Sawada Norimasa 澤田典均

… Alternative Names

SAWADA NORIMASA 澤田典均

SAWADA Norimasa 澤田典均

沢田典均サワダノリマサ

澤田典均サワダノリマサ

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Researcher Number	30154149
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 札幌医科大学, 医学部, 名誉教授 2016 – 2018: 札幌医科大学, 医学部, 教授 2012 – 2014: 札幌医科大学, 医学部, 教授 2007 – 2010: Sapporo Medical University, 医学部, 教授 2005: 札幌医大, 医学部, 教授 … More 2000 – 2005: 札幌医科大学, 医学部, 教授 1995 – 1999: SAPPORO MEDICAL UNIVERSITY SCHOOL of MEDICINE,DEPARTMENT of PATHOLOGY ASSOCLATE PROFESSOR, 医学部, 助教授 1991 – 1995: 札幌医科大学, 医学部, 講師 1992 – 1993: 札幌医科大学, 医学部・病理学第2講座, 講師 1992: Sapporo Medical University, Dept. Pathol., Assistant Professor, 医学部・病理学, 講師 1990: 札幌医大, 医学部・病理学, 助手 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Human pathology / Ophthalmology / Orthopaedic surgery Except Principal Investigator Human pathology / Experimental pathology / Otorhinolaryngology / Experimental pathology / Digestive surgery / Biological Sciences … More / Human pathology / Obstetrics and gynecology / Cerebral neurosurgery / 動物発生・生理学 Less
Keywords	Principal Investigator タイト結合 / occludin / 細胞電気抵抗 / claudin / ZO-1 / 糖尿病網膜症 / MAPK / GDNF / 血液脳関門 / 血液網膜関門 … More / バリア機能 / 血管内皮細胞 / 7H6(barmotin) / “タイト結合病” / 上皮細胞接着 / 細胞ストレス / フェンス機能 / 造腫瘍性 / シグナル伝達 / claudin-18 / tricellulin / JAM-A / gap junction / nuclear receptor / hepatocyte / enodothelial cells / tight junction / PI3K / ギャップ結合 / 核内レセプター型転写因子 / 肝細胞 / 7H6 antigen / Tight junction / Permeability / Brain capillary endothelium / Blood-brain barrier / Astocyte / 7H6 / 共焦点レーザー顕微鏡 / アストロサイト / 脳血管内皮細胞 / 脳血管関門 / Epithelial-mesenchymal interaction / Progesterone / Menstrual cycle / Human encometrium / Stromelysin 3 / 子宮内膜 / 上皮・間質相互作用 / stromelysin 3 / 上皮間質相互作用 / プロゲステロン / 性周期 / ヒト子宮内膜 / stromelysin3 / EMT / PKC / クローディン / 緑膿菌 / 肝線維症 / 膵癌 / ビタミンD受容体欠損マウス / Ca吸収機構 / Toll-like receptor / TSLP / 樹状細胞 / ヒト鼻粘膜 / 生体機能利用 / 細胞・組織 / 病理学 / サイトカイン / 肝(黄疸) / 膵管上皮 / 鼻アレルギー / Ca吸収 / AGE / VEGF / 血管透過性 / グリア細胞 / PKA / TER / 血液透過性 / neurturin / アクチン / Min mouse / SMC蛋白 … More Except Principal Investigator タイト結合 / Tight junction / tight junction / 細胞極性 / 病理学 / ギャップ結合 / 肝細胞 / HNF-4α / 血液組織関門 / クローディン / MMP-9 / MMP-2 / MMP-7 / 子宮内膜癌 / Barrier function / Molecular pathology / 転移抑制 / バリアー機能 / 分子病理学 / 咽頭癌 / 細胞間接着装置 / 核内受容体 / 肝予備能 / 組織幹細胞 / 細胞移植 / 浸潤 / ヒトケラチノサイト / LECラット / 肝癌 / adipokines / 頭頚部扁平上皮癌 / 膵癌 / ASPP2 / Angubindin-1 / claudin-1 / TEAD1/AREG / Hippo pathway / 悪性化 / LSR / 膵臓癌 / 実験病理学 / 糖尿病腎症 / 腎不全 / 糖尿病性腎症 / 糖尿病 / 腎メサンギウム細胞 / 星細胞 / レチノイン酸代謝酵素CYP26 / レチノイン酸 / ビタミンA / 子宮頸部 / 子宮頸部腺癌 / 治療・診断マーカー / 子宮頚部腺癌 / 子宮頚部 / blood-tissue barrier / junctional complex / cell proliferation / epithelial differentiation / epithelial polarization / nuclear receptor / プロテインキナーゼC / 細胞増殖 / 上皮分化 / carcinoma / immunohistochemistry / occludin / neoplasm / 不妊症 / 癌 / 免疫組織化学 / Occludin / 腫瘍 / Enodothelial cells / Protein kinase A / Cyclic AMP / MAP kinase / Blood-tissue barrier / Blood-brain barrier / Claudin / Tet-onシステム / 血管内皮細胞 / プロテインキナーゼA / サイクリックAMP / MAPキナーゼ / 血液脳関門 / differentiation / smooth-msucle actin / osteoblast / pericyte / 分化機能 / 平滑筋アクチン / 骨芽細胞 / 血管周皮細胞 / ペリサイト / IN SITU HYBRIDISATION / INVASION ASSAY / MATRIX METALLOPROTEINASE (MMP) / UTERINE ADENOCARCINOMA / UTERINE ADENOMYOSIS / 子宮内膜 / 子宮腺筋癌 / MMP7 / 子宮内膜症 / zymography / in situ hybridization / MMP / pump-1 / Matrix metalloproteinase(MMP) / In situ hybridization / Invasion assay / Matrix Metalloproteinase(MMP) / 子宮腺筋症 / Cell to cell communication / Cholestasis / Enteropathy / Motor protein / 細胞接着装置 / 染色体凝集 / 7H6抗原 / 細胞接着 / 分子モーター / バリアー調節因子 / 閉塞性黄疸 / 細胞間物質透過 / 異型性 / ヒト大腸癌 / バリア機能 / Hepatocarcinogenesis / Bile canalicular contraction / Liver disease / Inhibition of metastasis / Cytoskeleton / 細胞膜 / 毛細胆管 / 肝類洞内皮 / 細胞間接着 / レーザー顕微鏡 / 肝臓 / がんの転移 / 炎症 / 毛細胆管収縮 / エンドトキシン血症 / 血漿蛋白漏出抑制 / 機能病理学 / 細胞骨格 / Tubulin / Microtubule / Microtubule motor protein / Kinesin / 微小管モ-タ-蛋白 / チュブリン / チュ-ブリン / 微小管モ-タ- / チューブリン / 微小管 / 微小管モーター蛋白 / キネシン / 肝機能 / 肝予備機能 / 組織肝細胞 / 肝再生 / 肝臓外科学 / EMT / HPV / 腫瘍浸潤 / 鼻粘膜 / TSLP / 樹状細胞 / アレルギー / 細胞・組織 / タイト結合蛋白 / トランスポーター / 分子マーカー / 肝 / アシアロシンチグラフィー / プロテアーゼインヒビター / 肝幹細胞 / 接着装置 / 胆汁うっ滞 / 肝不全 / 新規分子 / 肝予備能評価 / シグナル伝達 / 分化 / 増殖 / 細胞分化 / 肝発がん / シアル酸転移酵素 / GD3ガングリオシド / GM3ガングリオシド / 接着 / 遺伝子導入 / ガングリオシド / グリオーマ / YACベクター / アデノウイルスベクター / テロメレース活性 / 子宮頚部前癌病変 / 三次元創傷治癒モデル / ヒト上皮由来培養細胞 / ヒト多段階発癌機構 / Cre組換え酵素 / 三次元培養系 / HPV16 / テロメア短縮化 / 子宮頸部前癌病変 / 発癌物質高感受性 / 発癌プロモーション / 慢性肝炎 / 子宮頚癌 / myc遺伝子 / TGFbeta / ヒト上皮細胞 / 銅 / 疾患モデル / 発癌機構 / 発癌プロモーター / 肝炎 / リン酸 / プロテインキナ-ゼ / アフィディコリン / ヒストンH1キナーゼ / リン酸化 / ヒストンH1 / DNA合成 / ラット Less

