Sasaki Takako 佐々木隆子

… Alternative Names

SASAKI Takako 佐々木隆子

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Researcher Number	30133193
Other IDs
Affiliation (Current)	2025: 大分大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 大分大学, 医学部, 客員研究員 2012 – 2020: 大分大学, 医学部, 助教 2017: 大分大学, 大学院医学研究科, 助教
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Basic Section 57060:Surgical dentistry-related / Basic Section 59010:Rehabilitation science-related / Neurology / Surgical dentistry
Keywords	Principal Investigator 細胞外マトリックス / fibulin-4 / 老化 / 弾性繊維 / 創傷治癒 / 腱 / Hemicentin / リコンビナント / hemicentin / 基底膜 … More / タンパク質 / 遺伝子変異 / アセンブリー / 弾性線維 / 変異 … More Except Principal Investigator コラーゲン / 細胞外マトリックス / circ（環状）RNA / 硬組織 / 非コードRNA / コラーゲン発現 / 骨 / 骨芽細胞 / 遺伝子発現調節 / マイクロRNA / 転写因子 / 遺伝子発現 / 転写 / 軟骨 / 長鎖非コード（lnc）RNA / モデルマウス / メカノトランスダクション / 離島調査 / 遺伝子 / 原因遺伝子 / 家系調査 / 弾性線維腫 / ヘパラン硫酸プロテオグリカン / 肝細胞増殖因子(HGF) / ヘパラン硫酸プロテオグリカン / 硫酸化 / 糖鎖 / 成体神経新生 / ヘパリン親和性増殖因子 / ヘパラン硫酸プロテオグリカン / 微小環境 / コラーゲン遺伝子 / 長鎖非コードRNA / 再生医療 / 骨代謝 Less

腱に含まれる弾性線維役割の解明：老化・創傷治癒での機能を検証Principal Investigator
- Principal Investigator
  
  佐々木隆子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Oita University
硬組織形成における非コードRNAネットワークを介するコラーゲン発現調節と臨床応用
- Principal Investigator
  
  吉岡秀克
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Oita University
弾性線維腫の原因遺伝子同定とモデルマウス開発―病態解明に向けて
- Principal Investigator
  
  藤原作平
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Oita University
Structural and functional analysis of human hemicentinsPrincipal Investigator
- Principal Investigator
  
  Sasaki Takako
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Oita University
Studies on the transcriptional regulation and function of fibrillar collagen genes in osteoblasts and chondrocytes
- Principal Investigator
  
  Matsuo Noritaka
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Oita University
Analysis of non-code RNAs and transcription factors for the regulation of collagen gene expression in the microenvironment of the hard tissues.
- Principal Investigator
  
  Yoshioka Hidekatsu
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Oita University
An investigation for optimal signal crosstalk in heparin binding growth factor promoting neurogenesis
- Principal Investigator
  
  Arikawa-Hirasawa Eri
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Functional analyses of fibulin-4 on matrix assemblyPrincipal Investigator
- Principal Investigator
  
  Sasaki Takako
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Oita University
Analysis of core fibril-forming collagen gene regulation in bone for appication of regenerative medicine
- Principal Investigator
  
  Yoshioka Hidekatsu
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Oita University
Transcriptional regulation of a novel collagen gene in chondrocytes
- Principal Investigator
  
  Matsuo Noritaka
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Oita University

All 2020 2019 2018 2017 2016 2015 2014 2012 Other

All Journal Article Presentation

[Journal Article] Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues2020
- Author(s)
  Lin MH, Pope BD 3rd, Sasaki T, Keeley DP, Sherwood DR, Miner JH
- Journal Title
  
  Dev Dyn
  
  Volume: ー Issue: 6 Pages: 775-788
- DOI
  10.1002/dvdy.159
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10215
[Journal Article] The pro-a1(V) collagen gene (Col5a1) is coordinately regulated by miR-29b with core promoter in cultured cells.2018
- Author(s)
  Zhang JJ, Yano H, Sasaki T, Matsuo N, Yoshioka H
- Journal Title
  
  Connect Tissue Res
  
  Volume: 59 Pages: 263-273
- DOI
  10.1080/03008207.2017.1370465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11848
[Journal Article] Expression and purification of recombinant fibulins in mammalian cells.2018
- Author(s)
  Hanada K, Sasaki T
- Journal Title
  
  Methods Cell Biol.
  
