Matsumoto Daisuke 松本大亮

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Daisuke Matsumoto 松本大亮

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Researcher Number	20889381
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員 2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 主任研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 主任研究員 2021 – 2023: 広島大学, 医系科学研究科(薬), 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Basic Section 38060:Applied molecular and cellular biology-related
Keywords	Principal Investigator ゲノム編集 / 相同組換え / 細胞周期 / 相同性組換え / CRISPR-Cas9 / スクリーニング / 遺伝子修復 / Anti-CRISPR

細胞周期S/G2期におけるCas9によるDNA切断後の相同組換え誘導因子の探索Principal Investigator
- Principal Investigator
  
  松本大亮
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Cas9を用いたゲノム編集におけるHDR効率向上に重要な要素の探索Principal Investigator
- Principal Investigator
  
  松本大亮
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Hiroshima University
Exploring the Elements Required for Accurate Genome Editing Using Autonomous Activated CRISPRPrincipal Investigator
- Principal Investigator
  
  Daisuke Matsumoto
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Hiroshima University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates2024
- Author(s)
  Matsumoto Daisuke、Matsugi Erina、Kishi Kanae、Inoue Yuto、Nigorikawa Kiyomi、Nomura Wataru
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 35 Issue: 1 Pages: 102124-102124
- DOI
  10.1016/j.omtn.2024.102124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13844, KAKENHI-PROJECT-23K23468
[Journal Article] Cas9-Geminin and Cdt1-fused anti-CRISPR protein synergistically increase editing accuracy2023
- Author(s)
  Daisuke Matsumoto, Kanae Kishi, Erina Matsugi, Yuto Inoue, Kiyomi Nigorikawa, Wataru Nomura
- Journal Title
  
  FEBS Letters
  
  Volume: 597 Issue: 7 Pages: 985-994
- DOI
  10.1002/1873-3468.14608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14740, KAKENHI-PROJECT-23K23468
[Journal Article] The history of genome editing: advances from the interface of chemistry & biology2023
- Author(s)
  Matsumoto Daisuke、Nomura Wataru
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 50 Pages: 7676-7684
- DOI
  10.1039/d3cc00559c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13844, KAKENHI-PROJECT-23K23468
[Journal Article] Molecular Switch Engineering for Precise Genome Editing2021
- Author(s)
  Daisuke Matsumoto, Wataru Nomura
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 32 Issue: 4 Pages: 639-648
- DOI
  10.1021/acs.bioconjchem.1c00088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21253, KAKENHI-PROJECT-19H02827, KAKENHI-PROJECT-21K14740
[Presentation] AAVベクターとSauCas9を利用した細胞周期依存型ゲノム編集の検討2024
- Author(s)
  松木依理奈、岸彩音、松本大亮、濁川清美、野村渉
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] Construction and optimization of screening system for high-precision Cas9 variants2024
- Author(s)
  Shahram Ahamadi, Komari Kubota, Daisuke Matsumoto, Kiyomi Nigorikawa, Wataru Nomura
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] 高精度ゲノム編集を志向した細胞周期依存的CRISPR活性化システムの検討2024
- Author(s)
  松本大亮
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] CRISPR activationを代替とする細胞内CRISPR-Cas9活性検出手法の確立2024
- Author(s)
  岸果苗、濁川清美、松本大亮、野村渉
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] Increased HDR Efficiency By Cell Cycle-Dependent Regulation of High-Fidelity Cas9 variants2024
- Author(s)
  Yuto Inoue, Daisuke Matsumoto, Kanae Kishi, Erina Matsugi, Kiyomi Nigorikawa , Wataru Nomura
- Organizer
  International Plant & Animal Genome Conference / PAG 32
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] Analysis of CRISPRa inhibition mechanism by anti-CRISPRs regulated by cell cycle progression2023
- Author(s)
  Kanae Kishi, Kiyomi Nigorikawa, Daisuke Matsumoto, Wataru Nomura
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] Cas9変異体を組み合わせた細胞周期依存型ゲノム編集法での正確性の向上2023
- Author(s)
  松本大亮、井上雄翔、岸果苗、松木依理奈、濁川清美、野村渉
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] Evaluation of inhibition of SauCas9 activity by Cdt1-fused anti-CRISPRs2023
- Author(s)
  Erina Matsugi, Ayane Kishi, Daisuke Matsumoto, Kiyomi Nigorikawa, Wataru Nomura
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] CRISPR-Cascadeサブユニットが形成する細胞内ヘテロ分子会合の解析2023
- Author(s)
  木野晴揮、大木公義、濁川清美、松本大亮、野村渉
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] CRISPR-Cascade構成分子の細胞内ヘテロ分子会合の解析2023
- Author(s)
  大木公義、木野晴暉、濁川清美、松本大亮、野村渉
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] 細胞周期依存型ゲノム編集のためのSaCas9に対するanti-CRISPR活性の解析2023
- Author(s)
  松木依理奈、長瀬興平、松本大亮、濁川清美、野村渉
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] 高精度なゲノム編集を可能とする手法の開発 -安全なゲノム編集を目指して-2023
- Author(s)
  松本大亮
- Organizer
  香川大学応用生命科学研究センター
- Invited
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] CRISPRaの仕組みを利用したanti-CRISPRの細胞内でのCas9阻害作用解析2023
- Author(s)
  岸果苗、濁川清美、長谷川有希、松本大亮、野村渉
- Organizer
  日本化学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] 細胞周期依存型ゲノム編集のSauCas9への適用と遺伝子デリバリー法の検討2023
- Author(s)
  岸彩音、松木依理奈、濁川清美、松本大亮、野村渉
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] 相同組み換え修復効率の向上を志向したSauCas9による細胞周期依存型ゲノム編集2023
- Author(s)
  松木依理奈、岸彩音、松本大亮、濁川清美、野村渉
- Organizer
  第69回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] タンパク質発現レベルの精密な制御によるゲノム編集効率の向上2023
- Author(s)
  井上雄翔、松本大亮、濁川清美、野村渉
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-23K13844
[Presentation] 相同性組換え修復を優先的に引き起こす引き起こすゲノム編集法の検討2023
- Author(s)
  松本大亮、松木依理奈、久保田小茉利、井上雄翔、岸果苗、濁川清美、野村　渉
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] 細胞周期依存的なhigh fidelity Cas9の活性化によるゲノム編集の正確性向上の検討2022
- Author(s)
  松本大亮、岸果苗、松木依理奈、井上雄翔、濁川清美、野村　渉
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] Development of Precise Genome Editing Technology by Cell Cycle Depending Activation of CRISPR-Cas92022
- Author(s)
  Daisuke Matsumoto, Kanae Kishi, Erina Matsugi, Yuto Inoue, Kiyomi Nigorikawa, Wataru Nomura
- Organizer
  CBI学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] 特定の細胞周期におけるタンパク質分解の複合化によるゲノム編集と精度の向上2022
- Author(s)
  井上雄翔、松本大亮、岸果苗、松木依理奈、濁川清美、野村渉
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] 特定の細胞周期でのCRISPR-Cas9活性化によるゲノム編集効率の向上2022
- Author(s)
  松本大亮、岸果苗、松木依理奈、井上雄翔、濁川清美、野村　渉
- Organizer
  ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] CRISPRaを用いた自律制御型ゲノム編集におけるAnti-CRISPR作用の解析2022
- Author(s)
  岸果苗、濁川清美、長谷川有希、松本大亮、野村渉
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] Cell cycle dependent expression of anti-CRISPR improves genome editing accuracy2021
- Author(s)
  Daisuke Matsumoto, Wataru Nomura
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-21K14740
[Presentation] 細胞周期依存的なCRISPR活性制御によるゲノム編集法の開発2021
- Author(s)
  松本　大亮、野村　渉
- Organizer
  2021年若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-21K14740

