Watanabe Kazuhito 渡辺和人

… Alternative Names

WATANABE Kazuhito 渡辺和人

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Researcher Number	30113038
External Links
Affiliation (based on the past Project Information) *help	2016 – 2018: 第一薬科大学, 薬学部, 教授 2013 – 2015: 北陸大学, 薬学部, 教授 2008 – 2010: Hokuriku University, 薬学部, 教授 2002 – 2005: Hokuriku University, Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Professor, 薬学部, 教授 2001: 北陸大学, 薬学部, 助教授 … More 1998 – 1999: 北陸大学, 薬学部, 助教授 1994 – 1995: 北陸大学, 薬学部, 助教授 1989 – 1992: 北陸大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Environmental and hygienic pharmacy / Environmental pharmacy / Environmental pharmacy / Biological pharmacy Except Principal Investigator Biological pharmacy / Biological pharmacy / Medical pharmacy
Keywords	Principal Investigator 細胞毒性 / cannabinoid / シトクロムP450 / anandamide / anandamide amidohydrolase / ES46.5K / 代謝 / テトラヒドロカンナビノール / カンナビノイド / ＣＹＰ … More / CYP / delta-9,11-THC / 合成CB受容体アゴニスト / JWH-073 / JWH-018 / CYP3A4 / ヒト肝ミクロソーム / CYP発現系 / HU-211 / HU-210 / 危険ドラッグ / hypothermia / catalepsy / tolerance development / pharmacological effect / 2-arachidonoylglycerol / endogenous cannabinoid / tetrahydrocannabinol / 体温下降作用 / カタレプシー / 耐性発現 / 薬理効果 / 水解酵素 / 2-アラキドノイルグリセロール / アナンダミド / 内因性カンナビノイド / reporter gene assay / MCF-7 / estrogen / Endocrine disrupting chemical / marijuana / 内分泌攪乱作用 / CBDA種 / 大麻抽出物 / レポータージーンアッセイ法 / エストロゲン / 内分泌撹乱作用 / E-スクリーン法 / THCA種 / 大麻吸煙抽出物 / interaction / cross-tolerance / antibody / cloning / substrate specificity / エステラーゼ / 相互作用 / 交叉耐性 / 抗体 / クローニング / 基質特異性 / 酸化的代謝 / アナンアミド加水分解 / CYP19 / ﾋﾄ胎盤ﾐｸﾛｿｰﾑ / ﾋﾄ肺ﾐｸﾛｿｰﾑ / ﾋﾄ脳ﾐｸﾛｿｰﾑ / ｼﾄｸﾛﾑP450 / ｶﾝﾅﾋﾞﾉｰﾙ / ｶﾝﾅﾋﾞｼﾞｵｰﾙ / ﾃﾄﾗﾋﾄﾞﾛｶﾝﾅﾋﾞﾉｰﾙ / ヒト胎盤ミクロソーム / ヒト肺ミクロソーム / ヒト脳ミクロソーム / 肺 / 脳 / カンナビノール / カンナビジオール / 大麻成分 / グルクロン酸抱合 / 構造活性相関 / 酵素誘導 / 酵素阻害 / LOX / COX … More Except Principal Investigator アルデヒド / MALDO / nucleoside / sleep / uridine / 中枢抑制系 / ヌクレオシド / 鎮痛 / ウリジン受容体 / 睡眠 / ウリジン / NAD(P) / 3-OH-β-ionone / MALCO / P450 / Oxygenase / Aldehyde / カンナビノイド / カルボン酸 / シトクロムP450 / central nervous system / uridine receptor / antinociceptive effect / receptor / Central nervous system / antinociception / Uridine receptor / レセプター / oxidation / dehydrogenase / microsomes / ketone / alcohol / 3-oxo-β-ionone / サル / NADP / NAD / 脱水素酸化 / 酸化 / 脱水素酵素 / ミクロソーム / 第2級アルコール / 9-fluorenol / 7-OH-delta-8-THC / Cloning / Cannabinoid / Alcohol / アルコーナ / クローニング / オキシゲナーゼ / アルコール / DELTA^8-Tetrahydrocannabinol-11-oic acid / Oxygen-18 / Aldehyde oxygenation / 11-Oxo-DELTA^8-tetrahydrocannabinol / Carboxylic acid / Cytochrome P450 / Δ^8-THC-11-oic acid / 11-oxo-Δ^8-THC / 酸素-18 / アルデヒドオキシゲナ-ゼ / テルデヒドオキシゲナ-ゼ / Δ^8ーTHCー11ーoic acid / 11ーoxoーΔ^8ーTHC / 酸素ー18 / オキシゲナ-ゼ / 大麻 / テトラヒドロカンナビノール / 乳がん / 大麻草 / 性差 / cDNAクロ-ニング / 酵素誘導 / モルモット / 種差 / トルイル酸 / トルアルデヒド / cDNAクローニング / aldehyde oxygenase Less

