Yamauchi Ichiro 山内一郎

Researcher Number	20844715
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator トランスクリプトーム / バセドウ病 / TSH / 甲状腺機能亢進症 / トランスポーター / ヨード / ペンドリン / 甲状腺刺激ホルモン / 抗甲状腺薬 / チアマゾール … More / トランスクリプトーム解析 / モデルマウス / 内分泌障害 / 免疫関連有害事象 / ニボルマブ / irAE / 自己抗体 / 下垂体 / 甲状腺 / PD-1 / 免疫チェックポイント阻害薬 Less

Research Projects
(3 results)
Research Products
(26 results)

ヨード輸送体ペンドリンは甲状腺機能亢進症の治療標的となるかPrincipal Investigator
- Principal Investigator
  
  山内一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kyoto University
Exploring therapeutic targets for hyperthyroidism using TSH-overexpressing mousePrincipal Investigator
- Principal Investigator
  
  Yamauchi Ichiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kyoto University
Endocrine-related adverse events induced by immune checkpoint inhibitors: from clinical features to mechanistic insightsPrincipal Investigator
- Principal Investigator
  
  Yamauchi Ichiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs2023
- Author(s)
  Yamauchi Ichiro、Hakata Takuro、Ueda Yohei、Sugawa Taku、Omagari Ryo、Teramoto Yasuo、Nakayama Shoji F.、Nakajima Daisuke、Kubo Takuya、Inagaki Nobuya
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 7 Pages: 107135-107135
- DOI
  10.1016/j.isci.2023.107135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16394
[Journal Article] High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases2022
- Author(s)
  Yamauchi Ichiro、Sakane Yoriko、Okuno Yukiko、Sugawa Taku、Hakata Takuro、Fujita Haruka、Okamoto Kentaro、Taura Daisuke、Yamashita Takafumi、Hirota Keisho、Ueda Yohei、Fujii Toshihito、Yasoda Akihiro、Inagaki Nobuya
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 8 Pages: 1-17
- DOI
  10.1210/endocr/bqac090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16394, KAKENHI-PROJECT-20K08877
[Journal Article] Identification by Liquid Chromatography?Tandem Mass Spectrometry and Liquid Chromatography?Quadrupole Time-of-Flight Mass Spectrometry of the Contributor to the Thyroid Hormone Receptor Agonist Activity in Effluents from Sewage Treatment Plants2022
- Author(s)
  Omagari Ryo、Yagishita Mayuko、Shiraishi Fujio、Nakayama Shoji F.、Terasaki Masanori、Tanigawa Tetsuya、Yamauchi Ichiro、Kubo Takuya、Nakajima Daisuke
- Journal Title
  
  Environmental Science & Technology
  
  Volume: 56 Issue: 19 Pages: 13709-13718
- DOI
  10.1021/acs.est.2c02648
- Data Source
  KAKENHI-PROJECT-22K16394
[Journal Article] Clinical features and thyroid dysfunction in adverse events involving the pituitary gland during PD‐1 blockade therapy2021
- Author(s)
  Yamauchi Ichiro, Taura Daisuke, Hakata Takuro, Fujita Haruka, Okamoto Kentaro, Ueda Yohei, Fujii Toshihito, Inagaki Nobuya
- Journal Title
  
  Clinical Endocrinology
  
  Volume: 94 Issue: 2 Pages: 258-268
- DOI
  10.1111/cen.14349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23942
[Journal Article] Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland2021
- Author(s)
  Yamauchi Ichiro, Yasoda Akihiro, Hakata Takuro, Yamashita Takafumi, Hirota Keisho, Ueda Yohei, Fujii Toshihito, Taura Daisuke, Sone Masakatsu, Inagaki Nobuya
- Journal Title
  
