Yanoshita Makoto 矢野下真

Researcher Number	20823199
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(歯), 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 広島大学, 医系科学研究科(歯), 助教 2018 – 2020: 広島大学, 病院(歯), 歯科診療医
Review Section/Research Field	Principal Investigator Basic Section 57070:Developmental dentistry-related / 0907:Oral science and related fields Except Principal Investigator Basic Section 57070:Developmental dentistry-related
Keywords	Principal Investigator 変形性顎関節症 / 顎関節症 / 軟骨 / 機械的負荷 / FAKシグナル / 骨代謝異常 / 過度な機械的負荷 / 特発性下顎頭吸収 / 関節円板転位 / 関節円板前方転位モデル … More / 関節円板前方転位 / FAK / 機械的刺激 / TMJ-OA / オートファジー / 顎関節 / 軟骨細胞 / レゾルビンD１ / レゾルビン / 不飽和脂肪酸 / 滑膜 / 炎症 / レゾルビンD1 … More Except Principal Investigator NFATC / 軟骨細胞 / 下顎頭軟骨 / 変形性顎関節症 / 顎関節症 / 変形性関節症 / Hippo シグナル / ヒアルロン酸 / 成長発育 / Nrp-1 / Sema3A / 下顎頭 / 骨組織 / 軟骨組織 / 機械的負荷 / １１Ｒ－ＶＩＶＩＴ / タモキシフェン / エストロゲン / 特発性下顎頭吸収 / 機械的刺激 / 軟骨 / MMP / 炎症 / 滑膜細胞 / FK506 / NFATｃ Less

Elucidation of the mechanism of cartilage destruction by inactivating Hippo signaling with low molecular weight HA and its application to a new treatment for TMJ-OA
- Principal Investigator
  
  麻川由起 (丹根由起)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
Analysis of bone metabolism abnormalities specific to the mandible head and the mechanism of suppression of ICR by FAK inhibition.Principal Investigator
- Principal Investigator
  
  矢野下真
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
The elucidation of ICR development via estrogen-NFAT signaling and the establishment of its remedy
- Principal Investigator
  
  廣瀬尚人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
Sema3Aによる下顎頭軟骨分化促進機構の解明と下顎後退症新規治療への応用
- Principal Investigator
  
  麻川由起 (丹根由起)
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
関節円板前方転位による変形性顎関節症モデルの新規確立とOAメカニズムの解明Principal Investigator
- Principal Investigator
  
  矢野下真
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
Investigation of the interaction between FAK and selective autophagy and Establishment of effective treatment for temporomandibular joint disorders with regulation of selective autophagyPrincipal Investigator
- Principal Investigator
  
  Yanoshita Makoto
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
The elucidation of TMJ-OA mechanics and the establishment of medication using NFATc inhibitors
- Principal Investigator
  
  Naoto Hirose
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
Establishment of effective treatment for temporomandibular joint disorders with Docosahexaenoic acid (DHA) and ResolvinPrincipal Investigator
- Principal Investigator
  
  Yanoshita Makoto
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] 著しい開口障害および下顎頭の変形を伴う不正咬合患者に対し行った包括的治療の一例2023
- Author(s)
  廣瀬尚人, 矢野下真, 大西梓, 西山沙由理, 久保尚毅, 北大樹, 壷井英里, 麻川由起, 谷本幸太郎
- Journal Title
  
  日顎関節会誌
  
  Volume: 35(1) Pages: 1-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10272
[Journal Article] Longitudinal effects of estrogen on mandibular growth and changes in cartilage during the growth period in rats2022
- Author(s)
  Kubo Naoki、Awada Tetsuya、Hirose Naoto、Yanoshita Makoto、Takano Mami、Nishiyama Sayuri、Tsuboi Eri、Kita Daiki、Ito Shota、Nakatani Ayaka、Onishi Azusa、Asakawa Yuki、Tanimoto Kotaro
- Journal Title
  
  Developmental Biology
  
  Volume: 492 Pages: 126-132
- DOI
  10.1016/j.ydbio.2022.10.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10273, KAKENHI-PROJECT-22K17230, KAKENHI-PROJECT-22K17231, KAKENHI-PROJECT-22K17253
[Journal Article] High-frequency Near-infrared Diode Laser Irradiation Suppresses IL-1β-induced Inflammatory Cytokine Expression and NF-κB Signaling Pathways in Human Primary Chondrocytes2021
- Author(s)
  Sakata S., Kunimastu R., Tsuka Y., Nakatani S., Gunji H., Yanoshita M., Kado I., Ito S., Putranti NAR., RC Prasetya., Hirose N., Tanimoto K.
- Journal Title
  
