoshinobu, et.al.
- Journal Title
  
  Leukemia Research
  
  Volume: 137 Pages: 107438-107438
- DOI
  10.1016/j.leukres.2024.107438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16309
[Journal Article] Effects of CD34<sup>+</sup> cell dose on engraftment and long‐term outcomes after allogeneic bone marrow transplantation2024
- Author(s)
  Oyama Takashi, Morita Kaoru, Kanda Yoshinobu, et.al.
- Journal Title
  
  Clinical Transplantation
  
  Volume: 38 Issue: 4
- DOI
  10.1111/ctr.15313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16309
[Journal Article] Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease2024
- Author(s)
  Nakano Hirofumi、Sato Kazuya、Izawa Junko、Takayama Norihito、Hayakawa Hiroko、Ikeda Takashi、Kawaguchi Shin-Ichiro、Mashima Kiyomi、Umino Kento、Morita Kaoru、Ito Ryoji、Ohno Nobuhiko、Tominaga Kaoru、Endo Hitoshi、Kanda Yoshinobu
- Journal Title
  
  ImmunoHorizons
  
  Volume: 8 Issue: 3 Pages: 228-241
- DOI
  10.4049/immunohorizons.2300115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-21K06760, KAKENHI-PROJECT-22K16309
[Journal Article] Early reversal of the lymphocyte‐to‐monocyte ratio after allogeneic‐hematopoietic stem cell transplantation is associated with reduced relapse and improved prognosis2023
- Author(s)
  Nagayama Takashi, Fujiwara Shin‐ichiro, Morita Kaoru, Kanda Yoshinobu
- Journal Title
  
  Clinical Transplantation
  
  Volume: 37 Issue: 12
- DOI
  10.1111/ctr.15116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16309
[Journal Article] Forodesine Enhances Immune Responses through Guanosine-Mediated TLR7 Activation while Preventing Graft-versus-Host Disease2023
- Author(s)
  Ikeda Takashi、Sato Kazuya、Kawaguchi Shin-ichiro、Izawa Junko、Takayama Norihito、Hayakawa Hiroko、Umino Kento、Morita Kaoru、Matsumoto Kana、Ushijima Kentaro、Kanda Yoshinobu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 212 Issue: 1 Pages: 143-153
- DOI
  10.4049/jimmunol.2300003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16309
[Journal Article] Relapsed and refractory multiple myeloma: A systematic review and network meta-analysis of the efficacy of novel therapies.2023
- Author(s)
  Minakata D, Fujiwara SI, Yokoyama D, Noguchi A, Aoe S, Oyama T, Koyama S, Murahashi R, Nakashima H, Hyodo K, Ikeda T, Kawaguchi SI, Toda Y, Ito S, Nagayama T, Mashima K, Umino K, Morita K, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Kanda Y.
- Journal Title
  
  Br J Haematol.
  
  Volume: 200 Issue: 6 Pages: 694-703
- DOI
  10.1111/bjh.18654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20J23420, KAKENHI-PROJECT-22K16309
[Journal Article] Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect.2023
- Author(s)
  Umino K, Morita K, Ikeda T, Kawaguchi SI, Nagayama T, Ito S, Minakata D, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Fujiwara SI, Kimura SI, Kako S, Doki N, Ozawa Y, Mori Y, Eto T, Hiramoto N, Nakamae H, Kanda J, Ichinohe T, Atsuta Y, Nakasone H, Morishima S, Kanda Y.
- Journal Title
  
  Blood.
  
