Kameda Hiraku 亀田啓

Researcher Number	20826127
Other IDs
Affiliation (Current)	2025: 北海道大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2018 – 2022: 北海道大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / 0904:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator ニューロメジンB / 副腎皮質刺激ホルモン / 下垂体腫瘍 / クッシング病 / ニューロメジンB受容体 / ACTH / 下垂体腺腫 / 新規治療薬

Neuromedin B receptor antagonists as a novel treatment for Cushing's disease.Principal Investigator
- Principal Investigator
  
  Kameda Hiraku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hokkaido University
Neuromedin B receptor antagonist as a new treatment for Cushing diseasePrincipal Investigator
- Principal Investigator
  
  Kameda Hiraku
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0904:Internal medicine of the bio-information integration and related fields
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] The Impact of Multicultural Interfacility Video Case Conference: A Novel Education Model After the COVID Pandemic.2023
- Author(s)
  Takako Araki, Hiraku Kameda, Masaaki Yamamoto, Toru Tateno, Yasumasa Iwasaki, Run Yu, Constance Chik, Hiba Hashmi, Angela Radulescu, Lynn A Burmeister, Hidenori Fukuoka
- Journal Title
  
  J Endocr Soc.
  
  Volume: 7 Issue: 4 Pages: 1-6
- DOI
  10.1210/jendso/bvad023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08907, KAKENHI-PROJECT-20K17481
[Journal Article] False Hypercortisolemia Due to Abnormal Albumin-Cortisol Binding in a Patient with Familial Dysalbuminemic Hyperthyroxinemia2022
- Author(s)
  Chiba Koki、Kameda Hiraku、Miya Aika、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Jin Shigeki、Matoba Kotaro、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Thyroid
  
  Volume: 32 Issue: 2 Pages: 219-220
- DOI
  10.1089/thy.2021.0460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis2022
- Author(s)
  Takahashi Yuka、Kameda Hiraku、Miya Aika、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Nishimura Hiroki、Kimura Hirokazu、Suzuki Masaru、Konno Satoshi、Shimizu Ai、Matsuno Yoshihiro、Okamoto Michinari、Motegi Hiroaki、Iwata Naoko、Fujisawa Haruki、Suzuki Atsushi、Sugimura Yoshihisa、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Pituitary
  
  Volume: 25 Issue: 2 Pages: 321-327
- DOI
  10.1007/s11102-021-01200-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17724, KAKENHI-PROJECT-20K17481
[Journal Article] Dipeptidyl peptidase‐4 inhibitor might exacerbate Graves’ disease: A multicenter observational case control study2021
- Author(s)
  Sekizaki Tomonori、Kameda Hiraku、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Takahashi Kiyohiko、Miyoshi Arina、Wada Norio、Takeuchi Jun、Nagai So、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 11 Pages: 1978-1982
- DOI
  10.1111/jdi.13578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Two Distinctive <i>POMC</i> Promoters Modify Gene Expression in Cushing Disease2021
- Author(s)
  Araki Takako、Tone Yukiko、Yamamoto Masaaki、Kameda Hiraku、Ben-Shlomo Anat、Yamada Shozo、Takeshita Akira、Yamamoto Masato、Kawakami Yasuhiko、Tone Masahide、Melmed Shlomo
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 106 Issue: 9 Pages: e3346-e3363
- DOI
  10.1210/clinem/dgab387
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08899, KAKENHI-PROJECT-20K08907, KAKENHI-PROJECT-20K17481
[Journal Article] The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study2021
- Author(s)
  Handa T, Nakamura A, Miya A, Nomoto H, Kameda H, Cho KY, Nagai S, Yoshioka N, Miyoshi H, Atsumi T.
- Journal Title
  
  Diabetol Metab Syndr
  
  Volume: 1 Issue: 1 Pages: 1-8
- DOI
  10.1186/s13098-021-00656-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring2021
- Author(s)
  Miya Aika、Nakamura Akinobu、Handa Takahisa、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Nagai So、Ito Yoichi M.、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-021-88749-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Silent pituitary adenoma and metabolic disorders: obesity, abnormal glucose tolerance, hypertension and dyslipidemia2021
- Author(s)
  Baba Natsuki、Kameda Hiraku、Nakamura Akinobu、Yong Cho Kyu、Nomoto Hiroshi、Mitsuhashi Tomoko、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 2 Pages: 195-200
- DOI
  10.1507/endocrj.EJ20-0185
- NAID
  130007992407
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)2021
- Author(s)
  Hashimoto-Kameda Reina、Cho Kyu Yong、Nomoto Hiroshi、Nakamura Akinobu、Omori Kazuno、Nagai So、Edagawa Sachiko、Kawata Shinichiro、Takeuchi Jun、Kameda Hiraku、Kurihara Yoshio、Aoki Shin、Atsumi Tatsuya、Miyoshi Hideaki
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 180 Pages: 109069-109069
- DOI
  10.1016/j.diabres.2021.109069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report2021
- Author(s)
  Yamauchi Yuki、Kameda Hiraku、Omori Kazuno、Tani Michio、Cho Kyu Yong、Nakamura Akinobu、Miyoshi Hideaki、Tanaka Shinya、Atsumi Tatsuya
- Journal Title
  
