Koike Hiroyuki 小池博之

Researcher Number	20821771
Other IDs	https://orcid.org/0000-0001-9934-6930
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2021 – 2022: 日本医科大学, 医学部, 講師 2019 – 2021: 日本医科大学, 医学部, 助教 2018: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 59040:Nutrition science and health science-related / 0909:Sports sciences, physical education, health sciences, and related fields Except Principal Investigator Basic Section 56070:Plastic and reconstructive surgery-related / Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator サルコペニア / マクロファージ / オルガノイド / 再生 / 骨格筋 / シングルセルRNAシークエンス / シングルセル解析 / 炎症 / 筋衛星細胞 / iPS細胞 … More / 循環 / 血液 / 肝臓 / 1細胞解析 / 骨格筋幹細胞 / 細胞間相互作用 / 加齢 / 幹細胞 / 筋再生 / 組織炎症 … More Except Principal Investigator 肥厚性瘢痕 / 疾患特異的iPS細胞 / ケロイド / 創傷治癒 / 異常瘢痕 / 遺伝子細胞治療 / がん免疫微小環境 / 間葉系幹細胞 / ヘルペスウイルス / 腫瘍溶解性ウイルス / がん遺伝子細胞治療 / オルガノイド Less

Regulatory Mechanisms of Skeletal Muscle Regeneration via Macrophage SubpopulationsPrincipal Investigator
- Principal Investigator
  
  小池博之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tokyo Medical and Dental University
疾患特異的iPS細胞を用いたケロイドの病態解明と治療法の確立
- Principal Investigator
  
  江浦重義
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Nippon Medical School
オルガノイドの代謝特性を利用した循環培養系の構築Principal Investigator
- Principal Investigator
  
  小池博之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tokyo Medical and Dental University
  Nippon Medical School
Single cell analysis for tissue regeneration and lipid metabolism in skeletal musclePrincipal Investigator
- Principal Investigator
  
  Koike Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tokyo Medical and Dental University
  Nippon Medical School
Modeling of innovative oncolytic viral therapy and elucidation of the underlying mechanism using an advanced organoid technology
- Principal Investigator
  
  Miyagawa Yoshitaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nippon Medical School
Analysis of interaction between skeletal muscle satellite cells and macrophages for maintenance of tissue homeostasisPrincipal Investigator
- Principal Investigator
  
  Koike Hiroyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nippon Medical School
Study of the muscle satellite cell-macrophage crosstalk and skeletal muscle regenerationPrincipal Investigator
- Principal Investigator
  
  小池博之
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0909:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Macrophage SREBP1 regulates skeletal muscle regeneration2024
- Author(s)
  Oishi Yumiko、Koike Hiroyuki、Kumagami Naoki、Nakagawa Yoshimi、Araki Masaya、Taketomi Yoshitaka、Miki Yoshimi、Matsuda Shigeru、Kim Hyeree、Matsuzaka Takashi、Ozawa Hitoshi、Shimano Hitoshi、Murakami Makoto、Manabe Ichiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1251784-1251784
- DOI
  10.3389/fimmu.2023.1251784
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19534, KAKENHI-PROJECT-23K18444, KAKENHI-PROJECT-22K06577, KAKENHI-PROJECT-22H00474, KAKENHI-PROJECT-21H03331, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-23K27603
[Journal Article] Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells2023
- Author(s)
  Matsuzaki Takahisa, Kawano Yuma, Horikiri Momoka, Shimokawa Yuko, Yamazaki Takashi, Okuma Nao, Koike Hiroyuki, Kimura Masaki, Kawamura Ryuzo, Yoneyama Yosuke, Furuichi Yasuro, Hakuno Fumihiko, Takahashi Shin-Ichiro, Nakabayashi Seiichiro, Okamoto Satoshi, Nakauchi Hiromitsu, Taniguchi Hideki, Takebe Takanori, et al
- Journal Title
  
