SAKURAI Hiromu 桜井弘

… Alternative Names

SAKURAI Tsutomu 桜井弘

櫻井弘サクライヒロシ

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Researcher Number	30065916
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2003 – 2006: 京都薬科大学, 薬学部, 教授 2004: 京都薬大, 薬学部, 教授 2003: 京都薬科大学, 代謝分析学教室, 教授 2000 – 2001: 京都薬科大学, 代謝分析学, 教授 1991 – 2000: Kyoto pharmaceutical University, Faculty of Pharmaceutical Sciences Department of Analytical Chemistry Professor, 薬学部, 教授 1991: Kyoto Pharmaceutical University, Department of Analytical Chemistry, Professor, 教授 1987 – 1990: 徳島大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Science and Engineering / Chemistry / Science and Engineering / Environmental pharmacy / 医薬分子機能学 / Physical pharmacy Except Principal Investigator Inorganic chemistry / Biological pharmacy / Hygiene / Synthetic chemistry / Chemical pharmacy / Physical pharmacy
Keywords	Principal Investigator 糖尿病 / 活性酸素 / 亜鉛錯体 / インスリン様作用 / バナジウム錯体 / バナジウム / 金属錯体 / フリーラジカル / ESR / 脂肪細胞 … More / 電子スピン共鳴(ESR) / 生物無機化学 / NIDDM / IDDM / diabetes / insulin-like action / 亜鉛 / 血糖降下作用 / インスリン / 血糖値 / ポドフィロトキシン / drug delivery system / hypoglycemic effect / insulin-mimetic action / zinc complex / vanadium complex / metabolic syndrome / diabetes mellitus / インスリンシグナル伝達経路 / アリキシン / インスリン注射 / 糖尿病治療薬 / ポルフィリン錯体 / ドラッグデリバリー系 / 糖尿病治療 / ドラッグデリバリーシステム / メタボリックシンドローム / Hairless mouse / Caffeic acid derivatives / Ascorbic acid derivatives / Zinc(II) ion / Chemiluminescence / UV-induced skin damage / Reactive oxygen species / Ultraviolet ray / 化学発光法 / 皮膚損害 / ラジカルスカベンジャー / 抗酸化剤 / 微弱光測定 / 化学発光学 / 皮膚障害 / ヘアレスマウス / カフェー酸 / アスコルビン酸 / 亜鉛(II)イオン / 化学発光 / 皮膚傷害 / 活性酸素種 / 太陽紫外光 / nitric oxide / vanadyl complex / vanadium / 一酸化窒素 / バナジル錯体 / metal ion / spin-label / spin probe / in vivo measurement / in vitro measurement / free radical / L-band ESR / X-band ESR / SOD / BCM-ESR / ESRイメージング / 薬物動態 / 常磁性金属イオン / L-バンドESR / X-バンドESR / インビボ計測 / スピンラベル / インビトロ計測 / スピンプローブ / hydroxyl radical / gel-filtration / metallothionein / copper / hepatoma / hepatitis / LEC rat / メタロチオネイン / 銅蓄積 / DNA / ヒドロキシルラジカル / ゲルクロマトグラフィー / 銅-メタロチオネイン / 肝炎・肝ガン / LECラット / adipocites / vanadium determination / vanadyl-cysteine methyl ester / blood glucose level / streptozotocin / vanadyl compounds / 遊離脂肪酸 / ESR(電子スピン共鳴法) / 脂肪組織 / ESR(電子スピン共鳴) / グルコ-ス / ノンスリン / 反応機構 / オレフィンの酸化反応 / 分子構造 / 合成ペプチド / 化学モデル / 活性中心 / チトクロムPー450 / ハンガリー、ドイツ / 国際研究者交流 / スペシエーション / 構造活性相関 / 作用機構 / NO(一酸化窒素) / 電極法 / β細胞 / ストレプトゾトシン / NO / DNA切断 / ポドフイロトキシン / 紫外線照射 / 塩基特異的DNA切断 / ESRースピントラップ法 / DNA切断反応 / VPー16 / 酸素化反応 / ハイパ-ポルフィリンスペクトル / チオ-ル化合物 / ポリエチレングリコ-ル結合ヘミン / チトクロムPー450モデル … More Except Principal Investigator DNA / 生理活性 / Anti-allergic drugs / Immunotherapy / Kinins / Arachidonic acid metabolites / Nasal hyperresponsiveness / Nasal blockage / Pollenosis / Allergic rhinitis / ヒスタミン / 遅発性反応 / トロンボキサン / ロイコトリエン / IgE / くしゃみ / 減感作療法 / アレルギー治療薬 / 免疫療法 / キニン / アラキドン酸代謝物 / 鼻過敏症 / 鼻閉 / 花粉症 / アレルギー性鼻炎 / Aspartic Acid Derivatives / DTA / TG / CD Spectra / Histidine Derivatives / Insulin-like Activities / X-Ray Analyses / Oxovanadium Complexes / N, N'-Ethylene-bis (amino acids) / 熱分析 / N,N'-エチレンビス-D-アミノ酸 / アスパラギン酸誘導体 / 熱天秤・示差熱分析 / CDスペクトル / ヒスチジン誘導体 / インスリン様作用 / X線解析 / オキソバナジウム錯体 / N,N'-エチレンビスアミノ酸 / prevention / hepatic function modifier / metallothionein / critical concentration / renal dysfunction / cadmium / 酸化窒素 / アポトーシス / メタロチオネイン / バイオマーカー / 回復 / 腎機能異常 / 肝機能異常 / メタロチオライン / 治療 / 予防 / 肝保護剤 / カドミウムチオネイン / 臨界濃度 / 腎障害 / カドミウム / Photodynamic Therapy / Active Oxygen / Intercalation / Molecular Recognition / Hybrid Compound / Antifungal Activity / Bioactivity / 生物機能 / 有機無機複合体 / シッフ塩基 / 血糖値の制御 / 配糖錯体 / 光線力学療法 / 活性酸素 / インターカレーション / 分子認識 / 複合体 / 抗菌活性 / Manganese-porphyrin complex / Naphthol / Naphthalene / Phase-transfer / Two-phase chemical model system / Cytochrome P-450 / リノール酸エチル / アセトアニリド / 相間分配 / 化学モデル / ポルフィリン錯体 / マンガン-ポリフィリン錯体 / 相関分配機構 / マンガン-ポルフィリン錯体 / ナフトール / ナフタレン / 相間分配機構 / 二相系化学モデル / シトクロムP-450 / P-450 model / oxidases model / Metal complex for enzyme model / Dimethyldithiosemi-carbazone-Cu complex / ^<62>Cu Generator system / ^<62>Zn / elsamicin A - iron complex / Platinum complexes / Antitumor metal complex / 脳血流核医学画像診断薬 / 99m-テクネチウム錯体 / P-450 / フェニルアラニンヒドロキシラ-ゼ / ジチオセミカルバゾン銅錯体 / 脳内SOD様薬剤 / 毒性軽減 / Pー450 / ヒスチジンペプチド-グリシン錯体 / モデル錯体 / Pー450モデル / オキシダ-ゼモデル / 酵素モデル金属錯体 / ジメチルジチオセミカルバゾン銅錯体 / 脳血流診断薬 / エルサミシンAー鉄錯体 / 白金錯体 / 制癌性金属錯体 / 核磁気共鳴法 / 放射化分析法 / 電子スピン共鳴法 / バナードビン / バナジウム結合物質 / バナジウム / ホヤ / 微量金属イオン / 複合系金属錯体 / 化学的構築 / 高次構造 / 反応制御 / 環境と医療 / 超機能システム / 生命金属元素 / 生物無機化学 / 多元金属錯体 Less