  bioRxiv
  
  Volume: －
- DOI
  10.1101/2021.01.14.426670
- Open Access
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] Endocrine-Disrupting Potential of 3,3',5-Triiodothyroacetic Acid via Cooperation of Negative Feedback and Heterogenous Distribution2024
- Author(s)
  Yamauchi I, Hakata T, Ueda Y, Sugawa T, Omagari R, TeramotoY, Nakayama SF, Nakajima D, Kubo T, Inagaki N
- Organizer
  21st International Congress of Endocrinology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] Endocrine-disrupting potential of 3,3',5-triiodothyroacetic acid (TRIAC)2023
- Author(s)
  Yamauchi I
- Organizer
  第66回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺学におけるトランスレーショナルリサーチの実践新規治療開発に向けたTSH受容体シグナルの分子機構解明2023
- Author(s)
  山内　一郎
- Organizer
  第66回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 既知化合物スクリーニングを基盤とした甲状腺ホルモン脱ヨード酵素の制御機構解明2023
- Author(s)
  山内　一郎
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺ホルモン脱ヨード酵素のトランスレーショナルリサーチ2023
- Author(s)
  山内　一郎
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 新規治療開発に向けたTSH受容体シグナルの分子機構解明2023
- Author(s)
  山内　一郎
- Organizer
  第66回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 脱ヨード酵素と甲状腺機能 20222022
- Author(s)
  山内一郎
- Organizer
  第65回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] Effects of peripheral iodothyronine deiodinases on thyroid hormone economy: Insights from the overexpressing mice.2022
- Author(s)
  Yamauchi I, Sakane Y, Yamashita T, Hakata T, Sugawa T, Fujita H, Okamoto K, Taura D, Hirota K, Ueda Y, Fujii T, Yasoda A, Inagaki N
- Organizer
  104th ENDO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 新規過剰発現マウスを用いた脱ヨード酵素による甲状腺ホルモン作用調節機構の解析2022
- Author(s)
  山内一郎、坂根依利子、山下貴史、伯田琢郎、須川琢、藤田晴香、岡本健太郎、田浦大輔、植田洋平、藤井寿人、八十田明宏、稲垣暢也
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 新規治療開発に向けたTSH受容体シグナルの分子機構解明2022
- Author(s)
  山内一郎
- Organizer
  第65回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 全エクソーム解析を行った中毒性多結節性甲状腺腫の1例2021
- Author(s)
  山内　一郎、伯田　琢郎、藤田　晴香、岡本　健太郎、植田　洋平、藤井　寿人、田浦　大輔、稲垣　暢也
- Organizer
  第64回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17508
[Presentation] 機能獲得型TSHR遺伝子変異を有する中毒性多結節性甲状腺腫の1例2021
- Author(s)
  山内　一郎、伯田　琢郎、藤田　晴香、岡本　健太郎、植田　洋平、藤井　寿人、田浦　大輔、稲垣　暢也
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17508
[Presentation] Ipilimumab/Nivolumab併用療法による下垂体関連有害事象の検討2020
- Author(s)
  藤田晴香、山内一郎、伯田琢郎、岡本健太郎、植田洋平、藤井寿人、田浦大輔、稲垣暢也
- Organizer
  第30回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による下垂体関連有害事象は甲状腺機能異常を合併する2020
- Author(s)
  山内一郎、田浦大輔、伯田琢郎、藤田晴香、岡本健太郎、植田洋平、藤井寿人、稲垣暢也
- Organizer
  第63回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] TSH過剰発現マウスの作成と甲状腺機能に関する検討2020
- Author(s)
  山内　一郎
- Organizer
  第63回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17508
[Presentation] Novel Autoantibodies for Thyroid-Specific Transcriptional Factors in Patients with Immune-Related Adverse Events Involving the Thyroid Gland2020
- Author(s)
  1.Yamauchi I, Yasoda A, Yamashita T, Ueda Y, Fujii T, Taura D, Sone M, Inagaki N.
- Organizer
  102nd ENDO Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による甲状腺機能異常の発症機序：新規自己抗体の意義2020
- Author(s)
  山内一郎、八十田明宏、山下貴史、植田洋平、藤井寿人、田浦大輔、曽根正勝、稲垣暢也
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による甲状腺機能異常：生命予後との関連を中心に2019
- Author(s)
  山内一郎, 八十田明宏, 藤井寿人, 田浦大輔, 曽根正勝, 稲垣暢也
- Organizer
  第28回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 甲状腺、下垂体、膵にニボルマブの免疫関連有害事象を生じた1例2019
- Author(s)
  4.岡本健太郎, 山内一郎, 八十田明宏, 植木絢子, 小倉雅仁, 藤井寿人, 田浦大輔, 曽根正勝, 稲垣暢也
- Organizer
  第28回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] イピリムマブ・ニボルマブ併用中に発症した続発性副腎不全の一例2019
- Author(s)
  57.藤田晴香, 山内一郎, 田浦大輔, 臼井亮太, 藤井寿人, 曽根正勝, 稲垣暢也
- Organizer
  第28回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による甲状腺機能異常の発症リスクと生命予後との関連2019
- Author(s)
  山内一郎，八十田明宏，藤井寿人，田浦大輔，曽根正勝，稲垣暢也
- Organizer
  第62回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23942

Yamauchi Ichiro 山内 一郎

Research Projects

Research Products

ヨード輸送体ペンドリンは甲状腺機能亢進症の治療標的となるかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring therapeutic targets for hyperthyroidism using TSH-overexpressing mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Endocrine-related adverse events induced by immune checkpoint inhibitors: from clinical features to mechanistic insightsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification by Liquid Chromatography?Tandem Mass Spectrometry and Liquid Chromatography?Quadrupole Time-of-Flight Mass Spectrometry of the Contributor to the Thyroid Hormone Receptor Agonist Activity in Effluents from Sewage Treatment Plants2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical features and thyroid dysfunction in adverse events involving the pituitary gland during PD‐1 blockade therapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Endocrine-Disrupting Potential of 3,3',5-Triiodothyroacetic Acid via Cooperation of Negative Feedback and Heterogenous Distribution2024

Author(s)

Organizer

Data Source

[Presentation] Endocrine-disrupting potential of 3,3',5-triiodothyroacetic acid (TRIAC)2023

Author(s)

Organizer

Data Source

[Presentation] 甲状腺学におけるトランスレーショナルリサーチの実践 新規治療開発に向けたTSH受容体シグナルの分子機構解明2023

Author(s)

Organizer

Data Source

[Presentation] 既知化合物スクリーニングを基盤とした甲状腺ホルモン脱ヨード酵素の制御機構解明2023

Author(s)

Organizer

Data Source

[Presentation] 甲状腺ホルモン脱ヨード酵素のトランスレーショナルリサーチ2023

Author(s)

Organizer

Data Source

[Presentation] 新規治療開発に向けたTSH受容体シグナルの分子機構解明2023

Author(s)

Organizer

Data Source

[Presentation] 脱ヨード酵素と甲状腺機能 20222022

Author(s)

Organizer

Data Source

[Presentation] Effects of peripheral iodothyronine deiodinases on thyroid hormone economy: Insights from the overexpressing mice.2022

Author(s)

Organizer

Data Source

[Presentation] 新規過剰発現マウスを用いた脱ヨード酵素による甲状腺ホルモン作用調節機構の解析2022

Author(s)

Yamauchi Ichiro 山内一郎

[Presentation] 甲状腺学におけるトランスレーショナルリサーチの実践新規治療開発に向けたTSH受容体シグナルの分子機構解明2023