  Volume: 143 Pages: 247-259
- DOI
  10.1016/bs.mcb.2017.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461661
[Journal Article] Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.2017
- Author(s)
  Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 5526-5526
- DOI
  10.1038/s41598-017-05835-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461661
[Journal Article] GABA promotes elastin synthesis and elastin fiber formation in normal human dermal fibroblasts (HDFs).2017
- Author(s)
  Uehara E, Hokazono H, Hida M, Sasaki T, Yoshioka H, Matsuo N
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 81 Pages: 1198-1205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11015
[Journal Article] Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts2017
- Author(s)
  Uehara E, Hokazono H, Sasaki T, Yoshioka H, Matsuo N
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 81 Issue: 2 Pages: 376-9
- DOI
  10.1080/09168451.2016.1238296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11015
[Journal Article] Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa2016
- Author(s)
  Sasaki T, Hanisch FG, Deutzmann R, Sakai LY, Sakuma T, Miyamoto T, Yamamoto T, Hannappel E, Chu ML, Lanig H, von der Mark K
- Journal Title
  
  Matrix Biol
  
  Volume: 56 Pages: 132-149
- DOI
  10.1016/j.matbio.2016.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04321, KAKENHI-PROJECT-26701006, KAKENHI-PROJECT-15K15082, KAKENHI-PROJECT-26461661, KAKENHI-PROJECT-15K15017, KAKENHI-PROJECT-16K18478
[Journal Article] 1)Sp1 upregulated the proximal promoter activity of the mouse collagen a1(XI) gene (Col11a1) in chondrocytes.2016
- Author(s)
  Watanabe K, Hida M, Sasaki T, Yana H, Kawano K, Yoshioka H, Matsuo N.
- Journal Title
  
  In Vitro Cell Dev Biol Anim
  
  Volume: 52 Issue: 2 Pages: 235-42
- DOI
  10.1007/s11626-015-9959-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893208, KAKENHI-PROJECT-24592270, KAKENHI-PROJECT-16K20064
[Journal Article] Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking.2016
- Author(s)
  Sasaki T, Stoop R, Sakai T, Hess A, Deutzmann R, Schlötzer-Schrehardt U, Chu M-L, von der Mark K
- Journal Title
  
  Matrix Biol.
  
  Volume: 50 Pages: 53-66
- DOI
  10.1016/j.matbio.2015.12.002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461661
[Journal Article] Forelimb Contractures and Abnormal Tendon Collagen Fibrillogenesis in Fibulin-4 Null Mice2016
- Author(s)
  Markova D, Pan, T-C, Zhang R-Z, Zhang G, Sasaki T, Arita M, Birk D, Chu M-L
- Journal Title
  
  Cell Tissue Res.
  
  Volume: 印刷中 Issue: 3 Pages: 637-646
- DOI
  10.1007/s00441-015-2346-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461661
[Journal Article] Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.2015
- Author(s)
  Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 35 Pages: 21443-21459
- DOI
  10.1074/jbc.m115.640425
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461661
[Journal Article] Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase.2015
- Author(s)
  Risa Nonaka, Takafumi Iesaki, Susana de Vega, Hiroyuki Daida, Takao Okada, Takako Sasaki, and Eri Arikawa-Hirasawa
- Journal Title
  
  Physiological Reports
  
  Volume: 3(1) Issue: 1 Pages: e12272-e12272
- DOI
  10.14814/phy2.12272
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790783, KAKENHI-PROJECT-15K09326, KAKENHI-PROJECT-14F04914
[Journal Article] Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.2014
- Author(s)
  Hida M, Hamanaka R, Okamoto O, Yamashita K, Sasaki T, Yoshioka H, Matsuo N.
- Journal Title
  
  In Vitro Cell Dev Biol Anim.
  
