KOKUBO Kota 小久保幸太

Researcher Number	20907711
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2024: 千葉大学, 大学院医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / 0803:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 喘息 / アレルギー性疾患 / Txnip / 酸化ストレス / Memory Th2細胞 / 抗原提示細胞 / T細胞 / T細胞分化 / 細胞老化 / Cytotoxic CD4+ T細胞 … More / Epigenetics / Single cell RNA-Seq / Memory CD4+ T細胞 / ROS Less

Research for an elimination mechanism of senescent antigen-presenting cells via induction of differentiation of cytotoxic CD4+ T cellsPrincipal Investigator
- Principal Investigator
  
  小久保幸太
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
Elucidation of the novel oxidative stress scavenging mechanism of Txnip that induces asthma exacerbationPrincipal Investigator
- Principal Investigator
  
  Kokubo Kota
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
Investigation of the mechanism of asthma exacerbation via memory Th2 cell formation by oxidative stress regulationPrincipal Investigator
- Principal Investigator
  
  KOKUBO Kota
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Chiba University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease2024
- Author(s)
  Tanaka Shigeru、Yamamoto Takuya、Iwata Arifumi、Kiuchi Masahiro、Kokubo Kota、Iinuma Tomohisa、Sugiyama Takahiro、Hanazawa Toyoyuki、Hirahara Kiyoshi、Ikeda Kei、Nakajima Hiroshi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 26 Issue: 1 Pages: 55-55
- DOI
  10.1186/s13075-024-03289-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-21K08436, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-21H02922
[Journal Article] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2023
- Author(s)
  Kokubo Kota、Hirahara Kiyoshi、Kiuchi Masahiro、Tsuji Kaori、Shimada Yuki、Sonobe Yuri、Shinmi Rie、Hishiya Takahisa、Iwamura Chiaki、Onodera Atsushi、Nakayama Toshinori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 2
- DOI
  10.1073/pnas.2218345120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-20K08769
[Journal Article] Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab2023
- Author(s)
  Suga Kensuke、Kiuchi Masahiro、Kageyama Takahiro、Kokubo Kota、Tanaka Shigeru、Iwata Arifumi、Suzuki Kotaro、Hirahara Kiyoshi、Nakajima Hiroshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 72 Issue: 4 Pages: 610-613
- DOI
  10.1016/j.alit.2023.06.002
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K16353, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K27607
[Journal Article] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients2023
- Author(s)
  Tsuji Kaori、Aoki Ami、Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Morimoto Yuki、Iinuma Tomohisa、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 72 Issue: 2 Pages: 335-338
- DOI
  10.1016/j.alit.2022.11.009
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-22K15484
[Journal Article] Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases2023
- Author(s)
  Onodera Atsushi、Kokubo Kota、Okano Mikiko、Onoue Miki、Kiuchi Masahiro、Iwamura Chiaki、Iinuma Tomohisa、Kimura Motoko Y.、Ebihara Nobuyuki、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 247 Pages: 108445-108445
- DOI
  10.1016/j.pharmthera.2023.108445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-22K09739, KAKENHI-PROJECT-22K15484, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-23K27607, KAKENHI-PROJECT-19H05650
[Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells2023
- Author(s)
  Kumagai Jin、Kiuchi Masahiro、Kokubo Kota、Yagyu Hiroyuki、Nemoto Masahiro、Tsuji Kaori、Nagahata Ken、Sasaki Atsushi、Hishiya Takahisa、Onoue Miki、Shinmi Rie、Sonobe Yuri、Iinuma Tomohisa、Yonekura Syuji、Shinga Jun、Hanazawa Toyoyuki、Koseki Haruhiko、Nakayama Toshinori、Yokote Koutaro、Hirahara Kiyoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 49 Pages: 2302903120-2302903120
- DOI
  10.1073/pnas.2302903120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-23K15339, KAKENHI-PROJECT-22K15484, KAKENHI-PLANNED-19H05745, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K27607, KAKENHI-PROJECT-19H05650
[Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022
- Author(s)
  Shinoda Kenta、Choe Andrea、Hirahara Kiyoshi、Kiuchi Masahiro、Kokubo Kota、Ichikawa Tomomi、Hoki Jason S.、Suzuki Akane S.、Bose Neelanjan、Appleton Judith A.、Aroian Raffi V.、Schroeder Frank C.、Sternberg Paul W.、Nakayama Toshinori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119(9) Issue: 9
- DOI
  10.1073/pnas.2108686119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754
[Journal Article] Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion2022
- Author(s)
  Iinuma Tomohisa、Kiuchi Masahiro、Hirahara Kiyoshi、Kurita Junya、Kokubo Kota、Yagyu Hiroyuki、Yoneda Riyo、Arai Tomoyuki、Sonobe Yuri、Fukuyo Masaki、Kaneda Atsushi、Yonekura Syuji、Nakayama Toshinori、Okamoto Yoshitaka、Hanazawa Toyoyuki
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 150 Issue: 4 Pages: 850-860.e5
- DOI
  10.1016/j.jaci.2022.06.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-22K09739, KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754
[Journal Article] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis2022
- Author(s)
  Kokubo Kota、Onodera Atsushi、Kiuchi Masahiro、Tsuji Kaori、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 945063-945063
- DOI
  10.3389/fimmu.2022.945063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24147
[Journal Article] CD4陽性T細胞と肺の線維化2022
- Author(s)
  平原潔, 小久保幸太, 中山俊憲
- Journal Title
  