  Lasers Med Sci
  
  Volume: 37(2) Pages: 1193-1201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10383
[Journal Article] ANGPTL2 induces synovial inflammation via LILRB22021
- Author(s)
  Nishiyama S., Hirose N., Yanoshita M., Takano M., Kubo N., Yamauchi Y., Onishi A., Ito S., Sakata S., Kita D., Asakawa-Tanne Y., Tanimoto K.:
- Journal Title
  
  Inflammation
  
  Volume: 44(3) Pages: 1108-1118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10383
[Journal Article] Orthodontic Treatment Combined with Miniscrew Anchorage for an Angle Class II Division 1 Case with Severe Crowding and TMDs2020
- Author(s)
  Hirose N., Yanoshita M., Onishi A., Yamauchi Y., Nishiyama Y., Takano M., Tsuboi E., Kubo N., Tanimoto K
- Journal Title
  
  Dental Research and Oral Health
  
  Volume: 3(3) Issue: 03
- DOI
  10.26502/droh.0027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10383
[Journal Article] FAK inhibition protects condylar cartilage under excessive mechanical stress2020
- Author(s)
  Yanoshita M., Hirose N., Sumi C., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Kunimatsu R., Tanimoto K
- Journal Title
  
  Oral diseases
  
  Volume: 26(8) Issue: 8 Pages: 1736-1746
- DOI
  10.1111/odi.13494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10383, KAKENHI-PROJECT-20K18781
[Journal Article] ANGPTL2 Induces Synovial Inflammation via LILRB22020
- Author(s)
  Sayuri Nishiyama, Naoto Hirose , Makoto Yanoshita , Mami Takano, Naoki Kubo, Yuka Yamauchi, Azusa Onishi, Shota Ito , Shuzo Sakata, Daiki Kita, Yuki Asakawa-Tanne, and Kotaro Tanimoto
- Journal Title
  
  Inflammation
  
  Volume: - Issue: 3 Pages: 1108-1118
- DOI
  10.1007/s10753-020-01406-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10383, KAKENHI-PROJECT-20K18781, KAKENHI-PROJECT-20K18783
[Journal Article] Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress2020
- Author(s)
  Hirose Naoto、Okamoto Yuki、Yanoshita Makoto、Asakawa Yuki、Sumi Chikako、Takano Mami、Nishiyama Sayuri、Su Shao‐Ching、Mitsuyoshi Tomomi、Kunimatsu Ryo、Tanne Kazuo、Tanimoto Kotaro
- Journal Title
  
  Cell Biology International
  
  Volume: 44 Issue: 4 Pages: 966-974
- DOI
  10.1002/cbin.11293
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21397, KAKENHI-PROJECT-19K10383, KAKENHI-PROJECT-20K18781
[Journal Article] High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes.2020
- Author(s)
  Sakata S, Kunimatsu R, Tsuka Y, Nakatani A, Hiraki T, Gunji H, Hirose N, Yanoshita M, Putranti NAR, Tanimoto K.
- Journal Title
  
  J Clin Med
  
  Volume: 24 Issue: 3 Pages: 881-881
- DOI
  10.3390/jcm9030881
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10385, KAKENHI-PROJECT-18K17256, KAKENHI-PROJECT-19K21397, KAKENHI-PROJECT-19K10383, KAKENHI-PROJECT-20K18759
[Journal Article] ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes.2019
- Author(s)
  Takano M, Hirose N, Sumi C, Yanoshita M, Nishiyama S, Onishi A, Asakawa Y, Tanimoto K
- Journal Title
  
  Cartilage
  
  Volume: 4 Issue: 2_suppl Pages: 1-13
- DOI
  10.1177/1947603519878242
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09833, KAKENHI-PROJECT-19K10383, KAKENHI-PROJECT-19K21397
[Journal Article] Elucidation of the inflammatory mechanism of mandibular cartilage development and the establishment of a prevention method for PCR using Sema3A Download Article: Download (PDF 362 kb)2019
- Author(s)
  Hirose, Naoto; Chikako, Sumi; Yanoshita, Makoto; Nishiyama, Sayuri; Tsuboi, Eri
- Journal Title
  
