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KUBO Takeshi  久保 武

ORCIDConnect your ORCID iD *help
… Alternative Names

久保 武  クボ タケシ

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Researcher Number 30107031
External Links
Affiliation (based on the past Project Information) *help 2008: 大阪大学, 大学院・医学系研究科, 教授
2006 – 2007: 大阪大学, 医学系研究科, 教授
2003 – 2004: 大阪大学, 医学系研究科, 教授
2001: 大阪大学, 医学系研究科, 助手
1999 – 2001: Osaka University, Medical School, Professor, 医学系研究科, 教授 … More
1993 – 1998: 大阪大学, 医学部, 教授
1990 – 1991: 大阪大学, 医学部, 助教授
1986 – 1987: 香川医科大学, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Otorhinolaryngology / Otorhinolaryngology
Except Principal Investigator
Otorhinolaryngology / Otorhinolaryngology / 人類学(含生理人類学)
Keywords
Principal Investigator
人工内耳 / 聴覚 / 動物モデル / 可塑性 / basic FGF / NCAM-H / gicerin / 人工内耳動物モデル / cochlear implant / Fos … More / 神経伝達物質 / 電気刺激 / FOS蛋白 / 情報伝達物質 / COCHLEAR IMPLANT / ANIMAL MODEL / AUDITION / PLASTICITY / FOS / NEUROTRANSMITTER / ELECTRIC STIMUTALTION / 聴覚の可塑性 / 有毛細胞の再生 / 神経回路形成 / 先天聾 / 誘導因子 / 鳥 / 反発因子 / auditory plasticity / regeneration of hair cell / neural network / congenital deafness / 先天聾動物モデル / カナマイシン / AMPAレセプター / NMDAレセプター / ラセン神経節 / HGF / グルタミン酸レセプター / 内耳コルチ器 / 蝸牛神経核 / 肝細胞成長因子 / グルタミン酸 / レセプター / 可塑的変化 / 上オリーブ核 / congenital deaf / Kanamycin / neuronal cell count / AMPA receptor / NMDA receptor / neurotrophic factor / 老化遺伝子 / Klotho / 聴覚低下 / 聴性脳幹反応 / 内リンパ電位 / 血管条 / 老化 / 蝸牛 / Klotho gene / klotho gene / ABR / sensorineural hearing loss / EP / 耳鳴 / Positron emission tomography / H_2^<15>O / 後抑制 / ^<11>C-flumazenil / 盲聾患者 / Cochlear implant / tinnitus / PET / H_2O_<15> / residual inhibition … More
Except Principal Investigator
Math1 / 人工内耳 / HLA (human leukocyte antigen) / 血管条 / Musashi1 / Notchシグナル伝達系 / 有毛細胞 / 支持細胞 / Hes1 / Notch signaling pathway / NIRS(近赤外分光法) / 難聴 / 小児 / 大脳聴覚野 / 発達 / ホミノイド / 2足歩行 / 進化 / 形態 / 生機根 / シミュレ-ション / 化石 / 生機構 / Hominoid / Bipedal Walking / Evolution / Morphology / Biomechanism / Simulation / Fossil / 自己免疫疾患 / PCR(polymerase chain reaction) / HLA(human leukocyte antigen) / 接着分子 / Na,K-ATPase / ラセン靭帯 / 内リンパ嚢 / I型アレルギー / ステロイド依存性難聴 / PCR法 / ICAM-1 / 血液-内耳関門 / 内リンパ曩 / 増殖期細胞 / フリーラジカル / autoimmune diseases / PCR (polymerase chain reaction) / adhesion molecule / Na, K-ATPase / spiral ligament / endolymphatic sac / anaphylaxis / 両耳聴 / ヒト / 補聴器 / HINT-J / 静寂下と雑音下 / 言語聴取能 / 雑音負荷 / 両耳装用効果 / 音源定位 / 上立 / ITD / 細胞外記録 / 層状核 / ヤキセイインコ / セキセイインコ / Laminaris / 聴覚 / 細胞内記録 / binaural hearing / hearing impaired subjects / cochlear implant / hearing aids / HINT Japanese / quiet and noisy circumstances / アデノウイルスベクター / HVJ-リポソーム / lacZ遺伝子 / マウス / 内耳 / コルチ器 / ラセン神経節細胞 / 呼吸上皮 / 水チャネル / 遺伝子導入 / 鼻粘膜 / adeno virus vector / HVJ-liposome / sensorineural hearing loss / gene delivery / klotho gene / 内耳感覚上皮 / 再生 / 活性化Notch1 / sensory epithelium of inner ear / regeneration / hair cell / supporting cell / activated Notch1 / 内耳発生 / 細胞分化 / 感覚上皮予定領域 / Notch-Hes1経路 / 蝸牛 / p27Kip1 / BrdU陽性細胞 / Notch伝達系 / 感覚上皮前駆細胞 / p27^<Kip1> / 増殖維持 / Development of inner ear / Hair cell / Supporting cell / Cell differentiation / Prosensory region / 上顎癌 / 鼻副鼻腔悪性腫瘍 / 遠隔成績 / 放射線治療後後遺症 / 上顎全摘出術々後変形 / 遠隔成積 / 放射線治療後遺症 / Nose-and paranasal malignancies / Long term result / Late effect of radiotherapy Less
  • Research Projects

    (13 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (27 People)
  •  A new approach to assess the central auditory system in Congenital deaf patients with cochlear implants.

