Saito Shun 齋藤駿

Researcher Number	20846117
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 理工学部(矢上), 講師
Affiliation (based on the past Project Information) *help	2023: 慶應義塾大学, 理工学部(矢上), 講師 2020 – 2022: 慶應義塾大学, 理工学部(矢上), 助教
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 放線菌 / 休眠遺伝子 / 生合成 / 耐熱性 / 生産制御 / 熱ショック代謝物（HSM） / 二次代謝 / 植物 / Couchioplanes / Actinomycetospora … More / Goodfellowiella / Phytohabitans / 耐熱性放線菌 / 化学コミュニケーション / 農業用資材 / 植物病原菌 / 植物生長 / 二次代謝物 / 希少放線菌 … More Except Principal Investigator 進化 / ケミカルバイオロジー / 微生物 / マクロファージ / 免疫抑制作用 / 病原真菌 / 共培養 / 天然物 / 休眠遺伝子 Less

Analysis for production regulation and thermotolerance promotion mechanisms of heat shock metabolite (HSM) produced by actinomycetePrincipal Investigator
- Principal Investigator
  
  齋藤駿
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Keio University
Development of bioactive compounds by activation of cryptic genes based on invasive evolution of pathogenic microorganisms
- Principal Investigator
  
  Arai Midori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Keio University
Search for novel plant growth regulators through elucidation of the secondary metabolic capacity of unexplored rare actinomycetesPrincipal Investigator
- Principal Investigator
  
  Saito Shun
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] (S)-3-Hydroxy-3-(2-oxopropyl)indolin-2-one with a nitric oxide production inhibitory activity produced by the human-derived Clostridium strain2024
- Author(s)
  Saito, S.; Banno, T.; Arai, M. A.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 88 Issue: 3 Pages: 316-321
- DOI
  10.1093/bbb/zbad172
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23H04884, KAKENHI-PROJECT-21H02639
[Journal Article] Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation2024
- Author(s)
  Suzuki, S.; Saito, S.; Narushima, Y.; Kodani, S.; Kagaya, N.; Suenaga, H.; Shin-ya, K.; Arai, M. A.
- Journal Title
  
  J. Antibiot.
  
  Volume: 77 Issue: 1 Pages: 30-38
- DOI
  10.1038/s41429-023-00673-4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23H04884, KAKENHI-PROJECT-21H02639
[Journal Article] Methodology for awakening the potential secondary metabolic capacity in actinomycetes2024
- Author(s)
  Saito Shun、Arai Midori A
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 20 Pages: 753-766
- DOI
  10.3762/bjoc.20.69
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13897
[Journal Article] Phytohabitols A-C, δ-lactone-terminated polyketides from an actinomycete of the genus Phytohabitans2022
- Author(s)
  S. Saito, Y. Xiaohanyao, T. Zhou, J. Nakajima-Shimada, E. Tashiro, D. W. Triningsih, E. Harunari, N. Oku, Y. Igarashi
- Journal Title
  
  Journal of Natural Products
  
  Volume: 85 Issue: 7 Pages: 1697-1703
- DOI
  10.1021/acs.jnatprod.2c00137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05848, KAKENHI-PROJECT-20K05732, KAKENHI-PROJECT-20K15461
[Journal Article] Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR412022
- Author(s)
  Saito, S.; Suzuki, S.; Arai, M. A.
- Journal Title
  
  J. Antibiot.
  
  Volume: 75 Issue: 9 Pages: 509-513
- DOI
  10.1038/s41429-022-00551-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02639, KAKENHI-PROJECT-20K15461
[Journal Article] Dihydromaniwamycin E, a heat-shock metabolite from thermotolerant Streptomyces sp. JA74, exhibits antiviral activity against influenza and SARS-CoV-2 viruses2022
- Author(s)
  Saito, S.; Funayama, K.; Kato, W.; Okuda, M.; Kawamoto, M.; Matsubara, T.; Sato, T.; Sato, A.; Otsuguro, S.; Sasaki, M.; Orba, Y.; Sawa, H.; Maenaka, K.; Shindo, K.; Imoto, M.; Arai, M. A.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 85 Issue: 11 Pages: 2583-2591
- DOI
  10.1021/acs.jnatprod.2c00550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02639, KAKENHI-PROJECT-20K15461
[Journal Article] Identification of 1 α,2β-epoxytagitinin C as a Notch inhibitor, oxidative stress mechanism and its anti-leukemia activity2022
- Author(s)
  Makita, Y.; Saito, S.; Tsuchiya, A.; Ishibashi, M.; Arai, M. A.
- Journal Title
  