Retinoic acid-deficient renal mesangial cells are responsible for the development of diabetic nephropathy
- Principal Investigator
  
  Osanai Makoto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Changes of tight junctions induced by extracellular stimuli determine cell shape and fate.Principal Investigator
- Principal Investigator
  
  SAWADA NORIMASA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
A novel tricellular tight junction molecule LSR in diagnosis and therapy for cancer
- Principal Investigator
  
  Takashi Kojima
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Evaluation of potential clinical application of tight junction proteins in cervical adenocarcinoma
- Principal Investigator
  
  Takasawa Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Patho-physiology of the tight junction-mainly focusing on human normal epithelial cells.Principal Investigator
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.
- Principal Investigator
  
  HIRATA Koichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University
Altered expression of tight junctions in nasopharyngeal and oropharyngeal carcinoma of EMT in EBV or HPV infection
- Principal Investigator
  
  TAKANO Kenichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
The role of dendritic cell-activating factor TSLP in allergic rhinitis
- Principal Investigator
  
  KAMEKURA Ryuta
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
The role of tight junction proteins in human pharyngeal carcinoma
- Principal Investigator
  
  KONDOH Atsushi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Pathobiology of the tight junction : from cell biology of paracellular pathway to bed-sidePrincipal Investigator
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver
- Principal Investigator
  
  HIRATA Koichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University
Regulation of biological barrier and cell polarity formation
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
骨粗鬆症とタイト結合:occludinノックアウトマウスを用いた解析Principal Investigator
- Principal Investigator
  
  沢田典均
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
Molecular mechanism of formation and regulation of the biological barrier
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Immunohistochemical analyses of occludin expression in human diseases and their application for diagnostic pathology
- Principal Investigator
  
  TOBIOKA Hirotoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
網膜グリア細胞の形質制御による糖尿病網膜症の予防と治療法の基礎研究Principal Investigator
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Sapporo Medical University
Molecular pathophysiology of the biological barrier regulation of molecular passage through paracellular spaces.Principal Investigator
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Reconstitution and regulation of the blood-tissue barrier
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
ギャップ結合による肝がん発生の抑制メカニズム
- Principal Investigator
  
  小島隆
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
遺伝子導入によるグリオーマ糖脂質抗原の細胞接着、浸潤における機能的解析
- Principal Investigator
  
  八巻稔明
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Sapporo Medical University
ギャップ結合による肝がん発生の抑制メカニズム
- Principal Investigator
  
  KOJIMA Takashi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
糖尿病網膜症と血液網膜関門のタイト結合Principal Investigator
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Sapporo Medical University
Induction of pericyte differentiation in human osteoblastic cell line
- Principal Investigator
  
  IKEDA Tatsuru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
血管内皮細胞のタイト結合蛋白と癌転移Principal Investigator
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Sapporo Medical University
血管内皮細胞のタイト結合蛋白7H6とがん細胞の血管外脱出の抑制Principal Investigator
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Sapporo Medical University
血管内皮細胞のタイト結合蛋白7H6とがん細胞の血管外脱出の抑制Principal Investigator
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Sapporo Medical University
Molecular Mechanisms of Formation of Blood-Brain-Barrier ; Effects of Astrocyte-Secreting FactorsPrincipal Investigator
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University School of Medicine
THE INVASION AND EXPRESSION OF MMPs IN UTERINE ADENOMYOSIS AND ADENOCARCINOMA
- Principal Investigator
  
  FUJII Miho
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE
ヒト上皮系培養細胞を用いた発癌研究
- Principal Investigator
  
  野田哲生
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
Molecular pathology of tight junctions-with special reference to the biological barrier function of the liver and digestive tract-
- Principal Investigator
  
  MORI Michio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL of MEDICINE
ヒトの上皮系培養細胞を用いた発癌研究
- Principal Investigator
  
  野田哲生
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
ヒトの上皮系培養細胞を用いた発癌研究
- Principal Investigator
  
  野田哲生
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
LECラットを用いた肝炎の発癌促進作用,特にプログレッション作用の研究
- Principal Investigator
  
  森道夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Sapporo Medical University
Hormonal regulation of stromelysin-3 in human endometrial tissues.Principal Investigator
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL of MEDICINE
LECラットを用いた肝炎の発癌プロモーション・プログレッション作用の研究
- Principal Investigator
  
  MORI Michio
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Sapporo Medical University
Molecular Pathology of Hepatocyte cytoskeleton
- Principal Investigator
  
  MORI Michio
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
DNA合成開始時におけるピストンH1キナーゼ活性化の意義
- Principal Investigator
  
  浅見行一
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  動物発生・生理学
- Research Institution
  Sapporo Medical University
Studies on the roles of kinesin in the function of cells by monoclonal antibodies.
- Principal Investigator
  
  HATTORI Atsuo
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY

[Book] Gap and tight junctions in liver: composition, regulation, and function. The Liver: Biology and Pathobiology, 5th Edition, edited by Arias IM, et al.2009
- Author(s)
  Kojima T, Sawada N, Yamaguchi H, Fort AG, Spray DC
- Publisher
  Lippincott Williams&Wilkins, Philadelphia
- Data Source
  KAKENHI-PROJECT-19390103
[Book] 病気と細胞内小器官(森道夫編著)2002
- Author(s)
  澤田典均
- Total Pages
  236
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue.2019
- Author(s)
  Aoyama T, Takasawa A, Takasawa K, Ono Y, Emori M, Murata M, Hayasaka T, Fujitani N, Osanai M, Yamashita T, Hasegawa T, Sawada N.
- Journal Title
  
  Am J Pathol.
  
