Miki Takayuki 三木卓幸

… Alternative Names

MIKI Takayuki 三木卓幸

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Researcher Number	20823991
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院工学系研究科(工学部), 特任講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京大学, 大学院工学系研究科(工学部), 特任講師 2019 – 2022: 東京工業大学, 生命理工学院, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Basic Section 38030:Applied biochemistry-related / Medium-sized Section 37:Biomolecular chemistry and related fields Except Principal Investigator Science and Engineering / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Keywords	Principal Investigator ペプチド / タンパク質間相互作用 / バイオセンサー / HDM2 / TICT / 蛋白質間相互作用 / 蛍光センサー / 細胞 / 蛋白質会合体 / 自己集合 … More / 蛋白質集積化 / 設計ペプチド / 液-液相分離 / self-sorting / Nck1 / cell engineering / in cell reconstitution / protein assembly / de novo peptide / His tag / 膜タンパク質 / 金属錯体 / 化学修飾 / ペプチドリガンド / Phage Display / hDM2 / Ni錯体 / ファージディスプレイ法 / 中分子医薬 / Ni(II)錯体 / His-tag / 膜蛋白質 / ファージディスプレイ … More Except Principal Investigator ダイナミクス / 固体物性 / 固体超分子ポリマー / エントロピー / 相分離 / 環境調和 / 自己修復ポリマー / 超分子プラスチック / タンパク質相互作用 / 薬剤複合体 / ファージ提示 / ペプチド Less

人工オルガネラの細胞内構築を可能とするペプチドタグ開発Principal Investigator
- Principal Investigator
  
  三木卓幸
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  The University of Tokyo
Solid-State Materials Science of Supramolecular Polymers and Their Applications
- Principal Investigator
  
  相田卓三
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
- Research Institution
  Institute of Physical and Chemical Research
PPI阻害剤のin cellアッセイを実現するRsHPセンサの開発Principal Investigator
- Principal Investigator
  
  三木卓幸
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  The University of Tokyo
Rational construction of artificial phase separation for cell engineering with designed peptidesPrincipal Investigator
- Principal Investigator
  
  Miki Takayuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Development of Tag-assisted Phage Display for screening of peptide drugPrincipal Investigator
- Principal Investigator
  
  MIKI Takayuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Construction of a Peptide Drug Discovery Platform Using Chemically Modified Peptide Phage Libraries
- Principal Investigator
  
  Mihara Hisakazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Tokyo Institute of Technology