高活性インスリン様金属錯体の構築と動的作用機構Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto Pharmaceutical University
Development of Metal Complexes with Antidialetic EffectPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  Kyoto Pharmaceutical University
高活性インスリン様亜鉛錯体の構築と動的機構の解明Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto Pharmaceutical University
高活性長期持続性経口抗糖尿病治療薬としてのバナジウムおよび亜鉛錯体の開発研究Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Analyses of induction mechanisms underlying nasal blockage and nasal hyperresponsiveness using an experimental model of allergic rhinitis
- Principal Investigator
  
  KOHNO Shigekatsu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
生体NOのバナジウムによる制御を目指したインスリン様バナジウム錯体の開発研究Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Research and Development of Protective Compounds against UV Iight-induced Skin Damage on the Basis of anti-ROS propertiesPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Plasma cadmium-metallothionein, new and ideal biomarker, based on its mechanism
- Principal Investigator
  
  NOMIYAMA Kazuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  JICHI MEDICAL SCHOOL
Syntheses of Vanadium Complexes with Bis-amino Acid Derivatives and Evaluations of their Insulin-like Activities
- Principal Investigator
  
  KOJIMA Yoshitane
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Inorganic chemistry
- Research Institution
  Osaka City University
複合系金属錯体による生物機能の制御
- Principal Investigator
  
  YANO Shigenobu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Inorganic chemistry
- Research Institution
  Nara Women's University
Studies on orally active antidiabetic vanadium complexes with low toxicity and long-term actionPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto Pharmaceutical University
ESR studies on biological free radicals in pharmaceutical sciencesPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Study on bioinorganic chemistry for the mechanism of the development of hapatitis-hepatoma in LEC ratsPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
抗ガン活性金属錯体による活性酸素生成とDNA切断反応Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
生物機能が求める多元金属錯体反応系の研究
- Principal Investigator
  
  YAMAUCHI Osamu
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Inorganic chemistry
- Research Institution
  Nagoya University
DEVELOPMENT OF METAL COMPLEXES WITH PHYSIOLOGICAL RESPONSE FUNCTION
- Principal Investigator
  
  YANO Shigenobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Synthetic chemistry
- Research Institution
  NARA WOMEN'S UNIVERSITY
金属-ポドフイロトキシン関連錯体による塩基特異的DNA切断反応Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
Studies of new chemical model of cytochrome P-450 with phase-transfer system
- Principal Investigator
  
  KITO Masahiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical Univ.
金属ーポドフィロトキシン関連錯体によるDNA鎖切断反応とその機構Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
ハイブリッドヘムを用いたチトクロムPー450反応の解析Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Bioinorganic Chemistry on Vanadium Complexes possessing Anti-diabetic ActionPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  The University of Tokushima
Pharmacological Studies on Bio-active Metal Complexes
- Principal Investigator
  
  YAMANE Yasuhiro
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
活性中心の合成ペプチドーヘム錯体によるPー450の分子構造と反応機構の解明Principal Investigator
- Principal Investigator
  
  桜井弘
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ホヤの血球細胞から抽出したバナジウム結合物質の精製と構造決定
- Principal Investigator
  