  Volume: in press Issue: 5 Pages: 1015-1028
- DOI
  10.1016/j.ajpath.2019.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-18K15084, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-18K09112, KAKENHI-PROJECT-19K16561, KAKENHI-PROJECT-19K16588, KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K10974
[Journal Article] Elevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinoma2019
- Author(s)
  Ino Y, Akimoto T, Takasawa A, Takasawa K, Aoyama T, Ueda A, Ota M, Magara K, Tagami Y, Murata M, Hasegawa T, Saito T, Sawada N, Osanai M
- Journal Title
  
  Histol Histopathol
  
  Volume: 18157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08697
[Journal Article] Immunoreactivity patterns of tight junction proteins are useful for differential diagnosis of human salivary gland tumors.2019
- Author(s)
  Aoyama T, Takasawa A, Murata M, Osanai M, Takano K, Hasagawa T, Sawada N.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 52 Issue: 1 Pages: 23-35
- DOI
  10.1007/s00795-018-0199-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-19K16561, KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698
[Journal Article] Retinoic acid-metabolizing enzyme CYP26A1 promotes skin carcinogenesis induced by DMBA2018
- Author(s)
  Osanai M, Takasawa A, Takasawa K, Murata M, Sawada N
- Journal Title
  
  Oncol Letter
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08697
[Journal Article] Cytotoxicity of Clostridium perfringens enterotoxin depends on the conditions of claudin-4 in ovarian carcinoma cells2018
- Author(s)
  Tanaka S, Aoyama T, Ogawa M, Takasawa A, Murata M, Osanai M, Saito T, Sawada N
- Journal Title
  
  Exp Cell Res
  
  Volume: 371 Issue: 1 Pages: 278-286
- DOI
  10.1016/j.yexcr.2018.08.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-17K08735, KAKENHI-PROJECT-16K08693
[Journal Article] Retinoic acid-metabolizing enzyme CYP26A1 promotes skin carcinogenesis induced by DMBA2018
- Author(s)
  Osanai M, Takasawa A, Takasawa K, Murata M, Sawada N
- Journal Title
  
  Oncol Lett
  
  Volume: 15 Pages: 9987-9993
- DOI
  10.3892/ol.2018.8599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-18K15084, KAKENHI-PROJECT-16K08693
[Journal Article] Estrogen/GPR30 signaling contributes to the malignant potentials of ER-negative cervical adenocarcinoma via regulation of claudin-1 expression2018
- Author(s)
  Akimoto T, Takasawa A, Takasawa K, Aoyama T, Murata M, Osanai M, Saito T, Sawada N
- Journal Title
  
  Neoplasia
  
  Volume: 10 Issue: 10 Pages: 1083-1093
- DOI
  10.1016/j.neo.2018.08.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-18K15084, KAKENHI-PROJECT-16K08693
[Journal Article] Surfactant protein A inhibits growth and adherence of uropathogenic Escherichia coli to protect the bladder from infection.2017
- Author(s)
  Hashimoto J., Takahashi M., Satio A., Murata M., Kurimura Y., Nishitani C., Takamiya R., Uehara Y., Hasegawa Y., Hiyama Y., Sawada N., Takahashi S., Masumori N., Kuroki Y., Ariki S.
- Journal Title
  
  J. Immunol.
  
  Volume: 198 Issue: 7 Pages: 2898-2905
- DOI
  10.4049/jimmunol.1502626
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339
[Journal Article] Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.2017
- Author(s)
  Takasawa K, Takasawa A, Osanai M, Aoyama T, Ono Y, Kono T, Hirohashi Y, Murata M, Sawada N.
- Journal Title
  
  Cancer Lett.
  
  Volume: 403 Pages: 66-73
- DOI
  10.1016/j.canlet.2017.05.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-16K21250
[Journal Article] Prognostic significance of the co-expression of EGFR and HER2 in adenocarcinoma of the uterine cervix.2017
- Author(s)
  Ueda A, Takasawa A, Akimoto T, Takasawa K, Aoyama T, Ino Y, Nojima M, Ono Y, Murata M, Osanai M, Hasegawa T, Saito T, Sawada N.
- Journal Title
  
  PLoS One
  
  Volume: 12(8) Issue: 2 Pages: 172-180
- DOI
  10.1016/j.yexcr.2018.03.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-16K21250, KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-18K15084
[Journal Article] Surfactant Protein A (SP-A) and SP-A-derived Peptide Attenuate Chemotaxis of Mast Cells Induced by Human β-defensin 3.2017
- Author(s)
  Uehara Y., Takahashi M., Murata M., Saito A., Takamiya R., Hasegawa Y., Kuronuma K., Chiba H., Hashimoto J., Sawada N., Takahashi H., Kuroki Y., Ariki S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 485 Issue: 1 Pages: 107-112
- DOI
  10.1016/j.bbrc.2017.02.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-15K09181
[Journal Article] Cytological findings of langerhans cell sarcoma in a case of quintuple cancer.2017
- Author(s)
  Tabata S, Murata M, Takasawa A, Fukuda A, Ogasawara J, Koseki T, Nakano K, Segawa K, Morita R, Hasegawa T, Sawada N.
- Journal Title
  
  Diagn Cytopathol.
  