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Effects of Hydrophobic Residues on the Intracellular Self-Assembly of De Novo Designed Peptide Tags and Their Orthogonality2022
- Author(s)
  Miki Takayuki、Kajiwara Keigo、Nakayama Sae、Hashimoto Masahiro、Mihara Hisakazu
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: ASAP Issue: 6 Pages: 2144-2153
- DOI
  10.1021/acssynbio.2c00058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14739
[Journal Article] Selection of fluorescent biosensors against galectin-3 from an NBD-modified phage library displaying designed α-helical peptides2021
- Author(s)
  Hashimoto Masahiro、Miki Takayuki、Chang Iou Ven、Tsutsumi Hiroshi、Mihara Hisakazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 37 Pages: 127835-127835
- DOI
  10.1016/j.bmcl.2021.127835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15696, KAKENHI-PROJECT-19H02838
[Journal Article] A guide-tag system controlling client enrichment into Y15 peptide-based granules for an in-cell protein recruitment assay2021
- Author(s)
  Miki Takayuki、Hashimoto Masahiro、Nakai Taichi、Mihara Hisakazu
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 86 Pages: 11338-11341
- DOI
  10.1039/d1cc03450b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14739
[Journal Article] Intracellular artificial supramolecules based on de novo designed Y15 peptides2021
- Author(s)
  Miki Takayuki、Nakai Taichi、Hashimoto Masahiro、Kajiwara Keigo、Tsutsumi Hiroshi、Mihara Hisakazu
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3412-3412
- DOI
  10.1038/s41467-021-23794-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K14739
[Journal Article] hDM2 protein-binding peptides screened from stapled α-helical peptide phage display libraries with different types of staple linkers2020
- Author(s)
  Anananuchatkul Teerapat、Tsutsumi Hiroshi、Miki Takayuki、Mihara Hisakazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 23 Pages: 127605-127605
- DOI
  10.1016/j.bmcl.2020.127605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02838
[Journal Article] Construction of a Stapled α-Helix Peptide Library Displayed on Phage for the Screening of Galectin-3-Binding Peptide Ligands2020
- Author(s)
  Anananuchatkul Teerapat、Chang Iou Ven、Miki Takayuki、Tsutsumi Hiroshi、Mihara Hisakazu
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 11 Pages: 5666-5674
- DOI
  10.1021/acsomega.9b03461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05351, KAKENHI-PROJECT-19K22249, KAKENHI-PROJECT-19K15696, KAKENHI-PROJECT-19H02838
[Presentation] 両親媒性YKペプチドタグによる細胞内液滴の人工構築とクライアントタンパク質の濃縮2023
- Author(s)
  橋本　匡浩・三木卓幸・高橋　広樹・中山　彩恵・三原久和
- Organizer
  日本化学会　第103春季年会
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] De novoペプチドによる相分離液滴の設計と細胞内構築2023
- Author(s)
  三木卓幸
- Organizer
  化生セミナー , 東京大学 (Faculty Host: 山東教授)
- Invited
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] YKペプチドタグによる細胞内での人工相分離液滴モデルの形成2022
- Author(s)
  三木卓幸・橋本　匡浩・高橋　広樹・中山　彩恵・三原久和
- Organizer
  第１６回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 自己集合性ペプチドタグによる超分子の細胞内構築2022
- Author(s)
  三木卓幸・橋本　匡浩・中井　太一・梶原　圭悟・高橋　広樹・中山　彩恵・三原久和
- Organizer
  第７１回高分子討論会
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 細胞内で液-液相分離を作る設計ペプチドの開発2022
- Author(s)
  三木卓幸
- Organizer
  ライフサイエンス部会材料分科会とLiHubの若手交流会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] Design of self-assembling peptide tags for protein-based supramolecular construction in living cells2022
- Author(s)
  Takayuki Miki・Masahiro Hashimoto・Hiroki Takahashi・Sae Nakayama・Hisakazu Mihara
- Organizer
  The 59th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] Development of self-assembling peptide tags fabricating protein clusters in living cells2022
- Author(s)
  Takayuki Miki
- Organizer
  Special Seminar Lecture, UC Berkeley, USA (Faculty Host: Prof. Chris Chang)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 細胞内で人工構造を建造2022
- Author(s)
  三木卓幸
- Organizer
  すずかけサイエンスディ2022
- Invited
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] Development of de novo peptide tags to form polymeric protein assemblies in living cells2022
- Author(s)
  Takayuki Miki
- Organizer
  Gordon Research Conference, Chemistry and Biology of Peptide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] De novoペプチド間の自己集合と蛋白質間相互作用の協奏による細胞内での液滴形成2022
- Author(s)
  中山　彩恵・三木卓幸・橋本　匡浩・高橋　広樹・梶原　圭悟・三原久和
- Organizer
  第３２回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] Development of self-assembling peptide tag for intracellular reconstitution of protein assembly2022
- Author(s)
  Takayuki Miki
- Organizer
  2022 PSK Annual Spring Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] Construction of intracellular protein supramolecular structures using self-assembling peptide tags2022
- Author(s)
  Takayuki Miki
- Organizer
  Syracuse University, USA (Host: Prof. Ivan Korendovych)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] INTRACELLULAR CONSTRUCTION OF PROTEIN CONDENSATES BY AMPHIPHILIC YK PEPTIDES AND EVALUATION OF MOLECULAR CHAPERONES INVOLVED IN MAINTAINING LIQUID DROPLETS2022
- Author(s)
  Hiroki Takahashi, Takayuki Miki, Masahiro Hashimoto and Hisakazu Mihara
- Organizer
  The 59th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] ペプチドを基軸とした細胞内蛋白質の検出・操作技術の開発2022
- Author(s)
  三木卓幸
- Organizer
  新科学技術推進協会(JACI) ライフサイエンス技術部会　材料分科会　勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 細胞内で自己集合するペプチドタグ開発２：蛋白質高次構造体の設計と構築2022
- Author(s)
  三木卓幸・高橋　広樹・橋本　匡浩・梶原　圭悟・中山　彩恵・三原久和
- Organizer
  日本化学会　第102回　春季年会
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 細胞内で自己集合するペプチドタグ開発１：クラスター形成を伴う蛋白質間相互作用解析2022
- Author(s)
  橋本　匡浩・三木卓幸・中井　太一・丹羽　達也・三原久和
- Organizer
  日本化学会　第102回　春季年会
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 蛍光修飾αヘリックス設計ペプチドを提示したファージライブラリによるgalectin-3検出蛍光バイオセンサーの探索2021
- Author(s)
  橋本匡浩、三木卓幸、Iou Ven Chang、堤　浩、三原久和
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19H02838
[Presentation] INTRACELLULAR RECONSTITUTION AND ANALYSIS OF PROTEIN COMPLEXES BY YN SELF-ASSEMBLING PEPTIDE TAGS2021
- Author(s)
  Takayuki Miki, Masahiro Hashimoto, Taichi Nakai, Keigo Kajiwara, Hisakazu Mihara
- Organizer
  The 58th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 蛍光修飾αヘリックス設計ペプチドを提示したファージライブラリによるgalectin-3検出蛍光バイオセンサーの探索2021
- Author(s)
  橋本　匡浩・三木　卓幸・Iou Ven Chang・堤　浩・三原　久和
- Organizer
  日本化学会　第１０1春季年会
- Data Source
  KAKENHI-PROJECT-19K15696
[Presentation] Construction of photoreactive group-modified phage libraries and selection against hDM22021
- Author(s)
  Keigo Namii、Takayuki Miki、Hisakazu Mihara
- Organizer
  The 58th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-19H02838
[Presentation] Ni(II)-NTA修飾ペプチドを提示したファージライブラリの構築とHisタグ融合蛋白質に対するリガンドスクリーニング2021
- Author(s)
  瀬古　健太・筧　翔太・三木　卓幸・Iou Ven Chang・堤　浩・三原　久和
- Organizer
  日本化学会　第１０1春季年会
- Data Source
  KAKENHI-PROJECT-19K15696
[Presentation] 蛍光修飾ファージライブラリを用いたスクリーニングによるgalectin-3検出蛍光バイオセンサーの開発2021
- Author(s)
  橋本匡浩、三木卓幸、Chang Iou Ven、堤　浩、三原久和
- Organizer
  第31回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H02838
[Presentation] Development of β-sheet Y15 peptide for integrating protein in cells2021
- Author(s)
  Takayuki Miki, Taichi Nakai, Masahiro Hashimoto, Keigo Kajiwara, Hiroshi Tsutsumi, Hisakazu Mihara
- Organizer
  The international chemical congress of pacific basin societies 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] 両親媒性ペプチドによる細胞内での蛋白質高次構造体の形成2021
- Author(s)
  三木卓幸・橋本匡浩・高橋広樹・梶原圭悟・中山彩恵・中井太一・三原久和
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14739
[Presentation] ベンゼンスルホンアミド修飾環状ペプチドファージライブラリの構築2020
- Author(s)
  滝聞宏基, Anananuchatku Teerapat, 梶原圭悟, 三木卓幸, 三原久和, 堤浩
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19H02838
[Presentation] 修飾ファージライブラリによるGalectin-3応答蛍光バイオセンサーの探索2020
- Author(s)
  橋本匡浩, 三木卓幸, Iou Ven Chang, 堤浩, 三原久和
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19H02838
[Presentation] A fluorophore-conjugated phage library for screening of a peptide-based fluorescent biosensor for Galectin-32019
- Author(s)
  Masahiro Hashimoto, Takayuki Miki, Iou Ven Chang, Hiroshi Tsutsumi, Hisakazu Mihara
- Organizer
  The 56th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-19K15696
[Presentation] Improvement of phage binding ability to target proteins in combination with his-tag and Ni(II)- complex interaction2019
- Author(s)
  Kenta Seko, Takayuki Miki, Teerapat Anananuchatkul, Hiroshi Tsutsumi, Hisakazu Mihara
- Organizer
  The 56th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-19K15696
[Presentation] Screening of peptide ligands for Galectin-3 using a designed stapled α-helix peptide phage library2019
- Author(s)
  Teerapat Anananuchatkul, Takayuki Miki, Hiroshi Tsutsumi, Hisakazu Mihara
- Organizer
  The 56th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-19H02838

