KUBO Takeshi 久保武

… Alternative Names

久保武クボタケシ

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Researcher Number	30107031
External Links
Affiliation (based on the past Project Information) *help	2008: 大阪大学, 大学院・医学系研究科, 教授 2006 – 2007: 大阪大学, 医学系研究科, 教授 2003 – 2004: 大阪大学, 医学系研究科, 教授 2001: 大阪大学, 医学系研究科, 助手 1999 – 2001: Osaka University, Medical School, Professor, 医学系研究科, 教授 … More 1993 – 1998: 大阪大学, 医学部, 教授 1990 – 1991: 大阪大学, 医学部, 助教授 1986 – 1987: 香川医科大学, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Otorhinolaryngology Except Principal Investigator Otorhinolaryngology / Otorhinolaryngology / 人類学(含生理人類学)
Keywords	Principal Investigator 人工内耳 / 聴覚 / 動物モデル / 可塑性 / basic FGF / NCAM-H / gicerin / 人工内耳動物モデル / cochlear implant / Fos … More / 神経伝達物質 / 電気刺激 / FOS蛋白 / 情報伝達物質 / COCHLEAR IMPLANT / ANIMAL MODEL / AUDITION / PLASTICITY / FOS / NEUROTRANSMITTER / ELECTRIC STIMUTALTION / 聴覚の可塑性 / 有毛細胞の再生 / 神経回路形成 / 先天聾 / 誘導因子 / 鳥 / 反発因子 / auditory plasticity / regeneration of hair cell / neural network / congenital deafness / 先天聾動物モデル / カナマイシン / AMPAレセプター / NMDAレセプター / ラセン神経節 / HGF / グルタミン酸レセプター / 内耳コルチ器 / 蝸牛神経核 / 肝細胞成長因子 / グルタミン酸 / レセプター / 可塑的変化 / 上オリーブ核 / congenital deaf / Kanamycin / neuronal cell count / AMPA receptor / NMDA receptor / neurotrophic factor / 老化遺伝子 / Klotho / 聴覚低下 / 聴性脳幹反応 / 内リンパ電位 / 血管条 / 老化 / 蝸牛 / Klotho gene / klotho gene / ABR / sensorineural hearing loss / EP / 耳鳴 / Positron emission tomography / H_2^<15>O / 後抑制 / ^<11>C-flumazenil / 盲聾患者 / Cochlear implant / tinnitus / PET / H_2O_<15> / residual inhibition … More Except Principal Investigator Math1 / 人工内耳 / HLA (human leukocyte antigen) / 血管条 / Musashi1 / Notchシグナル伝達系 / 有毛細胞 / 支持細胞 / Hes1 / Notch signaling pathway / NIRS(近赤外分光法) / 難聴 / 小児 / 大脳聴覚野 / 発達 / ホミノイド / 2足歩行 / 進化 / 形態 / 生機根 / シミュレ-ション / 化石 / 生機構 / Hominoid / Bipedal Walking / Evolution / Morphology / Biomechanism / Simulation / Fossil / 自己免疫疾患 / PCR(polymerase chain reaction) / HLA(human leukocyte antigen) / 接着分子 / Na,K-ATPase / ラセン靭帯 / 内リンパ嚢 / I型アレルギー / ステロイド依存性難聴 / PCR法 / ICAM-1 / 血液-内耳関門 / 内リンパ曩 / 増殖期細胞 / フリーラジカル / autoimmune diseases / PCR (polymerase chain reaction) / adhesion molecule / Na, K-ATPase / spiral ligament / endolymphatic sac / anaphylaxis / 両耳聴 / ヒト / 補聴器 / HINT-J / 静寂下と雑音下 / 言語聴取能 / 雑音負荷 / 両耳装用効果 / 音源定位 / 上立 / ITD / 細胞外記録 / 層状核 / ヤキセイインコ / セキセイインコ / Laminaris / 聴覚 / 細胞内記録 / binaural hearing / hearing impaired subjects / cochlear implant / hearing aids / HINT Japanese / quiet and noisy circumstances / アデノウイルスベクター / HVJ-リポソーム / lacZ遺伝子 / マウス / 内耳 / コルチ器 / ラセン神経節細胞 / 呼吸上皮 / 水チャネル / 遺伝子導入 / 鼻粘膜 / adeno virus vector / HVJ-liposome / sensorineural hearing loss / gene delivery / klotho gene / 内耳感覚上皮 / 再生 / 活性化Notch1 / sensory epithelium of inner ear / regeneration / hair cell / supporting cell / activated Notch1 / 内耳発生 / 細胞分化 / 感覚上皮予定領域 / Notch-Hes1経路 / 蝸牛 / p27Kip1 / BrdU陽性細胞 / Notch伝達系 / 感覚上皮前駆細胞 / p27^<Kip1> / 増殖維持 / Development of inner ear / Hair cell / Supporting cell / Cell differentiation / Prosensory region / 上顎癌 / 鼻副鼻腔悪性腫瘍 / 遠隔成績 / 放射線治療後後遺症 / 上顎全摘出術々後変形 / 遠隔成積 / 放射線治療後遺症 / Nose-and paranasal malignancies / Long term result / Late effect of radiotherapy Less