  Volume: 45(5) Issue: 5 Pages: 441-445
- DOI
  10.1002/dc.23628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K08698
[Journal Article] Elevated expression of JAM-A promotes neoplastic properties of lung adenocarcinoma.2017
- Author(s)
  Magara K, Takasawa A, Osanai M, Ota M, Tagami Y, Ono Y, Takasawa K, Murata M, Hirohashi Y, Miyajima M, Yamada G, Hasegawa T, Sawada N.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108(11) Issue: 11 Pages: 2306-2314
- DOI
  10.1111/cas.13385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698
[Journal Article] Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer.2016
- Author(s)
  Takasawa A, Murata M, Takasawa K, Ono Y, Osanai M, Tanaka S, Nojima M, Kono T, Hirata K, Kojima T, Sawada N.
- Journal Title
  
  Sci Rep
  
  Volume: 19(6) Issue: 1 Pages: 33582-33582
- DOI
  10.1038/srep33852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693
[Journal Article] Analysis of the expression and localization of tight junction transmembrane proteins, claudin-1, -4, -7, occludin and JAM-A, in human cervical adenocarcinoma.2016
- Author(s)
  Akimoto T, Takasawa A, Murata M, Kojima Y, Takasawa K, Nojima M, Aoyama T, Hiratsuka Y, Ono Y, Tanaka S, Osanai M, Hasegawa T, Saito T, Sawada N.
- Journal Title
  
  Histology and Histopathology
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460421
[Journal Article] Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma2016
- Author(s)
  Yusuke Ono, Yutaro Hiratsuka, Masaki Murata, Akira Takasawa, Rieko Fukuda, Masanori Nojima, Satoshi Tanaka, Makoto Osanai, Koichi Hirata, Norimasa Sawada
- Journal Title
  
  Virchows Archiv
  
  Volume: 469 Issue: 4 Pages: 417-426
- DOI
  10.1007/s00428-016-1984-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-16K08693
[Journal Article] Analysis of the expression and localization of tight junction transmembrane proteins, claudin-1, -4, -7, occludin and JAM-A, in human cervical adenocarcinoma.2016
- Author(s)
  Akimoto T, Takasawa A, Murata M, Kojima Y, Takasawa K, Nojima M, Aoyama T, Hiratsuka Y, Ono Y, Tanaka S, Osanai M,Hasegawa T, Saito T, Sawada N.
- Journal Title
  
  Histol Histopathol
  
  Volume: 31(8) Pages: 921-931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693
[Journal Article] Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer2016
- Author(s)
  Akira Takasawa, Masaki Murata, Kumi Takasawa, Yusuke Ono, Makoto Osanai, Satoshi Tanaka, Masanori Nojima, Tsuyoshi Kono, Koichi Hirata, Takashi Kojima, Norimasa Sawada
- Journal Title
  
  Scientific Reports
  
  Volume: - Issue: 1
- DOI
  10.1038/srep33582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-15K08350
[Journal Article] Increased expressions of claudin 4 and 7in atypical adenomatous hyperplasia and adenocarcinoma of the lung.2016
- Author(s)
  Yamada G, Murata M, Takasawa A, Nojima M, Mori Y, Sawada N, Takahashi H.
- Journal Title
  
  Med Mol Morphol
  
  Volume: 49(3) Issue: 3 Pages: 163-169
- DOI
  10.1007/s00795-016-0135-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693
[Journal Article] Claudins in cancer: bench to bedside.2016
- Author(s)
  Osanai M, Takasawa A, Murata M, Sawada N.
- Journal Title
  
  Pflugers Ach
  
  Volume: 469(1) Issue: 5 Pages: 55-67
- DOI
  10.3892/or.2016.5072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08693
[Journal Article] Claudins in cancer: bench to bedside2016
- Author(s)
  Makoto Osanai, Akira Takasawa, Masaki Murata, Norimasa Sawada
- Journal Title
  
  Pflugers Archiv
  
  Volume: - Issue: 1 Pages: 55-67
- DOI
  10.1007/s00424-016-1877-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698
[Journal Article] Increased expressions of claudin 4 and 7 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.2016
- Author(s)
  Yamada G, Murata M, Takasawa A, Nojima M, Mori Y, Sawada N, Takahashi H.
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460421
[Journal Article] Claudin-binder C-CPE mutants enhance permeability of insulin across human nasal epithelial cells.2015
- Author(s)
  Kojima T, Kondoh M, Keira T, Takano KI, Kakuki T, Kaneko Y, Miyata R, Nomura K, Obata K, Kohno T, Konno T, Sawada N, Himi T.
- Journal Title
  
  Drug Deliv.
  
  Volume: 3 Pages: 1-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08350
[Journal Article] Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway.2015
- Author(s)
  Kono T, Kondoh M, Kyuno D, Ito T, Kimura Y, Imamura M, Kohno T, Konno T, Furuhata T, Sawada N, Hirata K, Kojima T.
- Journal Title
  
  Pharmacl Res Perspect.
  
  Volume: 3 Issue: 6
- DOI
  10.1002/prp2.196
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08350
[Journal Article] Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.2015
- Author(s)
  Tsujiwaki M, Murata M, Takasawa A, Hiratsuka Y, Fukuda R, Sugimoto K, Ono Y, Nojima M, Tanaka S, Hirata K, Kojima T, Sawada N.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 48(1) Issue: 1 Pages: 33-43
- DOI
  10.1007/s00795-014-0074-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-15K08350
[Journal Article] An immunohistochemical marker panel including claudin-18, maspin, and p53 improves diagnostic accuracy of bile duct neoplasms in surgical and presurgical biopsy specimens.2015
- Author(s)
  Keira Y, Takasawa A, Murata M, Nojima M, Takasawa K, Ogino J, Higashiura Y, Sasaki A, Kimura Y, Mizuguchi T, Tanaka S, Hirata K, Sawada N, Hasegawa T.
- Journal Title
  
  Virchows Arch.
  
  Volume: 466(3) Issue: 3 Pages: 265-277
- DOI
  10.1007/s00428-014-1705-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-26460421
[Journal Article] Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.2015
- Author(s)
  Miyata R, Kakuki T, Nomura K, Ohkuni T, Ogasawara N, Takano K, Konno T, Kohno T, Sawada N, Himi T, Kojima T.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 761 Pages: 375-382
- DOI
  10.1016/j.ejphar.2015.04.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-15K10788, KAKENHI-PROJECT-26670746, KAKENHI-PROJECT-26293370
[Journal Article] Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.2014
- Author(s)
  Kyuno D, Yamaguchi H, Ito T, Kono T, Kimura Y, Imamura M, Konno T, Hirata K, Sawada N, Kojima T.
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 20(31) Issue: 31 Pages: 10813-10824
- DOI
  10.3748/wjg.v20.i31.10813
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659592
[Journal Article] c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elogation of human pancreatic cancer cell line HPAC in a Ca-switch model.2014
- Author(s)
  Konno T, Ninomiya T, Kohno T, Kikuchi S, Sawada N, Kojima T.
- Journal Title
  
  Histochem Cell Biol.
  
  Volume: 143(5) Issue: 5 Pages: 471-479
- DOI
  10.1007/s00418-014-1300-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-15K01419, KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-25750207
[Journal Article] Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells2014
- Author(s)
  Nomura K, Takano K, Himi T, Kojima T. (10名, 9, 10番)
- Journal Title
  
  Respir Res
  
  Volume: 18 Issue: 1 Pages: 15-21
- DOI
  10.1186/1465-9921-15-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-26293370
[Journal Article] Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.2014
- Author(s)
  Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S.
- Journal Title
  
  Biochemical and Biophysical Research Communications (BBRC).
  