CYP-Mediated Metabolism and Toxicity of Dangerous Drugs, Synthetic Cannabinoids,Principal Investigator
- Principal Investigator
  
  WATANABE KAZUHITO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Metabolism of major phytocannabinoids in human brain and lung microsomes and its toxicological implicationPrincipal Investigator
- Principal Investigator
  
  Watanabe Kazuhito
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Hokuriku University
Molecular mechanism for interaction of major cannabinoids with enzyme systemPrincipal Investigator
- Principal Investigator
  
  WATANABE Kazuhito
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts
- Principal Investigator
  
  TAKEDA Shuso
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokuriku University
Involvement of endogenous cannabinoids in the pharmacological effects of cannabinoidsPrincipal Investigator
- Principal Investigator
  
  WATANABE Kazuhito
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Hypnotic and antinociceptive effects of N3-substituted oxopyrimidines and their mechanism
- Principal Investigator
  
  KIMURA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Molecular structure and function of uridine receptor regulating sleep
- Principal Investigator
  
  KIMURA Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Endocrine disrupting effects of marijuana and its mechanismPrincipal Investigator
- Principal Investigator
  
  WATANABE Kazuhito
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Structures and Function of Novel Esterase and AmidohydrolasePrincipal Investigator
- Principal Investigator
  
  WATANABE Kazuhito
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Structure and Function of NAD/NADP Requirement Microsomal Alcohol Dehydrogensase
- Principal Investigator
  
  MATSUNAGA Tamihide
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Analyzes of Structure and Function of Novel Carbonyl Metabolic Enzymes : MALDO and MALCO
- Principal Investigator
  
  YAMAMOTO Ikuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
新規シトクロムP450アイソザイムMALDOの分子レベルにおける反応機構解析
- Principal Investigator
  
  YAMAMOTO Ikuo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Nobel Mechanism in Xenobiotic Metabolism-Oxygenation of Aldehydes to Carboxylic Acids
- Principal Investigator
  
  YAMAMOTO Ikuo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University

All 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2005 2003 Other

All Journal Article Presentation Book

[Book] The Handbook of Cannabis and Related Pathologies2017
- Author(s)
  K. Watanabe et al.
- Total Pages
  8
- Publisher
  Elsevier
- ISBN
  9780128007563
- Data Source
  KAKENHI-PROJECT-16K08354
[Book] Cannabinoids as potent inhibitors of human CYP1 enzymes, in The Handbook of Cannabis and Relaterd Pathologies2016
- Author(s)
  203)K. Watanabe, S. Yamaori, K. Masuda, T. Katsu, S. Narimatsu, and I. Yamamotｏ
- Total Pages
  10
- Publisher
  Ｅｌｓｅｖｉｅｒ
- Data Source
  KAKENHI-PROJECT-25460176
[Journal Article] Δ9-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPARα induction: A possible evidence for the cancellation of PPARβ/δ-mediated inhibition of PPARα in MDA-MB-231 cells2019
- Author(s)
  Hirao-Suzuki Masayo、Takeda Shuso、Watanabe Kazuhito、Takiguchi Masufumi、Aramaki Hironori
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 662 Pages: 219-225
- DOI
  10.1016/j.abb.2018.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08402, KAKENHI-PROJECT-16K08354
[Journal Article] Improved On-Site Protocol for the DNA-Based Species Identification of <i>Cannabis sativa</i> by Loop-Mediated Isothermal Amplification2018
- Author(s)
  Kitamura Masashi、Aragane Masako、Nakamura Kou、Adachi Tatsushi、Watanabe Kazuhito、Sasaki Yohei
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 8 Pages: 1303-1306
- DOI
  10.1248/bpb.b18-00272
- NAID
  130007429834
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] ?9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor2018
- Author(s)
  Kimura Toshiyuki、Takaya Makiko、Usami Noriyuki、Watanabe Kazuhito、Yamamoto Ikuo
- Journal Title
  