  J. Nat. Med.
  
  Volume: 76 Issue: 1 Pages: 234-243
- DOI
  10.1007/s11418-021-01584-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02639
[Journal Article] Mycetoindole, an N-acyl dehydrotryptophan with plant growth inhibitory activity from an actinomycete of the genus Actinomycetospora2021
- Author(s)
  Saito Shun、Oku Naoya、Igarashi Yasuhiro
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 75 Issue: 1 Pages: 44-47
- DOI
  10.1038/s41429-021-00474-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05827, KAKENHI-PROJECT-19K05848, KAKENHI-PROJECT-20K15461
[Journal Article] Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus <i>Couchioplanes</i>2021
- Author(s)
  Saito Shun、Indo Kanji、Oku Naoya、Komaki Hisayuki、Kawasaki Masashi、Igarashi Yasuhiro
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 17 Pages: 2939-2949
- DOI
  10.3762/bjoc.17.203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05827, KAKENHI-PROJECT-19K05848, KAKENHI-PROJECT-20K15461
[Journal Article] A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium2020
- Author(s)
  S. Satio, K. Atsumi, T. Zhou, K. Fukaya, D. Urabe, N. Oku, Md. R. U. Karim, H. Komaki, Y. Igarashi
- Journal Title
  
  Beilstain Journal of Organic Chemistry
  
  Volume: 16 Pages: 1100-1110
- DOI
  10.3762/bjoc.16.97
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05848, KAKENHI-PROJECT-20K15285, KAKENHI-PROJECT-20K15461, KAKENHI-PROJECT-20H03366
[Presentation] 放線菌が生産する熱ショック代謝物（HSM）のケミカルバイオロジー2024
- Author(s)
  齋藤駿
- Organizer
  日本農芸化学会2024年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K13897
[Presentation] Chemical biology of heat shock metabolites (HSM) produced by Streptomyces species2023
- Author(s)
  Shun Saito
- Organizer
  13th International Symposium on Bioorganic Chemistry (ISBOC-13)
- Data Source
  KAKENHI-PROJECT-23K13897
[Presentation] Chemical biology of heat shock metabolites (HSM) produced by Streptomyces species2023
- Author(s)
  齋藤駿
- Organizer
  Future Drug Discovery Empowered by Chemical Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15461
[Presentation] Co-culture of pathogenic fungi Aspergillus species and immune cells for activating silent genes2023
- Author(s)
  Y. Ujie, S. Saito, K. Fukaya, D. Urabe, T. Yaguchi, M. A. Arai
- Organizer
  Future Drug Discovery Empowered by Chemical Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 耐熱性放線菌HR41株が生産する熱ショック代謝物（HSM）の単離・構造決定および耐熱性促進活性評価2023
- Author(s)
  齋藤駿
- Organizer
  第37回日本放線菌学会
- Data Source
  KAKENHI-PROJECT-23K13897
[Presentation] Chemical biology of heat shock metabolites (HSM) produced by Streptomyces species2023
- Author(s)
  S. Saito, Y. Okumura, K. Funayama, W. Kato, M. A. Arai
- Organizer
  Future Drug Discovery Empowered by Chemical Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 微生物が生産する二次代謝物のケミカルバイオロジー研究2023
- Author(s)
  齋藤駿
- Organizer
  日本農芸化学会関東支部若手発案企画第7回天然物化学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K13897
[Presentation] 未研究放線菌における潜在的代謝能の覚醒化による新規天然物の探索研究2023
- Author(s)
  齋藤駿
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K13897
[Presentation] 麹菌Aspergillus luchuensisと動物細胞の共培養法による新規化合物の探索2022
- Author(s)
  浅野友里, 齋藤駿, 矢口貴志, 荒井緑
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 放線菌が生産する熱ショック代謝物 (HSM) の発見2022
- Author(s)
  齋藤駿
- Organizer
  日本農芸化学会関東支部2022年度大会
- Data Source
  KAKENHI-PROJECT-20K15461
[Presentation] 耐熱性放線菌JA74株が生産する熱ショック代謝物maniwamycin類の全合成及び生物活性評価2022
- Author(s)
  船山佳世，齋藤駿，加藤航，新藤一敏，川本芽子，松原輝彦，佐藤智典，乙黒聡子，前仲勝実，井本正哉，荒井緑
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 乳酸菌と動物細胞の共培養による有用物質の探索2022
