PAN YANG 潘洋

Researcher Number	20866389
Other IDs	https://orcid.org/0000-0001-7673-2599
Affiliation (Current)	2026: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2026: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 主任研究員 2020 – 2024: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator iPS細胞 / 発症分子メカニズム / 遺伝子 / オカルト黄斑ジストロフィ / iPRCs / iPSCs / RP1L1 / OMD / 発症機序 / 病因遺伝子 … More / 正常眼圧緑内障 / Splicing / Causative gene / causative gene / splicing / Normal-tension glaucoma / iPS cells / Ophthalmology / Mouse models / Genetic diseases Less

原発開放隅角緑内障家系で同定された新規原因遺伝子Xの機能解析Principal Investigator
- Principal Investigator
  
  潘洋
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
RP1L1遺伝子とそのオカルト黄斑ジストロフィ関連変異体の分子機能解析Principal Investigator
- Principal Investigator
  
  潘洋
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
METTL23 mutation alters histone H3R17 methylation in normal-tension glaucomaPrincipal Investigator
- Principal Investigator
  
  PAN YANG
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Ablation of Htra1 leads to sub-RPE deposits and photoreceptor abnormalities2025
- Author(s)
  Biswas Pooja、Woodard DaNae R.、Hollingsworth T.J.、Khan Naheed W.、Lazaro Danielle R.、Berry Anne Marie、Dagar Manisha、Pan Yang、Garland Donita、Shaw Peter X.、Oka Chio、Iwata Takeshi、Jablonski Monica M.、Ayyagari Radha
- Journal Title
  
  JCI Insight
  
  Volume: 10 Issue: 3
- DOI
  10.1172/jci.insight.178827
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] Role of ARMS2/HTRA1 risk alleles in the pathogenesis of neovascular age-related macular degeneration2024
- Author(s)
  Pan Yang、Iwata Takeshi
- Journal Title
  
  Taiwan Journal of Ophthalmology
  
  Volume: - Issue: 4 Pages: 531-539
- DOI
  10.4103/tjo.tjo-d-23-00152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] Exploring the Genetic Landscape of Childhood Glaucoma2024
- Author(s)
  Pan Yang、Iwata Takeshi
- Journal Title
  
  Children
  
  Volume: 11 Issue: 4 Pages: 454-454
- DOI
  10.3390/children11040454
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] Molecular genetics of inherited normal tension glaucoma2024
- Author(s)
  Pan Yang、Iwata Takeshi
- Journal Title
  
  Indian Journal of Ophthalmology
  
  Volume: - Issue: Suppl 3 Pages: S335-S344
- DOI
  10.4103/ijo.ijo_3204_23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus2024
- Author(s)
  Pan Yang、Iwata Takeshi
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 65 Issue: 14 Pages: 27-27
- DOI
  10.1167/iovs.65.14.27
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] アルギニンメチル基転移酵素METTL23変異と正常眼圧緑内障2023
- Author(s)
  潘洋，岩田岳
- Journal Title
  
  医学のあゆみ
  
  Volume: 287 Pages: 24507-24508
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] 正常眼圧緑内障の新しい原因遺伝子METTL23を同定2023
- Author(s)
  潘　洋,　須賀晶子, 木村至, 木村肇二郎, 峯岸　ゆり子, 中山　真央, 吉武　和敏, 家島　大介,　峰松　尚子, 山本　めぐみ, 間渕文彦, 高本光子,　志賀由己浩,　新家眞病, 柏木賢治, 相原一, 中澤徹, 岩田岳
- Journal Title
  
  日眼会誌
  
  Volume: 127 (4) Pages: 507-507
- Data Source
  KAKENHI-PROJECT-23K15923
[Journal Article] HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid2022
- Author(s)
  Ahamed Waseem、Yu Richard Ming Chuan、Pan Yang、Iwata Takeshi、Barathi Veluchamy Amutha、Wey Yeo Sia、Tun Sai Bo Bo、Qiu Beiying、Tan Alison、Wang Xiaomeng、Cheung Chui Ming Gemmy、Wong Tien Yin、Yanagi Yasuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 18 Pages: 10206-10206
- DOI
  10.3390/ijms231810206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18366
[Journal Article] Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration2022
- Author(s)
  Pan Yang、Fu Yingbin、Baird Paul N.、Guymer Robyn H.、Das Taraprasad、Iwata Takeshi
- Journal Title
  