  Forensic Toxicology
  
  Volume: 37 Issue: 1 Pages: 207-214
- DOI
  10.1007/s11419-018-0457-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines2018
- Author(s)
  Okazaki Hiroyuki、Hirao-Suzuki Masayo、Takeda Shuso、Takemoto Yukimi、Mizunoe Ramu、Haraguchi Koichi、Watanabe Kazuhito、Takiguchi Masufumi、Aramaki Hironori
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 5 Pages: 321-327
- DOI
  10.2131/jts.43.321
- NAID
  130006733269
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08402, KAKENHI-PROJECT-16K08354
[Journal Article] A Specific Probe Substrate for Evaluation of CYP4A11 Activity in Human Tissue Microsomes and a Highly Selective CYP4A11 Inhibitor: Luciferin-4A and Epalrestat2018
- Author(s)
  Yamaori Satoshi、Araki Noriyuki、Shionoiri Mio、Ikehata Kurumi、Kamijo Shinobu、Ohmori Shigeru、Watanabe Kazuhito
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 366 Issue: 3 Pages: 446-457
- DOI
  10.1124/jpet.118.249557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354, KAKENHI-PROJECT-16K08368
[Journal Article] The Duquenis reaction revisited: mass spectrometric estimation of chromophore structures derived from major phytocannabinoids2017
- Author(s)
  K. Watanabe et al.
- Journal Title
  
  Forensic Toxicol.
  
  Volume: 35 Issue: 1 Pages: 185-189
- DOI
  10.1007/s11419-016-0337-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] 危険ドラッグ・合成カンナビノイドの法規制2017
- Author(s)
  渡辺和人
- Journal Title
  
  第一薬科大学研究年報
  
  Volume: 33 Pages: 18-30
- NAID
  120006413946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] Cannabidiolic acid-mediated interference with AP-1 transcriptional activity in MDA-MB-231 breast cancer cells: possible involvement of its down-regulation in the abrogation of aggressiveness.2017
- Author(s)
  M. Suzuki, K. Watanabe et al.
- Journal Title
  
  Natural Product Communications
  
  Volume: 12 Pages: 759-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] 大麻の鑑識と最近の乱用薬物事情2017
- Author(s)
  8.池田　豊彌、渡辺　和人、正山　征洋
- Journal Title
  
  長崎国際大学論叢
  
  Volume: 17 Pages: 223-229
- NAID
  120006328643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] Expression levels of 30 Cyp mRNA in the mouse brain and neuroblastoma cell lines, C-1300N18 and NB2a; strong expression of Cyp 1b1.2017
- Author(s)
  S. Yamaori, K. Watanabe et al.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 4 Pages: 195-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] Cannabinoids as potent inhibitors of human CYP1 enzymes2017
- Author(s)
  K. Watanabe et al.
- Journal Title
  
  The Handbook of Cannabis and Related Pathologies
  
  Volume: chapter 84 Pages: 813-820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] Rapid identification of drug-type strains in Cannabis sativa using loop-mediated isothermal amplication assay2017
- Author(s)
  M. Kitamura et al.
- Journal Title
  
