MIYATA Kenichi 宮田憲一

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Miyata Kenichi 宮田憲一

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Researcher Number	20816938
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所がんエピゲノム研究部, 特任研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 公益財団法人がん研究会, がん研究所がんエピゲノムプロジェクト, 特任研究員 2018 – 2021: 公益財団法人がん研究会, がん研究所細胞老化プロジェクト, 研究員 2019: 公益財団法人がん研究会, がん研究所細胞老化プロジェクト, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator SASP / 細胞老化 / リピート領域 / 膵がん / エピゲノム / 多様性 / 乳がん / 反復配列 / がん転移 / オルガノイド / がん … More Except Principal Investigator … More エピゲノム / ecDNA / 腫瘍内不均一性 Less

腫瘍内不均一性の形成過程における染色体外DNAの果たす役割の解明
- Principal Investigator
  
  丸山玲緒
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
エピゲノム異常がもたらすがん細胞の多様性及び治療抵抗性獲得機構の解析Principal Investigator
- Principal Investigator
  
  宮田憲一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
リピート領域も包括したオミクス解析法による新たな細胞の特徴と機能の解明Principal Investigator
- Principal Investigator
  
  宮田憲一
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Analysis of tumor progression caused by aberrant senescence-like epigenome in breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  MIYATA Kenichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
The analysis of tumor cells showing the senescence-like gene expression profilePrincipal Investigator
- Principal Investigator
  
  Miyata Kenichi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 老化とがんにおけるSASPの役割2019
- Author(s)
  宮田憲一、高橋暁子
- Total Pages
  6
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-18K15254
[Book] 細胞老化とがん化2018
- Author(s)
  宮田　憲一、高橋暁子
- Total Pages
  6
- Publisher
  腫瘍内科
- Data Source
  KAKENHI-PROJECT-18K15254
[Journal Article] Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer2024
- Author(s)
  Murayama Takahiko、Nakayama Jun、Jiang Xinpei、Miyata Kenichi、Morris Alexander D.、Cai Kathy Q.、Prasad Rahul M.、Ma Xueying、Efimov Andrey、Belani Neel、Gerstein Emily R.、Tan Yinfei、Zhou Yan、Kim William、Maruyama Reo、Campbell Kerry S.、Chen Lu、Yang Yibin、Balachandran Siddharth、Ca?adas Israel
- Journal Title
  
  Cancer Discovery
  
  Volume: 14 Issue: 3 Pages: 468-491
- DOI
  10.1158/2159-8290.cd-23-0486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18247, KAKENHI-PROJECT-23K27446
[Journal Article] FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer?gene programs in basal-like breast cancer2023
- Author(s)
  Kumegawa Kohei、Yang Liying、Miyata Kenichi、Maruyama Reo
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13
- DOI
  10.3389/fonc.2023.1156111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-23K18247, KAKENHI-PROJECT-23K27446
[Journal Article] YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype2023
- Author(s)
  Chiba Masatomo、Miyata Kenichi、Okawa Hikaru、Tanaka Yoko、Ueda Koji、Seimiya Hiroyuki、Takahashi Akiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 22 Pages: 16399-16399
- DOI
  10.3390/ijms242216399
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18247, KAKENHI-PROJECT-22K07222, KAKENHI-PROJECT-22K19469, KAKENHI-PROJECT-23KJ0554, KAKENHI-PROJECT-23K24168, KAKENHI-PROJECT-23K24192
[Journal Article] Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin2023
- Author(s)
  Saeki Sumito、Kumegawa Kohei、Takahashi Yoko、Yang Liying、Osako Tomo、Yasen Mahmut、Otsuji Kazutaka、Miyata Kenichi、Yamakawa Kaoru、Suzuka Jun、Sakimoto Yuri、Ozaki Yukinori、Takano Toshimi、Sano Takeshi、Noda Tetsuo、Ohno Shinji、Yao Ryoji、Ueno Takayuki、Maruyama Reo
- Journal Title
  