  Impact
  
  Volume: Number 4 Issue: 4 Pages: 67-69
- DOI
  10.21820/23987073.2019.4.67
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11789, KAKENHI-PROJECT-19K21397
[Presentation] 顎関節症を有する重度骨格性上顎前突患者に対して顎関節症基本治療後に手術を併用した矯正歯科治療を行った一例2023
- Author(s)
  矢野下真, 廣瀬尚人, 西山沙由理, 壷井英里, 久保尚毅, 北大樹, 武居咲希, 中嶋亮介, 仲里みのり, 麻川由起, 谷本幸太郎
- Organizer
  第 36 回一般社団法人日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10273
[Presentation] 広島大学病院矯正歯科における小児の顎関節症の発現に関する臨床統計調査2023
- Author(s)
  ：壷井英里, 廣瀬尚人, 麻川由起, 矢野下真, 西山沙由理, 久保尚毅, 北大樹, 武居咲希, 仲里みのり, 中嶋亮介, 谷本幸太郎
- Organizer
  第 66 回中・四国矯正歯科学会大会
- Data Source
  KAKENHI-PROJECT-22K10273
[Presentation] 広島大学病院矯正歯科における小児の顎関節症の発現に関する臨床統計調査2023
- Author(s)
  壷井英里, 廣瀬尚人, 麻川由起, 矢野下真, 西山沙由理, 久保尚毅, 北大樹, 武居咲希, 仲里みのり, 中嶋亮介, 谷本幸太郎
- Organizer
  第66回中・四国矯正歯科学会大会（徳島）
- Data Source
  KAKENHI-PROJECT-22K10272
[Presentation] 顎関節症を有する重度骨格性上顎前突患者に対して、顎関節症基本治療後に手術を併用した矯正歯科治療を行った一例2023
- Author(s)
  矢野下真,　廣瀬尚人,　西山沙由理,　壷井英里, 久保尚毅,　北大樹, 武居咲希,　中嶋亮介, 仲里みのり, 麻川由起, 谷本幸太郎
- Organizer
  第36回一般社団法人日本顎関節学会総会・学術大会（東京）
- Data Source
  KAKENHI-PROJECT-22K10272
[Presentation] The surgical strategy of reconstruction for temporomandibular joint2023
- Author(s)
  大段慶十朗, 小野重弘, 中川貴之, 水田邦子, 石田陽子, 植月亮, 佐々木和起, 佐久間美雪, 深田翔平, 廣瀬尚人, 麻川由起, 矢野下真, 西山沙由理, 壷井英里, 久保尚毅, 加来真人, 谷本幸太郎, 相川友直
- Organizer
  第56回広島大学歯学会総会（広島）
- Data Source
  KAKENHI-PROJECT-22K10272
[Presentation] 週齢の違いがラット顎関節および血清中の Semaphorin３A 発現に与える影響2022
- Author(s)
  壷井英里, 廣瀬尚人, 麻川由起, 矢野下真, 大西梓, 高野真実, 西山沙由理, 久保尚毅, 北大樹, 谷本幸太郎
- Organizer
  第 35 回一般社団法人日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10273
[Presentation] 過度なメカニカルストレスによる下顎頭吸収メカニズムの検討2022
- Author(s)
  矢野下　真
- Organizer
  第35回日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K17230
[Presentation] 下顎頭の成長に伴うエストロゲンの下顎骨および軟骨への影響2022
- Author(s)
  久保尚毅, 廣瀬尚人, 粟田哲也, 矢野下　真, 西山沙由理, 壷井英里, 北　大樹, 大西　梓, 麻川由紀, 谷本幸太郎
- Organizer
  第35回日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K17230
[Presentation] 関節円板前方転位モデルラットにおける下顎頭の形態学的、組織学的変化2022
- Author(s)
  北　大樹, 矢野下　真, 廣瀬尚人, 西山沙由理, 壷井英里, 久保尚毅, 大西　梓, 麻川由起, 谷本幸太郎
- Organizer
  第35回日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K17230
[Presentation] 下顎頭の成長に伴うエストロゲンの下顎骨および軟骨への影響2022
- Author(s)
  久保尚毅, 廣瀬尚人, 粟田哲也, 矢野下真, 西山沙由理, 壷井英里, 北大樹, 大西梓, 麻川由紀, 谷本幸太郎
- Organizer
  第 35 回一般社団法人日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10273
[Presentation] 週齢の違いがラット顎関節および血清中のSemaphorin３A発現に与える影響2022
- Author(s)
  壷井英里, 廣瀬尚人, 麻川由起, 矢野下　真, 大西　梓, 高野真実, 西山沙由理, 久保尚毅, 北　大樹, 谷本幸太郎
- Organizer
  第35回日本顎関節学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K17230
[Presentation] ヒト初代培養軟骨細胞における炎症性サイトカインおよびマトリックスメタロプロテアーゼの IL-1β誘導性発現に対する高周波近赤外半導体レーザー照射の影響2021
- Author(s)
  坂田修三, 國松亮, 柄優至, 中谷文香, Putranti NAR., 矢野下真, 廣瀬尚人, 谷本幸太郎
- Organizer
  第 34 回日本顎関節学会学術大会（東京）
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] エストロゲン投与の下顎骨成長への影響と軟骨における変化2021
- Author(s)
  久保尚毅, 粟田哲也, 廣瀬尚人, 矢野下真, 高野真美, 西山沙友理, 壷井英里, 北大樹, 大西梓, 山内優佳, 松永萌, 谷本幸太郎
- Organizer
  第80回日本矯正歯科学会大会・第5回国際会議
- Data Source
  KAKENHI-PROJECT-20K18781
[Presentation] エストロゲン投与の下顎骨成長への影響と軟骨における変化2021
- Author(s)
  久保尚毅, 粟田哲也, 廣瀬尚人, 矢野下真, 高野真美, 西山沙友理, 壷井英里, 北大樹, 大西梓, 山内優佳, 松永萌, 谷本幸太郎
- Organizer
