Kakuda Keita 角田渓太

Researcher Number	20815500
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪大学, 大学院医学系研究科, 特任助教(常勤) 2021: 大阪大学, 医学系研究科, 特任助教(常勤) 2020: 大阪大学, 医学系研究科, 医員 2019: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Medium-sized Section 51:Brain sciences and related fields / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator α-シヌクレイン / 蛋白凝集 / 髄液 / パーキンソン病 / 脳脊髄液 / 凝集抑制因子 / タンパク質凝集 / マウスモデル / レビー小体 / 神経難病 / αーシヌクレイン … More Except Principal Investigator … More 蛋白質凝集 / パーキンソン病 / αシヌクレイン / ドラッグデリバリーシステム / 遺伝子治療 / 脳血管関門 / 霊長類 / 機能的アミロイド / PIP3 / 多系統萎縮症 / 疾患構造多型 / 構造多型 Less

タンパク質凝集体ストレスに対する新規リソソーム損傷応答経路の解明Principal Investigator
- Principal Investigator
  
  角田渓太
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Osaka
パーキンソン病霊長類モデルを用いた一過性血液脳関門開放による非侵襲的治療法の開発
- Principal Investigator
  
  馬場孝輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka University
Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid Fibrils
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka University
髄液中の凝集抑制因子による新規パーキンソン病治療開発Principal Investigator
- Principal Investigator
  
  角田渓太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Elucidate the pathomechanisms of alpha synuclein polymorphinsms imparts disease dievrsities
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka University
Development of a biomarker for Parkinson's Disease Using CSF Synuclein Aggregate MeasurementPrincipal Investigator
- Principal Investigator
  
  Kakuda Keita
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 医学と薬学 vol.77 no.72020
- Author(s)
  角田渓太
- Publisher
  自然科学社
- ISBN
  9784909260291
- Data Source
  KAKENHI-PROJECT-19K17034
[Journal Article] Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients2024
- Author(s)
  Ikenaka Kensuke、Kajiyama Yuta、Aguirre Cesar、Choong Chi‐Jing、Taniguchi Seira、Doi Junko、Wang Nan、Ajiki Takahiro、Ogawa Kotaro、Kakuda Keita、Kimura Yasuyoshi、Mochizuki Hideki
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 12 Issue: 1
- DOI
  10.1002/prp2.1174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15709
[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023
- Author(s)
  Choong Chi-Jing、Aguirre Cesar、Kakuda Keita、Beck Goichi、Nakanishi Hiroki、Kimura Yasuyoshi、Shimma Shuichi、Nabekura Kei、Hideshima Makoto、Doi Junko、Yamaguchi Keiichi、et al.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 145 Issue: 5 Pages: 573-595
- DOI
  10.1007/s00401-023-02555-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-23K24212, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-22K07538, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K23848
[Journal Article] Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles2023
- Author(s)
  Kakuda Keita、Ikenaka Kensuke、Kuma Akiko、Doi Junko、Aguirre Cesar、Wang Nan、Ajiki Takahiro、Choong Chi-Jing、Kimura Yasuyoshi、Badawy Shaymaa Mohamed Mohamed、Shima Takayuki、Nakamura Shuhei、Baba Kousuke、Nagano Seiichi、Nagai Yoshitaka、Yoshimori Tamotsu、Mochizuki Hideki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 1
- DOI
  10.1073/pnas.2312306120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18255, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22KJ2105, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K24212
[Journal Article] Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease2022
- Author(s)
  Hideshima Makoto、Kimura Yasuyoshi、Aguirre Cesar、Kakuda Keita、Takeuchi Toshihide、Choong Chi-Jing、Doi Junko、Nabekura Kei、Yamaguchi Keiichi、Nakajima Kichitaro、Baba Kousuke、Nagano Seiichi、Goto Yuji、Nagai Yoshitaka、Mochizuki Hideki、Ikenaka Kensuke
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 351-351
- DOI
  10.1038/s41598-021-04131-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17034, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-21H02841
[Presentation] Impaired lysophagy function exacerbates propagation of α-synuclein aggregation2023
- Author(s)
  Keita Kakuda, Kensuke Ikenaka , Junko Doi, Cesar Aguirre, Chi-Jing Choong, Yasuyoshi Kimura, Hideki Mochizuki
- Organizer
  INTERNATIONAL CONGRESS OF PARKINSON'S DISEASE AND MOVEMENT DISORDERS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15709
[Presentation] Novel interactions with lipids that promote α-synuclein aggregation and regulate structural polymorphism2023
- Author(s)
  Keita Kakuda, Kensuke Ikenaka, Chi-jing Choong, Cesar Aguirrre
- Organizer
  第66回日本神経化学会大会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-22K15709
[Presentation] Lysophagy protects against propagation of alpha-synuclein aggregation via lysosomal vesicle rupture2023
- Author(s)
  角田渓太，池中建介，土居純子， Cesar Aguirre， Chi-Jing Choong，木村康義，望月秀樹
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15709
[Presentation] The analysis of the interaction between α-synuclein and the lipids inducing pathological aggregation2022
- Author(s)
  角田　渓太
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15709
[Presentation] The analysis of the interaction between α-synuclein and the li pids inducing pathological aggregation2022
- Author(s)
  角田渓太
- Organizer
  第63回　日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17034
[Presentation] Lysophagy defends against propagation of α-synuclein aggregation through lysosomal rupture2022
- Author(s)
  角田　渓太
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-22K15709
[Presentation] Application of the amplification assay of α-synuclein aggregates to clinical biomarker and drug screening for Parkinson's disease2021
- Author(s)
  角田渓太
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K17034
[Presentation] Amplification of α-synuclein aggregates in cerebrospinal fluid by rapid ultrasonication-based assay.2019
- Author(s)
  Keita Kakuda
- Organizer
  International Congress of Parkinson’s Disease and Movement Disorders, Nice, France, 2019. Sep. 23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17034

1. 望月秀樹 (90230044)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. AGUIRRE・MARTINEZ CESAR (20865597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 池中建介 (70774058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 馬場孝輔 (90750159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高田昌彦 (00236233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 南部篤 (80180553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山口圭一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakuda Keita 角田 渓太

Research Projects

Research Products

Co-Researchers

タンパク質凝集体ストレスに対する新規リソソーム損傷応答経路の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

パーキンソン病霊長類モデルを用いた一過性血液脳関門開放による非侵襲的治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid Fibrils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

髄液中の凝集抑制因子による新規パーキンソン病治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidate the pathomechanisms of alpha synuclein polymorphinsms imparts disease dievrsities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a biomarker for Parkinson's Disease Using CSF Synuclein Aggregate MeasurementPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 医学と薬学 vol.77 no.72020

Author(s)

Publisher

ISBN

Data Source

[Journal Article] Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Impaired lysophagy function exacerbates propagation of α-synuclein aggregation2023

Author(s)

Organizer

Data Source

[Presentation] Novel interactions with lipids that promote α-synuclein aggregation and regulate structural polymorphism2023

Author(s)

Organizer

Data Source

[Presentation] Lysophagy protects against propagation of alpha-synuclein aggregation via lysosomal vesicle rupture2023

Author(s)

Organizer

Data Source

[Presentation] The analysis of the interaction between α-synuclein and the lipids inducing pathological aggregation2022

Author(s)

Organizer

Kakuda Keita 角田渓太