OHKUMA Seitaro 大熊誠太郎

Researcher Number	30152086
Other IDs
External Links
Affiliation (based on the past Project Information) *help	1996 – 2007: 川崎医科大学, 医学部, 教授 1986 – 1994: 京都府立医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator General pharmacology / 応用薬理学・医療系薬学 / Applied pharmacology Except Principal Investigator General pharmacology / Medical systems / Neurochemistry/Neuropharmacology / Biomedical engineering/Biological material science / 老化(加齢)
Keywords	Principal Investigator up-regulation / β-arrestin / adenylate cyclase / nadolol / β-アドレナリン受容体 / cerebral cortical neurons / 大脳皮質神経細胞 / conditioned place preference / ryanodine trceptors / methamphetamine … More / alcohol / High voltage-gated Ca channels / drug dependence / [^3H]diltiazem結合 / アルコール(エタノール) / L型高電位開口性Ca^<2+>チャネル / ジアゼパム結合阻害蛋白質 / α1サブユニット / アンフェタミン / ニコチン / モルヒネ / エタノール / [3H]diltiazem結合 / L型高電位開口性カルシウムチャネル / ethanol / methanphetamine / CPP / ryanodine受容体 / メタンフェミン / アルコール / 高電位開口性カルシウムチャネル / 薬物依存 / cerebrocortical neurons / [3H] CGP-12177 binding / β-adrenoceptors / [^3H]CGP-12177結合 / 3H]CGP-12177結合 / [3H]CGP-12177結合 / peroxynitrite scavenger / hydroxyl radical / neurotransmitter release / Voltage-dependent Ca^<2+> channels / Ca^<2+> influx / peroxynitrite / ヒドロキシルラジカル / 神経伝達物質放出 / テトロドトキシン / cyclicGMP(cGMP) / L型VDCC活性薬 / ヒドロキシラジカル / 電位依存性Ca^<2+>チャネル / cyclic GMP(cGMP) / Ca^<2+>流入 / パーオキシニトライト / Ca^<2+> channels / GABA / nitric oxide / protooncogenes / neurons / beta-adrenocentors / Protooncogenes / Immediate early gene(IEG) / Immediate early gene (IEG) / 初代培養神経細胞 / Up-regulation / 受容体発現調節 / [^3H]MK-801 binding / Ca influx / NG108-15 cells / ca-channel blocker / GABA_A receptor / neuronal death / NMDA receptor / NG108-15 / [^3H]MK-801結合 / Ca細胞内流入 / NG108-15細胞 / カルシウムチャネル拮抗薬 / GABA_A受容体 / 神経細胞死 / NMDA受容体 / Cerebral Cortical Neuron / Primary Culture / PI Turnover / Muscarinic Acetylcholine Receptor / Adenylate Cyclase / beta-Adrenergic Receptor / G Protein / 細胞内情報伝達系 / 神経細胞 / 初代培養 / イノシト-ルリン脂質代謝回転 / ムスカリン受容体 / アデニレ-トシクラ-ゼ / βーアドレナリン受容体 / G蛋白 … More Except Principal Investigator アストログリア / 初代培養神経細胞 / 免疫組織化学 / Glycoprotein / Distribution in Brain / Immunohistochemistry / Receptor Antibody / Functional Reconstitution / Functional Coupling / C1 Channel / Benzodiazepine Receptor / GABA receptor / 機能的共役 / クロライドチャンネル / hybrid型糖鎖 / 糖蛋白 / 脳内分布 / レセプター抗体 / 機能再構成 / クロライドチャンネル、機能的共役 / ベンゾジアゼピン・レセプター / GABAレセプター / ultrasound therapy / myocardial ischemia / microvasculature / arterialization / cardiovascular system / 超音波治療 / 心筋虚血 / 微小血管構築 / 血管新生 / 循環器・高血圧 / High voltage-gated calcium channels / Calcium-induced calcium release / Cav β subunits / Cav1.2 subunits / IP3 receptors / Ryanodine receptors / Reward effects / Drug dependence / 細胞内カルシウム濃度 / Ca^<2+>センサー蛋白 / 依存性薬物 / L型高電位開口性カルシウムチャネル / 高電位開口性カルシウムチャネル / Ca^<2+>誘発Ca^<2+>放出 / β3サブユニット / α1Cサブユニット / IP3受容体 / リアノジン受容体 / 報酬効果 / 薬物依存 / EDRF / mesenteric microcirculation / reactive hyperemia / H_2O_2 / 腸間膜動脈 / in vivo / 毛細血管 / ペンシル型CCD生体顕微鏡 / 内皮由来過分極因子 / CU, Zn-SOD KO mice / 微小循環 / 虚血再灌流 / 腸間膜微小循環 / 内皮由来拡張物質 / 腸間服微小循環 / 反応性充血 / 過酸化水素 / DEVELOPMENT / NEURO TROPIC FACTOR / OSTEOPOROSIS / OSTEOBLASTS / 骨芽細胞 / development / Xenopos laevis / 遺伝子発現 / 骨代謝 / 神経 / 発生 / 骨粗鬆症 / パーキンソン病 / 錐体外路機能制御 / 黒質-線条体系ドーパミンニューロン / 線条体-淡蒼球系GABAニューロン / 線条体-黒質系GABAニューロン / カイニン酸 / MPTP / GABA_Aレセプター / 機能変化 / 初代培養細胞 / オリゴデンドログリア / GABAニューロン / ニューロン / 神経伝達物質 / 脳白質変性症 / 薬理学的性質 / 可溶化 / 活性化 / GAB【A_B】レセプター / カルシウムイオン / peroxynitrite / NOラジカル / アセチルコリン放出 / 電位依存型Ca^<2+>チャネル / Ca^<2+>influx / GABA_A受容体 / NMDA受容体 / 脳虚血モデル / NGF・mRNA / NGF / pH変化 / グルタミン / グルタミン酸 / アシドーシス / アシド-シス / 初代培養 / グルタミン酸取り込み / GABA取り込み / 神経細胞死 / 脳虚血 / 前シナプス性ヘテロレセプタ- / 前シナプス性オ-トレセプタ- / ムスカリン性M_1レセプタ- / GABA_Aレセプタ- / GABAニュ-ロン / 大脳皮質 / GABA放出調節 / 培養細胞 / 病態生理学的役割 / Alzheimer病起因物質 / Alzheimer病 / 無血清培養法 / 誘発物質の同定 / 起因物質の同定 / アルツハイマ-病 Less