  BMC Endocrine Disorders
  
  Volume: 21 Issue: 1 Pages: 1-6
- DOI
  10.1186/s12902-021-00757-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Favorable effects of burosumab on tumor-induced osteomalacia caused by an undetectable tumor2021
- Author(s)
  Oe Yuki、Kameda Hiraku、Nomoto Hiroshi、Sakamoto Keita、Soyama Takeshi、Cho Kyu Yong、Nakamura Akinobu、Iwasaki Koji、Abo Daisuke、Kudo Kohsuke、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Medicine
  
  Volume: 100 Issue: 46 Pages: e27895-e27895
- DOI
  10.1097/md.0000000000027895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice2021
- Author(s)
  Kawata Shinichiro、Nakamura Akinobu、Miyoshi Hideaki、Yang Kelaier、Shigesawa Ikumi、Yamauchi Yuki、Tsuchida Kazuhisa、Omori Kazuno、Takahashi Kiyohiko、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 24 Issue: 3 Pages: 391-401
- DOI
  10.1111/dom.14586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-20K17481
[Journal Article] Use of magnetic resonance venography for inferior petrosal sinus sampling2021
- Author(s)
  Tokairin Kikutaro、Osanai Toshiya、Fujima Noriyuki、Ishizaka Kinya、Motegi Hiroaki、Ishi Yukitomo、Kameda Hiraku、Sugiyama Taku、Kazumata Ken、Nakayama Naoki
- Journal Title
  
  The Journal of Vascular Access
  
  Volume: 2021 Feb 24 Issue: 3 Pages: 1-8
- DOI
  10.1177/1129729821997263
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor2021
- Author(s)
  Oba-Yamamoto Chiho、Kameda Hiraku、Miyoshi Hideaki、Sekizaki Tomonori、Takase Takahiro、Yanagimachi Tsuyoshi、Fujita Yukihiro、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Nagai So、Atsumi Tatsuya
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 15 Pages: 2375-2383
- DOI
  10.2169/internalmedicine.4755-20
- NAID
  130008070652
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Successful management of a patient with active Cushing’s disease complicated with coronavirus disease 2019 (COVID-19) pneumonia2021
- Author(s)
  Yuno Akiko、Kenmotsu Yoshiyuki、Takahashi Yuka、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu ?Yong、Nakamura Akinobu、Yamashita Yu、Nakamura Junichi、Nakakubo Sho、Kamada Keisuke、Suzuki Masaru、Sugino Hirokazu、Inoshita Naoko、Konno Satoshi、Miyoshi Hideaki、Atsumi Tatsuya、Sawamura Yutaka、Shimatsu Akira
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 4 Pages: 477-484
- DOI
  10.1507/endocrj.EJ20-0613
- NAID
  130008030746
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Impact of sodium glucose cotransporter 2 inhibitors on renal function in participants with type 2 diabetes and chronic kidney disease with normoalbuminuria2020
- Author(s)
  Nakamura Akinobu、Miyoshi Hideaki、Kameda Hiraku、Yamashita Kumiko、Kurihara Yoshio
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 12 Issue: 1
- DOI
  10.1186/s13098-020-0516-9
- Data Source
  KAKENHI-PROJECT-19K21329
[Journal Article] Nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation2019
- Author(s)
  Sekizaki Tomonori、Kameda Hiraku、Oba Chiho、Yong Cho Kyu、Nakamura Akinobu、Miyoshi Hideaki、Osawa Takahiro、Shinohara Nobuo、Atsumi Tatsuya
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 10 Pages: 937-941
- DOI
  10.1507/endocrj.EJ19-0076
- NAID
  130007734468
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09155, KAKENHI-PROJECT-19K21329
[Journal Article] Protective effect of sodium?glucose cotransporter?2 inhibitors in patients with rapid renal function decline, stage G3 or G4 chronic kidney disease and type?2 diabetes2019
- Author(s)
  Miyoshi Hideaki、Kameda Hiraku、Yamashita Kumiko、Nakamura Akinobu、Kurihara Yoshio
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10 Issue: 6 Pages: 1510-1517
- DOI
  10.1111/jdi.13064
- Data Source
  KAKENHI-PROJECT-19K21329
[Journal Article] Excess growth hormone suppresses DNA damage repair in epithelial cells2019
- Author(s)
  Chesnokova Vera、Zonis Svetlana、Barrett Robert、Kameda Hiraku、Wawrowsky Kolja、Ben-Shlomo Anat、Yamamoto Masaaki、Gleeson John、Bresee Catherine、Gorbunova Vera、Melmed Shlomo
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 3
- DOI
  10.1172/jci.insight.125762
- Data Source
  KAKENHI-PROJECT-19K21329
[Journal Article] Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice2019
- Author(s)
  Omori Kazuno、Nakamura Akinobu、Miyoshi Hideaki、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Takagi Ryo、Hatanaka Kanako C.、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Metabolism
  