  Progress in Retinal and Eye Research
  
  Volume: online ahead of print Pages: 101159-101159
- DOI
  10.1016/j.preteyeres.2022.101159
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18366
[Journal Article] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022
- Author(s)
  Pan Yang、Suga Akiko、Kimura Itaru、Kimura Chojiro、Minegishi Yuriko、Nakayama Mao、Yoshitake Kazutoshi、Iejima Daisuke、Minematsu Naoko、Yamamoto Megumi、Mabuchi Fumihiko、Takamoto Mitsuko、Shiga Yukihiro、Araie Makoto、Kashiwagi Kenji、Aihara Makoto、Nakazawa Toru、Iwata Takeshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 21
- DOI
  10.1172/jci153589
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09689, KAKENHI-PROJECT-22K09787, KAKENHI-PROJECT-20K09786, KAKENHI-PROJECT-20K18366
[Journal Article] Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in?vitro2021
- Author(s)
  Pan Yang、Iejima Daisuke、Nakayama Mao、Suga Akiko、Noda Toru、Kaur Inderjeet、Das Taraprasad、Chakrabarti Subhabrata、Guymer Robyn H.、DeAngelis Margaret M.、Yamamoto Megumi、Baird Paul N.、Iwata Takeshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100456-100456
- DOI
  10.1016/j.jbc.2021.100456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09432, KAKENHI-PROJECT-20K18366
[Patent] 家族性正常眼圧緑内障の診断補助方法、診断キット及びバイオマーカー2025
- Inventor(s)
  岩田岳, 潘洋, 木村至
- Industrial Property Rights Holder
  岩田岳, 潘洋, 木村至
- Industrial Property Rights Type
  特許
- Filing Date
  2025
- Acquisition Date
  2025
- Data Source
  KAKENHI-PROJECT-23K15923
[Patent] 家族性正常眼圧緑内障の診断補助方法、診断キット及びバイオマーカー2021
- Inventor(s)
  潘　洋, 岩田　岳, 木村　至
- Industrial Property Rights Holder
  潘　洋, 岩田　岳, 木村　至
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K18366
[Presentation] Functional analysis of METTL23 c.84+60delAT in Normal-Tension Glaucoma2023
- Author(s)
  Pan Yang
- Organizer
  The 39th Asia-Pacific Academy of Ophthalmology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15923
[Presentation] Dominant Mutation in X gene is responsible for Normal Tension Glaucoma2022
- Author(s)
  Pan Yang
- Organizer
  第1回NHOネットワーク共同研究感覚器グループ会議・班会議
- Data Source
  KAKENHI-PROJECT-20K18366
[Presentation] Dominant Mutation in METTL23 gene is responsible for Normal tension glaucoma2022
- Author(s)
  Pan Yang
- Organizer
  The XXVth Biennial Meeting of the International Society of Eye Research (ISER) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18366
[Presentation] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022
- Author(s)
  Pan Yang
- Organizer
  第15回RRM
- Data Source
  KAKENHI-PROJECT-20K18366
[Presentation] The ARMS2 insertion/deletion leads to systemic upregulation of secreted HTRA1 levels in the blood in AMD patients2021
- Author(s)
  Yang Pan; Akiko Suga; Toru Noda; Inderjeet Kaur; Taraprasad Das; Subhabrata Chakrabarti; Robyn H Guymer; Margaret M DeAngelis; Paul N Baird; Takeshi Iwata
- Organizer
  2021 ARVO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18366
[Presentation] The ARMS2 insertion/deletion leads to increased circulating HTRA1 in AMD patients and in vitro2021
- Author(s)
  Yang Pan, Daisuke Iejima, Mao Nakayama, Akiko Suga, Toru Noda, Inderjeet Kaur, Taraprasad Das, Subhabrata Chakrabarti, Robyn H. Guymer, Margaret M. DeAngelis, Paul N. Baird, Takeshi Iwata
- Organizer
  第14回RRM
- Data Source
  KAKENHI-PROJECT-20K18366
[Presentation] 常染色体優性遺伝による正常眼圧緑内障の新規原因遺伝子の解明2020
- Author(s)
  潘洋１、木村至１、２、須賀晶子１、峰松尚子１、山本めぐみ１、間渕文彦３、柏木賢治３、志賀由己浩４、橋本和軌４、西口康二４、中澤徹４、高本光子５、相原一５、新家眞５、緑内障学会遺伝子研究班、岩田岳１
- Organizer
  Japanese Glaucoam Society
- Data Source
  KAKENHI-PROJECT-20K18366

1. SUGA Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 峯岸ゆり子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

PAN YANG 潘 洋

Research Projects

Research Products

Co-Researchers

原発開放隅角緑内障家系で同定された新規原因遺伝子Xの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RP1L1遺伝子とそのオカルト黄斑ジストロフィ関連変異体の分子機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Ablation of Htra1 leads to sub-RPE deposits and photoreceptor abnormalities2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of ARMS2/HTRA1 risk alleles in the pathogenesis of neovascular age-related macular degeneration2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring the Genetic Landscape of Childhood Glaucoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular genetics of inherited normal tension glaucoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アルギニンメチル基転移酵素METTL23変異と正常眼圧緑内障2023

Author(s)

Journal Title

Data Source

[Journal Article] 正常眼圧緑内障の新しい原因遺伝子METTL23を同定2023

Author(s)

Journal Title

Data Source

[Journal Article] HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in?vitro2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 家族性正常眼圧緑内障の診断補助方法、診断キット及びバイオマーカー2025

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

PAN YANG 潘洋