  道端齊
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  University of Toyama

All 2007 2006 2005 2004

All Journal Article Book Patent

[Book] 金属なしでは生きられない、活性酸素をコントロールする2006
- Author(s)
  桜井弘
- Total Pages
  106
- Publisher
  岩波書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Book] 生命元素事典2006
- Author(s)
  桜井弘
- Total Pages
  440
- Publisher
  オーム社
- Data Source
  KAKENHI-PROJECT-16001003
[Book] Pathophysiological and Biochemical Analyses of "Life-style Related or Intractable Diseases"-Target Validation for Drug Therapy-2006
- Author(s)
  桜井弘
- Total Pages
  263
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-16001003
[Book] Pathophysiological and Biochemical Analyses of "Life-style Related or Intractable Diseases" -Target Validation for Drug Therapy-2006
- Author(s)
  桜井弘
- Total Pages
  263
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Book] サプリメントデータブック2005
- Author(s)
  桜井弘(共編著)
- Total Pages
  446
- Publisher
  オーム社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Book] 第5版実験化学講座22-金属錯体・遷移金属クラスター2004
- Author(s)
  桜井弘
- Total Pages
  536
- Publisher
  丸善株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Book] シリーズ転換期の医学1 全人的医学へ2004
- Author(s)
  桜井弘, (岡本道雄, 井村裕夫編)
- Total Pages
  161
- Publisher
  岩波書店
- Data Source
  KAKENHI-PROJECT-16001003
[Book] 薬学のための無機化学2004
- Author(s)
  桜井弘
- Total Pages
  250
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-15390018
[Book] 第5版実験化学講座22-金属錯体・遷移金属クラスター2004
- Author(s)
  桜井弘, (日本化学会編)
- Total Pages
  536
- Publisher
  丸善株式会社
- Data Source
  KAKENHI-PROJECT-16001003
[Book] シリーズ転換期の医学1 全人的医学へ2004
- Author(s)
  桜井弘
- Total Pages
  161
- Publisher
  岩波書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Book] 金属元素が拓く21世紀の新しい化学の世界2004
- Author(s)
  桜井弘
- Total Pages
  215
- Publisher
  クバプロ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new type of orally active anti-diabetic Zn(II)-dithiocarbamate complexes2007
- Author(s)
  Yutaka Yoshikawa, Yusuke Adachi, Hiromu Sakurai
- Journal Title
  
  Life. Sci. 80(8)
  
  Pages: 759-766
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Development of metal complexes to treat diabetes mellitus and metabolic syndromes2007
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Kagaku 62(3)
  
  Pages: 12-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Introduction to the special edition : "Latest initiatives of R ＆ D in bio-metal science"2007
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Kinzoku 77(3)
  
  Pages: 3-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] 糖尿病・メタボリックシンドロームを治す金属錯体の開発研究2007
- Author(s)
  桜井弘
- Journal Title
  
  化学 62・3
  
  Pages: 12-15
- NAID
  40015308726
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Improvement of hyperglycemia and metabolic syndromes in type 2 diabetic KKA^y mice by oral administration of [meso-tetrakis(4- sulfonatophenyl)porhyrinato]oxovanadium(IV)(4-) complex2007
- Author(s)
  Tapan Kumar Saha, Yutaka Yoshikawa, Hiromu Sakurai
- Journal Title
  
  J. Pharm. Pharmacol 59
  
  Pages: 437-444
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] 医薬品としての金属-糖尿病治療の可能性2007
- Author(s)
  桜井弘
- Journal Title
  
  金属 77・3
  
  Pages: 42-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulinomimetic Zn complex (Zn(opt)_2) enhances insulin signaling pathway in 3T3-L1 adipocytes2007
- Author(s)
  Wanny Basuki, Makoto Hiromura, Hiromu Sakurai
- Journal Title
  
  J. Inorg. Biochem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] 特集にあたって「金属と生体-最近注目の研究動向」2007
- Author(s)
  桜井弘
- Journal Title
  
  金属 77・3
  
  Pages: 3-4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Metals in medicines-treatment of diabetes mellitus2007
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Kinzoku 77(3)
  
  Pages: 42-48
- NAID
  40015351516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Molecular mechanism for antidiabetic activity of [meso-tetrakis(4-sulfonatophenyl)- porphyrinato]oxovanadium(IV) [VO(tpps)] complex : studies on Akt phosphorylation and GLUT4 translocation in 3T3-L1 adipocytes2007
- Author(s)
  Wanny Basuki, Makoto Hiromura, Hiromu Sakurai
- Journal Title
  
  Bull. Chem. Soc. Jpn. (in press)
- NAID
  10019848775
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Binding constant of V^<IV>O to transferrin2006
- Author(s)
  Tamas Kiss, Tamas Jakusch, Saad Bouhsina, Hiromu Sakurai, Eva Anna Enyedy
- Journal Title
  
  Eur. J. Inorg. Chem. 2006(18)
  
  Pages: 3607-3613
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Inhibition mode and inhibitory effect in vivo to aipha-glucosidase of Zn(II) complex with picolinamide derivatives2006
- Author(s)
  Eriko Ueda, Yutaka Yoshikawa, Hiromu Sakurai, Yoshitane Kojima, Kinuyo Matsumoto, Naemi M. Kajiwara
- Journal Title
  
  Nippon Byotai Eiyogaku Kaishi 9(1)
  