  第 80 回日本矯正歯科学会大会・第 5 回国際会議（神奈川）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] ヒト滑膜細胞においてレゾルビン D1 は p-38、NF-kβ および AKT シグナルを介して炎症反応を抑制する2021
- Author(s)
  矢野下真, 廣瀬尚人, 西山沙由理, 大西梓, 山内優佳, 壷井英里, 久保尚毅, 北大樹, 麻川由起, 谷本幸太郎
- Organizer
  第 34 回一般社団法人日本顎関節学会学術大会（東京）
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] 下顎頭の内軟骨性骨化におけるSemaphorin3Aの役割2021
- Author(s)
  壷井英里, 廣瀬尚人, 麻川由起, 矢野下真, 大西梓, 高野真実, 西山沙由理, 久保尚毅, 北大樹, 谷本幸太郎
- Organizer
  第34回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18781
[Presentation] ヒト滑膜細胞においてレゾルビンD1はp-38、NF-kβおよびAKTシグナルを介して炎症反応を抑制す2021
- Author(s)
  矢野下真, 廣瀬尚人, 西山沙由理, 大西梓, 山内優佳, 壷井英里, 久保尚毅, 北大樹, 麻川由起, 谷本幸太郎
- Organizer
  第34回一般社団法人日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18781
[Presentation] 高周波近赤外半導体レーザー照射がヒト軟骨細胞の炎症サイトカインに及ぼす影響2021
- Author(s)
  坂田修三, 國松亮, 柄優至, 中谷文香, Putranti NAR., 矢野下真, 廣瀬尚人, 谷本幸太郎
- Organizer
  第 80 回日本矯正歯科学会大会・第 5 回国際会議（神奈川）
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] Role of Semaphorin3A in endochondral ossification of mandibular condyle2020
- Author(s)
  Tsuboi E., Asakawa Y., Hirose N., Yanoshita M., Takano M., Nishiyama S., Kubo N., Onishi A., Yamauchi Y., Tanimoto K
- Organizer
  The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society (Yokohama)
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] LILRB2 は滑膜細胞において ANGPTL2 により誘導された炎症を制御する2020
- Author(s)
  西山沙由理，廣瀬尚人，矢野下真，高野真実，壷井英里，久保尚毅，大西梓，山内優佳，谷本幸太郎
- Organizer
  第 33 回日本顎関節学会学術大会（京都）
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] 広島大学病院矯正歯科における過去5年間の顎関節症に関する統計調査2020
- Author(s)
  大西梓, 廣瀬尚人, 麻川由起, 粟田哲也, 矢野下真, 高野真実, 山内優佳, 西山沙由理, 壷井英里,久保尚毅,谷本幸太郎
- Organizer
  第33回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] An open bite case with temporomandibular disorders caused by a car accident ; a case report2020
- Author(s)
  Hirose N., Yanoshita M., Onishi A., Yamauchi Y., Nishiyama S., Takano M., Tsuboi E., Kubo N., Tanimoto K.
- Organizer
  The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] セマフォリン 3A は軟骨において過度な機械的負荷による炎症発現を抑制する2020
- Author(s)
  ：廣瀬尚人，矢野下真，高野真実，西山沙由理，大西梓，久保尚毅，麻川由起，谷本幸太郎
- Organizer
  第 33 回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18781
[Presentation] 軟骨に対する過度な機械的負荷時の FAK - MAPKs カスケードによる炎症反応メカニズムの解明2020
- Author(s)
  矢野下真，廣瀬尚人，高野真実，西山沙由理，壷井英里，大西梓，山内優佳，久保尚毅，麻川由起，谷本幸太郎
- Organizer
  第 33 回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18781
[Presentation] セマフォリン3Aは軟骨において過度な機械的負荷による炎症発現を抑制する2020
- Author(s)
  廣瀬尚人, 矢野下真, 高野真実, 西山沙由理, 大西梓, 久保尚毅, 麻川由起, 谷本幸太郎
- Organizer
  第33回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] Oral and maxillofacial features of 3 rare congenital diseases uncovered by the Japanese National Health Insurance2020
- Author(s)
  Onishi A, Hirose N, Yamauchi Y, Yanoshita M, Takano M, Nishiyama S, Kagawa H, Tsuboi E, Kubo N, Tanimoto K
- Organizer
  The 9th International Orthodontic Congress (Japan)
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] LILRB2 は滑膜細胞において ANGPTL2 により誘導された炎症を制御する2020
- Author(s)
  西山沙由理，廣瀬尚人，矢野下真，高野真実，壷井英里，久保尚毅，大西梓，山内優佳，谷本幸太郎
- Organizer
  第 33 回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18781
[Presentation] Familial cases with Hyper-IgE syndrome, Oral/maxillofacial features and Orthodontic treatment plan2020
- Author(s)
