Kawamoto Yusuke 河本佑介

Researcher Number	20869375
Other IDs	https://orcid.org/0000-0001-9655-8241
Affiliation (Current)	2025: 京都大学, 薬学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 京都大学, 薬学研究科, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (II) / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 核酸医薬 / 核酸医薬品 / 化学修飾 / 免疫原性 / Toll-like receptor / アンチセンス核酸 / 免疫刺激 / デンドリマー / DDS / アプタマー / 枝分かれ核酸

Research Projects
(2 results)
Research Products
(14 results)

Development of novel nucleic acid medicines utilizing hydrophobic intereactions with Toll-like receptorsPrincipal Investigator
- Principal Investigator
  
  河本佑介
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyoto University
Development of multivalent and multifunctional nucleic acids medicines using branching structuresPrincipal Investigator
- Principal Investigator
  
  河本佑介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kyoto University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Development of a Cytosolic DNA Sensor Agonist Using GALA Peptide-Conjugated DNA and Long Single-Stranded DNA2024
- Author(s)
  Umemura Keisuke、Kawamoto Yusuke、Takahashi Yuki、Takakura Yoshinobu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 21 Issue: 3 Pages: 1204-1213
- DOI
  10.1021/acs.molpharmaceut.3c00840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15225
[Journal Article] Development of potent unmethylated CpG DNA hydrogel by introducing i-motifs into long single-stranded DNA2023
- Author(s)
  Oda Wakana、Umemura Keisuke、Ito Koichi、Kawamoto Yusuke、Takahashi Yuki、Takakura Yoshinobu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 646 Pages: 123438-123438
- DOI
  10.1016/j.ijpharm.2023.123438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15225
[Journal Article] High Performance Liquid Chromatography2023
- Author(s)
  持田祐希, 河本佑介
- Journal Title
  
  Drug Delivery System
  
  Volume: 38 Issue: 4 Pages: 329-333
- DOI
  10.2745/dds.38.329
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2023-09-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-21K15225
[Journal Article] Development of nucleic acid medicines based on chemical technology2023
- Author(s)
  Kawamoto Yusuke、Wu You、Takahashi Yuki、Takakura Yoshinobu
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: 199 Pages: 114872-114872
- DOI
  10.1016/j.addr.2023.114872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15225
[Journal Article] Drug Delivery System to Improve Functions of Middle Molecules2023
- Author(s)
  河本佑介
- Journal Title
  
  Drug Delivery System
  
  Volume: 38 Issue: 2 Pages: 178-179
- DOI
  10.2745/dds.38.178
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2023-03-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-21K15225
[Journal Article] Enhanced Immunostimulatory Activity of Covalent DNA Dendrons2022
- Author(s)
  Kawamoto Yusuke、Liu Wen、Yum Ji Hye、Park Soyoung、Sugiyama Hiroshi、Takahashi Yuki、Takakura Yoshinobu
- Journal Title
  
  ChemBioChem
  
  Volume: 23 Issue: 4
- DOI
  10.1002/cbic.202100583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15225
[Journal Article] Telomere-specific chromatin capture using a pyrrole-imidazole polyamide probe for the identification of proteins and non-coding RNAs2021
- Author(s)
  Ide Satoru、Sasaki Asuka、Kawamoto Yusuke、Bando Toshikazu、Sugiyama Hiroshi、Maeshima Kazuhiro
- Journal Title
  
  Epigenetics & Chromatin
  
  Volume: 14 Issue: 1 Pages: 46-46
- DOI
  10.1186/s13072-021-00421-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15225, KAKENHI-PROJECT-21H02453, KAKENHI-PROJECT-23K21326, KAKENHI-PLANNED-20H05936
[Presentation] DNAデンドロンに導入した多価化DNAアプタマーの研究2024
- Author(s)
  河本佑介, Wu You, 朴昭映, 杉山弘, 高橋有己, 高倉喜信
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K15225
[Presentation] エンドソーム脱出促進ペプチドを利用した細胞質DNAセンサーを標的とする機能性核酸の開発2023
- Author(s)
  梅村圭祐, 河本佑介, 高橋有己, 高倉喜信
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-21K15225
[Presentation] i-モチーフを利用したpH応答性DNAハイドロゲルの開発と非メチル化CpG DNAの作用持続化への応用2023
- Author(s)
  梅村圭祐、小田和叶、伊藤公一、河本佑介、髙橋有己、髙倉喜信
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21K15225
[Presentation] デンドリマー様構造を有する核酸医薬の合成と評価2023
- Author(s)
  河本佑介, Wu You, 朴昭映, 杉山弘, 高橋有己, 高倉喜信
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21K15225
[Presentation] 枝分かれ構造を有する多価型核酸医薬品の開発2023
- Author(s)
  河本佑介, Wu You, 朴昭映, 杉山弘, 高橋有己, 高倉喜信
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-21K15225
[Presentation] デンドリマー様構造を有する枝分かれ型核酸医薬の開発2022
- Author(s)
  河本佑介, 劉聞, 廉知恵, 朴昭映, 杉山弘, 高橋有己, 高倉喜信
- Organizer
  日本核酸医薬学会第７回年会
- Data Source
  KAKENHI-PROJECT-21K15225
[Presentation] Immunostimulatory Activity of DNA Dendrimers2021
- Author(s)
  Yusuke Kawamoto, Wen Liu, Ji Hye Yum, Soyoung Park, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15225

Kawamoto Yusuke 河本 佑介

Research Projects

Research Products

Development of novel nucleic acid medicines utilizing hydrophobic intereactions with Toll-like receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of multivalent and multifunctional nucleic acids medicines using branching structuresPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Development of a Cytosolic DNA Sensor Agonist Using GALA Peptide-Conjugated DNA and Long Single-Stranded DNA2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of potent unmethylated CpG DNA hydrogel by introducing i-motifs into long single-stranded DNA2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Performance Liquid Chromatography2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Development of nucleic acid medicines based on chemical technology2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug Delivery System to Improve Functions of Middle Molecules2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Enhanced Immunostimulatory Activity of Covalent DNA Dendrons2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Telomere-specific chromatin capture using a pyrrole-imidazole polyamide probe for the identification of proteins and non-coding RNAs2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] DNAデンドロンに導入した多価化DNAアプタマーの研究2024

Author(s)

Organizer

Data Source

[Presentation] エンドソーム脱出促進ペプチドを利用した細胞質DNAセンサーを標的とする機能性核酸の開発2023

Author(s)

Organizer

Data Source

[Presentation] i-モチーフを利用したpH応答性DNAハイドロゲルの開発と非メチル化CpG DNAの作用持続化への応用2023

Author(s)

Organizer

Data Source

[Presentation] デンドリマー様構造を有する核酸医薬の合成と評価2023

Author(s)

Organizer

Data Source

[Presentation] 枝分かれ構造を有する多価型核酸医薬品の開発2023

Author(s)

Organizer

Data Source

[Presentation] デンドリマー様構造を有する枝分かれ型核酸医薬の開発2022

Author(s)

Organizer

Data Source

Kawamoto Yusuke 河本佑介