OGAWA Hirofumi 小川宏文

… Alternative Names

小川宏文オガワヒロフミ

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Researcher Number	30111743
Affiliation (based on the past Project Information) *help	2006: University of Toyama, Graduate School of Med. & Pharmaceut. Sci., Associate Professor 2005: 富山大学, 大学院・医学系研究科, 助教授 2004: 富山医科薬科大学, 大学院・医学系研究科, 助教授 1993 – 1994: 富山医科薬科大学, 医学部, 助教授 1986 – 1990: 富山医科薬科大学, 医学部, 助教授 1986: Associate Professor of Biochemistry at Toyama Med.& Pharmaceu. Univ., 医学部, 助教授
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator General medical chemistry / 物質生物化学
Keywords	Principal Investigator セリン脱水酵素 / ラット / mRNA / 遺伝子の構造 / クローニング / 開腹手術 / 視交叉上核 / Consensus sequences / Gene structure / Cloning … More / Serine dehydratase / Rat liver / GRE / グルココルチコイドレスポンスエレメント / プロモーター / 遺伝子クローニング / グアニド酢酸メチラーゼ / 核抽出液 / 試験管内転写実験 / アミノ酸配列 / コンセンサス配列 / スレオニン脱水酵素 / ラット肝酵素 / acetylvaline / genomic structure / enhancer core element / amino acid sequence / rat glycine methyltransferase / cDNA cloning / アセチルバリン / エンハンサーコアエレメント / グリシンメチラーゼ / CDNA / HMG-CoAレダクターゼ / DBP / 日内リズム / サーカディアンリズム / 遺伝子発現 / 転写制御 / DNaseI高感受性 / クロマチン / 日内変動 / シ-ケンスホモロジ- / 糖新生 / 相補的デオキシリボ核酸 / 塩基配列 / タンパク質の一次構造 / クロ-ニング / ヒト肝酵素 … More Except Principal Investigator AHCYL / Drug target / Tertiary structure / Site-specific modification / Suicide-like reaction / Catalytic mechanism / Adenosvlhomocysteinase / Adenosylhomocysteine / X線解析 / NAD結合 / 薬剤標的 / 立体構造 / 部位特異的変異導入 / 自殺様反応 / 反応機構 / アデノシルホモシステイナーゼ / アデノシルホモシステイン / NAD結合部位 / 一次構造 / CDNA / s-アデノシルホモシステイナーゼ Less

Structure-function relationship of adenosylhomocysteinase as a target for drug design
- Principal Investigator
  
  GOMI Tomoharu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Toyama
  Toyama Medical and Pharmaceutical University
日内リズムの分子機構Principal Investigator
- Principal Investigator
  
  小川宏文
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
セリン脱水酵素遺伝子の発現をマーカーとした日内リズムの分子機構の研究Principal Investigator
- Principal Investigator
  
  小川宏文
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
ラット肝セリン脱水酵素mRNAの日内変動の分子機構Principal Investigator
- Principal Investigator
  
  小川宏文
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
ヒト・肝セリン脱水酵素及びその遺伝子の構造と調節機構に関する研究Principal Investigator
- Principal Investigator
  
  小川宏文
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
Detection and purification of the promoter region-binding protein involved in the tissue-specific gene expressionPrincipal Investigator
- Principal Investigator
  
  OGAWA Hirofumi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
遺伝子操作によるS-アデノシルホモシスティナーゼの構造と機能の解析
- Principal Investigator
  
  藤岡基二
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Toyama Medical and Pharmaceutical University
The study on the structure and expression of the glycine methyltransferase gene from rat normal and tumor liversPrincipal Investigator
- Principal Investigator
  
  OGAWA Hirofumi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University

All 2005 2004

All Journal Article

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase:roles of His 54,Asp130,Glu155,Lys185,and Asp1892005
- Author(s)
  Yamada T., Takata Y., Komoto J., Gomi T., Ogawa H., Fujiok aM., and Takusagawa F.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 37(11)
  
  Pages: 2417-2435
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590220
[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp130, Glu155, Lys185, and Asp189.2005
- Author(s)
  Yamada T., Takata Y., Komoto J., Gomi T., Ogawa H., Fujioka M., Takusagawa F.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 37(11)
  
  Pages: 2417-2435
- Data Source
  KAKENHI-PROJECT-16590220
[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp 130, Gl u155, Lys185, and Asp189.2004
- Author(s)
  Yamada T., Takata Y., Komoto J., Gomi T., Ogawa H., Fujioka M., Takusagawa F.
- Journal Title
  
  mt. J. Biochem. Cell Biol. 37(11)
  
  Pages: 2417-2435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590220

1. FUJIOKA Motoji (30030000)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. GOMI Tomoharu (40135033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 古西清司 (20178289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OGAWA Hirofumi 小川 宏文

小川 宏文 オガワ ヒロフミ

Research Projects

Research Products

Co-Researchers

Structure-function relationship of adenosylhomocysteinase as a target for drug design

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

日内リズムの分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

セリン脱水酵素遺伝子の発現をマーカーとした日内リズムの分子機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ラット肝セリン脱水酵素mRNAの日内変動の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト・肝セリン脱水酵素及びその遺伝子の構造と調節機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection and purification of the promoter region-binding protein involved in the tissue-specific gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子操作によるS-アデノシルホモシスティナーゼの構造と機能の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study on the structure and expression of the glycine methyltransferase gene from rat normal and tumor liversPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase:roles of His 54,Asp130,Glu155,Lys185,and Asp1892005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp130, Glu155, Lys185, and Asp189.2005

Author(s)

Journal Title

Data Source

[Journal Article] Catalytic mechanism of S-adenosylhomocysteine hydrolase : roles of His 54, Asp 130, Gl u155, Lys185, and Asp189.2004

Author(s)

Journal Title

Description

Data Source

OGAWA Hirofumi 小川宏文

小川宏文オガワヒロフミ