Imai Shunsuke 今井駿輔

Researcher Number	20894413
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator Gタンパク質共役型受容体 / 動的構造 / NMR / バイアスリガンド / 溶液NMR法 / シグナル選択性 / 溶液NMR / GPCR

アロステリックモジュレータによるμオピオイド受容体活性向上機構の解明Principal Investigator
- Principal Investigator
  
  今井駿輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the dynamic structural basis controlling signal selectivity of the G protein-coupled receptor b2ARPrincipal Investigator
- Principal Investigator
  
  Imai Shunsuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Evaluation of Drug Responses to Human β2AR Using Native Mass Spectrometry2023
- Author(s)
  Tajiri Michiko、Imai Shunsuke、Konuma Tsuyoshi、Shimamoto Keiko、Shimada Ichio、Akashi Satoko
- Journal Title
  
  ACS Omega
  
  Volume: 8 Issue: 27 Pages: 24544-24551
- DOI
  10.1021/acsomega.3c02737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19236, KAKENHI-PLANNED-19H05774, KAKENHI-PROJECT-21H02619, KAKENHI-PROJECT-23K23480
[Journal Article] Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR2022
- Author(s)
  UEDA Takumi、KOFUKU Yutaka、TAKEUCHI Koh、IMAI Shunsuke、SHIRAISHI Yutaro、SHIMADA Ichio
- Journal Title
  
  Nihon Kessho Gakkaishi
  
  Volume: 64 Issue: 4 Pages: 279-284
- DOI
  10.5940/jcrsj.64.279
- ISSN
  0369-4585, 1884-5576
- Year and Date
  2022-12-15
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22K15052, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-21H02619
[Journal Article] Function-related dynamics of GPCRs2022
- Author(s)
  Ueda Takumi、Imai Shunsuke、Shimada Ichio
- Journal Title
  
  Journal of Magnetic Resonance
  
  Volume: 336 Pages: 107164-107164
- DOI
  10.1016/j.jmr.2022.107164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02619, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375
[Journal Article] Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR2021
- Author(s)
  Takeuchi Koh、Kofuku Yutaka、Imai Shunsuke、Ueda Takumi、Tokunaga Yuji、Toyama Yuki、Shiraishi Yutaro、Shimada Ichio
- Journal Title
  
  Membranes
  
  Volume: 11 Issue: 8 Pages: 604-604
- DOI
  10.3390/membranes11080604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21494, KAKENHI-PUBLICLY-20H04722, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-21H02619, KAKENHI-PROJECT-20K21473, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-23K21289
[Presentation] Structural equilibrium underlying ligand-dependent activation of beta2-adrenoreceptor2023
- Author(s)
  Shunsuke Imai
- Organizer
  IPR x RIKEN (BDR) Symposium 2023
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] Gタンパク質共役受容体（GPCR）の作動薬・拮抗薬をスクリーニングするネイティブ質量分析2022
- Author(s)
  田尻道子、今井駿輔、小沼剛、島本啓子、嶋田一夫、明石知子
- Organizer
  第70回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] ネイティブ質量分析によるGタンパク質共役受容体（GPCR）の作動薬・拮抗薬スクリーニング2022
- Author(s)
  田尻道子、今井駿輔、小沼剛、島本啓子、嶋田一夫、明石知子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] ミューオピオイド受容体のアロステリックモジュレーターによる活性化機構の解明2022
- Author(s)
  金子舜、今井駿輔、浅尾信央、幸福裕、上田卓見、嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] Structural equilibrium underlying ligand-dependent activation of b2-adrenoreceptor2022
- Author(s)
  Shunsuke Imai, Tomoki Yokomizo, Yutaka Kofuku, Yutaro Shiraishi, Takumi Ueda, Ichio Shimada
- Organizer
  29th International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] Activation mechanism of the μ-opioid receptor by an allosteric modulator2022
- Author(s)
  Shun Kaneko, Shunsuke Imai, Nobuaki Asao, Yutaka Kofuku, Takumi Ueda, Ichio Shimada
- Organizer
  the 29th International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] Gタンパク質共役型受容体b2ARのリガンド依存的活性化機構2022
- Author(s)
  今井駿輔、横溝智貴、幸福裕、白石勇太郎、上田卓見、嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] Structural equilibrium underlying ligand-dependent activation of beta2-adrenoreceptor2022
- Author(s)
  Shunsuke Imai
- Organizer
  The 7th International Symposium on Drug Discovery and Design by NMR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02619
[Presentation] Structural equilibrium underlying ligand-dependent activation of b2-adrenoreceptor.2021
- Author(s)
  Imai S, Yokomizo T, Kofuku Y, Shiraishi Y, Ueda T, Shimada I.
- Organizer
  22nd International Society of Magnetic Resonance Conference, 9th Asia-Pacific NMR Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02619

1. 明石知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 竹内恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 徳永裕二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Imai Shunsuke 今井 駿輔

Research Projects

Research Products

Co-Researchers

アロステリックモジュレータによるμオピオイド受容体活性向上機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the dynamic structural basis controlling signal selectivity of the G protein-coupled receptor b2ARPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Evaluation of Drug Responses to Human β2AR Using Native Mass Spectrometry2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Function-related dynamics of GPCRs2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Structural equilibrium underlying ligand-dependent activation of beta2-adrenoreceptor2023

Author(s)

Organizer

Data Source

[Presentation] Gタンパク質共役受容体（GPCR）の作動薬・拮抗薬をスクリーニングするネイティブ質量分析2022

Author(s)

Organizer

Data Source

[Presentation] ネイティブ質量分析によるGタンパク質共役受容体（GPCR）の作動薬・拮抗薬スクリーニング2022

Author(s)

Organizer

Data Source

[Presentation] ミューオピオイド受容体のアロステリックモジュレーターによる活性化機構の解明2022

Author(s)

Organizer

Data Source

[Presentation] Structural equilibrium underlying ligand-dependent activation of b2-adrenoreceptor2022

Author(s)

Organizer

Data Source

[Presentation] Activation mechanism of the μ-opioid receptor by an allosteric modulator2022

Author(s)

Organizer

Data Source

[Presentation] Gタンパク質共役型受容体b2ARのリガンド依存的活性化機構2022

Author(s)

Organizer

Data Source

[Presentation] Structural equilibrium underlying ligand-dependent activation of beta2-adrenoreceptor2022

Author(s)

Organizer

Data Source

[Presentation] Structural equilibrium underlying ligand-dependent activation of b2-adrenoreceptor.2021

Author(s)

Organizer

Data Source

Imai Shunsuke 今井駿輔