  Pages: 59-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Current state and future aspect of bio-coordination chemistry in next generation2006
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Chem. Indus. 57(4)
  
  Pages: 1-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Characterization and insulin-mimetic potential of oxidovanadium(IV) complexes derived from monoesters and - carboxylates of 2,5-dipicolinic acid2006
- Author(s)
  Jessica Gatjens, Beate Meier, Yusuke Adachi, Hiromu Sakurai, Dieter Rehder
- Journal Title
  
  Eur. J. Inorg. Chem. 2006(18)
  
  Pages: 3575-3585
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] バナジウムや亜鉛錯体による実験糖尿病治療への試み2006
- Author(s)
  桜井弘
- Journal Title
  
  ビタミン 80・11
  
  Pages: 549-554
- NAID
  110004851538
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Zinc(II) complexes with allixin-derivatives as oral therapeutics for type 2 diabetes2006
- Author(s)
  Yusuke Adachi, Yutaka Yoshikawa, Jiro Yoshida, Yukihiro Kodera, Akira Katoh, Yoshitane Kojima, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 17(1)
  
  Pages: 17-24
- NAID
  10018127407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Oral administration of zinc complex improves type 2 diabetes and metabolic syndromes2006
- Author(s)
  Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera, Tamas Kiss, Tamas Jakusch, Eva A. Enyedy, Yutaka Yoshikawa, Hiromu Sakurai
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351(1)
  
  Pages: 165-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Enhancement of insulin signaling pathway in adipocytes by oxovanadium(IV) complexes2006
- Author(s)
  Wanny Basuki, Makoto Hiromura, Yusuke Adachi, Kojiro Tayama, Masakazu Hattori, Hiromu Sakurai
- Journal Title
  
  Biochem. Biophys. Res. Commun. 349(3)
  
  Pages: 1163-1170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Novel vanadyl complexes with quinoxaline N^1,N^4-dioxide derivatives as potent in vitro insulin-mimetic compounds2006
- Author(s)
  Pabla Noblia, Marisol Vieites, Maria H.Torre, Antonio J.Costa-Filho, Hugo Cerecetto, Mercedes Gonzalez, Maria Laura Lavaggi, Yusuke Adachi, Hiromu Sakurai, Dinorah Gambino
- Journal Title
  
  J. Inorg. Biochem. 100(2)
  
  Pages: 281-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent : studies on structure - activity relationship for a series of hydroxypyrone - vanadium complexes2006
- Author(s)
  Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera, Akira Katoh, Jitsuya Takada, Hiromu Sakurai
- Journal Title
  
  J. Med. Chem. 49(11)
  
  Pages: 3251-3256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Normalizing effect of zinc(II) complex with 6-ethoxy picolinic acid on blood glucose levels in KK-Ay mice2006
- Author(s)
  Mika Morishita, Midori Nishide, Kinuyo Matsumoto, Yusuke Adachi, Yutaka Yoshikawa, Hiromu Sakurai, Naemi M. Kojiwara
- Journal Title
  
  Biomed. Res. Trace Elements 17(3)
  
  Pages: 342-345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Syntheses of vanadyl and zinc(II) complexes of 1-hydroxy-4,5,6-substituted 2(1H)-pyrimidinones and their insulin-mimetic activities2006
- Author(s)
  Mika Yamaguchi, Kei Wakasugi, Ryota Saito, Yusuke Adachi, Yutaka Yoshikawa, Hiromu Sakurai, Akira Katoh
- Journal Title
  
  J. Inorg. Biochem. 100(2)
  
  Pages: 260-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Inhibitiory effect of oxovanadium(IV), copper(II), and zinc(II) ions on the activity of an alpha-glucosidase from a Saccharomyces sp.2006
- Author(s)
  Yutaka Yoshikawa, Ryoko Hirata, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 17(4)
  
  Pages: 360-364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] 元素周期表と生体微量元素2006
- Author(s)
  桜井弘
- Journal Title
  
  試薬会誌 18
  
  Pages: 25-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Chemistry and biochemistry of insulin-mimetic vanadium and zinc complexes. Trial for treatment of diabetes mellitus2006
- Author(s)
  Hiromu Sakurai, Akira Katoh, Yutaka Yoshikawa
- Journal Title
  
  Bull. Chem. Soc. Jpn. 79(11)
  
  Pages: 1645-1664
- NAID
  10019372826
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Periodic table of elements and biotrace elements (minerals)2006
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Shiyaku Kaishi 18
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Oxovanadium(IV)-porphyrin complex as a potent insulin-mimetic. Treatment of experimental type 1 diabetic mice by the complex [meso-tetrakis(4-sulfonatopheny1)porphyrinato]oxovanadate(IV) (4-)2006
- Author(s)
  Tapan Kumar Saha, Yutaka Yoshikawa, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  Bull. Chem. Soc. Jpn. 79(8)
  
  Pages: 1191-1200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Improvement of diabetes, obesity and hypertension in type 2 diabetic KKAy mice by bis(allixinato)oxovanadium(IV) complex2006
- Author(s)
  Yusuke Adachi, Yutaka Yoshikawa, Jiro Yoshida, Yukihiro Kodera, Akira Katoh, Jitsuya Takada, Hiromu Sakurai
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345(3)
  
  Pages: 945-950
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] 次世代生命錯体化学の現況と展望2006
- Author(s)
  桜井弘
- Journal Title
  