    • Principal Investigator
      OOSAKI Yasuhiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  The investigation of the roles of Notch signaling pathway during the mammalian inner ear development and its application to the to the hair cell regeneration

    • Principal Investigator
      MURATA Junko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  Investigation for brain mechanisms of tinnitus using positron emission tomography(PET).Principal Investigator

    • Principal Investigator
      KUBO Takeshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  The role of Musashi1in the development and regeneration of vertebrate Inner ear

    • Principal Investigator
      MURATA Junko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  development of gene therapy for auditory and vestibular disorders-gene delivery into the cochlear

    • Principal Investigator
      DOI Katsumi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  auditory evaluation of klotho gene knock out (kl/kl) mousePrincipal Investigator

    • Principal Investigator
      KUBO Takeshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  Neuronal mechanisms of bilateral hearing in hearing impaired human subjects

    • Principal Investigator
      TAKAHASHI Yoshifumi
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  Changes in neuronal structure after auditory deprivation in rat cochlea.Principal Investigator

    • Principal Investigator
      KUBO Takeshi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  Basic and clinical aspect of immune-mediated inner ear disorders

    • Principal Investigator
      MOGI Goro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Oita Medical University
  •  聴覚の発達段階における内耳電気刺激の影響と可塑性Principal Investigator

    • Principal Investigator
      KUBO Takeshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Osaka University
  •  Auditory Plasticity in Cochlear Implant Animal ModelPrincipal Investigator

    • Principal Investigator
      KUBO Takeshi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      OSAKA UNIVERSITY
  •  Evolution of Hominoid Bipedalism

    • Principal Investigator
      MATANO Shozo
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      人類学(含生理人類学)
    • Research Institution
      Osaka University
  •  A study on the factors related with 10 year results for maxillary malignancies

    • Principal Investigator
      SAKAI Shun-ichi
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagawa Medical School

All 2007 2006 2005 2004

All Journal Article Presentation

  • [Journal Article] Mapping of Notch Activation during Cochlear Development in Mice : Implications for Determination of Prosensory Domain and Cell Fate Diversification2006

    • Author(s)
      Junko Murata, Akinori Tokunaga, Hideyuki Okano, Takeshi Kubo
    • Journal Title

      The Journal of Comparative Neurology 497

      Pages: 5502-5518

    • Data Source
      KAKENHI-PROJECT-18591866
  • [Journal Article] Mapping of notch activation during cochlear development in mice : implications for determination of prosensory domain and cell fate diversification.2006

    • Author(s)
      Murata J., Tokunga A., Okano H., Kubo T.
    • Journal Title

      The Journal of Comparative Neurology 497

      Pages: 502-518

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Journal Article] Mapping of notch activation during cochlear development in mice: implications for determination of prosensory domain and cell fate diversification2006

    • Author(s)
      Murata J, Tokunaga A, Okano H, Kubo T
    • Journal Title

      The Journal of Comparative Neurology 497

      Pages: 502-518

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Journal Article] Neural mechanism of residual inhibition of tinnitus in cochlear implant users.2005

    • Author(s)
      Y Osaki, H Nishimura, M Takasawa, M Imaizumi, Takayuki Kawashima, Takako Iwaki, N Oku, K Hashikawa, K Doi, T Nishimura, J Hatazawa, T Kubo.
    • Journal Title

      NeuroReport 16

      Pages: 1625-1628

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390518
  • [Journal Article] Neural mechanism of residual inhibition of tinnitus in cochlear implant users.2005

    • Author(s)
      Y Osaki, H Nishimura, M Takasawa, M Imaizumi, T Kawashima, T Iwaki, N Oku, K Hashikawa, K Doi, T Nishimura, J Hatazawa, T Kubo.
    • Journal Title

      NeuroReport 16

      Pages: 1625-1628

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390518
  • [Journal Article] Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice2004

    • Author(s)
      Murata, J., Murayama, A., Horii, A., Doi, K., Harada, T., Okano, H., Kubo T.
    • Journal Title

      Neuroscience letters 354

      Pages: 201-204

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591814
  • [Journal Article] N1m recovery from decline after exposure to noise with strong spectral contrasts.2004

    • Author(s)
      H.Okamoto, B.Ross, R.Kakigi, T.Kubo, C Pantev.
    • Journal Title