- Author(s)
  細内梨央, 齋藤駿, 荒井緑
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 病原真菌と免疫細胞の共培養法を用いた休眠遺伝子活性化による新規天然物の探索2022
- Author(s)
  氏江優希子，齋藤駿，矢口貴志，荒井緑
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 腸内細菌が生産する代謝物からの免疫機能制御物質の探索2022
- Author(s)
  細内梨央，齋藤駿，荒井緑
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 耐熱性放線菌JA74株が生産する熱ショック代謝物 (HSM) Maniwamycin 類の単離・構造決定および生物活性2022
- Author(s)
  齋藤駿
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-20K15461
[Presentation] 麹菌Aspergillus luchuensisと動物細胞の共培養法による新規化合物の探索2022
- Author(s)
  浅野友里, 齋藤駿, 矢口貴志, 荒井緑
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 耐熱性放線菌AY2株が生産する熱ショック代謝物 (HSM) の生産制御機構解析2022
- Author(s)
  齋藤駿
- Organizer
  2022年度日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-20K15461
[Presentation] 休眠遺伝子活性化を目指した病原真菌と免疫細胞の共培養2022
- Author(s)
  氏江優希子, 齋藤駿, 矢口貴志, 荒井緑
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] Ascl1発現阻害作用を有するヘテロ環含有ロカグラミド誘導体の創製 (第2報)2022
- Author(s)
  蒔田吉功，齋藤駿，石橋正己，荒井緑
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02639
[Presentation] 希少放線菌Couchioplanes属が生産する二次代謝物の解析研究2021
- Author(s)
  齋藤駿
- Organizer
  第35回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-20K15461
[Presentation] 放線菌が生産する熱ショック代謝物のケミカルバイオロジー2021
- Author(s)
  齋藤　駿
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20K15461

1. Arai Midori (40373261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. 五十嵐康弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 奥直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Saito Shun 齋藤 駿

Research Projects

Research Products

Co-Researchers

Analysis for production regulation and thermotolerance promotion mechanisms of heat shock metabolite (HSM) produced by actinomycetePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of bioactive compounds by activation of cryptic genes based on invasive evolution of pathogenic microorganisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for novel plant growth regulators through elucidation of the secondary metabolic capacity of unexplored rare actinomycetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] (S)-3-Hydroxy-3-(2-oxopropyl)indolin-2-one with a nitric oxide production inhibitory activity produced by the human-derived Clostridium strain2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methodology for awakening the potential secondary metabolic capacity in actinomycetes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phytohabitols A-C, δ-lactone-terminated polyketides from an actinomycete of the genus Phytohabitans2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR412022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dihydromaniwamycin E, a heat-shock metabolite from thermotolerant Streptomyces sp. JA74, exhibits antiviral activity against influenza and SARS-CoV-2 viruses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of 1 α,2β-epoxytagitinin C as a Notch inhibitor, oxidative stress mechanism and its anti-leukemia activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mycetoindole, an N-acyl dehydrotryptophan with plant growth inhibitory activity from an actinomycete of the genus Actinomycetospora2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus <i>Couchioplanes</i>2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 放線菌が生産する熱ショック代謝物（HSM）のケミカルバイオロジー2024

Author(s)

Organizer

Data Source

[Presentation] Chemical biology of heat shock metabolites (HSM) produced by Streptomyces species2023

Author(s)

Organizer

Data Source

Saito Shun 齋藤駿