Identification of common biological markers underlying establishment of drug dependence and an attempt to develop pharmacogenomic therapy
- Principal Investigator
  
  KATSURA Masashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kawasaki Medical School
Establishment of ischemic cardiomyopathy-targeted microbubble-ultrasound therapy : effects on three-dimensional architecture of coronary microvasculature
- Principal Investigator
  
  TOYOTA Eiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Kawasaki Medical School
Development of the pencil-typed imaging system to evaluate the disturbance of coronary microcirculation during coronary ischemia-reperfusion injury
- Principal Investigator
  
  YADA Toyotaka
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
An attempt to develop pharmacogenomic therapy and prevention of drug dependence.Principal Investigator
- Principal Investigator
  
  OHKUMA Seitaro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kawasaki Medical School
β-Adrenoceptor up-regulation and intracellular signal transduction systemsPrincipal Investigator
- Principal Investigator
  
  OHKUMA Seitaro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KAWASAKI MEDICAL SCHOOL
Survey of peroxynitrite scavengers and its application for pathophysiolgyPrincipal Investigator
- Principal Investigator
  
  OHKUMA Seitaro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KAWASAKI MEDICAL SCHOOL
Phamracological and molecular biological analyzes on regulatory mechanisms for neurotransmitter receptor expressionPrincipal Investigator
- Principal Investigator
  
  OHKUMA Seitaro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KAWASAKI MEDICAL SCHOOL
神経細胞死発症におけるNMDA受容体と他種伝達物質受容体相互作用の意義の解析
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
アストログリアにおける神経成長因子(NGF)の生成とその脳虚血に伴う変化の解析
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
Functional relationship between NMDA-induced neuronal injury and various neurotransmitter receptorsPrincipal Investigator
- Principal Investigator
  
  OHKUMA Seitaro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
Studies on the gene expression of OSF-1 in osteoblasts derived from normal and osteoporosis patients.
- Principal Investigator
  
  HASHIMOTO-GOTOH Tamotsu
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Kyoto Pref.Univ.of Medicine
脳虚血解除後の脳内微小環境における星状膠細胞の病態生理学的役割の解析
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
Alzheimer病の病態発現におけるAstrocytesの病態生理学的役割の解析
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
GABA作動性シナプスにおける前シナプス性オ-トレセプタ-の特性と機能の解析
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular biological analysis on regulatory mechanisms underlying the biosynthesis of GTP binding proteinPrincipal Investigator
- Principal Investigator
  
  OHKUMA Seitaro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
初代培養神経細胞を用いたアルツハイマ-病起因・誘発物質の同定とその性状の解析
- Principal Investigator
  
  KURIYAMA Kinya
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
錐体外路系の制御機構におけるGABA作働性ニューロンの役割に関する神経化学的研究
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
カルシウムイオンによるγ-アミノ酪酸(GABA)ーフレセプターの活性化とその意義
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto Prefectural University of Medicine
脳白質変性症における諸種伝達物質作働性ニューロンの機能変化解析と治療確立への応用
- Principal Investigator
  
  栗山欣弥
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto Prefectural University of Medicine
Purification of -aminobutyric acid (GABA) receptor and formation of monoclonal antibody against the purified receptor.
- Principal Investigator
  
  KURIYAMA Kinya
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2007 2006 2005 2004