  Yanoshita M., Hirose N., Takano M., Onishi A., Yamauchi Y., Nishiyama S., Kagawa H., Tsuboi E., Kubo N., Asakawa Y., Tanimoto K
- Organizer
  The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society (Yokohama)
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] 軟骨に対する過度な機械的負荷時のFAK - MAPKsカスケードによる炎症反応メカニズムの解明2020
- Author(s)
  矢野下真, 廣瀬尚人, 高野真実, 西山沙由理, 壷井英里, 大西梓, 山内優佳, 久保尚毅, 麻川由起, 谷本幸太郎
- Organizer
  第33回日本顎関節学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] Semaphorin3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress2019
- Author(s)
  Hirose Naoto、Yanoshita Makoto、Takano Mami、Sumi Chikako、Nishiyama Sayuri、Tsuboi Eri、Asakawa Yuki、Onishi Azusa、Yamauchi Yuuka、Tanimoto Kotaro
- Organizer
  The 97th General Session of International Association for Dental Research（Vancouver）, 2019.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21397
[Presentation] Anti - inflammatory effects of FAK inhibitor on condylar cartilage under excessive mechanical stress2019
- Author(s)
  Yanoshita Makoto、Hirose Naoto、Takano Mami、Sumi Chikako、Nishiyama Sayuri、Tsuboi Eri、Asakawa Yuki、Onishi Azusa、Yamauchi Yuuka、Tanimoto Kotaro
- Organizer
  The 97th General Session of International Association for Dental Research（Vancouver）, 2019.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21397
[Presentation] ANGPTL2 promotes inflammation via integrin α5β1 in chondrocytes2019
- Author(s)
  Takano Mami、Yanoshita Makoto、Hirose Naoto、Nishiyama Sayuri、Tsuboi Eri、Onishi Azusa、Yamauchi Yuuka、Asakawa Yuki、Tanimoto Kotaro
- Organizer
  The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint（Tokyo）, 2019.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21397
[Presentation] 下顎頭軟骨への過度な圧迫負荷付与時のFAK阻害剤の抗炎症効果－器官培養法を用いた検討－2019
- Author(s)
  矢野下真, 廣瀬尚人, 高野真実, 西山沙由理, 大西梓, 山内優佳, 壷井英里, 麻川由起, 谷本幸太郎
- Organizer
  第32回顎関節学会総会・学術大会（東京）第6回アジア顎関節学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] Anti - inflammatory effects of FAK inhibitor on condylar cartilage under excessive mechanical stress2019
- Author(s)
  Yanoshita M., Hirose N., Takano M., Sumi C., Nishiyama S., Tsuboi E., Asakawa Y., Onishi A., Yamauchi Y., Tanimoto K.
- Organizer
  The 97th General Session of International Association for Dental Research (Vancouver),
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] 軟骨細胞におけるANGPTL2による炎症促進メカニズムの解明2019
- Author(s)
  高野真実, 廣瀬尚人, 矢野下真, 西山沙由理, 壷井英里, 大西梓, 山内優佳, 麻川由起, 谷本幸太郎
- Organizer
  第32回顎関節学会総会・学術大会（東京）第6回アジア顎関節学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] Semaphorin3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress.2019
- Author(s)
  Hirose N., Sumi C., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K
- Organizer
  The 97th General Session of International Association for Dental Research (Vancouver)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10383
[Presentation] Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model2019
- Author(s)
  Yanoshita Makoto、Hirose Naoto、Takano Mami、Sumi Chikako、Nishiyama Sayuri、Tsuboi Eri、Asakawa Yuki、Onishi Azusa、Yamauchi Yuuka、Tanimoto Kotaro
- Organizer
  The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint（Tokyo）, 2019.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21397

