HAYANO Hiroki 早野博紀

Researcher Number	20866644
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 2020: 長崎大学, 医歯薬学総合研究科(歯学系), 研究協力員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 57050:Prosthodontics-related
Keywords	Principal Investigator 薬剤関連顎骨壊死 / マクロファージ / 細胞療法 / 病態形成機構 / 分化転換 / ビスホスホネート製剤 / リンパ管内皮細胞 / 極性変化 / 血管 / リンパ管 / DRONJ / BRONJ / MRONJ

Determination of pathophysiology of and fundamental development of treatement strategies for medication-related osteonecrosis of the jawPrincipal Investigator
- Principal Investigator
  
  早野博紀
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nagasaki University
Exploration of pathogenesis of medication-related osteonecrosis of the jaw based on macrophagesPrincipal Investigator
- Principal Investigator
  
  HAYANO Hiroki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Nagasaki University

All 2024 2023 2021 2020

All Journal Article Presentation

[Journal Article] Response to letter to the editor regarding, “Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice”2024
- Author(s)
  Kozutsumi Rhyohei、Kuroshima Shinichiro、Al-Omari Farah A.、Hayano Hiroki、Nakajima Kazunori、Kakehashi Hiroe、Sawase Takashi
- Journal Title
  
  Bone
  
  Volume: 181 Pages: 117010-117010
- DOI
  10.1016/j.bone.2023.117010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K16155, KAKENHI-PROJECT-23K19752, KAKENHI-PROJECT-21K09980, KAKENHI-PROJECT-23K24541, KAKENHI-PROJECT-23K27783
[Journal Article] Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions2023
- Author(s)
  Haruka Kaneko, Shinichiro Kuroshima, Ryohei Kozutsumi, Farah A. Al-Omari, Hiroki Hayano, Kazunori Nakajima, Takashi Sawase
- Journal Title
  
  J Clin Med.
  
  Volume: 12 Issue: 5 Pages: 1914-1914
- DOI
  10.3390/jcm12051914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18607, KAKENHI-PROJECT-23K24541, KAKENHI-PROJECT-21K09980, KAKENHI-PROJECT-23K27783
[Journal Article] Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice2023
- Author(s)
  Kozutsumi Ryohei、Kuroshima Shinichiro、Al-Omari Farah A.、Hayano Hiroki、Nakajima Kazunori、Kakehashi Hiroe、Sawase Takashi
- Journal Title
  
  Bone
  
  Volume: 177 Pages: 116899-116899
- DOI
  10.1016/j.bone.2023.116899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18364, KAKENHI-PROJECT-23K16155, KAKENHI-PROJECT-23K19752, KAKENHI-PROJECT-21K09980, KAKENHI-PROJECT-23K24541, KAKENHI-PROJECT-23K27783
[Journal Article] Gene expression analysis of fresh extraction wounds prior to onset of bisphosphonate-related osteonecrosis of the jaw-like lesions in mice: A preliminary animal study2021
- Author(s)
  Kuroshima S, Nakajima K, Sasaki M, Hayano H, Inoue M, Kozutsumi R, Sawase T
- Journal Title
  
  J Prosthodont Res
  
  Volume: 65 Issue: 4 Pages: 546-553
- DOI
  10.2186/jpr.JPR_D_20_00027
- NAID
  130008104554
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09664, KAKENHI-PROJECT-18H02994, KAKENHI-PROJECT-19H03844, KAKENHI-PROJECT-21K09980, KAKENHI-PROJECT-20K18607
[Journal Article] Distinct immunopathology in the early stages between different antiresorptive-related osteonecrosis of the jaw-like lesions in mice.2020
- Author(s)
  Hayano H, Kuroshima S, Sasaki M, Tamki S, Inoue M, Ishisaki A, Sawase T
- Journal Title
  