  J. Nat. Med.
  
  Volume: 71 Issue: 1 Pages: 86-95
- DOI
  10.1007/s11418-016-1031-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08354
[Journal Article] 大麻文化科学考その26　－　危険ドラッグ・デザイナードラッグとしての合成ンナビノイド関連化合物2016
- Author(s)
  渡辺和人、宇佐見則行、木村敏行、山本郁男
- Journal Title
  
  北陸大学紀要
  
  Volume: 40 Pages: 1-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460176
[Journal Article] Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness.2016
- Author(s)
  Takeda S, Himeno T, Kakizoe K, Okazaki H, Okada T, Watanabe K, Aramaki H
- Journal Title
  
  Journal of natural medicines
  
  Volume: 71 Issue: 1 Pages: 286-291
- DOI
  10.1007/s11418-016-1030-0
- NAID
  40021062820
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19167, KAKENHI-PROJECT-16K08354
[Journal Article] Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells2015
- Author(s)
  Yamaori S, Kinugasa Y, Jiang R, Takeda S, Yamamoto I, Watanabe K
- Journal Title
  
  Life Sci.
  
  Volume: 136 Pages: 87-93
- DOI
  10.1016/j.lfs.2015.07.007
- NAID
  120007100188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460167, KAKENHI-PROJECT-25460176
[Journal Article] Human brain microsomes: their abilities to metabolize tetrahydrocannabinols and cannabinol2013
- Author(s)
  K. Watanabe et al.
- Journal Title
  
  Forensic Toxicology
  
  Volume: 31 Issue: 2 Pages: 307-311
- DOI
  10.1007/s11419-013-0181-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460176
[Journal Article] Possible involvement of Cyp3a enzymes in the metabolism of tetrahydrocannabinols by mouse brain microsomes2011
- Author(s)
  Kazuhito Watanabe, Mai Fujinami, Satoshi Yamaori, Ikuo Yamamoto
- Journal Title
  
  Foren.Toxicol. 29
  
  Pages: 56-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Δ 9-Tetrahydrocannabinol and its major metabolite Δ 9-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors2011
- Author(s)
  Shuso Takeda, Rongrong Jiang, Hironori Aramaki, Masumi Imoto, Akihisa Toda, Reiko Eyanagi, Toshiaki Amamoto, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  J.Pharm.Sci. 100
  
  Pages: 1206-1211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Possible involvement of Cyp3a enzymes in the metabolism of tetrahydrocannabinols by mouse brain microsomes2011
- Author(s)
  K.Watanabe
- Journal Title
  
  Foren.Toxicol.
  
  Volume: 29 Pages: 56-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol : role of phenolic hydroxyl groups in the resorcinol moiety2011
- Author(s)
  Satoshi Yamaori, Juri Ebisawa, Yoshimi Okushima, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Life Sci. 88
  
  Pages: 730-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Characterization of major phytocannabinoids, cannabidiol and cannabianol, as isoformselective and potent inhibitors of human CYP1 enzymes2010
- Author(s)
  Satoshi Yamaori, Mika Kushihara, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Biochem.Pharmacol. 79
  
  Pages: 1691-1698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Aromatase in MCF-7 Breast Cancer Cell Growth Induced byΔ9-Tetrahydrocannabinol2009
- Author(s)
  Takeda, S., Yamamoto, I., Watanabe, K.
- Journal Title
  
  Toxicology 259
  
  Pages: 25-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] Cannabidiol-2', 6'-Dimethylether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor2009
- Author(s)
  Takeda, S., Usami, N., Yamamoto, I., Watanabe, K.
- Journal Title
  
  Drug Metab. Dispos. 37
  
  Pages: 1733-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] 大麻文化科学考(その20)第20章大麻に関する諸外国の法規制2009
- Author(s)
  渡辺和人
- Journal Title
  
  北陸大学紀要 33
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Cannabidiol-2',6' -dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor2009
- Author(s)
  Shuso Takeda, Noriyuki Usami, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Drug Metab.Dispos. 37
  
