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Obara Hisashi  小原 尚

ORCIDConnect your ORCID iD *help
Researcher Number 20919732
Affiliation (Current) 2025: 札幌医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help 2021 – 2024: 札幌医科大学, 医学部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related
Except Principal Investigator
Basic Section 56020:Orthopedics-related / Basic Section 56010:Neurosurgery-related
Keywords
Principal Investigator
骨髄間葉系幹細胞治療 / 脊髄損傷 / アデノ随伴ウイルス / Staggered lesion / 組織透明化 / MSC / 脊髄半切断
Except Principal Investigator
骨髄幹細胞 / 骨髄間葉系幹細胞 / 脊髄損傷 … More / 神経障害性疼痛 / 静脈内投与 / 脊髄障害性疼痛 / 神経絞扼モデル / 末梢神経 / 神経再生 / 間葉系幹細胞 / Spared nerve injuryモデル / 末梢神経障害モデル / 再生医療 / 静脈的投与 / AAV-CAG / エクソソーム / BDNF / MSC由来エクソソーム / MSC / 皮質脊髄路 / 組織透明化 / 神経回路再編 / アデノ随伴ウイルス / 軸索伸長 / 神経トレーサー / 脊髄障害性疼痛モデル Less
  • Research Projects

    (7 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (17 People)
  •  神経障害性疼痛・脊髄障害性疼痛に対する間葉系幹細胞の治療メカニズムの解析

    • Principal Investigator
      福士 龍之介
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Sapporo Medical University
  •  脊損に対する骨髄幹細胞治療で介在ニューロンの関与で再構築された神経回路の解析Principal Investigator

    • Principal Investigator
      小原 尚
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Sapporo Medical University
  •  Therapeutic strategies for cerebral infarction and spinal cord injury by activating plasticity throughout the central nervous system

    • Principal Investigator
      本望 修
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Sapporo Medical University
  •  Therapeutic efficacy of intravenous infusion of mesenchymal stem cells for myelopathic pain.

    • Principal Investigator
      Kurihara Kota
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Sapporo Medical University
  •  Development of innovative treatment for spinal cord injury using next-generation exosomes

    • Principal Investigator
      Hirota Ryosuke
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Sapporo Medical University
  •  Investigation of the therapeutic efficacy of bone marrow mesenchymal stem cells for neuropathic pain

    • Principal Investigator
      Fukushi Ryunosuke
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Sapporo Medical University
  •  MSC therapy for spinal cord injury

    • Principal Investigator
      Sasaki Masanori
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Sapporo Medical University

All 2024 2023 2022

All Journal Article Presentation

  • [Journal Article] Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury2023

    • Author(s)
      Kurihara Kota、Sasaki Masanori、Nagahama Hiroshi、Obara Hisashi、Fukushi Ryunosuke、Hirota Ryosuke、Yoshimoto Mitsunori、Teramoto Atsushi、Kocsis Jeffery D.、Yamashita Toshihiko、Honmou Osamu
    • Journal Title

      Brain Research

      Volume: 1817 Pages: 148484-148484

    • DOI

      10.1016/j.brainres.2023.148484

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09183, KAKENHI-PROJECT-23K24447
  • [Presentation] 慢性期脊髄損傷モデルラットに対する骨髄間葉系幹細胞の複数回投与による治療効果の検討2024

    • Author(s)
      栗原康太、小原尚、福士龍之介、廣田亮介、森田智慶、佐々木祐典、寺本篤史、本望修、山下敏彦
    • Organizer
      第53回日本脊椎脊髄病学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K09183
  • [Presentation] 慢性期脊髄損傷モデルラットに対する骨髄間葉系幹細胞の複数回投与による治療効果の検討2024

    • Author(s)
      栗原康太、小原尚、福士龍之介、廣田亮介、森田智慶、佐々木祐典、寺本篤史、本望修、山下敏彦
    • Organizer
      第97回日本整形外科学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K09183
  • [Presentation] 神経障害性疼痛モデルに対する骨髄幹細胞の経静脈的投与後の脊髄後角における遺伝子発現変化の検討2023

    • Author(s)
      福士 龍之介 佐々木 祐典 小原 尚 廣田 亮介 栗原 康太 本望 修 山下 敏彦
    • Organizer
      第42回 日本運動器移植・再生医学研究会
    • Data Source
      KAKENHI-PROJECT-21K09282
  • [Presentation] 神経障害性疼痛に対する骨髄間葉系幹細胞の治療効果の検討2023

    • Author(s)
      福士 龍之介 佐々木 祐典 小原尚 廣田 亮介 栗原 康太 本望 修 山下 敏彦
    • Organizer
      第52回 日本脊椎脊髄病学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K09282
  • [Presentation] 脊髄障害性疼痛に対する骨髄間葉系幹細胞の治療効果の検討2023

    • Author(s)
      福士 龍之介 佐々木 祐典 小原尚 廣田 亮介 栗原 康太 本望 修 山下 敏彦
    • Organizer
      第52回 日本脊椎脊髄病学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K09282
  • [Presentation] 神経障害性疼痛モデルに対する骨髄幹細胞の経静脈的投与後の脊髄後角における遺伝子発現変化の検討2023

    • Author(s)
      福士 龍之介 佐々木 祐典 小原 尚 廣田 亮介 栗原 康太 本望 修 山下 敏彦
    • Organizer
      第38回 日本整形外科学会基礎学会
    • Data Source
      KAKENHI-PROJECT-21K09282
  • [Presentation] 神経障害性疼痛に対する骨髄間葉系幹細胞の治療効果の検討2022

    • Author(s)
      福士龍之介 小原尚
    • Organizer
      第37回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-21K09282
  • 1.  Sasaki Masanori (20538136)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 7 results
  • 2.  本望 修 (90285007)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 7 results
  • 3.  Hirota Ryosuke (10815434)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 7 results
  • 4.  Fukushi Ryunosuke (00894065)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 8 results
  • 5.  佐々木 優子 (80631142)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 7 results
  • 6.  Kurihara Kota (20855803)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 7.  山下 敏彦 (70244366)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 8.  押切 勉 (70754612)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  岡 真一 (70789453)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  横山 貴裕 (60896116)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  寺島 嘉紀 (20438005)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  黄金 勲矢 (10724073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  佐々木 雄一 (00570136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  鵜飼 亮 (30896113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  小林 萬里 (50971074)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  山下 達郎 (60815439)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  中崎 公仁 (70722461)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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