  Bone
  
  Volume: - Pages: 115308-115308
- DOI
  10.1016/j.bone.2020.115308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09664, KAKENHI-PROJECT-16H05534, KAKENHI-PROJECT-20K18607, KAKENHI-PROJECT-18H02994
[Journal Article] Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice2020
- Author(s)
  Tamaki Saki、Kuroshima Shinichiro、Hayano Hiroki、Nakajima Kazunori、Kakehashi Hiroe、Ishisaki Akira、Sawase Takashi
- Journal Title
  
  Bone
  
  Volume: 141 Pages: 115560-115560
- DOI
  10.1016/j.bone.2020.115560
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11844, KAKENHI-PROJECT-20K18607, KAKENHI-PROJECT-18H02994
[Presentation] Gene expression profiling and histopathology/immunopathology in high-prevalence bisphosphonate-related osteonecrosis of the jaw in mice2020
- Author(s)
  Kuroshima S, Sasaki M, Nakajima K, Hayano H, Inoue M, Kozutsumi R, Sawase T
- Organizer
  30th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting Virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18607
[Presentation] 高頻度発現型BRONJマウスモデルを用いた早期における遺伝子パターン解析2020
- Author(s)
  黒嶋伸一郎，早野博紀，佐々木宗輝，中島和慶，澤瀬　隆
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K18607
[Presentation] 高頻度発現型BRONJ様病変の組織・免疫病理学所見と早期遺伝子プロファイル分析2020
- Author(s)
  黒嶋伸一郎，佐々木宗輝，中島和慶，早野博紀，井上真愛弥，澤瀬　隆
- Organizer
  公益社団法人日本補綴歯科学会　第129回学術大会
- Data Source
  KAKENHI-PROJECT-20K18607
[Presentation] Histopathology/immunopathology in high-prevalence bisphosphonate-related osteonecrosis of the jaw around implants in rat maxillae2020
- Author(s)
  Inoue M, Matsumoto C, Nakajima K, Hayano H, Kozutsumi R, Kuroshima S, Sawase T
- Organizer
  30th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting Virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18607
[Presentation] Relationship between gene profiles and histopathology/immunopathology in high-prevalence BRONJ-like lesions in mice2020
- Author(s)
  Kuroshima S, Sasaki M, Hayano H, Kozutsumi R, Inoue M, Sawase T
- Organizer
  30th Annual Congress of the European College of Gerodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18607

1. KUROSHIMA Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. KAKEHASHI Hiroe

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 澤瀬隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAYANO Hiroki 早野 博紀

Research Projects

Research Products

Co-Researchers

Determination of pathophysiology of and fundamental development of treatement strategies for medication-related osteonecrosis of the jawPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of pathogenesis of medication-related osteonecrosis of the jaw based on macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Response to letter to the editor regarding, “Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice”2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene expression analysis of fresh extraction wounds prior to onset of bisphosphonate-related osteonecrosis of the jaw-like lesions in mice: A preliminary animal study2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Distinct immunopathology in the early stages between different antiresorptive-related osteonecrosis of the jaw-like lesions in mice.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Gene expression profiling and histopathology/immunopathology in high-prevalence bisphosphonate-related osteonecrosis of the jaw in mice2020

Author(s)

Organizer

Data Source

[Presentation] 高頻度発現型BRONJマウスモデルを用いた早期における遺伝子パターン解析2020

Author(s)

Organizer

Data Source

[Presentation] 高頻度発現型BRONJ様病変の組織・免疫病理学所見と早期遺伝子プロファイル分析2020

Author(s)

Organizer

Data Source

[Presentation] Histopathology/immunopathology in high-prevalence bisphosphonate-related osteonecrosis of the jaw around implants in rat maxillae2020

Author(s)

Organizer

Data Source

[Presentation] Relationship between gene profiles and histopathology/immunopathology in high-prevalence BRONJ-like lesions in mice2020

Author(s)

Organizer

Data Source

HAYANO Hiroki 早野博紀