  Pages: 1733-1737
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Modulation of Δ9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase2009
- Author(s)
  Shuso Takeda, Ikuo Yamamoto, Kazuito Watanabe
- Journal Title
  
  Toxicology 259
  
  Pages: 25-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptorindependent signaling2008
- Author(s)
  Shuso Takeda, Satoshi Yamaori, Erina Motoya, Tamihide Matsunaga, Toshiyuki Kimura, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Toxicology 245
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling2008
- Author(s)
  Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K.
- Journal Title
  
  Toxicology 245
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis2008
- Author(s)
  Takeda, S., Misawa, K., Yamamoto, I., Watanabe, K.
- Journal Title
  
  Drug Metab. Dispos. 36
  
  Pages: 1917-1921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] Generation of reactive oxygen species during mouse hepatic microsomal metabolism of cannabidiol and cannabidiol hydoxyquinone2008
- Author(s)
  Noriyuki Usami, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Life Sci. 83
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] 大麻文化科学考(その19)第19章カンナビノイド生合成経路一再考2008
- Author(s)
  渡辺和人
- Journal Title
  
  北陸大学紀要 32
  
  Pages: 1-11
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] 大麻文化科学考(その19)2008
- Author(s)
  渡辺和人, 木村敏行, 山折大, 竹田修三, 宇佐見則行, 山本郁男
- Journal Title
  
  紀要(北陸大学) 32
  
  Pages: 1-11
- NAID
  120005469103
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis2008
- Author(s)
  Shuso Takeda, Koichiro Misawa, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Drug Metab.Dispos. 36
  
  Pages: 1917-1921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Stereospecific and regioselective hydrolysis of cannabinoid esters by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterases of rabbit and porcine Liver2005
- Author(s)
  K.Watanabe et al.
- Journal Title
  
  Biol.Pharm.Bull. 28・9
  
  Pages: 1743-1747
- NAID
  110003666503
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Marijuana extracts possess the effects like the endocrine disrupting chemicals2005
- Author(s)
  K.Watanabe et al.
- Journal Title
  
  Toxicology 206・3
  
  Pages: 471-478
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation of 7β-hydroxy-D^8-tetrahydrocannabinol to 7-oxo-Δ^8-tetrahydrocannabinol in monkey liver microsomes2005
- Author(s)
  Tatsuya Funahashi, Yuuki Tanaka, Satoshi Yamaori, Toshiyuki Kimura, Tamihide Matsunaga, Shigeru Ohmori, Takashi Kageyama, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Drug Metab.Pharmacokinet. 20
  
  Pages: 358-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes2005
- Author(s)
  Tatsuya Funahashi, Hideharu Ikeuchi, Satoshi Yamaori, Toshiyuki Kimura, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  J.Health Sci. 51
  
  Pages: 363-375
- NAID
  10016657733
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Effective NADH-dependent oxidation of 7β-hydroxy-Δ^8-tetrahydrocannabinol to the corresponding ketone by Japanese monkey hepatic microsomes2005
- Author(s)
  Tamihide Matsunaga, Shinsuke Higuchi, Kazuhito Watanabe, Takashi Kageyama, Shigeru Ohmori, Ikuo Yamamoto
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 646-651
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Identification and determination of cannabinoids in both commercially available and cannabis oils stored long term2005
- Author(s)
  Mamoru Yotoriyama, Eiji Ishiharajima, Yoko Kato, Akiko Nagato, Setsuko Sekita, Kazuhito Watanabe, Ikuo Yamamoto
- Journal Title
  
  J.Health Sci. 51
  
  Pages: 483-487
- NAID
  10016658147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Marijuana extracts possess the effects like the endocrine disrupting chemicals2005
- Author(s)
  K.Watanabe et al.
- Journal Title
  
