YOSHIDA Hideo 吉田秀夫

Researcher Number	30116131
External Links
Affiliation (based on the past Project Information) *help	2006 – 2010: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2008: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教授 1986 – 2002: 徳島大学, 歯学部, 助教授
Review Section/Research Field	Principal Investigator 外科・放射線系歯学 / Surgical dentistry / 病態科学系歯学(含放射線系歯学) / Social dentistry / Surgical dentistry Except Principal Investigator Surgical dentistry / 外科・放射線系歯学 / 病態科学系歯学(含放射線系歯学) / Surgical dentistry
Keywords	Principal Investigator アポトーシス / HGF / in situ hybridization / 姉妹染色分体交換 / ヒト唾液腺癌細胞 / GFP / HSV-tk / 二次口蓋突起 / 形態形成 / サイトケラチン … More Except Principal Investigator ヒト唾液腺癌細胞 / アポトーシス / 分化誘導 / DNA hypomethylation / 口腔癌 / 唾液腺癌細胞 / 造腫瘍性ヒト唾液腺介在部導管上皮細胞 / 唾液腺腺房細胞 / 分化因子 / dibutyryl cAMP / Hexamethylene bisacetamide / Human salivary cancer cells / Apoptosis / FdUMP / 細胞分化 / HPLC / HSG cell line / deoxyribonucleosidetriphosphate / cell cycle / OK-432 / 放射線 / 5-フルオロウラシル / TSC-22 / LAK細胞 / 末梢リンパ球亜群 / Oral cancer / LAK cells / 唾液腺上皮細胞 / 唾液腺筋上皮細胞 / 分化因子遺伝子 / 癌免疫療法 / TLR / BRM / 個別化治療 / Hesamethylene bisacetamide / 8-chloroadenosine3':5'-cyclic monophosphate / 分化誘導療法 / プロテイン・キナーゼC / プロテイン・キナーゼA / 8-chloroadenosine 3':5'-cyclic monophosphate / 高転移性ヒト唾液腺癌細胞 / 不死化正常ヒト唾液腺細胞 / ニューロフイラメント / グリア線維酸性蛋白 / エトポシド / 5-fluoro-2'-deoxyuridine / 高転移性唾液腺癌細胞 / 8ーchloro odenosine 3':5'ーcyclic monophosphate / プロテイン・キナ-ゼC / Hー7 / Human salivary gland cancer cells / 8-chloroadenosine 3' : 5'-cyclic monophosphate / Differentiation therapy / Protein kinase C / Protein kinase A / 細胞分化誘導剤 / スクリーニングシステム / 唾液腺由来腺様扁平上皮癌細胞 / 抗癌剤 / 口腔小唾液腺由来腺様扁平上皮癌細胞 / 造腫瘍性ヒト腺房細胞癌細胞 / 分化誘導剤 / Cellular differentiation-inducing agents / Screening system / Salivary adenoid squamous carcinoma-forming cells / Anti-tumor agents / 薬物受容体 / サイトケラチン / プロテオソーム / プレクチン / Drug receptor / Cellular differentiation / Cytokeratin / Proteosome / Plectin / 唾液腺粘液嚢胞 / 蛋白分解酵素 / TGF-β1 / Human salivary gland duct cells / Cyst / TGF-beta1 / MMP-2 / HSG ell ine / deoxyribonucleosidetriphesphete / ヌクレオチドプール / 増殖・分化 / リポタイコ酸 / 頭頸部癌 / サイトカイン / リポソーム / キラー細胞 / 頭頚部癌 / キラー活性 / lipoteichoic acid / radiation / 5-fluorouracil / head and neck cancer / cytokine / liposome / killer cells / ベスナリノン / p21^<Waf1> / 唾液腺癌 / 口腔扁平皮癌 / p27^<Kipl> / 転写活性化能 / 抗腫瘍効果 / 5-Fluorouracil / p27^<Kip1> / 口腔扁平上皮癌 / p21^<WAF> / p27^<kip1> / TGF-β / p21^<WAF1> / vesnarinone / cellular differentiation / apoptosis / p21^<waf1> / salivary gland cancer / oral squamous cell carcinoma / p27^<Klp1> / 免疫応答 / killerリンパ球 / NK細胞 / 抹消リンパ球亜群 / 癌細胞表現形質 / 口腔癌治療 / Killerリンパ球 / ADCC / リンパ球亜群 / 単クローン抗体 / Killer リンパ球 / Immune response / Killer lymphocyte / NK cells / Subsets of peripheral blood lymphocyte / Phenotype of cancer cells / Therapy of Oral cancer / インタ-ロイキン2 / 局所免疫療法 / 放射線治療 / インターロイキン2 / Interleukin 2 / Local immunotherapy / Subsets of peripheral blood lymphocytes / Radiotherapy Less