  Volume: 50 Pages: 358-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592270
[Presentation] XXVII型コラーゲンα１鎖遺伝子の転写調節機構の解析2019
- Author(s)
  樋田真理子、矢野博之、佐々木隆子、吉岡秀克、松尾哲孝
- Organizer
  第４２回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K11015
[Presentation] The pro-a1(V) collagen gene (Col5a1) is coordinately regulated by mir-29b with core promoter in cultured cells.2017
- Author(s)
  Juan Juan Zhang, Hiroyuki Yano, Takako Sasaki, Noritaka Matsuo, Hidekatsu Yoshioka
- Organizer
  第４９回日本結合組織学会
- Data Source
  KAKENHI-PROJECT-17K11848
[Presentation] Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking2017
- Author(s)
  Sasaki T, Stoop R, Sakai T, Hess A, Deutzmann R, Schloetzer-Schrehardt U, Chu ML, von der Mark K.
- Organizer
  Gordon Research Conference on Collagen
- Data Source
  KAKENHI-PROJECT-26461661
[Presentation] XXVII型コラーゲンα1鎖遺伝子(Col27a1)の転写調節機構の解析2017
- Author(s)
  樋田真理子、佐藤はるな、佐々木隆子、吉岡秀克、松尾哲孝
- Organizer
  日本生化学会、九州支部例会
- Data Source
  KAKENHI-PROJECT-17K11015
[Presentation] fibulin-4欠損による骨コラーゲン線維形成異常2016
- Author(s)
  佐々木隆子、Reinout Stoop, Takao Sakai, Andreas Hess, Rainer Deutzmann, Ursula Schloetzer-Schrehardt,Mon-Li, Dhu and Klaus von der Mark
- Organizer
  第４８回結合組織学会学術大会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-26461661
[Presentation] XI型コラーゲンα1鎖遺伝子（Col11a1）の転写調節機構の解明2015
- Author(s)
  渡邊啓次郎、樋田真理子、佐々木隆子、河野憲司、吉岡秀克、松尾哲孝
- Organizer
  第39回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Place of Presentation
  豊泉荘（大分県、別府市）
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-24592270
[Presentation] 50.大動脈内皮のeNOS遺伝子発現の活性化におけるパールカンの役割2015
- Author(s)
  野中里紗、家崎貴史、Susana de Vega1、佐々木隆子、山田吉彦,
- Organizer
  第４７回結合組織学会学術大会
- Place of Presentation
  コクヨホール　東京
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15K09326
[Presentation] マウスXXVII型コラーゲンα１鎖遺伝子の転写調節機構の解析2012
- Author(s)
  樋田真理子、松尾哲孝、山下広平、足立佐和子、佐々木隆子、吉岡秀克
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24592270
[Presentation] 血管異常ならびに皮膚脆弱症を呈する患者で同定されたfibulin-4ミスセンス変異の及ぼす構造と機能への影響
- Author(s)
  佐々木隆子、Franz-Georg Hanisch, Rainer Deutzmann, Lynn Sakai, Ewald Hannappel, Mon-Li Chu, Harald Lanig, Klaus von der Mark
- Organizer
  日本結合組織学会
- Place of Presentation
  コクヨホール（東京都港区）
- Year and Date
  2015-05-15 – 2015-05-16
- Data Source
  KAKENHI-PROJECT-26461661

1. Matsuo Noritaka (10284788)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. YOSHIOKA Hidekatsu (00222430)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. 矢野博之 (50448552)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. FUJIWARA Sakuhei (90181411)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKAMOTO Osamu (40284799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. UTANI Atsushi (10292707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Arikawa-Hirasawa Eri (50245718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIMATA Koji (10022641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KEREVER Aurelien (70623594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 濱中良志 (60274750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 関根章博 (30425631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石川一志 (80600452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 花田克浩 (90581009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 宮本達雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 樋田真理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 野中里紗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasaki Takako 佐々木 隆子

SASAKI Takako 佐々木 隆子

Research Projects

Research Products

Co-Researchers

腱に含まれる弾性線維役割の解明：老化・創傷治癒での機能を検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

硬組織形成における非コードRNAネットワークを介するコラーゲン発現調節と臨床応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

弾性線維腫の原因遺伝子同定とモデルマウス開発―病態解明に向けて

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural and functional analysis of human hemicentinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the transcriptional regulation and function of fibrillar collagen genes in osteoblasts and chondrocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of non-code RNAs and transcription factors for the regulation of collagen gene expression in the microenvironment of the hard tissues.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An investigation for optimal signal crosstalk in heparin binding growth factor promoting neurogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analyses of fibulin-4 on matrix assemblyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of core fibril-forming collagen gene regulation in bone for appication of regenerative medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional regulation of a novel collagen gene in chondrocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The pro-a1(V) collagen gene (Col5a1) is coordinately regulated by miR-29b with core promoter in cultured cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression and purification of recombinant fibulins in mammalian cells.2018

Author(s)

Journal Title

DOI

Data Source

Sasaki Takako 佐々木隆子

SASAKI Takako 佐々木隆子