  Volume: 455(3-4) Issue: 3-4 Pages: 205-211
- DOI
  10.1016/j.bbrc.2014.10.148
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-26670178
[Journal Article] Isogladine maleate regulates gap junctional intercellular communication-dependent epithelial barrier in human nasal epithelial cells.2014
- Author(s)
  Miyata R, Nomura K, Kakuki T, Takano K, Kohno T, Konno T, Sawada N, Himi T, Kojima T.
- Journal Title
  
  J Membr Biol.
  
  Volume: 248(2) Issue: 2 Pages: 327-336
- DOI
  10.1007/s00232-015-9774-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-26293370, KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-26670746
[Journal Article] Expression of tricellulin in epithelial cells and non-epithelial cells.2013
- Author(s)
  Kojima T, Ninomiya T, Konno T, Kohno T, Taniguchi M, Sawada N.
- Journal Title
  
  Histol Histopathol
  
  Volume: 28 Pages: 1383-1392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.2013
- Author(s)
  Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S, Hirakawa S, Nomura K, Takasawa A, Murata M, Tanaka S, Fuchimoto J, Fujii N, Tsutsumi H, Himi T, Sawada N.
- Journal Title
  
  PLoS One
  
  Volume: 8(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer.2013
- Author(s)
  Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
- Journal Title
  
  Carcinogenesis
  
  Volume: 34(6) Pages: 1232-1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells.2013
- Author(s)
  Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H.
- Journal Title
  
  PLoS One
  
  Volume: 8(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Tight junction-related human diseases.2013
- Author(s)
  Sawada N.
- Journal Title
  
  Pathol Int
  
  Volume: 63(1) Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions2013
- Author(s)
  Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N
- Journal Title
  
  Cell Tissue Res
  
  Volume: 351(1) Issue: 1 Pages: 73-84
- DOI
  10.1007/s00441-012-1512-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells.2013
- Author(s)
  Hirakawa S, Kojima T, Obata K, Okabayashi T, Yokota SI, Nomura K, Obonai T, Fuchimoto J, Himi T, Tsutsumi H, Sawada N.
- Journal Title
  
  J Med Virol
  
  Volume: 85(12) Pages: 2141-2150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano.2013
- Author(s)
  Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.
- Journal Title
  
  Cell Tissue Res.
  
  Volume: 354 Issue: 2 Pages: 481-494
- DOI
  10.1007/s00441-013-1676-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells2012
- Author(s)
  Fuchimoto J, Kojima T, Himi T(全12名2, 11番)
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 26(6) Issue: 6 Pages: 433-8
- DOI
  10.2500/ajra.2012.26.3814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24791795
[Journal Article] Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells2012
- Author(s)
  Kojima T, Sawada N
- Journal Title
  
  Ann N Y Acad Sci
  
  Volume: 1257 Issue: 1 Pages: 85-92
- DOI
  10.1111/j.1749-6632.2012.06579.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089
[Journal Article] Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines2012
- Author(s)
  Ogawa M, Kojima T, Someya M, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 138(2) Issue: 2 Pages: 323-338
- DOI
  10.1007/s00418-012-0956-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Targeting claudin-4 in human pancreatic cancer2012
- Author(s)
  Kojima T, Kyuno D, Sawada N
- Journal Title
  
  Expert Opinion on Therapeutic Targets
  
  Volume: 16 Issue: 9 Pages: 881-887
- DOI
  10.1517/14728222.2012.708340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089
[Journal Article] Regulation of IL-33 and TSLP in human nasal fibroblasts by proinflammatory cytokines2012
- Author(s)
  Nomura K, Kojima T, Himi T(全7名2. 6番)
- Journal Title
  
  Laryngoscope
  
  Volume: 122(6) Issue: 6 Pages: 1185-92
- DOI
  10.1002/lary.23261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659750
[Journal Article] The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis2012
- Author(s)
  Kamekura R, Kojima T, Himi T(全6名2, 6番)
- Journal Title
  
  Clin Exp Allergy
  
  Volume: 42(2) Issue: 2 Pages: 218-28
- DOI
  10.1111/j.1365-2222.2011.03867.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23590405, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659750
[Journal Article] Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer2012
- Author(s)
  Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N
- Journal Title
  
  Prostate
  
  Volume: 72(4) Issue: 4 Pages: 351-360
- DOI
  10.1002/pros.21436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23659187, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids.2011
- Author(s)
  Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
- Journal Title
  
  Acta Otolaryngol. 131
  
  Pages: 116-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791628
[Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.2011
- Author(s)
  Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T
- Journal Title
  
  Acta Otolaryngol. inpress
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791628
[Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
- Author(s)
  Kamekura R, Kojima T, Takashima A, Koizumi JI, Ogasawara N, Go M, Takano KI, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Histochem Cell Biol 133
  
  Pages: 339-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Kamekura RPPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.2010
- Author(s)
  Ogasawara N, Kojima T, Go M, Ohkuni T, Koizumi J, Masaki T, Murata M, Tanaka S, Fuchimoto J, Himi T, Sawada N
- Journal Title
  
  Pharmacol Res 61(6)
  
  Pages: 489-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Kamekura RThymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
- Author(s)
  Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Histochem Cell Biol 133(3)
  
  Pages: 339-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth.2010
- Author(s)
  Sawada K, Ariki S, Kojima T, Saito A, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Mitsuzawa H, Yokota SI, Sawada N, Fujii N, Takahashi H, Kuroki Y
- Journal Title
  
  J Biol Chem 285
  
  Pages: 8434-8443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1.2010
- Author(s)
  Osanai M, Sawada N, Lee GH
- Journal Title
  
  Oncogene 29
  
  Pages: 1135-1144
- NAID
  120002187918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
- Author(s)
  Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
- Journal Title
  
  Histochem Cell Biol. 133
  
  Pages: 339-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791628
[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth2010
- Author(s)
  Sawada K, et al.
- Journal Title
  
  J Biol Chem 285
  
  Pages: 8434-8443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.2009
- Author(s)
  (7)Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, Go M, Takano K, Himi T, Sawada N.
- Journal Title
  
  Med Mol Morphol. 22
  
  Pages: 204-211
- NAID
  10027269508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791628
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes.2009
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 1463-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.2009
- Author(s)
  Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, Go M, Takano K, Himi T, Sawada N
- Journal Title
  