The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Social dentistry
- Research Institution
  The University of Tokushima
Comprehensive analysis of Toll-like receptor-related genes in oral cancer patients and development of individual cancer immunotherapy
- Principal Investigator
  
  OKAMOTO Masato
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Musashino University
Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  University of Tokushima
The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokushima University
Study on differentiation and apoptosis-inducing therapy for head and neck cancer by vesnarinone
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Lipoteichoic acid : Augmentation of the therapeutic effect of radiation and 5-fluorouracil in head and neck cancer
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Influence of antineoplastic drug (5-fluorouracil) to the dNTP pool of a human salivary gland adenocarcinoma cell line (HSG)
- Principal Investigator
  
  NISHIDA Toshinobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Tokushima
Detection of Novel Drug Receptor and Mechanism of Induction of Differentiation and Apoptosis in Human Salivary Cancer Cells
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Study for both the establishment of in vivo model system for the development of salivary mucous cyst and its treatment
- Principal Investigator
  
  AZUMA Masayuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of screening system for searching cellular differentiation-inducing agents by utlizing human salivary cancer cells
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
ニューキノロン剤のヒト培養細胞に及ぼす細胞遺伝学的影響Principal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Study of Differentiation Therapy for Salivary Gland Cancer
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  THE UNIVERSITY OF TOKUSHIMA
ヒト唾液腺癌細胞における筋上皮或いは腺房細胞に分化誘導する細胞性因子の産生と特性
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞における筋上皮或は腺房細胞に分化誘導する細胞性因子の産生と特性
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ras癌遺伝子p21の発現と構造異常からみた口腔粘膜癌での高転移症例の早期診断Principal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Local Immunotherapy of Oral Cancer with LAK Cells and Interleukin 2
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
The experimental chemotherapy on human salivary gland cancer.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Tokushima University
Immune Responses Associated with Killer-Lymphocyte Population in Oral Cancer and their Therapeutic Significance
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima

All 2009 2008

All Journal Article Presentation

[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation2009
- Author(s)
  Yoshida K, Okamura H, Amorim BR, Hinode D, Yoshida H, Haneji T.
- Journal Title
  
  Exp Cell Res. 315(12)
  
  Pages: 2105-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009
- Author(s)
  Kaya Yoshida, et al
- Journal Title
  
  Experimental Cell Resarch 315
  
  Pages: 2105-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009
- Author(s)
  Kaya Yoshida
- Journal Title
  
  Experimental Cell Resarch (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] 骨芽細胞の分化におけるPKRの役割について2008
- Author(s)
  吉田賀弥
- Journal Title
  
  四国歯学会雑誌 20(2)
  
  Pages: 223-227
- NAID
  120005821553
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] 骨芽細胞の分化におけるPKRの役割について2008
- Author(s)
  吉田賀弥
- Journal Title
  
  四国歯学会誌 20(2)
  
  Pages: 223-227
- NAID
  120005821553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKRと骨代謝2008
- Author(s)
  吉田賀弥
- Journal Title
  
  電気学会研究会資料 OQD-08-30
  
  Pages: 1-4
- NAID
  10025661042
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRと骨代謝2008
- Author(s)
  吉田賀弥
- Organizer
  電気学会光・量子デバイス研究会
- Place of Presentation
  京都大学宇治キャンパス(京都府)
- Year and Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRによるSTAT1の発現調節機構の解明2008
- Author(s)
  吉田賀弥, 岡村裕彦, 羽地達次
- Organizer
  第50回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  TOC有明コンベンションホール(東京都)
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20390536

1. SATO Mitsunobu (00028763)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. YURA Yoshiaki (00136277)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YANAGAWA Tetsuo (40136263)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. AZUMA Masayuki (20144983)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. HARADA Koji (60253217)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OKAMOTO Masato (10243718)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAWAMATA Hitoshi (70224847)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 洪英満

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HINODE Daisuke (70189801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. YOSHIOKA Masami (90243708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIDA Kaya (60363157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. KAYAMA Shizuo (50432761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAJI Ryoji (30204390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NISHIDA Toshinobu (50156080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IGA Hiroki (40175188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. BANDO Takashi (80208727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKEGAWA Yoshihiro (40035754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 上野明道 (80136267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 林良夫 (00127854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIDA Hideo 吉田 秀夫

Research Projects

Research Products

Co-Researchers

The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

YOSHIDA Hideo 吉田秀夫