Takada Yuri 高田悠里

Researcher Number	20902357
Other IDs
Affiliation (Current)	2025: 大阪大学, 産業科学研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪大学, 産業科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator 固相合成 / 創薬 / タンパク質間相互作用 / 構造活性相関 / ペプチド / 有機化学 / PROTAC / タンパク質分解誘導剤 / 人工知能 / 化合物ライブラリー … More Except Principal Investigator … More 創薬 / がん / エピジェネティクス / 複合体 / キメラ分子 / in situクリックケミストリー / 阻害薬 / 医薬品 / 標的誘導型合成 Less

Development of chimera molecules targeting epigenetic complexes
- Principal Investigator
  
  鈴木孝禎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of molecular technologies for target protein degradationPrincipal Investigator
- Principal Investigator
  
  Takada Yuri
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Osaka University
Development of innovative drug candidates by target guided synthesis
- Principal Investigator
  
  Suzuki Takayoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Discovery of PPI inhibitory peptides through large compound library and AIPrincipal Investigator
- Principal Investigator
  
  Takada Yuri
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells2024
- Author(s)
  Ota Y, Itoh Y, Takada Y, Yamashita Y, Hu C, Horinaka M, Sowa Y, Masuda M, Sakai T, Suzuki T
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 100 Pages: 117632-117632
- DOI
  10.1016/j.bmc.2024.117632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795
[Journal Article] Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning2024
- Author(s)
  Nurani Atika、Yamashita Yasunobu、Taki Yuuki、Takada Yuri、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 173-178
- DOI
  10.1248/cpb.c23-00577
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 12024
- Author(s)
  Takada Yuri、Adachi Kyohei、Fujinaga Yuka、Yamashita Yasunobu、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 155-160
- DOI
  10.1248/cpb.c23-00671
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity2024
- Author(s)
  Terao Mitsuhiro、Yamashita Yasunobu、Takada Yuri、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 98 Pages: 117579-117579
- DOI
  10.1016/j.bmc.2023.117579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18186, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] Discovery of selective histone deacetylase 1 and 2 inhibitors: screening of a focused library constructed by click chemistry, kinetic binding analysis, and biological evaluation2023
- Author(s)
  Itoh Y, Zhan P, Tojo T, Jaikhan P, Ota Y, Suzuki M, Li Y, Hui Z, Moriyama Y, Takada Y, Yamashita Y, Oba M, Uchida S, Masuda M, Ito S, Sowa Y, Sakai T, Suzuki T
- Journal Title
  
  J Med Chem
  
  Volume: 66 Issue: 22 Pages: 15171-15188
- DOI
  10.1021/acs.jmedchem.3c01095
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-20K15959, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-23K23487
[Journal Article] Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)2022
- Author(s)
  Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Chem. Commun.
  
  Volume: 58 Issue: 29 Pages: 5051-5056
- DOI
  10.1039/d2cc00272h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K20719
[Journal Article] Medicinal Chemistry Research on Targeting Epigenetic Complexes2022
- Author(s)
  Yuri Takada, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 7 Pages: 664-675
- DOI
  10.5059/yukigoseikyokaishi.80.664
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-07-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K20719
[Journal Article] Cancer-cell-selective targeting by arylcyclopropylamine-vorinostat conjugates2022
- Author(s)
  Ota Y, Itoh Y, Kurohara T, Singh R, Elboray EE, Hu C, Zamani F, Mukherjee A, Takada Y, Yamashita Y, Morita M, Horinaka M, Sowa Y, Masuda M, Sakai T, Suzuki T
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 10 Pages: 1568-1573
- DOI
  10.1021/acsmedchemlett.2c00126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-20F40107, KAKENHI-PROJECT-21K20719
[Journal Article] Recent progress on small molecules targeting epigenetic complexes2022
- Author(s)
  Itoh Yukihiro、Takada Yuri、Yamashita Yasunobu、Suzuki Takayoshi
- Journal Title
  
  Current Opinion in Chemical Biology
  
  Volume: 67 Pages: 102130-102130
- DOI
  10.1016/j.cbpa.2022.102130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-21K20719
[Journal Article] Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group2021
- Author(s)
  Kurohara Takashi、Tanaka Keita、Takahashi Daisuke、Ueda Satoshi、Yamashita Yasunobu、Takada Yuri、Takeshima Hirokazu、Yu Shengwang、Itoh Yukihiro、Hase Koji、Suzuki Takayoshi
- Journal Title
  