1. 柴田識人 (30391973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. NOMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsumoto Daisuke 松本 大亮

Daisuke Matsumoto 松本 大亮

Research Projects

Research Products

Co-Researchers

細胞周期S/G2期におけるCas9によるDNA切断後の相同組換え誘導因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cas9を用いたゲノム編集におけるHDR効率向上に重要な要素の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the Elements Required for Accurate Genome Editing Using Autonomous Activated CRISPRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cas9-Geminin and Cdt1-fused anti-CRISPR protein synergistically increase editing accuracy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The history of genome editing: advances from the interface of chemistry & biology2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Switch Engineering for Precise Genome Editing2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] AAVベクターとSauCas9を利用した細胞周期依存型ゲノム編集の検討2024

Author(s)

Organizer

Data Source

[Presentation] Construction and optimization of screening system for high-precision Cas9 variants2024

Author(s)

Organizer

Data Source

[Presentation] 高精度ゲノム編集を志向した細胞周期依存的CRISPR活性化システムの検討2024

Author(s)

Organizer

Data Source

[Presentation] CRISPR activationを代替とする細胞内CRISPR-Cas9活性検出手法の確立2024

Author(s)

Organizer

Data Source

[Presentation] Increased HDR Efficiency By Cell Cycle-Dependent Regulation of High-Fidelity Cas9 variants2024

Author(s)

Organizer

Data Source

[Presentation] Analysis of CRISPRa inhibition mechanism by anti-CRISPRs regulated by cell cycle progression2023

Author(s)

Organizer

Data Source

[Presentation] Cas9変異体を組み合わせた細胞周期依存型ゲノム編集法での正確性の向上2023

Author(s)

Organizer

Data Source

[Presentation] Evaluation of inhibition of SauCas9 activity by Cdt1-fused anti-CRISPRs2023

Author(s)

Organizer

Data Source

[Presentation] CRISPR-Cascadeサブユニットが形成する細胞内ヘテロ分子会合の解析2023

Author(s)

Organizer

Data Source

[Presentation] CRISPR-Cascade構成分子の細胞内ヘテロ分子会合の解析2023

Matsumoto Daisuke 松本大亮

Daisuke Matsumoto 松本大亮