Nagaoka Atsuko 長岡敦子

Researcher Number	20844632
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 大学病院, 助教 2022: 福島県立医科大学, 医学部, 博士研究員 2019 – 2021: 福島県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator 死後脳 / プロリン / 統合失調症 / 双極性障害 / 自殺 / 1－プロリン－5－カルボン酸 / アミノ酸 / オルニチン / グルタミン酸 / postmortem brain … More / schizophrenia / proline / ALDH18A1 / PEPD / ALDH4A1 / P5Cシンセターゼ / プロリダーゼ Less

Identification of checkpoint regulators of suicidal behavior using postmortem brains of bipolar disorderPrincipal Investigator
- Principal Investigator
  
  長岡敦子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tohoku University
Metabolomic analysis of proline metabolic pathway in postmortem brain of schizophreniaPrincipal Investigator
- Principal Investigator
  
  Nagaoka Atsuko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tohoku University
  Fukushima Medical University
Expression study of molecules in the proline metabolic pathway in the postmortem brain of patients with schizophreniaPrincipal Investigator
- Principal Investigator
  
  Nagaoka Atsuko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Fukushima Medical University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Marked alteration of phosphoinositide signaling‐associated molecules in postmortem prefrontal cortex with bipolar disorder2024
- Author(s)
  Hino Mizuki、Kunii Yasuto、Shishido Risa、Nagaoka Atsuko、Matsumoto Junya、Akatsu Hiroyasu、Hashizume Yoshio、Hayashi Hideki、Kakita Akiyoshi、Tomita Hiroaki、Yabe Hirooki
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 44 Issue: 1 Pages: 121-128
- DOI
  10.1002/npr2.12409
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07524, KAKENHI-PROJECT-21K15715, KAKENHI-PROJECT-20H04018
[Journal Article] Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis2023
- Author(s)
  Miyahara Kazusa、Hino Mizuki、Shishido Risa、Nagaoka Atsuko、Izumi Ryuta、Hayashi Hideki、Kakita Akiyoshi、Yabe Hirooki、Tomita Hiroaki、Kunii Yasuto
- Journal Title
  
  Translational Psychiatry
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41398-023-02449-8
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] The influence of tissue pH and RNA integrity number on gene expression of human postmortem brain2023
- Author(s)
  Miyahara Kazusa、Hino Mizuki、Yu Zhiqian、Ono Chiaki、Nagaoka Atsuko、Hatano Masataka、Shishido Risa、Yabe Hirooki、Tomita Hiroaki、Kunii Yasuto
- Journal Title
  
  Frontiers in Psychiatry
  
  Volume: 14
- DOI
  10.3389/fpsyt.2023.1156524
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease2023
- Author(s)
  Hirai Shinobu、Sakuma Atsuhiro、Kunii Yasuto、Shimbo Hiroko、Hino Mizuki、Izumi Ryuta、Nagaoka Atsuko、Yabe Hirooki、Kojima Rika、Seki Erika、Arai Nobutaka、Komori Takashi、Okado Haruo
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 163 Pages: 74-79
- DOI
  10.1016/j.jpsychires.2023.04.011
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophrenia2023
- Author(s)
  Shishido Risa、Kunii Yasuto、Hino Mizuki、Izumi Ryuta、Nagaoka Atsuko、Hayashi Hideki、Kakita Akiyoshi、Tomita Hiroaki、Yabe Hirooki
- Journal Title
  
  Frontiers in Psychiatry
  
  Volume: 14
- DOI
  10.3389/fpsyt.2023.1183696
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics2023
- Author(s)
  Miyahara Kazusa、Hino Mizuki、Shishido Risa、Izumi Ryuta、Nagaoka Atsuko、Hayashi Hideki、Kakita Akiyoshi、Yabe Hirooki、Tomita Hiroaki、Kunii Yasuto
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 166 Pages: 10-16
- DOI
  10.1016/j.jpsychires.2023.08.007
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain2022
- Author(s)
  Izumi Ryuta、Hino Mizuki、Nagaoka Atsuko、Shishido Risa、Kakita Akiyoshi、Hoshino Mikio、Kunii Yasuto、Yabe Hirooki
- Journal Title
  
  Neuroscience Research
  
  Volume: 175 Pages: 73-81
- DOI
  10.1016/j.neures.2021.09.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-16K21734, KAKENHI-ORGANIZER-18H05428, KAKENHI-PUBLICLY-21H00180, KAKENHI-PROJECT-21K15715
[Journal Article] Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model2022
- Author(s)
  Iwakura Yuriko、Kawahara-Miki Ryoka、Kida Satoshi、Sotoyama Hidekazu、Gabdulkhaev Ramil、Takahashi Hitoshi、Kunii Yasuto、Hino Mizuki、Nagaoka Atsuko、Izumi Ryuta、Shishido Risa、Someya Toshiyuki、Yabe Hirooki、Kakita Akiyoshi、Nawa Hiroyuki
- Journal Title
  