  Med Mol Morphol 42
  
  Pages: 204-211
- NAID
  10027269508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390353
[Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells.2009
- Author(s)
  Ogasawara N, Kojima T, Go M, Fuchimoto J, Kamekura R, Koizumi J, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Biochem Biophys Res Commun 389
  
  Pages: 543-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] ヒト鼻粘膜の機能解析から見えてくること2009
- Author(s)
  氷見徹夫, 郷充, 近藤敦, 高野賢一, 正木智之, 小泉純一, 亀倉隆太, 大國毅, 小笠原徳子, 小島隆, 澤田典均
- Journal Title
  
  耳鼻咽喉科展望 52
  
  Pages: 9-18
- NAID
  130004911712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes.2009
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Son S, Takano K-I, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 1463-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390353
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Kamekura RInduction of JAM-A during differentiation of human THP-1 dendritic cells.2009
- Author(s)
  Ogasawara N, Kojima T, Go M, Fuchimoto J, Koizumi JI, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Biochem Biophys Res Commun 389(3)
  
  Pages: 543-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Thymic stromal lymphopoietin enhances tight junction barrier function of human nasal epithelial cells.2009
- Author(s)
  Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 338
  
  Pages: 283-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Kamekura RThymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.2009
- Author(s)
  Kojima T, Koizumi JI, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 338(2)
  
  Pages: 283-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, Osanai M, Murata M, Kojima T, Sawada N
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy2008
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Inatomi S, Ohguro H, Sawada N
- Journal Title
  
  Clinical Ophthalmology 2
  
  Pages: 233-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
- Author(s)
  Koizumi J, Kojima T, Ogasawara N,, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39(3)
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway2008
- Author(s)
  Hatakeyama N, Kojima T, Iba K, Murata M, Thi MM, Spray DC, Osanai M, Chiba H, Ishii S, Yamashita T, Sawada N
- Journal Title
  
  Cell Tissue Res 334
  
  Pages: 243-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma2008
- Author(s)
  Satake S, Semba S, Matsuda Y, Usami Y, Chiba H, Sawada N, Kasuga M, Yokozaki H
- Journal Title
  
  Pathol Int 58
  
  Pages: 156-163
- NAID
  10027375982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Tight junction proteins claudin-2 and-12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.2008
- Author(s)
  Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H
- Journal Title
  
  Mol Biol Cell 19
  
  Pages: 1912-1921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transmembrane proteins of tight junctions2008
- Author(s)
  Chiba H, Osanai M, Murata M, Kojima T, Sawada N
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma.2008
- Author(s)
  Satake S, Semba S, Matsuda Y, Usami Y, Chiba H, Sawada N, Kasuga M, Yokozaki H
- Journal Title
  
  Pathol Int 58
  
  Pages: 156-163
- NAID
  10027375982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9.2008
- Author(s)
  Nishikiori N, Sawada N, Ohguro H
- Journal Title
  
  Jpn J Ophthalmol 52
  
  Pages: 195-203
- NAID
  10024154041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation2008
- Author(s)
  Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Mol Pharmacol 74
  
  Pages: 432-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway.2008
- Author(s)
  Hatakeyama N, Kojima T, Iba K, Murata M, Thi MM, Spray DC, Osanai M, Chiba H, Ishii S, Yamashita T, Sawada N
- Journal Title
  
  Cell Tissue Res 334
  
  Pages: 243-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transforming growth factor-β induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes2008
- Author(s)
  Kojima T, Takano K, Yamamoto T, Imamura M, Murata M, Son S, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Liver Int 28
  
  Pages: 534-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy.2008
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Inatomi S, Ohguro H, Sawada N
- Journal Title
  
  Clinical Ophthalmology 2
  
  Pages: 233-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Expression of thymic stromal lymphopoietin (TSLP) in allergic rhinitis: Induction of tight junction proteins in nasal epithelial cells and dendritic cells by epithelial-derived TSLP.2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J,, Kojima T, Koizumi J, Ogasawara N, Kurose M, Takano K, Go M, Himi T, Sawada N
- Journal Title
  
  Inflammation and Regeneration 28(3)
  
  Pages: 160-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] 粘膜のバリアと抗原サンプリング-鼻粘膜を介した新しい治療戦略にむけて2008
- Author(s)
  亀倉隆太, 小笠原徳子, 小泉純一, 黒瀬誠, 高野賢一, 澤田典均, 氷見徹夫
- Journal Title
  
  耳鼻咽喉科展望 51
  
  Pages: 32-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma2008
- Author(s)
  Nakayama F, Semba S, Usami Y, Chiba H, Sawada N, Yokozaki H
- Journal Title
  
  Pathobiology 75
  
  Pages: 177-185
- NAID
  120001408357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008
- Author(s)
  Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Mol Pharmacol 74
  
  Pages: 432-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transforming growth factor-βinduces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes.2008
- Author(s)
  Kojima T, Takano K, Yamamoto T, Imamura M, Murata M, Son S, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Liver Int 28
  
  Pages: 534-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Expression of thymic stromal lymphopoietin (TSLP) in allergic rhinitis : Induction of tight junction proteins in human nasal epithelial cells and dendritic cells by epithelial-derived TSLP.2008
- Author(s)
  Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Takano K, Go M, Himi T, Sawada N
- Journal Title
  
  Inflammation and Regeneration 28
  
  Pages: 160-165
- NAID
  10022602492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.2008
- Author(s)
  Nakayama F, Semba S, Usami Y, Chiba H, Sawada N, Yokozaki H
- Journal Title
  
  Pathobiology 75
  
  Pages: 177-185
- NAID
  120001408357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008
- Author(s)
  郷充, 小島隆,, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Mol Pharmacol 74(2)
  
  Pages: 432-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791207
[Journal Article] Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca^<2+> absorption between enterocytes2008
- Author(s)
  Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H
- Journal Title
  
  Mol Biol Cell 19
  
  Pages: 1912-1921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Heterogeneous expression of claudin-4 in human colorectal cancer : decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis2007
- Author(s)
  Ueda J, Semba S, Chiba H, Sawada N, Seo Y, Kasuga M, Yokozaki H
- Journal Title
  
  Pathobiology 74
  
  Pages: 32-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Ohguro H, Sawada N
- Journal Title
  
  Invest Ophthalmol Vis Sci 48
  
  Pages: 2224-2229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells.2007
- Author(s)
  Osanai M, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1557-1562
- NAID
  10019997370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions.2007
- Author(s)
  Imamura M, Kojima T, Lan M, Son S, Murata M, Osanai M, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 1951-1962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Gastric and intestinal claudin expression at the invasive front of gastric carcinoma.2007
- Author(s)
  Matsuda Y, Semba S, Ueda J, Fuku T, Hasuo T, Chiba H, Sawada N, Kuroda Y, Yokozaki H
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1014-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span2007
- Author(s)
  Kurose M, Kojima T, Koizumi J, Kamekura R, Ninomiya T, Murata M, Ichimiya S, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 330
  