  Toxicology 206
  
  Pages: 471-478
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Stereospecific and regioselective hydrolysis of cannabinoid esters by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterases of rabbit and porcine liver2005
- Author(s)
  Kazuhito Watanabe, Tamihide Matsunaga, Toshiyuki Kimura, Tatsuya Funahashi, Satoshi Yamaori, Yukihiro Shoyama, Ikuo Yamamoto
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1743-1747
- NAID
  110003666503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Synthesis of N^3-substituted uridine and related pyrimidine nucleosides and their antinociceptive effects in mice2005
- Author(s)
  T.Shimizu, T.Kimura, T.Funahashi, K.Watanabe, I.K.Ho, I.Yamamoto
- Journal Title
  
  Chem.Pharm.Bull. 53
  
  Pages: 313-318
- NAID
  10016652649
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590075
[Journal Article] Stereospecific and regioselective hydrolysis of cannabinoid esters by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterases of rabbit and porcine liver2005
- Author(s)
  K.Watanabe et al.
- Journal Title
  
  Biol. Pharm. Bull. 28・9
  
  Pages: 1743-1747
- NAID
  110003666503
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Marijuana extracts possess the effects like the endocrine disrupting chemicals2005
- Author(s)
  Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono, Ikuo Yamamoto
- Journal Title
  
  Toxicology 206 (3)
  
  Pages: 471-478
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] N^3-Phenacyluridine as a new type of antinociceptive compound in mice2003
- Author(s)
  T.Kimura, T.Shimizu, T.Funahashi, M.Nagakura, K.Watanabe, K.Tachibana, S.Kondo, I.K.Ho, I.Yamamoto
- Journal Title
  