  Volume: 142 Issue: 11 Pages: 1008-1021
- DOI
  10.1182/blood.2023019799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08737, KAKENHI-PROJECT-22K08463, KAKENHI-PROJECT-23K07863, KAKENHI-PROJECT-22K16309
[Journal Article] Dimethyl fumarate ameliorates graft‐versus‐host disease by inhibiting T‐cell metabolism and immune responses through a reactive oxygen species‐dependent mechanism2022
- Author(s)
  Mashima Kiyomi、Sato Kazuya、Ikeda Takashi、Izawa Junko、Takayama Norihito、Hayakawa Hiroko、Kawaguchi Shin‐Ichiro、Nakano Hirofumi、Nagayama Takashi、Umino Kento、Morita Kaoru、Tominaga Kaoru、Endo Hitoshi、Kanda Yoshinobu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 00 Issue: 6 Pages: 1-5
- DOI
  10.1111/bjh.18082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17841, KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-21K06760, KAKENHI-PROJECT-22K08463
[Journal Article] Comparison of alemtuzumab, anti-thymocyte globulin, and post-transplant cyclophosphamide for graft-versus-host disease and graft-versus-leukemia in murine models2021
- Author(s)
  Mashima Kiyomi、Oh Iekuni、Fujiwara Ken、Izawa Junko、Takayama Norihito、Nakano Hirofumi、Kawasaki Yasufumi、Minakata Daisuke、Yamasaki Ryoko、Morita Kaoru、Ashizawa Masahiro、Yamamoto Chihiro、Hatano Kaoru、Sato Kazuya、Ohmine Ken、Fujiwara Shin-Ichiro、Ohno Nobuhiko、Kanda Yoshinobu
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 1 Pages: 1-14
- DOI
  10.1371/journal.pone.0245232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17841
[Journal Article] Identification of endoscopic factors that predict poor responses to steroids in patients with gastrointestinal acute graft-versus-host disease2021
- Author(s)
  Morita Kaoru、Fujiwara Shin-ichiro、Ikeda Takashi、Kawaguchi Shin-ichiro、Toda Yumiko、Ito Shoko、Nagayama Takashi、Mashima Kiyomi、Umino Kento、Minakata Daisuke、Nakano Hirofumi、Yamasaki Ryoko、Ashizawa Masahiro、Yamamoto Chihiro、Hatano Kaoru、Sato Kazuya、Oh Iekuni、Ohmine Ken、Kanda Yoshinobu
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 56 Issue: 4 Pages: 963-967
- DOI
  10.1038/s41409-020-01096-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17841
[Journal Article] Mesenchymal stromal cells inhibit aerobic glycolysis in activated T-cells by negatively regulating hexokinase II activity through PD-1/PD-L1 interaction.2021
- Author(s)
  Kawasaki, Y., Sato, K., Mashima, K., Nakano, H., Ikeda, T., Umino, K., Morita, K., Izawa, J., Takayama, N., Hayakawa, H., Tominaga, K., Endo, H., Kanda, Y.
- Journal Title
  
  Biology of Blood and Marrow Transplantation
  
  Volume: 27 Issue: 3 Pages: 231.e1-231.e8
- DOI
  10.1016/j.jtct.2020.11.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-17K08497, KAKENHI-PROJECT-17K11248, KAKENHI-PROJECT-19K17841
[Patent] 特許権2023
- Inventor(s)
  森田薫、神田善伸、海野健斗
- Industrial Property Rights Holder
  森田薫、神田善伸、海野健斗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-079282
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K16309
[Presentation] Antibody-mediated immunity to DBY/HLA class II complex formation in chronic GVHD and GVL effect2023
- Author(s)
  森田薫、海野健斗、仲宗根秀樹、森島聡子、神田善伸
- Organizer
  第85回日本血液学会
- Data Source
  KAKENHI-PROJECT-22K16309
[]

1. Sato Kazuya (60382917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 神田善伸 (30334379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 遠藤仁司 (50221817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 森島聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morita Kaoru 森田 薫

Research Projects

Research Products

Co-Researchers

mechanisms of vasculopathy in chronic GVHDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lipid-derived acetyl-CoA promotes lipid-specific gene expression in alloreactive T-cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DBY/HLA class II complex formation on the vascular endothelium leads to cGVHD in female-to-male HSCTPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cost-Effectiveness of Anti-BCMA Chimeric Antigen Receptor T Cell Therapy in Relapsed/Refractory Multiple Myeloma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase 2 trial of induction with dasatinib and consolidation with hyper-CVAD plus dasatinib followed by allografting for Ph-positive acute lymphoblastic leukemia in adults2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of CD34<sup>+</sup> cell dose on engraftment and long‐term outcomes after allogeneic bone marrow transplantation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early reversal of the lymphocyte‐to‐monocyte ratio after allogeneic‐hematopoietic stem cell transplantation is associated with reduced relapse and improved prognosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Forodesine Enhances Immune Responses through Guanosine-Mediated TLR7 Activation while Preventing Graft-versus-Host Disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relapsed and refractory multiple myeloma: A systematic review and network meta-analysis of the efficacy of novel therapies.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dimethyl fumarate ameliorates graft‐versus‐host disease by inhibiting T‐cell metabolism and immune responses through a reactive oxygen species‐dependent mechanism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of alemtuzumab, anti-thymocyte globulin, and post-transplant cyclophosphamide for graft-versus-host disease and graft-versus-leukemia in murine models2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of endoscopic factors that predict poor responses to steroids in patients with gastrointestinal acute graft-versus-host disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal stromal cells inhibit aerobic glycolysis in activated T-cells by negatively regulating hexokinase II activity through PD-1/PD-L1 interaction.2021

Author(s)

Journal Title

Morita Kaoru 森田薫