Dokainish Hisham ＤｏｋａｉｎｉｓｈＨｉｓｈａｍ

Researcher Number	20825575
Other IDs	https://orcid.org/0000-0002-4387-4790
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所ワクチン開発研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2020 – 2021: 国立研究開発法人理化学研究所, 開拓研究本部, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator Enhance sampling / Enzyme catalysis / Chrosimate Mutase / Enhanced Sampling / MD simaulation / Catalysis / enhanced sampling / Protein dynamics / IDR

Computational investigation of the role of disordered regions in enzymatic reactionsPrincipal Investigator
- Principal Investigator
  
  Dokainish Hisham
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein2022
- Author(s)
  Dokainish Hisham M、Re Suyong、Mori Takaharu、Kobayashi Chigusa、Jung Jaewoon、Sugita Yuji
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.75720
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06532, KAKENHI-PROJECT-19K12229, KAKENHI-PROJECT-20K15737, KAKENHI-PLANNED-21H05249, KAKENHI-PLANNED-21H05157, KAKENHI-PROJECT-19H05645
[Journal Article] Structural Ramifications of Spike Protein D614G Mutation in SARS-CoV-22022
- Author(s)
  Dokainish Hisham M.、Sugita Yuji
- Journal Title
  
  BioRxiv
  
  Volume: －
- DOI
  10.1101/2022.01.24.477651
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15737
[Journal Article] Unraveling SARS-CoV-2 spike protein activation pathway reveals unprecedented cryptic pockets2022
- Author(s)
  Dokainish Hisham M.、Re Suyong、Mori Takaharu、Kobayashi Chigusa、Jung Jaewoon、Sugita Yuji
- Journal Title
  
  Biophysical Journal
  
  Volume: 121 Issue: 3 Pages: 457a-457a
- DOI
  10.1016/j.bpj.2021.11.491
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15737
[Journal Article] Unraveling the Coupling between Conformational Changes and Ligand Binding in Ribose Binding Protein Using Multiscale Molecular Dynamics and Free-Energy Calculations2021
- Author(s)
  Ren Weitong、Dokainish Hisham M.、Shinobu Ai、Oshima Hiraku、Sugita Yuji
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 125 Issue: 11 Pages: 2898-2909
- DOI
  10.1021/acs.jpcb.0c11600
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05645, KAKENHI-PROJECT-20K15737
[Journal Article] Exploring Large Domain Motions in Proteins Using Atomistic Molecular Dynamics with Enhanced Conformational Sampling2020
- Author(s)
  Dokainish Hisham M.、Sugita Yuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 1 Pages: 270-270
- DOI
  10.3390/ijms22010270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05645, KAKENHI-PROJECT-20K15737
[Presentation] Unraveling SARS-CoV-2 spike protein activation pathway reveals unprecedented cryptic pockets2022
- Author(s)
  Dokainish Hisham M.,
- Organizer
  The Biophysical Society Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15737
[Presentation] Extensive Sampling of Spike protein down, one-up, one-open, and two-up-like Conformations and Transitions in SARS-Cov-2.2021
- Author(s)
  Dokainish Hisham M.,
- Organizer
  The Biophysical Society of Japan Meeting,
- Data Source
  KAKENHI-PROJECT-20K15737

1. YU Isseki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 杉田有治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 森貴治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 伊藤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Dokainish Hisham Ｄｏｋａｉｎｉｓｈ Ｈｉｓｈａｍ

Research Projects

Research Products

Co-Researchers

Computational investigation of the role of disordered regions in enzymatic reactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Ramifications of Spike Protein D614G Mutation in SARS-CoV-22022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unraveling SARS-CoV-2 spike protein activation pathway reveals unprecedented cryptic pockets2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unraveling the Coupling between Conformational Changes and Ligand Binding in Ribose Binding Protein Using Multiscale Molecular Dynamics and Free-Energy Calculations2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring Large Domain Motions in Proteins Using Atomistic Molecular Dynamics with Enhanced Conformational Sampling2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Unraveling SARS-CoV-2 spike protein activation pathway reveals unprecedented cryptic pockets2022

Author(s)

Organizer

Data Source

[Presentation] Extensive Sampling of Spike protein down, one-up, one-open, and two-up-like Conformations and Transitions in SARS-Cov-2.2021

Author(s)

Organizer

Data Source

Dokainish Hisham ＤｏｋａｉｎｉｓｈＨｉｓｈａｍ