  Res.Commun.Mol.Pathol.Pharmacol. 113
  
  Pages: 57-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590075
[Presentation] 繊維型大麻草主成分 Cannabidiolic acid の抗侵害作用2018
- Author(s)
  渡辺　和人、山折大、宇佐見則行、竹田修三、小松生明、荒牧弘範
- Organizer
  日本薬学会第138年会、2018.3.27、金沢.
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] Comparative metabolism of HU-210 and HU-211 in human liver microsomes: role of particular CYP enzymes.2018
- Author(s)
  K. Watanabe et al.
- Organizer
  TIAFT (The International Association for Forensic Toxicologists) 2018, 2018. 8.26~30, Ghent Belgium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] 繊維型大麻草主成分 Cannabidiolic acid の抗侵害作用2018
- Author(s)
  渡辺和人ほか
- Organizer
  日本薬学会第138年会、2018.3.27、金沢.
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] HU-210のヒト肝ミクロソームによる代謝および関与する主なCYP分子種2018
- Author(s)
  渡辺和人ほか
- Organizer
  日本法中毒学会第37年会、2018.7.6~7、東京
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] Comparative metabolism of HU-210 and HU-211 in human liver microsomes: Role of particular CYP enzymes.2018
- Author(s)
  Kazuhito Watanabe, Noriyuki Usami, Satoshi Yamaori, Yuji Hasegawa and Hironori Aramaki.
- Organizer
  TIAFT (The International Association for Forensic Toxicologists) 2018, 2018. 8.26~30, Ghent Belgium.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] 繊維型大麻草成分 cannabidiolic acid (CBDA) によるアクチンストレスファイバー形成の調節とその意義2017
- Author(s)
  竹田修三、渡辺和人ほか
- Organizer
  第44回日本毒性学会学術年会、2017.7.10~12、横浜
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] Metabolic interactions of major phytocannabinoids with human CYP2J2 enzyme2017
- Author(s)
  K. Watanabe
- Organizer
  ICRS2017, 27th Annual ICRS Symposium on the Cannabinoids
- Place of Presentation
  Le Centre Sheraton Montreal, Montreal, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] 合成カンナビノイド JWH-018による脳の内因性カンナビノイドanandamideおよび2-arachidonoylglycerolの増加とその機構： CB1-KOマウスを用いた解析2017
- Author(s)
  李任時、渡辺和人ほか
- Organizer
  第34回日本薬学会九州支部大会、2017.11.25~26、熊本.
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] ヒト小腸ミクロソームによるカンナビジオールおよびカンナビノールの代謝に関与する主要なCYP分子種2017
- Author(s)
  渡辺　和人
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、仙台市
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] 繊維型大麻草成分 cannabidiolic acid (CBDA) によるがん細胞 migration の抑制：アクチンストレスファイバーの形成に連関したメカニズム2017
- Author(s)
  竹田修三、渡辺和人ほか
- Organizer
  フォーラム2017 衛生薬学・環境トキシコロジー、2017.9.1~2、仙台
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] Metabolic interactions of major phytocannabinoids with human CYP2J2 enzyme.2017
- Author(s)
  K. Watanabe et al.
- Organizer
  ICRS (International Cannabinoid Research Society) 2017, the 27th Annual Symposium on the Cannabinoids, 2017.6.23~27, Montreal Canada.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] 繊維型大麻草成分 cannabidiolic acid (CBDA) によるPPARβを介したCOX-2の発現抑制機構2017
- Author(s)
  鈴木雅代、渡辺和人ほか
- Organizer
  フォーラム2017 衛生薬学・環境トキシコロジー、2017.9.1~2、仙台
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] Metabolism of tetrahydrocannabinols by human intestinal microsomes2016
- Author(s)
  K. Watanabe
- Organizer
  TIAFT 2016, the 54th Annual Meeting of the International Association of Forensic Toxicologists
- Place of Presentation
  Brisbane Convention & Exhibition Centre, Brisbane, Australia
- Year and Date
  2016-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08354
[Presentation] Inducibility of CYP enzymes by cannabidiol2015
- Author(s)
  K.Watanabe, S. Yamaori, R. Jiang, Y. Kinugasa, Y. Okushima and I. Yamamoto
- Organizer
  25th Annual Symposium of the ICRS
- Place of Presentation
  Wolfville, Canada
- Year and Date
  2015-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] Potency and mechanism of CYP2J2 inhibition by major phytocannabinoids2015
- Author(s)
  S. Yamaori, Y. Nagata, S. Ohmori, I. Yamamoto and K. Watanabe
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] 発芽過程における大麻草種子 mRNAの発現変化2015
- Author(s)
  北村雅史、地中　啓、中村　耕、荒金眞佐子、渡辺和人、佐々木陽平
- Organizer
  日本法科学技術学会第21回学術集会
- Place of Presentation
  柏の葉カンファレンスセンター（柏市、千葉県）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] 合成カンナビノイドの歴史的経緯（シンポジウム：合成カンナビノイドを考える）2015
- Author(s)
  渡辺和人
- Organizer
  日本法中毒学会第34年会
- Place of Presentation
  九州大学医学部百年講堂（福岡市）
- Year and Date
  2015-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] ﾋﾄCYP19による主要カンナビノイドの代謝2015
- Author(s)
  渡辺和人ほか
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] Metabolism of major phytocannabinoids by human placenta microsomes and CYP192015
- Author(s)
  K. Watanabe, K. Inoue, M. Murai, N. Usami, S. Yamaori and I. Yamamoto
- Organizer
  TIAFT 2015, the 53rd Annual Meeting of the International Association of Forensic Toxicologists
- Place of Presentation
  Firenze, Italy
- Year and Date
  2015-08-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] Characterization of structural requirements for potent mechanism-based inhibition of human CYP1A1 by cannabidiol2014
- Author(s)
  K. Watanabe et al.
- Organizer
  The 24th Annual International Cannabinoid Research Society Symposium on Cannabinoids
- Place of Presentation
  Baveno, Italy
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] 脳ミクロソームCYPによるテトラヒドロカンナビノールの代謝2009
- Author(s)
  渡辺和人
- Organizer
  日本法中毒学会第28年会
- Place of Presentation
  北陸大学薬学部(金沢市)
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20590127
[Presentation] Inducibility of CYP enzymes by cannabidiol
- Author(s)
  K. Watanabe et al.
- Organizer
  ICRS2015
- Place of Presentation
  Wolfville, Canada
- Year and Date
  2015-06-28 – 2015-07-02
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] Characterization of structural requirement for potent mechanism-based inhibition of hhuman CYP1A1 by cannabidiol
- Author(s)
  K. Watanabe et al.
- Organizer
  ICRS2014
- Place of Presentation
  Baveno, Italy
- Year and Date
  2014-06-28 – 2014-07-03
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] ヒト脳ミクロソームによる主要カンナビノイドの代謝
- Author(s)
  渡辺和人ほか
- Organizer
  フォーラム2014:衛生薬学環境トキシコロジー
- Place of Presentation
  つくば市
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] Inhibitory effects of major phytocannabinoids on human cytochrome P450s and its toxicological significance in drug interactions
- Author(s)
  K. Watanabe
- Organizer
  Symposium of Preventive Pharmacy, 2013 Spring Annual Convention of Pharmaceutical Society of Korea
- Place of Presentation
  Suncheon, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] ヒト脳および肺Microsomal Aldehyde Oxygenase (MALDO) による11-oxo-tetrahydrocannabinol の代謝
- Author(s)
  渡辺和人ほか
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] Metabolism of major phytocannabinoids by human placenta microsomes and CYP19
- Author(s)
  K. Watanabe et al.
- Organizer
  TIAFT2015
- Place of Presentation
  Firenze, Italy
- Year and Date
  2015-08-30 – 2015-09-05
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] 合成カンナビノイドの歴史的経緯
- Author(s)
  渡辺和人
- Organizer
  日本法中毒学会第34年会
- Place of Presentation
  福岡市
- Year and Date
  2015-06-26 – 2015-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-25460176
[Presentation] 大麻主成分のDuquenois反応－呈色物質の質量分析による構造解析
- Author(s)
  渡辺和人ほか
- Organizer
  日本法中毒学会第34年会
- Place of Presentation
  福岡市
- Year and Date
  2015-06-26 – 2015-06-27
- Data Source
  KAKENHI-PROJECT-25460176