  STAR Protocols
  
  Volume: 4 Issue: 3 Pages: 102471-102471
- DOI
  10.1016/j.xpro.2023.102471
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19924, KAKENHI-PROJECT-23K18576, KAKENHI-PROJECT-22K06923, KAKENHI-PUBLICLY-22H05423, KAKENHI-PROJECT-22H00302, KAKENHI-PROJECT-20H04079
[Journal Article] Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids2023
- Author(s)
  Ouchi Rie、Koike Hiroyuki
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 11 Pages: 1133534-1133534
- DOI
  10.3389/fcell.2023.1133534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19924
[Journal Article] Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair2023
- Author(s)
  Watanabe Aiko、Koike Hiroyuki、Kumagami Naoki、Shimba Shigeki、Manabe Ichiro、Oishi Yumiko
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 6747-6747
- DOI
  10.1038/s41598-023-33830-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19534, KAKENHI-PROJECT-21H03331, KAKENHI-PROJECT-23K27603
[Journal Article] VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes2022
- Author(s)
  Yuzawa Ryo、Koike Hiroyuki、Manabe Ichiro、Oishi Yumiko
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1377-1377
- DOI
  10.1038/s41598-022-05354-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-21H03331
[Journal Article] Mechanisms of Cooperative Cell-Cell Interactions in Skeletal Muscle Regeneration.2022
- Author(s)
  Koike H, Manabe I and Oishi Y.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 42 Issue: 1 Pages: 48-48
- DOI
  10.1186/s41232-022-00234-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19534, KAKENHI-PROJECT-21H03331, KAKENHI-PROJECT-20H03679
[Journal Article] Mechanical guidance of self-condensation patterns of differentiating progeny2022
- Author(s)
  Matsuzaki Takahisa、Shimokawa Yuko、Koike Hiroyuki、Kimura Masaki、Kawano Yuma、Okuma Nao、Kawamura Ryuzo、Yoneyama Yosuke、Furuichi Yasuro、Hakuno Fumihiko、Takahashi Shin-Ichiro、Nakabayashi Seiichiro、Okamoto Satoshi、Nakauchi Hiromitsu、Taniguchi Hideki、Takebe Takanori、Yoshikawa Hiroshi Y.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 10 Pages: 105109-105109
- DOI
  10.1016/j.isci.2022.105109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06923, KAKENHI-PROJECT-22K19924, KAKENHI-PUBLICLY-22H05423, KAKENHI-PROJECT-21H04822, KAKENHI-PROJECT-21H04830, KAKENHI-PROJECT-22H00302, KAKENHI-PROJECT-20H04079, KAKENHI-PROJECT-21H02991, KAKENHI-PROJECT-20K21117
[Journal Article] Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling.2022
- Author(s)
  Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko T, Orekhov A, Yui N, Manabe I, Oishi Y.
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 22
- DOI
  10.1172/jci.insight.138539
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19534, KAKENHI-PROJECT-21H03331, KAKENHI-PROJECT-23K21625, KAKENHI-PROJECT-23K24777, KAKENHI-PROJECT-20H03679
[Journal Article] 骨格筋萎縮に対するビタミンA誘導体の機能評価2022
- Author(s)
  小池博之, 大石由美子
- Journal Title
  
  実験医学
  
  Volume: 40 Pages: 1027-1031
- Data Source
  KAKENHI-PROJECT-21H03331
[Journal Article] Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy2021
- Author(s)
  Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi, Y.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 118 Issue: 35
- DOI
  10.1073/pnas.2102895118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03679, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04938, KAKENHI-PUBLICLY-20H04956, KAKENHI-PROJECT-20H00551, KAKENHI-PROJECT-19H03648, KAKENHI-PROJECT-21H03331, KAKENHI-PROJECT-21K06961, KAKENHI-PROJECT-21K19554, KAKENHI-PROJECT-21K17154
[Journal Article] 骨格筋組織再生を対象としたシングルセルRNA-seq解析2021
- Author(s)
  小池博之 , 大石由美子
- Journal Title
  