All Journal Article Book

[Book] グッドマン・ギルマン薬理書(上) 薬物治療の基礎と臨床(第11版)2007
- Author(s)
  大熊誠太郎
- Total Pages
  1206
- Publisher
  廣川書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500302
[Book] コア・カリキュラム対応医学一般〔改訂2版〕(今西二郎編)2005
- Author(s)
  大熊誠太郎, 桂昌司(分担)
- Total Pages
  346
- Publisher
  金芳堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390175
[Book] 医学薬理学(改訂4版)(遠藤政夫、栗山欣弥、大熊誠太郎、田中利夫、樋口宗史編)2005
- Author(s)
  大熊誠太郎
- Total Pages
  739
- Publisher
  南山堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390175
[Book] 医科薬理学2005
- Author(s)
  大熊誠太郎
- Total Pages
  739
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-15390175
[Book] 覚せい剤精神病と麻薬依存(佐藤光源、櫻井映子編)2004
- Author(s)
  大熊誠太郎, 桂昌司(分担)
- Total Pages
  186
- Publisher
  東北大学出版会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390175
[Journal Article] Expression of β-adrenergic receptor up-regulation is mediated by two different processes.2006
- Author(s)
  Ohkuma S., et. al.
- Journal Title
  
  Brain Res. 1112
  
  Pages: 114-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500302
[Journal Article] Expression of β-adrenergic receptor up-regulation is mediated by two different processes.2006
- Author(s)
  Ohkuma, S.
- Journal Title
  
  Brain Research 1112
  
  Pages: 114-125
- Data Source
  KAKENHI-PROJECT-18500302
[Journal Article] Expression of β-adrenergic receptor up-regulation is mediated by two different processes2006
- Author(s)
  Ohkuma, S.
- Journal Title
  
  Brain Research 1112
  
  Pages: 114-125
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500302
[Journal Article] 【アルコール依存症最近の話題】アルコール症の薬物療法2005
- Author(s)
  大熊誠太郎他
- Journal Title
  
  最新精神医学 10
  
  Pages: 375-381
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390175
[Journal Article] アルコール長期曝露によるL型高電位開口性カルシウムチャネルの機能変化とその意義2005
- Author(s)
  桂昌司, 大熊誠太郎
- Journal Title
  
  日本アルコール・薬物医学会雑誌 40
  
  Pages: 205-212
- NAID
  10016593172
- Data Source
  KAKENHI-PROJECT-15390175
[Journal Article] Chronic nicotine treatment upregulates L-type high voltage-gated calcium channels.2005
- Author(s)
  Katsura, M., Ohkuma, S.
- Journal Title
  
  J.Pharmacol.Sci. 97
  
  Pages: 344-347
- Data Source
  KAKENHI-PROJECT-15390175
[Journal Article] 【アルコール依存症最近の話題】アルコール症の薬物療法2005
- Author(s)
  大熊誠太郎, 桂昌司
- Journal Title
  
  最新精神医学雑誌 10
  
  Pages: 375-381
- Data Source
  KAKENHI-PROJECT-15390175
[Journal Article] 内在性不安誘発物質の脳内発現変化とその意義2004
- Author(s)
  桂昌司, 大熊誠太郎
- Journal Title
  
  日本神経精神薬理学雑誌 24
  
  Pages: 119-123
- NAID
  10013150185
- Data Source
  KAKENHI-PROJECT-15390175
[Journal Article] Pharmacological basis for management of drug dependence2004
- Author(s)
  Katsura, M., Ohkuma, S.
- Journal Title
  
  Ann.N.Y.Acad.Sci. 1025
  
  Pages: 578-583
- Data Source
  KAKENHI-PROJECT-15390175

1. KURIYAMA Kinya (20079734)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. KATSURA Masashi (80204452)

# of Collaborated Projects: 8 results

# of Collaborated Products: 7 results
3. TAGUCHI Jun-ichi (50188132)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HIROUCHI Masaaki (70181196)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 土橋康成 (50106390)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 橋本恒一 (00172867)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HASHIMOTO-GOTOH Tamotsu (00237942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TSUJIMURA Atsushi (50236890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRASAWA Taisuke (40079851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIMOSATO Kazuaki (60154316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. WATANABE Satoru (90069055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YADA Toyotaka (00210279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMOTO Hiroshi (10299183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. GOTO Masami (50148699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OGASAWARA Yasuo (10152365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIBASAKI Masahiro (80412162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TOYOTA Eiji (30248215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YOSHIDA Kiyoshi (60322583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NEISHI Yoji (80319946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 城守美佐 (70177939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KAJIYA Fumihiko (70029114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHKUMA Seitaro 大熊 誠太郎

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An attempt to develop pharmacogenomic therapy and prevention of drug dependence.Principal Investigator

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β-Adrenoceptor up-regulation and intracellular signal transduction systemsPrincipal Investigator

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Survey of peroxynitrite scavengers and its application for pathophysiolgyPrincipal Investigator

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Phamracological and molecular biological analyzes on regulatory mechanisms for neurotransmitter receptor expressionPrincipal Investigator

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Functional relationship between NMDA-induced neuronal injury and various neurotransmitter receptorsPrincipal Investigator

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Molecular biological analysis on regulatory mechanisms underlying the biosynthesis of GTP binding proteinPrincipal Investigator

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OHKUMA Seitaro 大熊誠太郎

[Book] コア・カリキュラム対応医学一般〔改訂2版〕(今西二郎編)2005

[Book] 医学薬理学(改訂4版)(遠藤政夫、栗山欣弥、大熊誠太郎、田中利夫、樋口宗史編)2005