1. YAMAMOTO Ikuo (50069746)

# of Collaborated Projects: 9 results

# of Collaborated Products: 13 results
2. MATSUNAGA Tamihide (40209581)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. YAMAORI Satoshi (40360218)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. USAMI Noriyuki (60257483)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. FUNAHASHI Tatsuya (60343646)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. TATEDA Shuso (00460379)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
7. KIMURA Toshiyuki (20234370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. NARIMATSU Shizuo (20113037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岡崎裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Kazuhito 渡辺 和人

WATANABE Kazuhito 渡辺 和人

Research Projects

Research Products

Co-Researchers

CYP-Mediated Metabolism and Toxicity of Dangerous Drugs, Synthetic Cannabinoids,Principal Investigator

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Metabolism of major phytocannabinoids in human brain and lung microsomes and its toxicological implicationPrincipal Investigator

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Molecular mechanism for interaction of major cannabinoids with enzyme systemPrincipal Investigator

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Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts

Principal Investigator

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Involvement of endogenous cannabinoids in the pharmacological effects of cannabinoidsPrincipal Investigator

Principal Investigator

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Hypnotic and antinociceptive effects of N3-substituted oxopyrimidines and their mechanism

Principal Investigator

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Molecular structure and function of uridine receptor regulating sleep

Principal Investigator

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Endocrine disrupting effects of marijuana and its mechanismPrincipal Investigator

Principal Investigator

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Structures and Function of Novel Esterase and AmidohydrolasePrincipal Investigator

Principal Investigator

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Structure and Function of NAD/NADP Requirement Microsomal Alcohol Dehydrogensase

Principal Investigator

Project Period (FY)

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Research Institution

Analyzes of Structure and Function of Novel Carbonyl Metabolic Enzymes : MALDO and MALCO

Principal Investigator

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新規シトクロムP450アイソザイムMALDOの分子レベルにおける反応機構解析

Principal Investigator

Project Period (FY)

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Research Institution

Nobel Mechanism in Xenobiotic Metabolism-Oxygenation of Aldehydes to Carboxylic Acids

Principal Investigator

Project Period (FY)

Watanabe Kazuhito 渡辺和人

WATANABE Kazuhito 渡辺和人