  Pages: 63-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Gastric and intestinal claudins expression at the invasive front of gastric carcinoma2007
- Author(s)
  Matsuda Y, Semba S, Ueda J, Fuku T, Hasuo T, Chiba H, Sawada N, Kuroda Y, Yokozaki H
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1014-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system.2007
- Author(s)
  Koizumi J, Kojima T, Kamekura R, Kurose M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Membr Biol 218
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Cellular retinoic acid bioavailability determines epithelial integrity : role of retinoic acid receptor alpha agonists in colitis2007
- Author(s)
  Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions.2007
- Author(s)
  Imamura M, Kojima T, Lan M, Son S, Murata M, Osanai M, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 1951-1962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390353
[Journal Article] 肝細胞タイト結合, claudinと肝小葉.2007
- Author(s)
  小島隆, 村田雅樹, 澤田典均
- Journal Title
  
  肝胆膵 55(1)
  
  Pages: 45-54
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells.2007
- Author(s)
  Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1027-1034
- NAID
  120002187916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Ohguro H, Sawada N
- Journal Title
  
  Invest Ophth Vis Sci 48
  
  Pages: 2224-2229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system2007
- Author(s)
  Koizumi J, Kojima T, Kamekura R, Kurose M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Membr Biol 218
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] nduction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span.2007
- Author(s)
  Kurose M, Kojima T, Koizumi J, Kamekura R, Ninomiya T, Murata M, Ichimiya S, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 330
  
  Pages: 63-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] A novel monoclonal antibody against second extracellular loop of occludin disrupts epithelial cell polarity2007
- Author(s)
  Tokunaga Y, Kojima T, Osanai M, Murata M, Chiba H, Tobioka H, Sawada N
- Journal Title
  
  J Histochem Cytochem 55
  
  Pages: 735-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression patterns of claudin family of tight-junction proteins in the mouse prostate.2007
- Author(s)
  Sakai N, Chiba H, Fujita H, Akashi Y, Osanai M, Kojima T, Sawada N
- Journal Title
  
  Histochem Cell Biol 127
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Connexins induce and maintain tight junctions in epithelial cells.2007
- Author(s)
  Kojima T, Murata M, Go M, Spray DC, Sawada N
- Journal Title
  
  J Membr Biol 217
  
  Pages: 13-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, Sawada N
- Journal Title
  
  Diabetes 56
  
  Pages: 1333-1340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis.2007
- Author(s)
  Ueda J, Semba S, Chiba H, Sawada N, Seo Y, Kasuga M, Yokozaki H
- Journal Title
  
  Pathobiology 74
  
  Pages: 32-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells2007
- Author(s)
  Osanai M, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1557-1562
- NAID
  10019997370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis.2007
- Author(s)
  Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy.2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, Sawada N
- Journal Title
  
  Diabetes 56
  
  Pages: 1333-1340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] A novel monoclonal antibody against the second extracellular loop of occludin disrupts epithelial cell polarity.2007
- Author(s)
  Tokunaga Y, Kojima T, Osanai M, Murata M, Chiba H, Tobioka H, Sawada N
- Journal Title
  
  J Histochem Cytochem 55
  
  Pages: 735-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions2007
- Author(s)
  Imamura M, Kojima T, Lan M, Son S, Murata M, Osanai M, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 1951-1962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells2007
- Author(s)
  Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1027-1034
- NAID
  120002187916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression patterns of claudin family of tight-junction proteins in the mouse prostate2007
- Author(s)
  Sakai N, Chiba H, Fujita H, Akashi Y, Osanai M, Kojima T, Sawada N
- Journal Title
  
  Histochem Cell Biol 127
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Tight junctions and human diseases.2003
- Author(s)
  Sawada N et al.
- Journal Title
  
  Med Electron.Microsc. 36
  
  Pages: 147-156
- NAID
  10011995656
- Data Source
  KAKENHI-PROJECT-15590306
[Journal Article] "すきま"の細胞生物学細胞間接着装置タイト結合とヒト疾患2003
- Author(s)
  澤田典均他
- Journal Title
  
  札幌医学雑誌 72
  
  Pages: 1-7
- NAID
  110000453515
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] Tight junctions and human diseases2003
- Author(s)
  Sawada N et al.
- Journal Title
  
  Med Electron Microsc 36
  
  Pages: 147-156
- NAID
  10011995656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] Tight junctions and human diseases2003
- Author(s)
  Sawada N.
- Journal Title
  
  Med Electron Microsc. 36
  
  Pages: 147-156
- NAID
  10011995656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590306
[Journal Article] Tight junctions and human disease.2003
- Author(s)
  Sawada N et al.
- Journal Title
  
  Med Electron Microsc. 36
  
  Pages: 147-156
- NAID
  10011995656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590306
[Journal Article] "すきま"の細胞生物学-細胞間接着装置タイト結合とヒト疾患-2003
- Author(s)
  澤田典均他
- Journal Title
  
  札幌医学雑誌 72
  
  Pages: 1-7
- NAID
  110000453515
- Data Source
  KAKENHI-PROJECT-15590306
[Journal Article] "すきま"の細胞生物学細胞間接着装置タイト結合とヒト疾患2003
- Author(s)
  澤田典均他
- Journal Title
  
  札幌医学雑誌 72
  
  Pages: 1-7
- NAID
  110000453515
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590306
[Journal Article] Tight junctions and human diseases.2003
- Author(s)
  Sawada N et al.
- Journal Title
  
  Med Electron Microsc. 36
  
  Pages: 147-156
- NAID
  10011995656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] すきまの細胞生物学-細胞間接着装置タイト結合とヒト疾患-2003
- Author(s)
  澤田典均
- Journal Title
  
