KANAYAMA KENGO 金山健剛

Researcher Number	20835102
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2022: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator iPS細胞 / SETDB1 / 肝細胞 / エピジェネティック / 発生 / 肝幹・前駆細胞 / 再生医療 / 胆管 / 幹細胞 Except Principal Investigator 肝細胞癌 / 免疫チェックポイント / 癌免疫逃避機構 / 腫瘍微小環境

Investigation of tumor immune escape mechanisms in liver cancer using allograft mouse model
- Principal Investigator
  
  Chiba Tetsuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Significance of histone methyltransferase SETDB1 in hepatocyte differentiation and its application to regenerative medicinePrincipal Investigator
- Principal Investigator
  
  KANAYAMA KENGO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma.2023
- Author(s)
  Qiang N, Ao J, Nakamura M, Chiba T, Kusakabe Y, Kaneko T, Kurosugi A, Kogure T, Ma Y, Zhang J, Ogawa K, Kan M, Iwanaga T, Sakuma T, Kanayama K, Kanzaki H, Kojima R, Nakagawa R, Kondo T, Nakamoto S, Muroyama R, Kato J, Mimura N, Ma A, Jin J, Kato N.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 118 Pages: 110068-110068
- DOI
  10.1016/j.intimp.2023.110068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-23K27577
[Journal Article] A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis.2022
- Author(s)
  Sakuma T, Nakamura M, Chiba T, Iwanaga T, Kan M, Kojima R, Ao J, Ma Y, Unozawa H, Fujita N, Kanayama K, Kanzaki H, Koroki K, Kobayashi K, Nakagawa R, Kanogawa N, Kiyono S, Kondo T, Saito T, Ogasawara S, Nakamoto S, Muroyama R, Kato J, Kishimoto T, Kato N.
- Journal Title
  
  Lab Invest.
  
  Volume: 102 Issue: 10 Pages: 1150-1157
- DOI
  10.1038/s41374-022-00807-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma2021
- Author(s)
  Ao Junjie、Tawada Akinobu、Kato Naoya et al
- Journal Title
  
  Journal of Cancer
  
  Volume: 12 Issue: 9 Pages: 2694-2701
- DOI
  10.7150/jca.56436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08276
[Journal Article] EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma2021
- Author(s)
  Kusakabe Y, Chiba T, Zen Y, Otsuka M, Kaneda A, Iwama A, Kato N, et al
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 21396-21396
- DOI
  10.1038/s41598-021-00889-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-19K17482, KAKENHI-PROJECT-20K08276
[Journal Article] The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma2021
- Author(s)
  Kanzaki H、Chiba T、Ao J、Koroki K、Kanayama K、Maruta S、Maeda T、Kusakabe Y、Kobayashi K、Kanogawa N、Kiyono S、Nakamura M、Kondo T、Saito T、Nakagawa R、Ogasawara S、Suzuki E、Ooka Y、Muroyama R、Nakamoto S、Yasui S、Tawada A、Arai M、Kanda T、Maruyama H、Mimura N、Kato J、Zen Y、Ohtsuka M、Iwama A、Kato N
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 5303-5303
- DOI
  10.1038/s41598-021-84117-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-20K17041, KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08276
[Journal Article] Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients2021
- Author(s)
  Tokunaga Mamoru、Okimoto Kenichiro、Akizue Naoki、Ishikawa Kentaro、Hirotsu Yosuke、Amemiya Kenji、Ota Masayuki、Matsusaka Keisuke、et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17671-17671
- DOI
  10.1038/s41598-021-97249-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K17451, KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K07956, KAKENHI-PROJECT-18K07408, KAKENHI-PROJECT-23K21402
[Journal Article] Acquisition of mesenchymal-like phenotypes and overproduction of angiogenic factors in lenvatinib-resistant hepatocellular carcinoma cells2021
- Author(s)
  Ao J, Chiba T, Shibata S, Kurosugi A, Qiang N, Ma Y, Kan M, Iwanaga T, Sakuma T, Kanzaki H, Kanayama K, Kojima R, Kusakabe Y, Nakamura M, Saito T, Nakagawa R, Kondo T, Ogasawara S, Suzuki E, Muroyama R, Kato J, Mimura N, Kanda T, Maruyama H, Kato N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 549 Pages: 171-178
- DOI
  10.1016/j.bbrc.2021.02.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Analyses of intermediate-stage hepatocellular carcinoma patients receiving TACE prior to designing clinical trials.2020
- Author(s)
  Koroki K, Ogasawara S, Ooka Y, Kanzaki H, Kanayama K, Maruta S, Maeda T, Yokoyama M, Wakamatsu T, Inoue M, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Yasui S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato J, Kuboki S, Ohtsuka Miyazaki M, Yokosuka O, Kato N.
- Journal Title
  