1. Naoto Hirose (50611935)

# of Collaborated Projects: 5 results

# of Collaborated Products: 31 results
2. 谷本幸太郎 (20322240)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
3. 國松亮 (40580915)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
4. 麻川由起 (50526241)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. TANNE Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results
6. SUMI Chikako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. NISHIYAMA Sayuri

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. TSUBOI Eri

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 柄優至

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yanoshita Makoto 矢野下 真

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of cartilage destruction by inactivating Hippo signaling with low molecular weight HA and its application to a new treatment for TMJ-OA

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Analysis of bone metabolism abnormalities specific to the mandible head and the mechanism of suppression of ICR by FAK inhibition.Principal Investigator

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The elucidation of ICR development via estrogen-NFAT signaling and the establishment of its remedy

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Sema3Aによる下顎頭軟骨分化促進機構の解明と下顎後退症新規治療への応用

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関節円板前方転位による変形性顎関節症モデルの新規確立とOAメカニズムの解明Principal Investigator

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Investigation of the interaction between FAK and selective autophagy and Establishment of effective treatment for temporomandibular joint disorders with regulation of selective autophagyPrincipal Investigator

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The elucidation of TMJ-OA mechanics and the establishment of medication using NFATc inhibitors

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Establishment of effective treatment for temporomandibular joint disorders with Docosahexaenoic acid (DHA) and ResolvinPrincipal Investigator

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[Journal Article] 著しい開口障害および下顎頭の変形を伴う不正咬合患者に対し行った包括的治療の一例2023

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[Journal Article] Longitudinal effects of estrogen on mandibular growth and changes in cartilage during the growth period in rats2022

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[Journal Article] High-frequency Near-infrared Diode Laser Irradiation Suppresses IL-1β-induced Inflammatory Cytokine Expression and NF-κB Signaling Pathways in Human Primary Chondrocytes2021

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[Journal Article] ANGPTL2 induces synovial inflammation via LILRB22021

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[Journal Article] Orthodontic Treatment Combined with Miniscrew Anchorage for an Angle Class II Division 1 Case with Severe Crowding and TMDs2020

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[Journal Article] FAK inhibition protects condylar cartilage under excessive mechanical stress2020

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[Journal Article] ANGPTL2 Induces Synovial Inflammation via LILRB22020

Yanoshita Makoto 矢野下真

[Presentation] 顎関節症を有する重度骨格性上顎前突患者に対して顎関節症基本治療後に手術を併用した矯正歯科治療を行った一例2023

[Presentation] ヒト初代培養軟骨細胞における炎症性サイトカインおよびマトリックスメタロプロテアーゼの IL-1β誘導性発現に対する高周波近赤外半導体レーザー照射の影響2021