TANAKA Toshinori 田中利典

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TANAKA Toshinori PhD. 田中利典

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Researcher Number	30146154
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Affiliation (based on the past Project Information) *help	2010 – 2011: 自治医科大学, 医学部, 講師 2008: 自治医科大学, 医学部・感染免疫学講座ウイルス学部門, 講師 2007 – 2008: 自治医科大学, 医学部, 講師 1988 – 1996: 自治医科大学, 医学部, 講師 1994: Jichi Med.Sch.Dept.of Virology Ass.Prof. … More 1990: Jichi Medical School, Lecturer of Virology, 医学部, 講師 1990: 自治医科大学, 医学部・, 講師 1986: Lecturer, Jichi Medical School, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Virology Except Principal Investigator Virology / Virology / 小児科学 / Pediatrics
Keywords	Principal Investigator competive PCR / M gene / NS gene / MDCK cells / Influenza Virus / Persist Infection / competivePCR法 / NS遺伝子(ゲノム) / RT-PCR法 / 潜伏感染 … More / NP遺伝子 / M遺伝子 / NS遺伝子 / MDBK細胞 / インフルエンザウイルス … More Except Principal Investigator インフルエンザウイルス / DI-RNA / 欠落変異 / NS遺伝子 / インフルエンザB型ウイルス / レオ3型ウイルス / 胆道閉鎖症 / 劇症肝炎 / 放出機構 / 感染性cDNAクローン / E型肝炎ウイルス / NS2蛋白 / DIウイルス / ウイルス粒子形成 / Protease inhibitor / Activation of virus / hemagglutinin (HA) / bacterial protease / Influenza virus / Influenza pneumonia / プロテアーゼ阻害剤 / 赤血球凝集素(HA)の解裂活性化 / 細菌性プロテアーゼ / プロテア-ゼ阻害剤 / ウイルスの活性化 / 赤血球凝集素(HA) / 細菌性プロテア-ゼ / インフルエンザ肺炎 / Sequencing / NS Gene / Viral RNA / Viral Protein / Influenza B Virus / シークエンシング / ウイルス核酸 / ウイルス蛋白 / NS2 protein / RNA transfection / packaging of RNA / virion assembly / DI virus / influenza virus / 干渉 / ゲノムRNAパッケージング / RNA転写・複製 / インフルエンザNS2蛋白 / RNAトランスフェクション / RNAパッケージングシグナル / RNA polymerase / DI particle / Replication, transcription / Nonstructural NS2 / Influenza A virus / RNAポリメラーゼ遺伝子 / RNAの転写,複製 / インフルエンザウイルスA型 / RNAの転写の複製 / インフルエンザウイルスA / RNAポリメラーゼ / 干渉性欠損ウイルス / RNAの転写・複製 / 非構成蛋白NS2 / インンフルエンザウイルスA / Protein transport / Epithelial cells / M protein / Mictotubules / Budding polarity / Tryptase Clara / Tropism / Sendai virus / MDCK細胞 / 糖蛋白 / 細胞内蛋白輸送 / 細胞骨格系 / F1-R株 / HVJ / 蛋白輸送 / 上皮細胞 / M蛋白 / 微小管 / トリプターゼ・クララ / 出芽極性 / 臓器特異性 / センダイウイルス / Reovirus type 3 / Bi liary atresia / viral genes / copetitive PCR / polymerase chain reaction / latent infection / influevza virus / 遺伝子の塩基配列 / pUC19ベクター / 競合的PCR / PCR / ウイルス遺伝子 / 潜伏感染 / cytopathic effect / NS1 protein / deletion mutation / nucleotide sequence / NS gene / influenza B virus / CPE / RNA合成 / 変異体 / 細胞破壊 / NS1蛋白 / 塩基配列 / Polymerase Chain Reaction / Immunocytochemistry / Reovirus Type 3 / Biliary Atresia / ライソゾ-ム / ノ-ザン・ブロット法 / PCR法 / 免疫組織化学 / MVB sorting / Tsg101 / PSAPモチーフ / ORF3蛋白質 / ゲノム変異 / 細胞レセプター候補分子 / 吸着 / 感受性細胞 / 感染性 cDNA クローン / 感染培養系 / ORF2抗原 / 中和抗体 / ORF3抗原 / ORF3欠損変異ウイルス / 蛍光抗体法 / モノクローナル抗体 / 細胞培養 / 分子 / RNAパッケージング / ゲノムRNA Less

Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEV
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
インフルエンザウイルスゲノムRNA分節のパッケージングにおけるNS2蛋白の役割
- Principal Investigator
  
  ODAGIRI Takato
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Recognition mechanism of the RNA segments of influenza virus by the NS2 protein at the virion assembly step.
- Principal Investigator
  