1. Mihara Hisakazu (30183966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 堤浩 (70398105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 相田卓三 (00167769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HUANG HUBIAO (40894829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三苫伸彦 (90768673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 堤浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

Miki Takayuki 三木 卓幸

MIKI Takayuki 三木 卓幸

Research Projects

Research Products

Co-Researchers

人工オルガネラの細胞内構築を可能とするペプチドタグ開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Solid-State Materials Science of Supramolecular Polymers and Their Applications

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PPI阻害剤のin cellアッセイを実現するRsHPセンサの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Rational construction of artificial phase separation for cell engineering with designed peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Tag-assisted Phage Display for screening of peptide drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of a Peptide Drug Discovery Platform Using Chemically Modified Peptide Phage Libraries

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Effects of Hydrophobic Residues on the Intracellular Self-Assembly of De Novo Designed Peptide Tags and Their Orthogonality2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selection of fluorescent biosensors against galectin-3 from an NBD-modified phage library displaying designed α-helical peptides2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A guide-tag system controlling client enrichment into Y15 peptide-based granules for an in-cell protein recruitment assay2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracellular artificial supramolecules based on de novo designed Y15 peptides2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] hDM2 protein-binding peptides screened from stapled α-helical peptide phage display libraries with different types of staple linkers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of a Stapled α-Helix Peptide Library Displayed on Phage for the Screening of Galectin-3-Binding Peptide Ligands2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 両親媒性YKペプチドタグによる細胞内液滴の人工構築とクライアントタンパク質の濃縮2023

Author(s)

Organizer

Data Source

[Presentation] De novoペプチドによる相分離液滴の設計と細胞内構築2023

Author(s)

Organizer

Data Source

[Presentation] YKペプチドタグによる細胞内での人工相分離液滴モデルの形成2022

Miki Takayuki 三木卓幸

MIKI Takayuki 三木卓幸