A new approach to assess the central auditory system in Congenital deaf patients with cochlear implants.
- Principal Investigator
  
  OOSAKI Yasuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
The investigation of the roles of Notch signaling pathway during the mammalian inner ear development and its application to the to the hair cell regeneration
- Principal Investigator
  
  MURATA Junko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
Investigation for brain mechanisms of tinnitus using positron emission tomography(PET).Principal Investigator
- Principal Investigator
  
  KUBO Takeshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
The role of Musashi1in the development and regeneration of vertebrate Inner ear
- Principal Investigator
  
  MURATA Junko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
development of gene therapy for auditory and vestibular disorders-gene delivery into the cochlear
- Principal Investigator
  
  DOI Katsumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
auditory evaluation of klotho gene knock out (kl/kl) mousePrincipal Investigator
- Principal Investigator
  
  KUBO Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
Neuronal mechanisms of bilateral hearing in hearing impaired human subjects
- Principal Investigator
  
  TAKAHASHI Yoshifumi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
Changes in neuronal structure after auditory deprivation in rat cochlea.Principal Investigator
- Principal Investigator
  
  KUBO Takeshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
Basic and clinical aspect of immune-mediated inner ear disorders
- Principal Investigator
  
  MOGI Goro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita Medical University
聴覚の発達段階における内耳電気刺激の影響と可塑性Principal Investigator
- Principal Investigator
  
  KUBO Takeshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
Auditory Plasticity in Cochlear Implant Animal ModelPrincipal Investigator
- Principal Investigator
  
  KUBO Takeshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  OSAKA UNIVERSITY
Evolution of Hominoid Bipedalism
- Principal Investigator
  
  MATANO Shozo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  人類学(含生理人類学)
- Research Institution
  Osaka University
A study on the factors related with 10 year results for maxillary malignancies
- Principal Investigator
  
  SAKAI Shun-ichi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagawa Medical School

All 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Mapping of Notch Activation during Cochlear Development in Mice : Implications for Determination of Prosensory Domain and Cell Fate Diversification2006
- Author(s)
  Junko Murata, Akinori Tokunaga, Hideyuki Okano, Takeshi Kubo
- Journal Title
  
  The Journal of Comparative Neurology 497
  
  Pages: 5502-5518
- Data Source
  KAKENHI-PROJECT-18591866
[Journal Article] Mapping of notch activation during cochlear development in mice : implications for determination of prosensory domain and cell fate diversification.2006
- Author(s)
  Murata J., Tokunga A., Okano H., Kubo T.
- Journal Title
  
  The Journal of Comparative Neurology 497
  
  Pages: 502-518
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591866
[Journal Article] Mapping of notch activation during cochlear development in mice: implications for determination of prosensory domain and cell fate diversification2006
- Author(s)
  Murata J, Tokunaga A, Okano H, Kubo T
- Journal Title
  
  The Journal of Comparative Neurology 497
  
  Pages: 502-518
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591866
[Journal Article] Neural mechanism of residual inhibition of tinnitus in cochlear implant users.2005
- Author(s)
  Y Osaki, H Nishimura, M Takasawa, M Imaizumi, Takayuki Kawashima, Takako Iwaki, N Oku, K Hashikawa, K Doi, T Nishimura, J Hatazawa, T Kubo.
- Journal Title
  
  NeuroReport 16
  
  Pages: 1625-1628
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390518
[Journal Article] Neural mechanism of residual inhibition of tinnitus in cochlear implant users.2005
- Author(s)
  Y Osaki, H Nishimura, M Takasawa, M Imaizumi, T Kawashima, T Iwaki, N Oku, K Hashikawa, K Doi, T Nishimura, J Hatazawa, T Kubo.
- Journal Title
  
  NeuroReport 16
  
  Pages: 1625-1628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390518
[Journal Article] Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice2004
- Author(s)
  Murata, J., Murayama, A., Horii, A., Doi, K., Harada, T., Okano, H., Kubo T.
- Journal Title
  
  Neuroscience letters 354
  
  Pages: 201-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591814
[Journal Article] N1m recovery from decline after exposure to noise with strong spectral contrasts.2004
- Author(s)
  H.Okamoto, B.Ross, R.Kakigi, T.Kubo, C Pantev.
- Journal Title
  
  Hearing Research 196
  
  Pages: 77-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390518
[Journal Article] N1m recovery from decline after exposure to noise with strong spectral contrasts.2004
- Author(s)
  H.Okamoto, B.Ross, R.Kakigi, T.Kubo, Christ Pantev.
- Journal Title
  
  Hearing Research 196
  
  Pages: 77-86
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390518
[Journal Article] Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice2004
- Author(s)
  Murata, J., Murayama, A., Horii A., Doi, K., Harada, T., Okano, H., Kubo, T.
- Journal Title
  