  ODAGIRI Takato
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Persistence of Viral genes in a variant MDCK cells after productive Replication of a mutant of influenza virus A/WSNPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshinori
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School, Dept.of Virology
LONG TERM PERSISTENCE OF VIRAL CENES IN DIVIDING HOST CELLS IN CULTURE AFTER PRODUCTIVE REPLICATION OF A MUTANT OF INFLUENZA VIRUS A/WSN.
- Principal Investigator
  
  TOBITA Kiyotake
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Reovirus type 3Infection in Biliary Atresia
- Principal Investigator
  
  MATSUI Akira
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  小児科学
- Research Institution
  JICHI MEDICAL SCHOOL
Identification of Determinants for Tropism of Sendai virus
- Principal Investigator
  
  TASHIRO Masato
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Control of genomic RNA replication by the nonstructural protein NS2 of influenza A virus.
- Principal Investigator
  
  ODAGIRI Takato
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Functions of the mutated NS1 protein of influenza B virus which has a long caroxyl terminal deletion.
- Principal Investigator
  
  TOBITA Kiyotake
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Reovirus Type 3 as a Causative Agent of Biliary Atresia- Immunocytochemical and Molecular Biological Study
- Principal Investigator
  
  MATSUI Akira M. D.
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jichi Medical School, Faculty of Medicine
Fundamental researches on the pathogenesis and therapy of influenza virus pneumonia
- Principal Investigator
  
  TASHIRO Masato
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Sequence Analysis of the NS Gene of an NS Mutant of Influenza B Virus.
- Principal Investigator
  
  TOBITA Kiyotake
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School

All 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food2012
- Author(s)
  Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume: 157(2) Pages: 235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 12) Pages: 2838-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 2) Pages: 269-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation2010
- Author(s)
  Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H.
- Journal Title
  
  J Clin Microbiol
  
  Volume: 48(4) Pages: 1112-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] ORF3 protein of hepatitis E virus is essential for virion release from infected cells.2009
- Author(s)
  Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  J Gen Virol doi:10.1099/Vir.0.010561-0(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Development and characterization of a genotype 4 hepatitis E virus cell culture system using the HE-JF5/15F strain recovered from a fulminant hepatitis patient.2009
- Author(s)
  Tanaka T, Takahashi M, Takahashi H, Ichiyama K, Hoshino Y, Nagashima S, Mizuo H, Okamoto H
- Journal Title
  
  J Clin Microbiol 47
  
  Pages: 1906-1910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells.2009
- Author(s)
  Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  J Gen Virol 90(2)
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.2008
- Author(s)
  Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  Arch Virol 153
  
  Pages: 1703-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture system.2008
- Author(s)
  Takahashi M, Hoshino Y, Tanaka T, Takahashi H, Nishizawa T, Okamoto H
- Journal Title
  
  Arch Virol 153
  
  Pages: 657-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture.2008
- Author(s)
  Lorenzo FR, Tanaka T, Takahashi H, Ichiyama K, Hoshino Y, Yamada K, Inoue J, Takahashi M, Okamoto H
- Journal Title
  
  Virus Res 137
  
  Pages: 86-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Development and evaluation of an efficient cell-culture system for Hepatitis E virus.2007
- Author(s)
  Tanaka T, Takahashi M, Kusano E, Okamoto H.
- Journal Title
  
  J Gen Virol 88
  
  Pages: 903-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system.2007
- Author(s)
  Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H
- Journal Title
  
  J Clin Microbiol 45(11)
  
  Pages: 3671-3679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima, S., Takahashi, M., Jirintai, Tanaka, T., Nishizawa, T., Yasuda J, Okamoto, H
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390090

1. ODAGIRI Takato (80177237)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. TASHIRO Masato (90111343)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. TOBITA Kiyotake (00077174)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MATSUI Akira M. D. (00159146)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKAMOTO Hiroaki (30177092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. TAKAHASHI Masaharu (70326841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
7. SASAKI Nobuhiko (40225884)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAGASHIMA Shigeo (60433116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. KOBAYASHI Tominari (00634164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KASANO Yasuo MD. (70204360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ARAKAWA Yoichi (00175184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 早瀬行治 (50254909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 浜野雄二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HAMANO Yuhji MD.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TANAKA Toshinori 田中 利典

TANAKA Toshinori PhD. 田中 利典

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Persistence of Viral genes in a variant MDCK cells after productive Replication of a mutant of influenza virus A/WSNPrincipal Investigator

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[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food2012

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[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.2011

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[Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells2011

TANAKA Toshinori 田中利典

TANAKA Toshinori PhD. 田中利典