  Volume: 98 Pages: 27-36
- DOI
  10.1016/j.metabol.2019.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-19K21329
[Presentation] Mechanism of adrenal steroid hormone synthesis enhancement in type 2 diabetes mellitus and the effects of DHCR24 inhibitor.2022
- Author(s)
  Kamigaki R, Kameda H, Shibayama Y, Nomoto H, Cho KY, Nakamura A, Jin S, Matoba K, Miyoshi H, Atsumi T.
- Organizer
  The Endocrine Society’s annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] A Case of Nephrogenic Diabetes Insipidus Diagnosed at an Advanced Age in a Female Patient with an AVPR2 Gene Mutation and Skewed X Inactivation2022
- Author(s)
  Nakata K, Kameda H, Kuwabara S, Yasui A, Takahashi Y, Miya A, Nomoto H, Cho KY, Nakamura A, Miyoshi H, Okada E, Nozu K, Atsumi T.
- Organizer
  The Endocrine Society’s annual meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] Neuromedin B receptor antagonist suppresses ACTH secretion and cell proliferation in human and mouse corticotroph adenoma2022
- Author(s)
  Sekizaki T, Kameda H, Nakamura A, Miya A, Nomoto H, Cho KY, Motegi H, Miyoshi H, Atsumi T.
- Organizer
  The Endocrine Society’s annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] GH産生下垂体腺腫におけるβ-カテニンの細胞内局在と臨床所見との関連2022
- Author(s)
  桑原咲、亀田啓、野本博司、曺圭龍、中村昭伸、伊師雪友、茂木洋晃、藤村幹、渥美達也.
- Organizer
  第48回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] 細胞株、マウス、患者由来腺腫細胞を用いた、クッシング病に対するニューロメジンB受容体拮抗薬の増殖・ホルモン分泌抑制効果の検討2022
- Author(s)
  関崎知紀、亀田啓、宮愛香、野本博司、曺圭龍、茂木洋晃、中村昭伸、三好秀明、渥美達也．
- Organizer
  日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] Neuromedin B receptor antagonist suppress Pomc expression and cell proliferation in AtT-20 cells2019
- Author(s)
  亀田　啓
- Organizer
  16th Pituitary Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21329
[Presentation] クッシング病への挑戦：基礎研究から臨床応用へ　講演1：HPA axis調節因子とその異常クッシング病への挑戦：基礎研究から臨床応用へ講演1：HPA axis調節因子とその異常2019
- Author(s)
  亀田　啓
- Organizer
  第92回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21329
[Presentation] クッシング病の新規治療薬の探索2019
- Author(s)
  亀田　啓, 関崎　知紀, 曺　圭龍, 中村　昭伸, 三好　秀明, 渥美　達也
- Organizer
  第56回日本臨床分子医学会
- Data Source
  KAKENHI-PROJECT-19K21329

1. NAKAMURA Akinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 竹下章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 山田正三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 藤沢治樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山本雅昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kameda Hiraku 亀田 啓

Research Projects

Research Products

Co-Researchers

Neuromedin B receptor antagonists as a novel treatment for Cushing's disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuromedin B receptor antagonist as a new treatment for Cushing diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The Impact of Multicultural Interfacility Video Case Conference: A Novel Education Model After the COVID Pandemic.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] False Hypercortisolemia Due to Abnormal Albumin-Cortisol Binding in a Patient with Familial Dysalbuminemic Hyperthyroxinemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dipeptidyl peptidase‐4 inhibitor might exacerbate Graves’ disease: A multicenter observational case control study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Distinctive <i>POMC</i> Promoters Modify Gene Expression in Cushing Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Silent pituitary adenoma and metabolic disorders: obesity, abnormal glucose tolerance, hypertension and dyslipidemia2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Favorable effects of burosumab on tumor-induced osteomalacia caused by an undetectable tumor2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of magnetic resonance venography for inferior petrosal sinus sampling2021

Kameda Hiraku 亀田啓