HIGUCHI Hiroshi 樋口宗史

… Alternative Names

樋口宗史ヒグチヒロシ

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Researcher Number	30150337
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2005 – 2006: 新潟大学, 医歯学系, 教授 2003: 新潟大学, 大学院・医歯学総合研究科, 教授 2001: GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES, PROFESSOR, 大学院・医歯学総合研究科, 教授 1997 – 2000: NIIGATA UNIVERSITY SCHOOL OF MEDIVINE,DEPARTMENT OF PHARMACOLOGY,PROFESSOR, 医学部, 教授 1992 – 1996: 大阪大学, 医学部, 助教授 1990 – 1991: 大阪大学, 医学部, 助手 1988: 大阪大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / 応用薬理学・医療系薬学 / General pharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator General pharmacology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator Neuropeptide Y / NDF1 / Enkephalin A / transcriptional factor / depolarization / transcription / gene transcription / Zebrafish / NGF / JAK-STAT … More / Leptin / drug-induced regulation / cis-element / neural differentiation / CAT assay / 降圧剤 / Gene expression / In situ hybridization / transcription factor / differentiation / calmodulin / enkephalin A / neuropeptide Y / in situ hybridization / repression / NGF response element / ZFH / δEF1 / Headgear / Transcription factor / Differntiation / Depolarization / Calmodulin / transcriptiona factor / gene expression / enkepalin A / pheochromocytoma / SHR / depdarization / Cis-elenent / transcriptional factors / Nuclear Run-on Assay / Chloramphenicol Acetyltransferase Assay / Synaptic Plasticity / Adrenergic Agents / Antihypertensive Drugs / Gene Expression / Nuclear Runーon assay / Nuclear Runーonアッセイ / CATアッセイ / Nuclear Runーon アッセイ / CAT アッセイ / シナプス可塑性 / アドレナリン作働薬 / 中枢摂食制御 / 摂食中枢 / 視床下部 / 遺伝子発現 / ニューロペプチドY / 摂食関連ペプチド / 中核摂食制御 / Ost / malformation / dioxin / Oncogene / cDNA / knock-out mouse / peptide YY / receptor / RT-PCR / cloning / Y3 … More Except Principal Investigator RT-PCR / neuropeptideY / gicerin / 薬物依存 / モルヒネ / Adenylate cyclasse / Heart / Muscarinic acetylcholine receptor / PI代謝 / ムスカリニックレセプター / Pエレスポンス / アテニレートシクラーゼ / PIレスポンス / アデニレートシクラーゼ / 受容体サブタイプ / ムスカリン様アセチルコリン受容体 / hippocampal slice / NG108-15 cell / patch-clamp technique / T-type Ca^<2+>_channel / NPY受容体 / ホールセル記録 / 電位依存性電流 / スライスパッチクランプ / スライス培養 / ラット海馬 / 海馬スライス / NG108-15細胞 / パッチクランプ / T型カルシウム電流 / reactive astrocytes / cell movement / synaptogenesis / neurite outgrowth factor cell adhesion / 癌化 / 発生 / 腎臓 / 神経察知伸展因子 / 活性ドメイン / ギセリン / シナプス形成 / 細胞接着因子 / イムノグロブリン / gicerin(ギセリン) / 突起伸展因子 / 反応性アストログリア / 神経再生 / 細胞移動 / 神経突起伸展 / 細胞接着 / casein / cAMP response element / DNA-binding protein / puraalpha / ssCRE-BP / dependence / tolerance / morphine / メタンフェタミン / ISDB法 / DNA結合蛋白 / 小脳 / 大脳 / cDNAクローニング / 転写因子 / 一本鎖CRE結合蛋白 / CAMPレスポンスエレメント / purα / cAMPレスポンスエレメント / DNA結合蛋白質 / pur α / カゼイン / 一本鎖CRE結合蛋白質 / 依存耐性 / 転写調節因子 / コカイン / アンフェタミン / in situ DNA-Protein Binding Less

RNAiを用いた摂食関連遺伝子の機能ターゲッティング法の開発Principal Investigator
- Principal Investigator
  
  樋口宗史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Niigata University
Effect of neuropeptideY on the T-type Ca^<2+> channel current
- Principal Investigator
  
  OKADA Masayoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kansai Medical University
  Niigata University
ゼブラフィッシュ胚を用いたダイオキシンの神経奇形・発癌機構の解明Principal Investigator
- Principal Investigator
  
  樋口宗史
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Niigata University
ヒトNeuropeptide Y受容体(Y3及びY5)のクローニングと機能解析Principal Investigator
- Principal Investigator
  
  樋口宗史
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
TRANSCRPTIONAL REGgiATlON AS A NEW DRUG ACTION SITE-NOVEL TRANSCRPTIONAL FACTORS INVOLVED IN NEURAL DIFFERENTIATION AND MEMORYPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hiroshi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  NIIGATA UNIVERSITY
シナプス可塑性に関わる神経ペプチド遺伝子の転写制御と転写因子Principal Investigator
- Principal Investigator
  
  樋口宗史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
TRANSCRIPTIONAL REGULATION OF NEURON-SPECIFIC GENES AND MODULATION BY DRUGSNOVEL TRANSCRIPRION FACTORS INVOLVED IN NEURAL DIFFERENTIATION AND MEMORYPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  NIIGATA UNIVERSITY
  Osaka University
Structures and functions of gicerin, a novel cell adhesion molecule.
- Principal Investigator
  
  MIKI Naomasa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka University
Molecular mechanism and prevention of drug dependence
- Principal Investigator
  
  MIKI Naomasa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Gene expression of neuro-specific genes and their regulation by drugs-identification of transcriptional factors which are involved in neral differentiation and memory.Principal Investigator
- Principal Investigator
  