  ChemBioChem
  
  Volume: 22 Issue: 22 Pages: 3158-3163
- DOI
  10.1002/cbic.202100255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K07552
[Journal Article] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach2021
- Author(s)
  Prakash Muthuraj、Itoh Yukihiro、Fujiwara Yoshie、Takahashi Yukari、Takada Yuri、Mellini Paolo、Elboray Elghareeb E.、Terao Mitsuhiro、Yamashita Yasunobu、Yamamoto Chika、Yamaguchi Takao、Kotoku Masayuki、Kitao Yuki、Singh Ritesh、Roy Rohini、Obika Satoshi、Oba Makoto、Wang Dan Ohtan、Suzuki Takayoshi
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15810-15824
- DOI
  10.1021/acs.jmedchem.1c01107
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K21488, KAKENHI-PROJECT-21H02580
[Presentation] E3リガンド構造によるステープル化を基盤としたペプチド性PROTACの創製研究2024
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] ヘテロクロマチンタンパク質HP1を阻害する低分子化合物の同定2024
- Author(s)
  徳山あかり、山下泰信、前田亮、高田悠里、伊藤幸裕、立花誠、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] BRD4を標的としたスクアレート型コバレントドラッグの創製研究2024
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] クリックケミストリーを利用したGLS1 PROTACライブラリーの構築2024
- Author(s)
  林海伶、伊藤幸裕、山下泰信、高田悠里、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Discovery of hydrophobic tag-based degraders targeting lysine-specific demethylase 12024
- Author(s)
  SHENGWANG YU, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Discovery of SNAIL1 Peptide-Based Inhibitors of Lysine-Specific Demethylase 12024
- Author(s)
  Yuka Fujinaga, Yuri Takada, Kyohei Adachi, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  The 27th SANKEN International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] ペプチドライブラリーの構築とスクリーニングを基盤としたCBX7阻害薬の創製研究2024
- Author(s)
  山﨑伊吹、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 新規セレブロン(CRBN)リガンドの同定2023
- Author(s)
  安藤貴章、伊藤幸裕、高田悠里、山下泰信、鈴木孝禎
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] タンパク質分解誘導活性を持つペプチド化合物の創製を指向したステープル化2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Improved cellular activity of KDM5B inhibitor prodrugs through structure-based drug design2023
- Author(s)
  Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Design, synthesis, and biological evaluation of SNAIL1 peptide-based inhibitors of lysine-specific demethylase 12023
- Author(s)
  Yuri Takada, Kyohei Adachi, Yuka Fujinaga, Hiroaki Kawanami, Yasunobu Yamashita, Yukihiro Itoh, and Takayoshi Suzuki
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein2023
- Author(s)
  高田悠里、Muthuraj Prakash、伊藤幸裕、藤原芳江、高橋ゆかり、Paolo Mellini、Elghareeb E. Elboray、寺尾允太、山下泰信、山本知佳、山口卓男、Ritesh Singh、小比賀聡、大庭誠、王丹、鈴木孝禎
- Organizer
  第３回大津会議合同研究発表会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Design, synthesis, and biological evaluation of proteolysis targeting chimeras (PROTACs) targeting G9a methyltransferase2023
- Author(s)
  Anirban Mukherjee, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] SNAIL1の配列を基盤としたペプチド性LSD1阻害薬および分解誘導薬の開発2023
- Author(s)
  高田悠里
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 創薬への応用を指向したスクアラミドの反応性検証2023
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] 創薬への応用を指向したスクアラミドの反応性検証2023
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Development of SNAIL1 Peptide-Based Inhibitors of Lysine-Specific Demethylase 12023
- Author(s)
  Yuri Takada, Kyohei Adachi, Yuka Fujinaga, Hiroaki Kawanami, Yasunobu Yamashita, Yukihiro Itoh, and Takayoshi Suzuki
- Organizer
  International Mini-Symposium on Peptide Design and Functional Extension, A Satellite Symposium of the 60th Japanese Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 架橋部位にE3リガンド構造を持つペプチド性PROTACの創製研究2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第40回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] CBX7 阻害薬創製に向けたペプチドライブラリーの構築とスクリーニング2023
- Author(s)
  山崎伊吹、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein2023
- Author(s)
  高田悠里、Muthuraj Prakash、伊藤幸裕、藤原芳江、高橋ゆかり、Paolo Mellini、Elghareeb E. Elboray、寺尾允太、山下泰信、山本知佳、山口卓男、Ritesh Singh、小比賀聡、大庭誠、王丹、鈴木孝禎
- Organizer
  第３回大津会議合同研究発表会
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] 細胞評価系での活性向上を目指したKDM5B阻害薬の創製研究2023
- Author(s)
  寺尾允太、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Synthesis and evaluation of optically pure phenylcyclopropylamine-drug conjugates targeting LSD12023
- Author(s)
  Chenliang Hu、Yosuke Ota、Yukihiro Itoh、Farzad Zamani、Anirban Mukherjee,、Yuri Takada、Yasunobu Yamashita、Takayoshi Suzuki
- Organizer
  第26回産研国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] 逆電子要請型 Diels-Alder 反応に基づく標的タンパク質分解誘導薬PROTAC の創製研究2023
- Author(s)
  Yu Shengwang、伊藤幸裕、山下泰信、高田悠里、鈴木孝禎
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Synthesis and evaluation of optically pure phenylcyclopropylamine-drug conjugates targeting LSD12023
- Author(s)
  Chenliang Hu、Yosuke Ota、Yukihiro Itoh、Farzad Zamani、Anirban Mukherjee,、Yuri Takada、Yasunobu Yamashita、Takayoshi Suzuki
- Organizer
  第26回産研国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 細胞評価系での活性向上を目指したKDM5B阻害薬の創製研究2023
- Author(s)
  寺尾允太、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein2023
- Author(s)
  Yuri Takada，Muthuraj Prakash，Yukihiro Itoh，Yoshie Fujiwara，Yukari Takahashi，Paolo Mellini，Elghareeb E. Elboray，Mitsuhiro Terao，Yasunobu Yamashita，Chika Yamamoto，Takao Yamaguchi，Ritesh Singh，Satoshi Obika，Makoto Oba，Dan Ohtan Wang，Takayoshi Suzuki