  Neuroscience letters 354
  
  Pages: 201-204
- Data Source
  KAKENHI-PROJECT-15591814
[Journal Article] Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice2004
- Author(s)
  Murata, J., Murayama, A., Horii, A., Doi, K., Harada, T., Okano, H., Kubo, T.
- Journal Title
  
  Neuroscience letters 354
  
  Pages: 201-204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591814
[Presentation] Notch-Hes1経路のマウス蝸牛感覚上皮予定領域決定への関与の可能性-増殖制御と未分化性の維持について2007
- Author(s)
  村田潤子, 土井勝美, 堀井新, 森鼻哲生, 久保武
- Organizer
  第17回日本耳科学会総会・学術講演会
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591866
[Presentation] Hes1 Contribute to the Proliferative Capacity of Sensory Precursors in Addition to the Cell Diversification during Mammalian Inner Ear Development.2007
- Author(s)
  Murata J, Tokunaga A, Ohtsuka T, Kageyama R, Doi, K, Horn A, Tamura T, Kubo T, Okano H
- Organizer
  2007 ARO Midwinter Research Meeting
- Place of Presentation
  Denver, Colorado, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591866
[Presentation] The possible contribution of the Notch-Hes1 pathway to the prosensory formation in the developing cochlea : About the regulation of cell proliferation and the maintenance of undifferentiated state.2007
- Author(s)
  Murata J, Doi K, Horii A, Shikina T, Kawashima T, Morihana T, Kubo T
- Organizer
  The 17th Annual Meeting of the Otological Society of Japan
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591866
[Presentation] Notch-Hes1経路のマウス蝸牛感覚上皮予定領域決定への関与の可能性-増殖制御と未分化性の維持について2007
- Author(s)
  村田潤子、土井勝美, 堀井新、森鼻哲生、久保武
- Organizer
  第17回に本耳科学会総会・学術講演会
- Place of Presentation
  福岡国際会議場、博多,福岡
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-18591866
[Presentation] Hes1 Contributes the Proliferative Capacity of Sensory Precursors in Addition to the Cell Diversification during Mammalian Inner Ear Development.2007
- Author(s)
  Murata J, Tokunaga A, Ohtsuka T, Kageyama R, Doi K, Horii A, Tamura M, Iwaki T, Kubo T, Okano H
- Organizer
  2007 ARO Midwinter Research Meeting
- Place of Presentation
  Denver, Colorado, U.S.A.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591866
[Presentation] The regulation of the proliferative capacity of auditory sensory precursor cells by the Notch signaling pathway.2006
- Author(s)
  Murata J, Doi K, Horii A, Shikina T, Kawashima T, Morihana T, Hayama M, Okano H, Kubo T
- Organizer
  The 16th Annual Meeting of the Otological Society of Japan
- Place of Presentation
  Aomori, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591866
[Presentation] Notch伝達系による内耳感覚上皮前駆細胞の増殖制御について2006
- Author(s)
  村田潤子, 土井勝美, 堀井新, 識名崇, 川島貴之, 森鼻哲生, 端山昌樹, 岡野栄之, 久保武
- Organizer
  第16回日本耳科学会総会・学術講演会
- Place of Presentation
  青森
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591866

1. DOI Katsumi (40243224)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MURATA Junko (80332740)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. OOSAKI Yasuhiro (30437321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATANO Shozo (30028724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YAMAZAKI Nobuhisa (70101996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISHIDA Hidemi (60027480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ENDO Banri (20011504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MOGI Goro (20035190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWAUCHI Hideyuki (50161279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KANZAKI Jin (00051441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKASAKA Tomonori (80004646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAI Yoshiaki (10046998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YANAGITA Noriyuki (00023804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKAHASHI Yoshifumi (80283779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAMURA Manabu (50273644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NISHIMURA Hiroshi (80362698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. OKANO Hideyuki (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. SAKAI Shun-ichi (90162263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KITAOKU Shigeo (10186231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MIYAGUCHI Mamoru (70166130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ITOH Mahito (50159919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 木村替 (20161565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 馬場悠男 (90049221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 高橋光明 (50094652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 富山俊一 (00094665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 坂田義治 (70178557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SAKATA Yoshiharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBO Takeshi 久保 武

久保 武 クボ タケシ

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Investigation for brain mechanisms of tinnitus using positron emission tomography(PET).Principal Investigator

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auditory evaluation of klotho gene knock out (kl/kl) mousePrincipal Investigator

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Changes in neuronal structure after auditory deprivation in rat cochlea.Principal Investigator

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聴覚の発達段階における内耳電気刺激の影響と可塑性Principal Investigator

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Auditory Plasticity in Cochlear Implant Animal ModelPrincipal Investigator

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[Journal Article] Mapping of Notch Activation during Cochlear Development in Mice : Implications for Determination of Prosensory Domain and Cell Fate Diversification2006

Author(s)

Journal Title

Data Source

[Journal Article] Mapping of notch activation during cochlear development in mice : implications for determination of prosensory domain and cell fate diversification.2006

KUBO Takeshi 久保武

久保武クボタケシ