  医学のあゆみ
  
  Volume: 283 Pages: 4-9
- Data Source
  KAKENHI-PROJECT-21K20754
[Journal Article] Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch2022
- Author(s)
  Okano Mikiko、Hirahara Kiyoshi、Kiuchi Masahiro、Onoue Miki、Iwamura Chiaki、Kokubo Kota、Hishiya Takahisa、Morimoto Yuki、Ikehara Yuzuru、Murakami Akira、Ebihara Nobuyuki、Nakayama Toshinori
- Journal Title
  
  Immunity
  
  Volume: 55 Issue: 12 Pages: 2352-2368.e7
- DOI
  10.1016/j.immuni.2022.09.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20K08769
[Journal Article] 局所免疫応答における組織常在性メモリーT細胞2022
- Author(s)
  小久保幸太, 平原潔
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 78 Pages: 438-443
- Data Source
  KAKENHI-PROJECT-21K20754
[Journal Article] 局所免疫応答における組織常在性メモリーT細胞2022
- Author(s)
  小久保幸太, 平原潔
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 78 Pages: 438-443
- Data Source
  KAKENHI-PROJECT-22K15484
[Journal Article] Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity2022
- Author(s)
  Iwamura Chiaki、Hirahara Kiyoshi、Kiuchi Masahiro、Ikehara Sanae、Azuma Kazuhiko、Shimada Tadanaga、Kuriyama Sachiko、Ohki Syota、Yamamoto Emiri、Inaba Yosuke、Shiko Yuki、Aoki Ami、Kokubo Kota、et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 33 Pages: 2203437119-2203437119
- DOI
  10.1073/pnas.2203437119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15484, KAKENHI-PROJECT-22K15485, KAKENHI-PLANNED-22H05189, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K08351, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-23K24337, KAKENHI-PROJECT-20K08769
[Journal Article] CD4陽性T細胞と肺の線維化2022
- Author(s)
  平原潔, 小久保幸太, 中山俊憲
- Journal Title
  
  医学のあゆみ
  
  Volume: 283 Pages: 4-9
- Data Source
  KAKENHI-PROJECT-22K15484
[Journal Article] CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system2021
- Author(s)
  Nakayama Toshinori、Hirahara Kiyoshi、Kimura Motoko Y、Iwamura Chiaki、Kiuchi Masahiro、Kokubo Kota、Onodera Atsushi、Hashimoto Kahoko、Motohashi Shinichiro
- Journal Title
  
  International Immunology
  
  Volume: 33(12) Issue: 12 Pages: 699-704
- DOI
  10.1093/intimm/dxab053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PROJECT-19K16683, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K08769, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351
[Journal Article] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021
- Author(s)
  Kiuchi Masahiro、Onodera Atsushi、Kokubo Kota、Ichikawa Tomomi、Morimoto Yuki、Kawakami Eiryo、Takayama Naoya、Eto Koji、Koseki Haruhiko、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218 Issue: 4 Pages: 3-8
- DOI
  10.1084/jem.20201690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07164, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-21K20754
[Journal Article] The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue - Protection Versus Pathology -2021
- Author(s)
  Kiyoshi Hirahara、Kota Kokubo、Ami Aoki、Masahiro Kiuchi、Toshinori Nakayama
- Journal Title
  
  Frontiers in Immunology
  
  Volume: - Pages: 616309-616309
- DOI
  10.3389/fimmu.2021.616309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20K20383, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K20754
[Journal Article] Epigenetic regulation of inflammation by CxxC domain‐containing proteins2021
- Author(s)
  Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Nakayama Toshinori
- Journal Title
  
  Immunological Reviews
  
  Volume: 305(1) Issue: 1 Pages: 137-151
- DOI
  10.1111/imr.13056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K20754, KAKENHI-PROJECT-20KK0351
[Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2024
- Author(s)
  Kota Kokubo
- Organizer
  第52回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15484
[Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2023
- Author(s)
  Kota Kokubo, Kiyoshi Hirahara, Masahiro Kiuchi, Kaori Tsuji, Yuki Shimada, Yuri Sonobe, Rie Shinmi, Takahisa Hishiya, Chiaki Iwamura, Atsushi Onodera, and Toshinori Nakayama.
- Organizer
  cSIMVa symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15484
[Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2023
- Author(s)
  Kota Kokubo, Kiyoshi Hirahara, Masahiro Kiuchi, Kaori Tsuji, Yuki Shimada, Yuri Sonobe, Rie Shinmi, Takahisa Hishiya, Chiaki Iwamura, Atsushi Onodera, and Toshinori Nakayama
- Organizer
  cSIMVa symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20754
[Presentation] 病原性Th2細胞による難治性アレルギ－性気道炎症の病態制御2021
- Author(s)
  中山俊憲、市川智巳、小久保幸太、木内政宏、青木亜美、平原潔
- Organizer
  第70回日本アレルギ－学会学術大会
- Data Source
  KAKENHI-PROJECT-21K20754
[Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討2021
- Author(s)
  青木亜美、辻香織、小久保幸太、木内政宏、平原潔、中山俊憲
- Organizer
  第70回日本アレルギ－学会学術大会
- Data Source
  KAKENHI-PROJECT-21K20754

1. FUKUYO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 木内政宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

KOKUBO Kota 小久保 幸太

Research Projects

Research Products

Co-Researchers

Research for an elimination mechanism of senescent antigen-presenting cells via induction of differentiation of cytotoxic CD4+ T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the novel oxidative stress scavenging mechanism of Txnip that induces asthma exacerbationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of asthma exacerbation via memory Th2 cell formation by oxidative stress regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD4陽性T細胞と肺の線維化2022

Author(s)

Journal Title

Data Source

[Journal Article] Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch2022

Author(s)

Journal Title

DOI

Data Source

KOKUBO Kota 小久保幸太