  札幌医学雑誌 72
  
  Pages: 1-7
- NAID
  110000453515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590306
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Presentation] CYP24A1-indiced vitamin D insufficiency promotes breast cancer growth2017
- Author(s)
  Osanai M, Takasawa A, Takasawa K, Murata M, Sawada N
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08697
[Presentation] Claudin-18 はEGFR/ERK 経路を介して胆道癌悪性化に関与する2017
- Author(s)
  高澤啓，小山内誠，澤田典均
- Organizer
  2017年　日本癌学会
- Data Source
  KAKENHI-PROJECT-17K08697
[Presentation] 子宮頚部腺癌におけるタイト結合関連たんぱく質の免疫組織化学的検討2016
- Author(s)
  高澤　啓、秋元　太志、村田　雅樹、青山　智志、田中　敏、小山内　誠、長谷川　匡、澤田　典均
- Organizer
  日本病理学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460421
[Presentation] 肝細胞移植の展望2012
- Author(s)
  中村幸雄、水口徹、川本雅樹、太田盛道、目黒誠、信岡隆幸、木村康利、古畑智久、平田公一、谷水直樹、三高俊広、村田雅樹、沢田典均
- Organizer
  第112回日本外科学会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-22390259
[Presentation] ヒト膵管上皮細胞培養系の確立とタイト結合蛋白claudinを標的とした膵癌治療基礎解析.2009
- Author(s)
  山口洋志, 小島隆, 伊東竜哉, 木村康利, 澤田典均, 平田公一
- Organizer
  第40回日本膵臓学会
- Place of Presentation
  東京
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 正常ヒト鼻粘膜上皮バリア調節機構へのTLRの関与.2009
- Author(s)
  大國毅, 小島隆, 小笠原徳子, 正木智之, 氷見徹夫, 澤田典均
- Organizer
  第8回コネキシン研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体PPAR-γを介したヒト鼻粘膜におけるタイト結合の発現調節機構.2009
- Author(s)
  小笠原徳子, 小島隆, 郷充, 亀倉隆太, 大國毅, 正木智之, 村田雅樹, 田中敏, 千葉英樹, 氷見徹夫, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 新規タイト結合蛋白tricellulinのJun N-terminal kinase (JNK)経路を介した発現調節機構の解明.2009
- Author(s)
  小島隆, 澤田典均
- Organizer
  第8回コネキシン研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 膵癌細胞株のPKCシグナル異常におけるタイト結合蛋白の変化.2009
- Author(s)
  伊東竜哉, 小島隆, 山口洋志, 村田雅樹, 田中敏, 千葉英樹, 平田公一, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] タイト結合:すきまの細胞生物学からヒト病態へ2008
- Author(s)
  澤田典均
- Organizer
  第21回日本外科感染症学会
- Place of Presentation
  札幌
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体PPAR-gammaを介したヒト鼻粘膜上皮細胞および樹状細胞のタイト結合の発現調節機構.2008
- Author(s)
  小笠原徳子, 小島隆, 郷充, 亀倉隆太, 澤田典均, 氷見徹夫
- Organizer
  日本アレルギー学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] ヒト鼻粘膜におけるタイト結合蛋白tricellulinの発現調節2008
- Author(s)
  大國毅, 小島隆, 亀倉隆太, 小笠原徳子, 菊池真, 二宮孝文, 氷見徹夫, 澤田典均
- Organizer
  第40回日本臨床分子形態学学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体PPAR-gammaを介したヒト鼻粘膜上皮細胞および樹状細胞のタイト結合の発現調節機構.2008
- Author(s)
  小笠原徳子, 小島隆, 郷充, 亀倉隆太, 澤田典均, 氷見徹夫
- Organizer
  第29回日本炎症再生学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く.ワークショップ「細胞接着・細胞外基質・細胞間相互作用」2007
- Author(s)
  千葉英樹, 村田雅樹, 小山内誠, 二宮孝文, 小島隆, 澤田典均
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 肝疾患の病態とタイト結合2007
- Author(s)
  澤田典均, 他
- Organizer
  第4回日本病理学会カンファレンス「肝疾患研究の最前線:現状と課題」
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 肝疾患の病態とタイト結合.2007
- Author(s)
  澤田典均, 村田雅樹, 小山内誠, 千葉英樹小島隆
- Organizer
  第4回日本病理学会カンファレンス「肝疾患研究の最前線:現状と課題」
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く2007
- Author(s)
  千葉英樹, 村田雅樹, 小山内誠, 二宮孝文, 小島隆, 澤田典均
- Organizer
  ワークショップ「細胞接着・細胞外基質・細胞間相互作用」第40回日本発生生物学会・第59回日本細胞生物学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590398
[Presentation] 胆道癌におけるclaudin-18の発現と調節機構および機能解析
- Author(s)
  高澤啓、村田雅樹、計良淑子、田中敏、澤田典均
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26460421

1. KOJIMA Takashi (30260764)

# of Collaborated Projects: 9 results

# of Collaborated Products: 68 results
2. CHIBA Hideki (00295346)

# of Collaborated Projects: 8 results

# of Collaborated Products: 52 results
3. MORI Michio (00045288)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. HATTORI Atsuo (90208538)

# of Collaborated Projects: 4 results

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5. KOKAI Yasuo (20178239)

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6. MURATA Masaki (10404592)

# of Collaborated Projects: 4 results

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7. TOBIOKA Hirotoshi (90291559)

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8. TANAKA Satoshi (30374250)

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17. OYAMADA Yumiko (40231245)

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18. HIRATA Koichi (50136959)

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19. MITAKA Toshihiro (50231618)

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21. KAWAMOTO Masaki (70404605)

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22. NAKAMURA Yukio (50516648)

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23. KAMEKURA Ryuta (70404697)

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24. GO Mitsuru (80448604)

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25. TAKANO Kenichi (70404689)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
26. OYAMADA Masahito (30183255)

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27. 増井徹 (50150082)

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28. INATOMI Syuichiro (10437999)

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29. KONDOH Atsushi (40457718)

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32. YAMA Naoya (20404709)

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33. TATSUMI Hiroomi (70404613)

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34. OTA Shigenori (90457705)

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35. FUJII Miho (00260761)

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36. KUDO Ryuichi (70045409)

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37. SAGAE Satoru (00187056)

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38. ENDO Toshiaki (90213595)

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39. IKEDA Tatsuru (40202890)

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40. Osanai Makoto (60381266)

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58. 高橋素子

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Sawada Norimasa 澤田 典均

SAWADA NORIMASA 澤田 典均

SAWADA Norimasa 澤田 典均

沢田 典均 サワダ ノリマサ

澤田 典均 サワダ ノリマサ

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Changes of tight junctions induced by extracellular stimuli determine cell shape and fate.Principal Investigator

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Patho-physiology of the tight junction-mainly focusing on human normal epithelial cells.Principal Investigator

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Pathobiology of the tight junction : from cell biology of paracellular pathway to bed-sidePrincipal Investigator

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骨粗鬆症とタイト結合:occludinノックアウトマウスを用いた解析Principal Investigator

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Sawada Norimasa 澤田典均

SAWADA NORIMASA 澤田典均

SAWADA Norimasa 澤田典均

沢田典均サワダノリマサ

澤田典均サワダノリマサ