  HIGUCHI Hiroshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
薬物の耐性依存をモデルとした化学記憶の分子機構
- Principal Investigator
  
  MIKI Naomasa
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Drug-induced regulation of neuroactive peptide precursor gene expression -Neuropeptide Y and enkephalin A precursor genes-Principal Investigator
- Principal Investigator
  
  HIGUCHI Hiroshi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Relationship between subtypes and cellular responses in muscarinic acetylcholine receptor system
- Principal Investigator
  
  YOSHIDA Hiroshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University Faculity of Medicine

All 2007 2006 2005 2004

All Journal Article Book

[Book] ローレンス臨床薬理学2006
- Author(s)
  樋口宗史
- Total Pages
  36
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-17659071
[Book] クーパー神経薬理学-生化学からのアプローチ2005
- Author(s)
  樋口宗史
- Total Pages
  364
- Publisher
  メディカル・サイエンス・インターナショナル
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] Potentiation by neuropeptide Y of histamine H_1 receptor-mediated contraction in rat blood vessels.2007
- Author(s)
  Piao H., Nagai S., Tsurumaki T., Niki T., Higuchi H.
- Journal Title
  
  Vascul. Pharmacol. 46
  
  Pages: 260-270
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] Suppression of mental stress-induced change by tandospirone, an anxiolytic, in cardiovascular function.2006
- Author(s)
  Nagai S., Urayama K., Higuchi H.
- Journal Title
  
  Acta Medica Biol. 54
  
  Pages: 103-108
- NAID
  110006447061
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] Potentiation by neuropeptide Y of 5HT_<2A> receptor-mediated contraction in porcine coronary artery.2006
- Author(s)
  Tsurumaki, T., Nagai, S., Bo, X., Toyosato, A., Higuchi, H.
- Journal Title
  
  Eur. J. Pharmacol. 544
  
  Pages: 111-117
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] NPY-Y5受容体ノックアウトマウスの摂食ペプチド発現の制御と摂食2006
- Author(s)
  樋口宗史, 山口剛, 仁木剛史
- Journal Title
  
  日薬理誌 127
  
  Pages: 92-96
- NAID
  10017495235
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] Transcriptional regulation of neuronal genes and its effect on neural functions.2005
- Author(s)
  H.Higuchi
- Journal Title
  
  J.Pharmacol.Sci. 98
  
  Pages: 198-199
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] Transcriptional regulation of neuropeptide Y gene by leptin and its effect on feeding.2005
- Author(s)
  H.Higuchi, A.Hasegawa, T.Yamaguchi
- Journal Title
  
  J.Pharmacol.Sci. 98
  
  Pages: 225-231
- Data Source
  KAKENHI-PROJECT-17659071
[Journal Article] Effect of neuropeptideY on the T-type Ca^<2+> channel current expressed in NG1-8015 cells2004
- Author(s)
  Okada M, Hasagawa A, Higuchi H
- Journal Title
  
  Acta Medica et Biologica 52
  
  Pages: 103-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500254
[Journal Article] Effect of neuropeptideY on the T-type Ca2+ channel current expressed in NG1-8015 cells2004
- Author(s)
  Okada M, Hasagawa A, Higuchi H
- Journal Title
  
  Acta Medica et Biologica 52
  
  Pages: 103-110
- Data Source
  KAKENHI-PROJECT-15500254

1. MIKI Naomasa (40094445)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. OSUGI Takeshi (50176880)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KUO Che-hui (50126570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MURAOKA Osamu (20283765)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. WATANABE Yasuhiro (90127324)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OKADA Masayoshi (40334677)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. YAMAGUCHI Tsuyoshi (70323970)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 吉田豊 (40182795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 茂里康

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TANAKA Hidekazu (70273638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIDA Hiroshi (70028273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. UCHIDA Shuji (90028639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 仁木剛史 (90377193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 王小兵 (30243207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 平英一 (60263240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 仲澤幹雄 (80143759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中広全延 (00172388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YANAGITA Tomoji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIGUCHI Hiroshi 樋口 宗史

樋口 宗史 ヒグチ ヒロシ

Research Projects

Research Products

Co-Researchers

RNAiを用いた摂食関連遺伝子の機能ターゲッティング法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of neuropeptideY on the T-type Ca^<2+> channel current

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゼブラフィッシュ胚を用いたダイオキシンの神経奇形・発癌機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトNeuropeptide Y受容体(Y3及びY5)のクローニングと機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TRANSCRPTIONAL REGgiATlON AS A NEW DRUG ACTION SITE-NOVEL TRANSCRPTIONAL FACTORS INVOLVED IN NEURAL DIFFERENTIATION AND MEMORYPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

シナプス可塑性に関わる神経ペプチド遺伝子の転写制御と転写因子Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

TRANSCRIPTIONAL REGULATION OF NEURON-SPECIFIC GENES AND MODULATION BY DRUGSNOVEL TRANSCRIPRION FACTORS INVOLVED IN NEURAL DIFFERENTIATION AND MEMORYPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structures and functions of gicerin, a novel cell adhesion molecule.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism and prevention of drug dependence

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene expression of neuro-specific genes and their regulation by drugs-identification of transcriptional factors which are involved in neral differentiation and memory.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬物の耐性依存をモデルとした化学記憶の分子機構

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Drug-induced regulation of neuroactive peptide precursor gene expression -Neuropeptide Y and enkephalin A precursor genes-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relationship between subtypes and cellular responses in muscarinic acetylcholine receptor system

Principal Investigator

Project Period (FY)

Research Category

Research Field

HIGUCHI Hiroshi 樋口宗史

樋口宗史ヒグチヒロシ