  Neurochemical Research
  
  Volume: in press Issue: 9 Pages: 2715-2727
- DOI
  10.1007/s11064-022-03599-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03944, KAKENHI-PROJECT-20K21265, KAKENHI-PROJECT-22K19142, KAKENHI-PROJECT-21K15715, KAKENHI-PROJECT-22H00358, KAKENHI-PROJECT-20H03597, KAKENHI-PLANNED-18H05429, KAKENHI-PUBLICLY-21H00180, KAKENHI-PUBLICLY-22H05486, KAKENHI-PROJECT-22H00469
[Journal Article] Detailed Postmortem Profiling of Inflammatory Mediators Expression Revealed Post-inflammatory Alternation in the Superior Temporal Gyrus of Schizophrenia2021
- Author(s)
  Izumi Ryuta、Hino Mizuki、Wada Akira、Nagaoka Atsuko、Kawamura Takashi、Mori Tsutomu、Sainouchi Makoto、Kakita Akiyoshi、Kasai Kiyoto、Kunii Yasuto、Yabe Hirooki
- Journal Title
  
  Frontiers in Psychiatry
  
  Volume: 12 Pages: 1-8
- DOI
  10.3389/fpsyt.2021.653821
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06399, KAKENHI-PROJECT-21K15715
[Journal Article] 統合失調症死後脳におけるタンパク定量解析-ALDH4A1とその発現に影響する遺伝子多型2021
- Author(s)
  長岡敦子、國井泰人、日野瑞城、泉竜太、宍戸理紗、矢部博興
- Journal Title
  
  生物学的精神医学誌
  
  Volume: 32(4) Pages: 186-190
- NAID
  130008134591
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia2021
- Author(s)
  Kunii Yasuto、Matsumoto Junya、Izumi Ryuta、Nagaoka Atsuko、Hino Mizuki、Shishido Risa、Sainouchi Makoto、Akatsu Hiroyasu、Hashizume Yoshio、Kakita Akiyoshi、Yabe Hirooki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 15 Pages: 8280-8280
- DOI
  10.3390/ijms22158280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15522, KAKENHI-PUBLICLY-21H00180, KAKENHI-PROJECT-21K15715
[Journal Article] 精神疾患ブレインバンクと死後脳研究の現在2021
- Author(s)
  國井泰人、長岡敦子、日野瑞城、泉竜太、宍戸理紗、矢部博興
- Journal Title
  
  日本生物学的精神医学会誌
  
  Volume: 32(4) Pages: 179-185
- NAID
  130008134590
- Data Source
  KAKENHI-PROJECT-21K15715
[Journal Article] ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism2020
- Author(s)
  Nagaoka Atsuko、Kunii Yasuto、Hino Mizuki、Izumi Ryuta、Nagashima Chisato、Takeshima Akari、Sainouchi Makoto、Nawa Hiroyuki、Kakita Akiyoshi、Yabe Hirooki
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 123 Pages: 119-127
- DOI
  10.1016/j.jpsychires.2020.02.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08053, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K23948
[Presentation] Comprehensive analysis of amino acid levels in postmortem brains of patients with schizophrenia.2024
- Author(s)
  Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Masataka hatano, Yuto Hosogai, Hideomi Hamasaki, Akiyoshi Kakita, Itaru Miura, Yasuto Kunii, Hiroaki Tomita
- Organizer
  NEURO2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15715
[Presentation] 統合失調症死後脳におけるプロリン代謝経路分子の解析2024
- Author(s)
  長岡敦子、日野瑞城、旗野将貴、細貝優人、宍戸理紗、柿田明美、三浦至、國井泰人、富田博秋
- Organizer
  第18回日本統合失調症学会
- Data Source
  KAKENHI-PROJECT-21K15715
[Presentation] 福島精神疾患ブレインバンクの取り組みについて2022
- Author(s)
  長岡敦子,國井泰人, 大沼裕美,日野瑞城,泉竜太,宍戸理紗,矢部博興
- Organizer
  第7回クリニカルバイオバンク委員会
- Data Source
  KAKENHI-PROJECT-21K15715
[Presentation] 統合失調症病態におけるプロリン代謝経路分子の解析-死後脳研究2021
- Author(s)
  長岡敦子、國井泰人、日野瑞城、泉竜太、宍戸理紗、齊ノ内信、柿田明美、矢部博興
- Organizer
  第43回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-21K15715
[Presentation] 統合失調症死後脳におけるタンパク定量解析-ALDH4A1とその発現に影響する遺伝子多型2020
- Author(s)
  9.長岡敦子、國井泰人、日野瑞城、泉竜太、宍戸理紗、齊ノ内信、那波宏之、柿田明美、矢部博興
- Organizer
  第42回日本生物学的精神医学
- Data Source
  KAKENHI-PROJECT-19K23948

1. 能智正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 笠井清登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 國井泰人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 日野瑞城

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 松本純弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 矢部博興

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 星野幹雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 喜田聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagaoka Atsuko 長岡 敦子

Research Projects

Research Products

Co-Researchers

Identification of checkpoint regulators of suicidal behavior using postmortem brains of bipolar disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolomic analysis of proline metabolic pathway in postmortem brain of schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Expression study of molecules in the proline metabolic pathway in the postmortem brain of patients with schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Marked alteration of phosphoinositide signaling‐associated molecules in postmortem prefrontal cortex with bipolar disorder2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The influence of tissue pH and RNA integrity number on gene expression of human postmortem brain2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophrenia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detailed Postmortem Profiling of Inflammatory Mediators Expression Revealed Post-inflammatory Alternation in the Superior Temporal Gyrus of Schizophrenia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 統合失調症死後脳におけるタンパク定量解析-ALDH4A1とその発現に影響する遺伝子多型2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 精神疾患ブレインバンクと死後脳研究の現在2021

Author(s)

Journal Title

Nagaoka Atsuko 長岡敦子