  化学工業 57・4
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Solution equilibrium characterization of insulin-mimetic Zn(II) complexes2006
- Author(s)
  Tamas Jakusch, Krisztina Gajda-Schrantz, Yusuke Adachi, Hiromu Sakurai, Tamas Kiss, Laszlo Horvath
- Journal Title
  
  J. Inorg. Biochem. 100(9)
  
  Pages: 1521-1526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Oxovanadium (IV) and (V) complexes with 3-hydroxy-4(1H)-pyridinones and 1-hydroxy-2(1H)-pyrimidinones - synthesis, structural characteristics, and their insulin-mimetic activities2006
- Author(s)
  Akira Katoh, Mika Yamaguchi, Kazutoshi Taguchi, Ryota Saito, Yusuke Adachi, Yutaka Yoshikawa, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 17(1)
  
  Pages: 1-10
- NAID
  10018127338
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Possible mode of action for insulinomimetic activity of vanadyl(IV) compounds in adipocytes2006
- Author(s)
  Kenji Kawabe, Yutaka Yoshikawa, Yusuke Adachi, Hiromu Sakurai
- Journal Title
  
  Life Sci 78(24)
  
  Pages: 2860-2866
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A proposal for the treatment of experimental diabetes mellitus by vanadium and zinc complexes2006
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Vitamines 80(11)
  
  Pages: 549-554
- NAID
  110004851538
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A novel drug delivery system for type 1 diabetes : insulin-mimetic vanadyl-poly(γ-glutamic acid) complex2006
- Author(s)
  Subarna Karmaker, Tapan Kumar Saha, Yutaka Yoshikawa, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  J. Inorg. Biochem. 100(9)
  
  Pages: 1535-1546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Chemistry and biochemistry of insulin-mimetic vanadium and zinc complexes. Trial for treatment of diabetes mellitus2006
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Bull.Chem.Soc.Jpn. 79・11
  
  Pages: 1645-1664
- NAID
  10019372826
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Chemistry and biochemistry of insulin-mimetic vanadium and zinc complexes. Trial for treatment of diabetes mellitus2006
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Bull. Chem. Soc. Jpn. 79・11
  
  Pages: 1645-1664
- NAID
  10019372826
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A family of insulinomimetic zinc(II) complexes of amino ligands with Zn(Nn) (n=3 and 4) coordination modes2005
- Author(s)
  Yutaka Yoshikawa, Mayuko Kondo, Hiromu Sakurai, Yoshitane Kojima
- Journal Title
  
  J. Inorg. Biochem. 99(7)
  
  Pages: 1497-1503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats2005
- Author(s)
  Sayuri Kataoka, Hiroyuki Yasui, Makoto Hiromura, Hiromu Sakurai
- Journal Title
  
  Life Sci. 77(22)
  
  Pages: 2814-2829
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] バナジウムの糖尿病治療への適用2005
- Author(s)
  桜井弘
- Journal Title
  
  Clin.Calcium 15(1)
  
  Pages: 49-57
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] New developments of insulinomimetic dinuclear vanadyl(IV)-tartrate complexes2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Pure Appl. Chem. 77・9
  
  Pages: 1629-1640
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulinomimetic activity of vanadyl-porphyrin complexes2005
- Author(s)
  Tapan Kumar Saha, Yutaka Yoshikawa, Yusuke Adachi, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 16(4)
  
  Pages: 328-331
- NAID
  10018624872
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] 元素の利用と生体機能2005
- Author(s)
  桜井弘
- Journal Title
  
  Research on Gluconate 3
  
  Pages: 1-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new anti-diabetic Zn(II)-hinokitiol (β-thujaplicin) complex with Zn(O_4) coordination mode2005
- Author(s)
  Mizuki Yamane, Yusuke Adachi, Yutaka Yoshikawa, Hiromu Sakurai
- Journal Title
  
  Chem. Lett. 34(12)
  
  Pages: 1694-1695
- NAID
  10016892342
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulinomimetic activity of Zn(II) complexes with Zn(S_4) coordination mode - in vitro and in vivo studies -2005
- Author(s)
  Yutaka Yoshikawa, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements
  
  Pages: 358-360
- NAID
  10018624961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Synthesis and insulin-mimetic activities of metal complexes with 3-hydroxypyridine-2-carboxylic acid2005
- Author(s)
  Misaki Nakai, Fumi Sekiguchi, Makoto Obata, Chikara Ohtsuki, Yusuke Adachi, Hiromu Sakurai, Chris Orvig, Dieter Rehder, Shigenobu Yano
- Journal Title
  
  J. Inorg. Biochem. 99(6)
  
  Pages: 1275-1282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] New developments of insulinomimetic dinuclear vanadyl(IV)-tartrate complexes2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Pure Appl.Chem. 77(9)
  
  Pages: 1629-1640
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] New developments of insulinomimetic dinuclear vanadyl(IV)-tartrate complexes2005
- Author(s)
  Hiromu Sakurai, Satoko Funakoshi, Yusuke Adachi
- Journal Title
  
  Pure Appl. Chem. 77(9)
  
  Pages: 1629-1640
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The pharmacology of the insulinomimetic effect of zinc complexes2005
- Author(s)
  Hiromu Sakurai, Yusuke Adachi
- Journal Title
  
  BioMetals 18(4)
  