  Breast Cancer Research
  
  Volume: 25 Issue: 1 Pages: 21-21
- DOI
  10.1186/s13058-023-01617-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19468, KAKENHI-PROJECT-21H02770, KAKENHI-PROJECT-20K07708, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-22K16473
[Journal Article] Identification of Novel Senescent Markers in Small Extracellular Vesicles2023
- Author(s)
  Misawa Tomoka、Hitomi Kazuhiro、Miyata Kenichi、Tanaka Yoko、Fujii Risa、Chiba Masatomo、Loo Tze Mun、Hanyu Aki、Kawasaki Hiroko、Kato Hisaya、Maezawa Yoshiro、Yokote Koutaro、Nakamura Asako J.、Ueda Koji、Yaegashi Nobuo、Takahashi Akiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 3 Pages: 2421-2421
- DOI
  10.3390/ijms24032421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07222, KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-22KJ0248, KAKENHI-PROJECT-20K16344
[Journal Article] Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment2023
- Author(s)
  Miyata Kenichi、Zhou Xiangyu、Nishio Mika、Hanyu Aki、Chiba Masatomo、Kawasaki Hiroko、Osako Tomo、Takeuchi Kengo、Ohno Shinji、Ueno Takayuki、Maruyama Reo、Takahashi Akiko
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 32
- DOI
  10.1073/pnas.2305046120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18247, KAKENHI-PROJECT-23K24168, KAKENHI-PROJECT-23K27446
[Journal Article] RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells2022
- Author(s)
  Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A.
- Journal Title
  
  Commun Biol
  
  Volume: 5 Issue: 1 Pages: 1420-1420
- DOI
  10.1038/s42003-022-04369-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-22KJ3105, KAKENHI-PROJECT-21K19419, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-19H03156, KAKENHI-PLANNED-18H05532, KAKENHI-PLANNED-17H06426, KAKENHI-PUBLICLY-22H05599, KAKENHI-PROJECT-23K23810
[Journal Article] Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression2022
- Author(s)
  Miyata Kenichi、Takahashi Akiko
- Journal Title
  