  Liver Cancer
  
  Volume: 9 Issue: 5 Pages: 596-612
- DOI
  10.1159/000508809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Interferon-γ induced PD-L1 expression and soluble PD-L1 production in gastric cancer.2020
- Author(s)
  Imai Y, Chiba T, Kondo T, Kanzaki H, Kanayama K, Ao J, Kojima R, Kusakabe Y, Nakamura M, Saito T, Nakagawa R, Suzuki E, Nakamoto S, Muroyama R, Tawada A, Matsumura T, Nakagawa T, Kato J, Kotani A, Matsubara H, Kato N.
- Journal Title
  
  Oncol Lett
  
  Volume: 20 Issue: 3 Pages: 2161-2168
- DOI
  10.3892/ol.2020.11757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716, KAKENHI-PROJECT-20H03749
[Journal Article] Long-term administration of Tolvaptan to patients with decompensated cirrhosis.2020
- Author(s)
  Kanayama K, Chiba T, Kobayashi K, Koroki K, Maruta S, Kanzaki H, Kusakabe Y, Saito T, Kiyono S, Nakamura M, Ogasawara S, Suzuki E, Ooka H, Yasui S, Nakamoto S, Kanda T, Maruyama H, Kato J, Kato N.
- Journal Title
  
  Int J Med Sci
  
  Volume: 17 Issue: 7 Pages: 874-880
- DOI
  10.7150/ijms.41454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Potential of Lenvatinib for an Expanded Indication from the REFLECT Trial in Patients with Advanced Hepatocellular Carcinoma.2020
- Author(s)
  Maruta S, Ogasawara S, Ooka Y, Obu M, Inoue M, Itokawa N, Haga Y, Seki A, Okabe S, Azemoto R, Itobayashi E, Atsukawa M, Sugiura N, Mizumoto H, Koroki K, Kanayama K, Kanzaki H, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato N.
- Journal Title
  
  Liver Cancer
  
  Volume: 9 Issue: 4 Pages: 382-396
- DOI
  10.1159/000507022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan.2020
- Author(s)
  Ogasawara S, Ooka Y, Itokawa N, Inoue M, Okabe S, Obu M, Atsukawa M, Itobayashi E, Mizumoto H, Sugiura N, Azemoto R, Kanayama K, Kanzaki H, Maruta S, Maeda T, Kusakabe Y, Yokoyama M, Kobayashi K, Kiyono S, Nakamura M, Saito T, Suzuki E, Nakamoto S, Yasui S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato N
- Journal Title
  
  Invest New Drugs
  
  Volume: 38 Issue: 1 Pages: 172-180
- DOI
  10.1007/s10637-019-00801-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 同種移植肝癌モデルマウスを用いたマルチキナーゼ阻害剤の肝癌微小環境への影響の検討2020
- Author(s)
  金山健剛，千葉哲博，加藤直也
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Serum angiopoietin 2 as a diagnostic and prognostic biomarkers in hepatocellular carcinoma.2020
- Author(s)
  Chiba T，Ao J，Kanzaki H，Shibata S，Kakiuchi R，Sakaue A，Qiang N，Ma Y，Kanayama K, Kojima R，Kusakabe Y，Nakamura M，Saito T，Nakagawa R，Kondo T，Ogasawara S，Suzuki E，Muroyama R，Kondo T，Maruyama H，Kato J，Kato N.
- Organizer
  米国肝臓学会議 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] An improved diet-induced murine model for nonalcoholic fatty liver disease with rapid progression of steatohepatitis and fibrosis.2020
- Author(s)
  Nakmaura M，Chiba T，Sakuma T，Iwanaga T，Fujita N，Ao J，Ma Y，Kanayama K， Kanzaki H，Koroki K，Kobayashi K，Nakagawa R，Kanogawa N，Kiyono S，Kondo T， Saito T，Ogasawara S，Ooka Y，Suzuki E，Nakamoto S，Muroyama R，Kato N.
- Organizer
  米国肝臓学会議 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276

1. Chiba Tetsuhiro (00381583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 太和田暁之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 荒井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 大塚将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KANAYAMA KENGO 金山 健剛

Research Projects

Research Products

Co-Researchers

Investigation of tumor immune escape mechanisms in liver cancer using allograft mouse model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of histone methyltransferase SETDB1 in hepatocyte differentiation and its application to regenerative medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acquisition of mesenchymal-like phenotypes and overproduction of angiogenic factors in lenvatinib-resistant hepatocellular carcinoma cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analyses of intermediate-stage hepatocellular carcinoma patients receiving TACE prior to designing clinical trials.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interferon-γ induced PD-L1 expression and soluble PD-L1 production in gastric cancer.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term administration of Tolvaptan to patients with decompensated cirrhosis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential of Lenvatinib for an Expanded Indication from the REFLECT Trial in Patients with Advanced Hepatocellular Carcinoma.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 同種移植肝癌モデルマウスを用いたマルチキナーゼ阻害剤の肝癌微小環境への影響の検討2020

Author(s)

Organizer

Data Source

KANAYAMA KENGO 金山健剛