  Pages: 319-323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A highly potent insulin-mimetic zinc(II) complex with a Zn(S_2O_2) coordination mode : bis(1,6-dimethy1-3-hydroxy-5-methoxy-2-pentyl-1,4- dihydropyridine-4-thionato)zinc(II)2005
- Author(s)
  Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera, Hiromu Sakurai
- Journal Title
  
  Chem. Lett. 34(5)
  
  Pages: 656-657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Synthesis, structure, and in vitro and in vivo insulinomimetic activities of the zinc(II)-6-ethylpicolinate complex2005
- Author(s)
  Yoshitane Kojima, Yutaka Yoshikawa, Eriko Ueda, Noriko Kishimoto, Makoto Tadokoro, Hiromu Sakurai
- Journal Title
  
  Bull. Chem. Soc. Jpn. 78(3)
  
  Pages: 451-455
- NAID
  10015431988
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Therapeutic potential of vanadium in treating diabetes mellitus2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Clin. Calcium 15(1)
  
  Pages: 49-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1 in the liver microsomes of streptozotocin-induced type 1 diabetic rats2005
- Author(s)
  Sayuri Kataoka, Makoto Hiromura, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  Trace Nutri. Res. 22
  
  Pages: 19-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new type of orally active insulin-mimetic vanadyl-porphyrin complex : meso-tetrakis({4-sulfonatophenyl}- porphyrinato)oxovanadium(IV)2005
- Author(s)
  Tapan Kumar Saha, Yusuke Adachi, Yutaka Yoshikawa, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  Chem. Lett. 34(10)
  
  Pages: 1350-1351
- NAID
  10019351781
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The pharmacology of the insulinomimetic effect of zinc compounds2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Biometals 18(4)
  
  Pages: 319-323
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] High potent antidiabetic vanadyl and zinc complexes2005
- Author(s)
  Hiromu Sakurai, Yusuke Adachi, Makoto Hiromura
- Journal Title
  
  5th International Symposium on Trace Elements in Human : New Perspectives 16(4)
  
  Pages: 126-132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The pharmacology of the insulinomimetic effect of zinc complexes2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  BioMetals 18・4
  
  Pages: 319-323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The biofunction of elements2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Research on Gluconate 3
  
  Pages: 1-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide2005
- Author(s)
  Eriko Ueda, Yutaka Yoshikawa, Hiromu Sakurai, Yoshitane Kojima, Naemi M. Kajiwara
- Journal Title
  
  Chem. Pharm. Bull. 53(4)
  
  Pages: 451-452
- NAID
  10016653321
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] バナジウムの糖尿病治療への適用2005
- Author(s)
  桜井弘
- Journal Title
  
  Clin. Calcium 15・1
  
  Pages: 49-57
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulinomimetic activity of vanadyl complexes with halogenated picolinic acids2005
- Author(s)
  Kojiro Tayama, Yusuke Adachi, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 16(4)
  
  Pages: 348-351
- NAID
  10018127453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Antidiabetic activity of Zn(II) complexes with a derivative of L-glutamine2005
- Author(s)
  Kinuyo Matsumoto, Shuhei Yamamoto, Yutaka Yoshikawa, Matsumi Doe, Yoshitane Kojima, Hiromu Sakurai, Hiroko Hashimoto, Naemi M. Kajiwara
- Journal Title
  
  Bull. Chem. Soc. Jpn. 78(6)
  
  Pages: 1077-1081
- NAID
  10016143280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Improvement of diabetic states in streptozotocin-induced type 1 diabetic rats by vanadyl sulfate in enteric-coated capsules2005
- Author(s)
  Jun Fugono, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  J. Pharm. Pharmacol. 57(5)
  
  Pages: 665-669
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] High potent antidiabetic vanadyl and zinc complexes2005
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  5^<th> Internl Symp. on Trace Elements in Human : New Perspect.
  
  Pages: 126-132
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Substituent effect of insulinomimetic vanadyl-picolinate complexes2005
- Author(s)
  Kojiro Tayama, Yusuke Adachi, Hiroyuki Yasui, Hiromu Sakurai
- Journal Title
  
  Trace Nutri. Res. 22
  
  Pages: 135-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulinomimetic vanadyl-hydroxythiazolethione complexes with VO(S_2O_2) coordination mode : the correlation between the activity and Hammett's substituent constant2004
- Author(s)
  Akira Katoh, Mika Yamaguchi, Ryota Saito, Yusuke Adachi, Hiromu Sakurai
- Journal Title
  
  Chem. Lett 33(10)
  
  Pages: 1274-1275
- NAID
  10013658108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] ミネラルの利用と生体機能2004
- Author(s)
  桜井弘
- Journal Title
  
  月刊フードケミカル 4
  
  Pages: 19-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] New bioactive zinc(II) complexes with peptides and their derivatives : synthesis, structure, and in vitro insulinomimetic activity2004
- Author(s)
  Eriko Ueda, Yutaka Yoshikawa, Noriko Kishimoto, Makoto Tadokoro, Hiromu Sakurai, Naemi M. Kajiwara, Yoshitane Kojima
- Journal Title
  
  Bull. Chem. Soc. Jpn. 77(5)
  
  Pages: 981-986
- NAID
  10012940689
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds : implications for clinical use2004
- Author(s)
  Hiromu Sakurai, Jun Fugono, Hiroyuki Yasui
- Journal Title
  
  Mini-Reviews in Med. Chem. 4(1)
  