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] HDAC8 選択的分解誘導薬の創製とその生物学的評価2022
- Author(s)
  山下泰信、Jiranan Chotitumnavee、高橋ゆかり、高田悠里、飯田哲也、大庭誠、伊藤幸裕、鈴木孝禎
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] Synthesis and evaluation of optically pure phenylcyclopropylamine-drug conjugates targeting LSD12022
- Author(s)
  Chenliang Hu、Yosuke Ota、Yukihiro Itoh、Farzad Zamani、Anirban Mukherjee、Yuri Takada、Yasunobu Yamashita、Takayoshi Suzuki
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] RNA脱メチル化酵素FTO阻害薬の創製2022
- Author(s)
  高田悠里、Muthuraj Prakash、伊藤幸裕、藤原芳江、高橋ゆかり、Paolo Mellini、Elghareeb E. Elboray、寺尾允太、山下泰信、山本知佳、山口卓男、Ritesh Singh、小比賀聡、大庭誠、王丹、鈴木孝禎
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] RNA創薬への応用を志向したビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第20回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] ビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第16回年会
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] 二核ビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 二核ビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 創薬、ケミカルバイオロジー研究を指向したスクアラミドの反応性検証2022
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] SBDD によるKDM5B 選択的阻害薬の創製研究2022
- Author(s)
  寺尾允太、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] 創薬、ケミカルバイオロジー研究を指向したスクアラミドの反応性検証2022
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] RNA創薬を志向した金属錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] Synthesis and evaluation of optically pure phenylcyclopropylamine-drug conjugates targeting LSD12022
- Author(s)
  Chenliang Hu、Yosuke Ota、Yukihiro Itoh、Farzad Zamani、Anirban Mukherjee、Yuri Takada、Yasunobu Yamashita、Takayoshi Suzuki
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] RNA創薬への応用を志向したビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第20回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] 二核ビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] 二核ビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719
[Presentation] RNA脱メチル化酵素FTO阻害薬の創製2022
- Author(s)
  高田悠里、Muthuraj Prakash、伊藤幸裕、藤原芳江、高橋ゆかり、Paolo Mellini、Elghareeb E. Elboray、寺尾允太、山下泰信、山本知佳、山口卓男、Ritesh Singh、小比賀聡、大庭誠、王丹、鈴木孝禎
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] SBDD によるKDM5B 選択的阻害薬の創製研究2022
- Author(s)
  寺尾允太、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] RNA創薬を志向した金属錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４２年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04795
[Presentation] ビスマス(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第16回年会
- Data Source
  KAKENHI-PROJECT-22K15251
[Presentation] HDAC8 選択的分解誘導薬の創製とその生物学的評価2022
- Author(s)
  山下泰信、Jiranan Chotitumnavee、高橋ゆかり、高田悠里、飯田哲也、大庭誠、伊藤幸裕、鈴木孝禎
- Organizer
  第39 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K20719

1. Suzuki Takayoshi (90372838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 山下泰信 (10873408)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 伊藤幸裕 (30636402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. HORINAKA Mano

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 酒井敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Takada Yuri 高田 悠里

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Development of chimera molecules targeting epigenetic complexes

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Development of molecular technologies for target protein degradationPrincipal Investigator

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Development of innovative drug candidates by target guided synthesis

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Discovery of PPI inhibitory peptides through large compound library and AIPrincipal Investigator

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[Journal Article] Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells2024

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[Journal Article] Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning2024

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[Journal Article] A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 12024

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[Journal Article] Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity2024

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[Journal Article] Discovery of selective histone deacetylase 1 and 2 inhibitors: screening of a focused library constructed by click chemistry, kinetic binding analysis, and biological evaluation2023

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[Journal Article] Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)2022

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[Journal Article] Medicinal Chemistry Research on Targeting Epigenetic Complexes2022

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[Journal Article] Cancer-cell-selective targeting by arylcyclopropylamine-vorinostat conjugates2022

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[Journal Article] Recent progress on small molecules targeting epigenetic complexes2022

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Takada Yuri 高田悠里