  医学のあゆみ
  
  Volume: 276 Pages: 443-447
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] マクロファージ亜集団との細胞間相互作用解析に向けた骨格筋再生機構のモデル化2024
- Author(s)
  小池博之
- Organizer
  第12回AAA（Academy of Aging and CArdiovascular-Diabetes Research）
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] Cell-cell interactions of post-injury muscle regeneration and tissue repair2023
- Author(s)
  Hiroyuki Koike
- Organizer
  From basic discovery to preclinical modeling: at the forefront of muscle disease therapies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] 加齢による筋損傷後再生不全のメカニズム2022
- Author(s)
  大石由美子 , 小池博之
- Organizer
  第64回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] 筋損傷後の再生・修復を主導する骨格筋マクロファージの多様性2021
- Author(s)
  大石由美子, 小池博之
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] マクロファージのSREBP1aは腫瘍の増殖を制御する2021
- Author(s)
  高田賢, 小池博之, 佐藤日向, 大石由美子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] 骨格筋幹細胞とマクロファージ亜集団の相互作用による組織修復制御2021
- Author(s)
  小池博之, 大石由美子
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] 骨髄球系細胞が持つ細胞内時計の錯乱が筋再生に及ぼす影響2021
- Author(s)
  渡辺藍子, 小池博之, 大石由美子
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] マクロファージの「脂質」による再生・組織修復の制御2021
- Author(s)
  大石由美子, 小池博之
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H03331
[Presentation] Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells2021
- Author(s)
  Hiroyuki Koike
- Organizer
  Frontiers of stem cell and organoid technology (FSO2021): From Basic to Bedside
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] 多能性幹細胞を用いたヒト肝臓と周辺臓器の一括創出2021
- Author(s)
  小池博之
- Organizer
  第20回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] シングルセルトランスクリプトーム解析からみた骨格筋再生における細胞間相互作用の変化2020
- Author(s)
  小池博之, 大石由美子
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] CD206陽性マクロファージは創傷治癒を制御する2020
- Author(s)
  本田梓, 早川清雄, 小池博之, 小川令, 大石由美子
- Organizer
  第88回日本医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] 不飽和脂肪酸代謝による骨格筋再生における免疫細胞の機能制御2020
- Author(s)
  小池博之
- Organizer
  第43回日本分子生物学会年会 2020年12月3日日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] 免疫細胞と骨格筋幹細胞のクロストークによる再生制御機構2020
- Author(s)
  小池博之
- Organizer
  第88回日本医科大学医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] Zinc-finger transcription factor KLF5 is involved in the pathogenesis of muscle atrophy2019
- Author(s)
  劉琳 , 小池博之 , 林晋一郎 , 淺原弘嗣 , 大石由美子
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] 時計遺伝子 Bmal1 欠損によるマクロファージ形質変化の阻害は筋再生を遅延させる2019
- Author(s)
  渡辺藍子 , 小池博之 , 大石由美子
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] 不飽和脂肪酸代謝遺伝子の欠損による単球の遊走能低下は筋再生を遅延させる2019
- Author(s)
  熊上尚樹 , 小池博之 , 渡辺藍子 , 早川清雄 , 眞鍋一郎 , 大石由美子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] マクロファージの細胞内時計の錯乱が筋再生に与える影響2019
- Author(s)
  渡辺藍子 , 小池博之 , 大石由美子
- Organizer
  第7回若手による骨格筋細胞研究会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] マクロファージの細胞内時計錯乱による炎症応答の遷延が筋再生に与える影響2019
- Author(s)
  渡辺藍子 , 小池博之 , 大石由美子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] シングルセルトランスクリプトームによる骨格筋再生における細胞間相互作用解析2019
- Author(s)
  小池博之 , 大石由美子
- Organizer
  第1回 PHILOSOPHY
- Data Source
  KAKENHI-PROJECT-19K20178
[Presentation] Zn-finger transcription factor Klf5 is involved in the pathogenesis of muscle atrophy in vivo2018
- Author(s)
  Lin Liu, Hiroyuki Koike, Yumiko Oishi
- Organizer
  The 41st Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-18H06413

1. Miyagawa Yoshitaka (90415604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 酒井真志人 (40643490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 江浦重義 (00366361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 土肥輝之 (10575385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小川令 (70398866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大石由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. 米山鷹介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koike Hiroyuki 小池 博之

Research Projects

Research Products

Co-Researchers

Regulatory Mechanisms of Skeletal Muscle Regeneration via Macrophage SubpopulationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患特異的iPS細胞を用いたケロイドの病態解明と治療法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

オルガノイドの代謝特性を利用した循環培養系の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single cell analysis for tissue regeneration and lipid metabolism in skeletal musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modeling of innovative oncolytic viral therapy and elucidation of the underlying mechanism using an advanced organoid technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of interaction between skeletal muscle satellite cells and macrophages for maintenance of tissue homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the muscle satellite cell-macrophage crosstalk and skeletal muscle regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Macrophage SREBP1 regulates skeletal muscle regeneration2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of Cooperative Cell-Cell Interactions in Skeletal Muscle Regeneration.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanical guidance of self-condensation patterns of differentiating progeny2022

Author(s)

Journal Title

DOI

Koike Hiroyuki 小池博之