  Pages: 41-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulinomimetic activity of zinc(II) complexes with halogenated picolinic acids2004
- Author(s)
  Shuhei Yamamoto, Yutaka Yoshikawa, Eriko Ueda, Tetsushi Yamashita, Naemi M. Kajiwara, Hiromu Sakurai, Yoshitane Kojima
- Journal Title
  
  Biomed. Res. Trace Elements 15(1)
  
  Pages: 85-87
- NAID
  10028287164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new insulin-mimetic bis(allixinato)zinc(II) complex : structure-activity relationship of zinc(II) complexes2004
- Author(s)
  Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera, Akira Kato, Yutaka Yoshikawa, Yoshitane Kojima, Hiromu Sakurai
- Journal Title
  
  J. Biol. Inorg. Chem. 9(7)
  
  Pages: 885-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Synthesis and insulinomimetic activities of novel mono- and tetranuclear oxovanadium(IV) complexes with 3-hydroxypyridine-2- carboxylic acid2004
- Author(s)
  Misaki Nakai, Makoto Obata, Fumi Sekiguchi, Masako Kato, Motoo Shiro, Akio Ichimura, Isamu Kinoshita, Masahiro Mikuriya, Toshifumi Inohara, Kenji Kawabe, Hiromu Sakurai, Chris Orvig, Shigenobu Yano
- Journal Title
  
  J. Inorg. Biochem. 98(1)
  
  Pages: 105-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The physiological effects of the undercurrent water from Mt. Fuji on type 2 diabetic KK-A^y mice2004
- Author(s)
  Yusuke Adachi, Ippei Motomura, Rie Ueda, Hiroyuki Yasui, Ayako Kiyomasu, Jitsuya Takada, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 15(1)
  
  Pages: 76-78
- NAID
  10028287137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new candidate for insulinomimetic vanadium complex : synergism of oxovanadium(IV)porphyrin and sodium ascorbate2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Bioorg. Med. Chem. Lett. 14・5
  
  Pages: 1093-1096
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes2004
- Author(s)
  Yutaka Yoshikawa, Eriko Ueda, Yoshitane Kojima, Hiromu Sakurai
- Journal Title
  
  Life Sci. 75(6)
  
  Pages: 741-751
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new candidate for insulinomimetic vanadium complex : synergism of oxovanadium(IV)porphyrin and sodium ascorbate.2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14・5
  
  Pages: 1093-1096
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Insulin-mimetic Vanadyl(IV) complexes as evaluated by both glucose-uptake and inhibition of free fatty acids (FFA)-release in isolated rat adipocytes2004
- Author(s)
  Yusuke Adachi, Hiromu Sakurai
- Journal Title
  
  Chem. Pharm. Bull 52(4)
  
  Pages: 428-433
- NAID
  110003615582
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] New vanadium(V) complexes with salicylaldehyde semicarbazone derivatives synthesis, characterization, and in vitro insulin-mimetic activity-crystal structure of [V^vO_2(salicylaldehyde semicarbazone)]2004
- Author(s)
  Pabla Noblia, Enrique J.Baran, Lucia Otero, Patricia Draper, Hugo Cerecetto, Mercedes Gonzalez, Oscar E.Piro, Eduardo E.Castellano, Toshifumi Inohara, Yusuke Adachi, Hiromu Sakurai, Dinorah Gambino
- Journal Title
  
  Eur. J. Inorg. Chem. 2004(2)
  
  Pages: 322-328
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds : implications for clinical use2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Mini-Reviews in Med. Chem. 4・1
  
  Pages: 41-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] The use of biofuctions of minerals2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Foodchemical 4
  
  Pages: 19-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new candidate for insulinomimetic vanadium complex : synergism of oxovanadium(IV)porphyrin and sodium ascorbate2004
- Author(s)
  Hiromu Sakurai, Toshifumi Inohara, Yusuke Adachi, Keiji Kawabe, Hiroyuki Yasui, Jitsuya Takada
- Journal Title
  
  Bioorg. Med. Chem. Lett. 14(5)
  
  Pages: 1093-1096
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds : Implication for clinical use2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Mini-Review in Med.Chem. 4
  
  Pages: 41-48
- Data Source
  KAKENHI-PROJECT-15390018
[Journal Article] Insulin-miemtic effects of bis(allixinato)zinc(II) complex2004
- Author(s)
  Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera, Akira Katoh, Yutaka Yoshikawa, Hiromu Sakurai
- Journal Title
  
  Trace Nutri. Res. 21
  
  Pages: 73-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] バナジウム2004
- Author(s)
  桜井弘
- Journal Title
  
  日本臨床社 62・12
  
  Pages: 322-325
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] A new condidate for insulimomimetic vanadium complex : Synergism of oxovanadium(IV)porphyrin and sodium ascorbate2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 1093-1096
- Data Source
  KAKENHI-PROJECT-15390018
[Journal Article] Vanadium2004
- Author(s)
  Hiromu Sakurai
- Journal Title
  
  Comprehensive Manual for Biochemical and Immunological Aspects of Clinical Pathology (2) 6th Edition, Nippon Rinsho 62(12)
  
  Pages: 322-325
- NAID
  40016932849
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Journal Article] Comparative study of insulin-mimetic activity of vanadium and zinc complexes2004
- Author(s)
  Yusuke Adachi, Hiromu Sakurai
- Journal Title
  
  Biomed. Res. Trace Elements 15(4)
  