  Nucleus
  
  Volume: 277 Issue: 1 Pages: 74-78
- DOI
  10.1080/19491034.2022.2034269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-19H03507
[Journal Article] Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer2021
- Author(s)
  Kenichi Miyata, Yoshinori Imai, Satoshi Hori, Mika Nishio, Tze Mun Loo, Ryo Okada, Liying Yang, Tomoyoshi Nakadai, et. al.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 35
- DOI
  10.1073/pnas.2025647118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07651, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-20K16163, KAKENHI-PUBLICLY-20H04789, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-18H04034, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-19H03507
[Journal Article] DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses2020
- Author(s)
  Hitomi Kazuhiro、Okada Ryo、Loo Tze Mun、Miyata Kenichi、Nakamura Asako J.、Takahashi Akiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3720-3720
- DOI
  10.3390/ijms21103720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15073, KAKENHI-PROJECT-20K16163, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-19K22571, KAKENHI-PROJECT-18J10977
[Journal Article] Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer2019
- Author(s)
  Loo Tze Mun、Miyata Kenichi、Tanaka Yoko、Takahashi Akiko
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 304-311
- DOI
  10.1111/cas.14266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-18K15073, KAKENHI-PROJECT-18K15254, KAKENHI-PROJECT-19K22571
[Presentation] Intratumoral Heterogeneity in Patient-Derived Breast Cancer Organoids: Identifying Shared and Unique Cellular States2023
- Author(s)
  佐伯澄人、粂川昂平、高橋洋子、大迫智、亜森馬合木特、尾辻和尊、宮田憲一、鈴鹿淳、尾崎由起範、高野利美、野田哲生、大野真司、八尾良司、上野貴之、丸山玲緒
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27446
[Presentation] 転移能を有する乳がん由来オルガノイドの異種移植における腫瘍内不均一性の評価2023
- Author(s)
  土屋あい, 粂川昂平, 佐伯澄人, 尾辻和尊, 楊麗英, 鈴鹿淳, 宮田憲一, 高橋洋子, 野田哲生, 大野真司, 井本滋, 上野貴之, 丸山玲緒
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27446
[Presentation] オルガノイドのマルチオミックス解析による膵癌遠隔転移可塑性メカニズムの解明2023
- Author(s)
  古川貴光, 宮田憲一, 柴田智華子, 楊麗英, 粂川昂平, 佐伯澄人, 三重尭文, 岡本武士, 武田剛志, 春日章良, 佐々木隆, 尾阪将人, 笹平直樹, 野田哲生, 丸山玲緒
- Organizer
  第82回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K18247
[Presentation] Analysis of the effect of epigenetic abnormalities on cancer cell diversity2023
- Author(s)
  宮田憲一、丸山玲緒
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27446
[Presentation] 転移能を有する乳がん由来オルガノイドの異種移植における腫瘍内不均一性の評価2023
- Author(s)
  土屋あい, 粂川昂平, 佐伯澄人, 尾辻和尊, 楊麗英, 鈴鹿淳, 宮田憲一, 高橋洋子, 野田哲生, 大野真司, 井本滋, 上野貴之, 丸山玲緒
- Organizer
  第82回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K18247
[Presentation] Intratumoral Heterogeneity in Patient-Derived Breast Cancer Organoids: Identifying Shared and Unique Cellular States2023
- Author(s)
  佐伯澄人、粂川昂平、高橋洋子、大迫智、亜森馬合木特、尾辻和尊、宮田憲一、鈴鹿淳、尾崎由起範、高野利美、野田哲生、大野真司、八尾良司、上野貴之、丸山玲緒
- Organizer
  第82回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K18247
[Presentation] Analysis of the effect of epigenetic abnormalities on cancer cell diversity2023
- Author(s)
  宮田憲一、丸山玲緒
- Organizer
  第82回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K18247
[Presentation] オルガノイドのマルチオミックス解析による膵癌遠隔転移可塑性メカニズムの解明2023
- Author(s)
  古川貴光, 宮田憲一, 柴田智華子, 楊麗英, 粂川昂平, 佐伯澄人, 三重尭文, 岡本武士, 武田剛志, 春日章良, 佐々木隆, 尾阪将人, 笹平直樹, 野田哲生, 丸山玲緒
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27446
[Presentation] 細胞老化特異的なノンコーディングRNAによる発がん機構の解析2022
- Author(s)
  宮田憲一、高橋暁子、丸山玲緒
- Organizer
  日本遺伝学会第94回大会
- Data Source
  KAKENHI-PROJECT-20K16344
[Presentation] DRY×WET 研究で老化細胞の特徴を炙り出す2022
- Author(s)
  宮田憲一
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16344
[Presentation] Analysis of noncoding RNA and chromatin organization in senescent cells2020
- Author(s)
  Kenichi Miyata, Akiko Takahashi
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16344
[Presentation] 細胞老化特異的なノンコーディングRNAによる発がん機構の解析2020
- Author(s)
  宮田憲一、高橋暁子
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K16344
[Presentation] The Analysis of Epigenetic alteration in cellular senescence and cancer：細胞老化とがんにおけるエピゲノム異常の解析2020
- Author(s)
  高橋暁子, 宮田憲一, 羅智文, 菅原祥
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16344
[Presentation] Senescence-associated non-coding RNA provokes chromosomal instability and tumour formation in microenvironment2019
- Author(s)
  Akiko Takahashi, Kenichi Miyata
- Organizer
  11th JCA-AACR joint conference
- Data Source
  KAKENHI-PROJECT-18K15254
[Presentation] 細胞老化特異的なノンコーディングRNAは発がん機構を促進する2019
- Author(s)
  宮田憲一、高橋暁子
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究
- Data Source
  KAKENHI-PROJECT-18K15254
[Presentation] Senescence-associated non-coding RNA promotes chromosomal instability and tumour formation2018
- Author(s)
  Akiko Takahashi, Kenichi Miyata
- Organizer
  EMBO workshop
- Data Source
  KAKENHI-PROJECT-18K15254
[Presentation] Exosome from senescent cells promotes tumorigenesis2018
- Author(s)
  Akiko Takahashi, Ryo Okada, Tze Mun Loo, Kenichi Miyata
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15254
[Presentation] 細胞老化によって発現亢進するnon-coding RNAは染色体不安定性を惹起する2018
- Author(s)
  宮田憲一、高橋暁子
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15254
[Presentation] 老化細胞が分泌するSASP因子の解析2018
- Author(s)
  高橋暁子、岡田　遼、宮田憲一、羅　智文
- Organizer
  第91回日本生化学会総会
- Data Source
  KAKENHI-PROJECT-18K15254
[Presentation] Exosomes secreted from senescent cells act as one of SASP factors2018
- Author(s)
  Akiko Takahashi, Ryo Okada, Kazunori Hitomi, Tze Mun Loo, Kenichi Miyata
- Organizer
  第5回日本細胞外小胞学会JSEV
- Data Source
  KAKENHI-PROJECT-18K15254

1. 丸山玲緒 (60607985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 粂川昂平 (40897112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. IMAI Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 羅智文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 八尾良司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田中陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中太智義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYATA Kenichi 宮田 憲一

Miyata Kenichi 宮田 憲一

Research Projects

Research Products

Co-Researchers

腫瘍内不均一性の形成過程における染色体外DNAの果たす役割の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エピゲノム異常がもたらすがん細胞の多様性及び治療抵抗性獲得機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リピート領域も包括したオミクス解析法による新たな細胞の特徴と機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of tumor progression caused by aberrant senescence-like epigenome in breast cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of tumor cells showing the senescence-like gene expression profilePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 老化とがんにおけるSASPの役割2019

Author(s)

Total Pages

Publisher

Data Source

[Book] 細胞老化とがん化2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer?gene programs in basal-like breast cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Novel Senescent Markers in Small Extracellular Vesicles2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells2022

Author(s)

Journal Title

DOI

Data Source

MIYATA Kenichi 宮田憲一

Miyata Kenichi 宮田憲一