      Hearing Research 196

      Pages: 77-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390518
  • [Journal Article] N1m recovery from decline after exposure to noise with strong spectral contrasts.2004

    • Author(s)
      H.Okamoto, B.Ross, R.Kakigi, T.Kubo, Christ Pantev.
    • Journal Title

      Hearing Research 196

      Pages: 77-86

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390518
  • [Journal Article] Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice2004

    • Author(s)
      Murata, J., Murayama, A., Horii A., Doi, K., Harada, T., Okano, H., Kubo, T.
    • Journal Title

      Neuroscience letters 354

      Pages: 201-204

    • Data Source
      KAKENHI-PROJECT-15591814
  • [Journal Article] Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice2004

    • Author(s)
      Murata, J., Murayama, A., Horii, A., Doi, K., Harada, T., Okano, H., Kubo, T.
    • Journal Title

      Neuroscience letters 354

      Pages: 201-204

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591814
  • [Presentation] Notch-Hes1経路のマウス蝸牛感覚上皮予定領域決定への関与の可能性-増殖制御と未分化性の維持について2007

    • Author(s)
      村田潤子, 土井勝美, 堀井新, 森鼻哲生, 久保武
    • Organizer
      第17回日本耳科学会総会・学術講演会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Presentation] Hes1 Contribute to the Proliferative Capacity of Sensory Precursors in Addition to the Cell Diversification during Mammalian Inner Ear Development.2007

    • Author(s)
      Murata J, Tokunaga A, Ohtsuka T, Kageyama R, Doi, K, Horn A, Tamura T, Kubo T, Okano H
    • Organizer
      2007 ARO Midwinter Research Meeting
    • Place of Presentation
      Denver, Colorado, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Presentation] The possible contribution of the Notch-Hes1 pathway to the prosensory formation in the developing cochlea : About the regulation of cell proliferation and the maintenance of undifferentiated state.2007

    • Author(s)
      Murata J, Doi K, Horii A, Shikina T, Kawashima T, Morihana T, Kubo T
    • Organizer
      The 17th Annual Meeting of the Otological Society of Japan
    • Place of Presentation
      Fukuoka, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Presentation] Notch-Hes1経路のマウス蝸牛感覚上皮予定領域決定への関与の可能性-増殖制御と未分化性の維持について2007

    • Author(s)
      村田潤子、土井勝美, 堀井新、森鼻哲生、久保 武
    • Organizer
      第17回に本耳科学会総会・学術講演会
    • Place of Presentation
      福岡国際会議場、博多,福岡
    • Year and Date
      2007-10-18
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Presentation] Hes1 Contributes the Proliferative Capacity of Sensory Precursors in Addition to the Cell Diversification during Mammalian Inner Ear Development.2007

    • Author(s)
      Murata J, Tokunaga A, Ohtsuka T, Kageyama R, Doi K, Horii A, Tamura M, Iwaki T, Kubo T, Okano H
    • Organizer
      2007 ARO Midwinter Research Meeting
    • Place of Presentation
      Denver, Colorado, U.S.A.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Presentation] The regulation of the proliferative capacity of auditory sensory precursor cells by the Notch signaling pathway.2006

    • Author(s)
      Murata J, Doi K, Horii A, Shikina T, Kawashima T, Morihana T, Hayama M, Okano H, Kubo T
    • Organizer
      The 16th Annual Meeting of the Otological Society of Japan
    • Place of Presentation
      Aomori, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • [Presentation] Notch伝達系による内耳感覚上皮前駆細胞の増殖制御について2006

    • Author(s)
      村田潤子, 土井勝美, 堀井新, 識名崇, 川島貴之, 森鼻哲生, 端山昌樹, 岡野栄之, 久保武
    • Organizer
      第16回日本耳科学会総会・学術講演会
    • Place of Presentation
      青森
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591866
  • 1.  DOI Katsumi (40243224)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  MURATA Junko (80332740)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 3.  OOSAKI Yasuhiro (30437321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MATANO Shozo (30028724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YAMAZAKI Nobuhisa (70101996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ISHIDA Hidemi (60027480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ENDO Banri (20011504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MOGI Goro (20035190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KAWAUCHI Hideyuki (50161279)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KANZAKI Jin (00051441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TAKASAKA Tomonori (80004646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NAKAI Yoshiaki (10046998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YANAGITA Noriyuki (00023804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TAKAHASHI Yoshifumi (80283779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TAMURA Manabu (50273644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  NISHIMURA Hiroshi (80362698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 17.  OKANO Hideyuki (60160694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 18.  SAKAI Shun-ichi (90162263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KITAOKU Shigeo (10186231)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MIYAGUCHI Mamoru (70166130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ITOH Mahito (50159919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  木村 替 (20161565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  馬場 悠男 (90049221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  高橋 光明 (50094652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  富山 俊一 (00094665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  坂田 義治 (70178557)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  SAKATA Yoshiharu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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