  Pages: 351-354
- NAID
  10028287362
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] +4価オキソバナジウムおよび/または+2価亜鉛を含有する単核および複核錯体による抗糖尿病薬剤2007
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2007-038795
- Filing Date
  2007-02-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] 亜鉛-ポルフィリン誘導体錯体による経口2型糖尿病治療薬2006
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2006-133257
- Filing Date
  2006-05-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] 亜鉛-ポルフィリン誘導体錯体による経ロ2型糖尿病治療薬2006
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2006-133257
- Filing Date
  2006-05-12
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] 亜鉛錯体による抗糖尿病薬剤2005
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2005-182212
- Filing Date
  2005-06-22
- Acquisition Date
  2007-01-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] アディポネクチン上昇作用を有する亜鉛有機錯体2005
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2005-336898
- Filing Date
  2005-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] アニオン性ポリアミノ酸/金属複合体からなる抗糖尿病薬剤2005
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2005-297940
- Filing Date
  2005-10-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003
[Patent] 糖尿病合併症治療薬2005
- Inventor(s)
  桜井弘
- Industrial Property Rights Holder
  桜井弘
- Industrial Property Number
  2005-189149
- Filing Date
  2005-06-29
- Acquisition Date
  2007-01-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16001003

1. YASUI Hiroyuki (20278443)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. TAWA Riichi (80142587)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YAMAUCHI Osamu (70029643)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NAGANO Tetsuo (20111552)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OKA Shigenori (10268097)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 今倉康宏 (10112640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KITO Masahiro (00153148)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YANO Shigenobu (60011186)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. FUJII Yuki (50007564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OKURA Ichiro (90089821)

# of Collaborated Projects: 2 results

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11. OTSUKA Masami (40126008)

# of Collaborated Projects: 2 results

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12. TAKESHIMA Shigeo (60236461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. KOJIMA Yoshitane (40047139)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
14. YAMANE Yasuhiro (40009155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NOJI Masahide (70080190)

# of Collaborated Projects: 1 results

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16. SUGIURA Yukio (40025698)

# of Collaborated Projects: 1 results

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17. YOKOYAMA Akira (90025685)

# of Collaborated Projects: 1 results

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18. SANO Yoshiyuki (30257779)

# of Collaborated Projects: 1 results

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19. KIKUGAWA Kiyomi (90120146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OZAWA Toshihiko (40160858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. UTSUMI Hideo (20101694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KANAMORI Kan (00019001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NOMIYAMA Kazuo (80048967)

# of Collaborated Projects: 1 results

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24. YOKOI Katsuhiko (10200883)

# of Collaborated Projects: 1 results

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25. NOMIYAMA Hiroko (70049039)

# of Collaborated Projects: 1 results

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26. MASAOKA Toshio (30063978)

# of Collaborated Projects: 1 results

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27. YAHAGIHARA Naohisa (40230271)

# of Collaborated Projects: 1 results

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28. TSUKUBE Hiroshi (00144725)

# of Collaborated Projects: 1 results

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29. KOHNO Shigekatsu (50082988)

# of Collaborated Projects: 1 results

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30. NABE Takeshi (40228078)

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31. TAKENAKA Hiroshi (40137162)

# of Collaborated Projects: 1 results

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32. YOSHIKAWA Yutaka (20388028)

# of Collaborated Projects: 1 results

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33. HIROMURA Makoto (30411036)

# of Collaborated Projects: 1 results

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34. 木村栄一 (30034010)

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35. 大川尚士 (00037219)

# of Collaborated Projects: 1 results

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36. 鈴木晋一郎 (70116052)

# of Collaborated Projects: 1 results

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37. 上山憲一 (80093376)

# of Collaborated Projects: 1 results

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38. 道端齊 (00111740)

# of Collaborated Projects: 1 results

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39. 前田光子 (90131531)

# of Collaborated Projects: 1 results

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40. 川崎紘一 (40068242)

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41. 宮崎元一 (50009164)

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42. 木村行男 (70085273)

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43. 北泰行 (00028862)

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44. HANAKI Akira

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45. HARADA Akira

# of Collaborated Projects: 1 results

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46. ADACHI Hidenari

# of Collaborated Projects: 1 results

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47. ONO Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKURAI Hiromu 桜井 弘

SAKURAI Tsutomu 桜井 弘

櫻井 弘 サクライ ヒロシ

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Co-Researchers

高活性インスリン様金属錯体の構築と動的作用機構Principal Investigator

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Development of Metal Complexes with Antidialetic EffectPrincipal Investigator

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高活性インスリン様亜鉛錯体の構築と動的機構の解明Principal Investigator

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Review Section

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高活性長期持続性経口抗糖尿病治療薬としてのバナジウムおよび亜鉛錯体の開発研究Principal Investigator

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生体NOのバナジウムによる制御を目指したインスリン様バナジウム錯体の開発研究Principal Investigator

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Research and Development of Protective Compounds against UV Iight-induced Skin Damage on the Basis of anti-ROS propertiesPrincipal Investigator

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Studies on orally active antidiabetic vanadium complexes with low toxicity and long-term actionPrincipal Investigator

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ESR studies on biological free radicals in pharmaceutical sciencesPrincipal Investigator

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Study on bioinorganic chemistry for the mechanism of the development of hapatitis-hepatoma in LEC ratsPrincipal Investigator

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SAKURAI Hiromu 桜井弘

SAKURAI Tsutomu 桜井弘

櫻井弘サクライヒロシ