HASHIMOTO Shu 橋本修

Researcher Number	30159090
Other IDs
External Links
Affiliation (Current)	2022: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2014: 日本大学, 医学部, 教授 1998 – 2005: 日本大学, 医学部, 講師 2002 – 2003: 日本医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Neurology
Keywords	Principal Investigator MAP kinase / COPD / 気道上皮細胞 / MAPキナーゼ / ASK1 / アポトーシス / airway epithelial cell / 気道炎症 / bronchial asthma / A20 … More / インフルエンザウイルス / RANTES / IL-8 / Influenza virus infection / cytokine / 気管支喘息 / 酸化ストレス / 気道平滑筋 / 気道リモデリング / 肺血管内皮細胞 / 喫煙 / MMP9 / TIMP / oxidative stress / COPPD / ASK-1 / 炎症 / toll lie receptor / Toll-like recetor / Toll-like receptor / toll-like receptor … More Except Principal Investigator 結核性髄膜炎 / NAT2 / 遺伝子多型 / 治療 / 気管上皮細胞 / 高浸透圧 / 運動誘発性喘息 / サイトカイン / p38MAPキナーゼ / JNK / 高侵透圧 / p38 MAPキナーぜ / 低温ストレス / 高浸透圧ストレス / p38マップキナーゼ / exercise-induced asthma / hyperosmolarity / cooling / cytokine / airway epithelial cell / MAP kinase / インターフェロンβ / インターフェロンγ / 肺線維症 / 間質性肺炎 / 線維芽細胞 / Interferon-g / Interferon-b / Pulmonary Fibrosis / Interstitial Pneuminia / Fibroblast Less

Development of personalized treatment based on polymorphism of drug-metabolizing enzyme gene in tuberculous meningitis
- Principal Investigator
  
  KAMEI Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nihon University
Analysis of molecular and genetic mechanism in the pathogenesis of COPD and bronchial asthmaPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Shu, 堀江孝至
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nihon University
Analysis of signaling molecules in the pathogenesis of COPD and bronchial asthmaPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Shu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nihon University
Research in Mechanisms of Action Regarding Inhibitory Effects of Interferon-γ and -β in Intracellular Signal Transduction.
- Principal Investigator
  
  AZUMA Arata
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Analysis of the mechanism in the production of airway inflammation caused by influenza virus infection : role of mitogen-activated protein kinase in bronchial epitheliumPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Shu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nihon University
Analysis of the intracellular signals regulating hyperosmolarity-and cooling-induced cytokine expression in bronchial epithelium
- Principal Investigator
  
  HORIE Takashi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nihon University

All 2006 2005 2004 2003

All Journal Article Book

[Book] 酸化ストレスナビゲーター基礎編細胞応答制御第III章細胞応答制御B.各種細胞の応答5.気道上皮細胞2005
- Author(s)
  橋本修
- Total Pages
  321
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15390260
[Book] 酸化ストレスナビゲーター基礎編細胞応答制御第III章細胞応答制御B.各種細胞の応答5.軌道上皮細胞2005
- Author(s)
  橋本修
- Total Pages
  331
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Book] Mitogen-activated protein kinase in airway inflammation, in Proceedings of the 24^<th> Symposium of the Collegium Internationale Allergologium, Ring J, Bienenstock J and Togisas AG.Ed.Hogrefe2004
- Author(s)
  橋本修
- Total Pages
  353
- Publisher
  Huber Publishers
- Data Source
  KAKENHI-PROJECT-14570568
[Book] Mitogen-activated protein kinase in airway inflammation, in Proceedings of the 24^<th> Symposium of the Collegium Internationale Allergologium, Ring J, Bienenstock J and Togisas AG. Ed. Hogrefe2004
- Author(s)
  橋本修
- Total Pages
  353
- Publisher
  Huber Publishers
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Book] COPDのマネージメント2004
- Author(s)
  橋本修
- Total Pages
  115
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15390260
[Book] 病態生理のトピックス.6.細胞内刺激伝達系。SIRSの病態と治療2003
- Author(s)
  橋本修
- Total Pages
  317
- Publisher
  医薬ジャーナル社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] An inhibitory effect of A20 on NF-kB activation in airway epithelium upon influenza virus infection2006
- Author(s)
  橋本修
- Journal Title
  
  Eur J Pharmacol (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] An inhibitory effect of A20 on NE-kB activation in airway epithelium upon influenza virus infection.2006
- Author(s)
  Onose A, Hashimoto_S, Hayashi S, Maruoka S, Kumasawa F, Mizumura K, Jibiki I, Matsumoto K, Gon Y, Kobayashi T, Takahashi N, Shibata Y, Abiko Y, Shibata T, Shimizu K, Horie T.
- Journal Title
  
  Eur J Pharmacol. (Accepted for the publication)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.2006
- Author(s)
  Mizumura K, Takeda K, Hashimoto_S, Horie T, Ichijo H.
- Journal Title
  
  J Cell Physiol. 206(2)
  
  Pages: 363-370
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] An inhibitory effect of A20 on NF-kB activation in airway epithellum upon influenza virus infection2006
- Author(s)
  橋本修
- Journal Title
  
  Eur J Pahrmacol (印刷中)
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Interferon-□ Inhibits Bleomycin-Induced Lung Fibrosis by Decreasing TGF-β and Thrombospondin.2005
- Author(s)
  A Azuma, YJ Li, J Usuki, S Abe, K Matsuda, S Henmi, Y Miyauchi, A Izawa, S Sone, S Hashimoto, S Kudoh
- Journal Title
  
  Am J Respir Crit Care Med 171
  
  Pages: 1040-1047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570569
[Journal Article] Apoptosis signal- regulating kinase 1 in leukotriene D_4-induced activator protein-1 in airway smooth muscle cells.2005
- Author(s)
  橋本修
- Journal Title
  
  Eur J Pharmacol 517
  
  Pages: 11-16
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] 症例とQ&Aで学ぶガイドラインに基づく喘息診療運動誘発性喘息2005
- Author(s)
  橋本修
- Journal Title
  
  今日の治療 13(3)
  
  Pages: 261-269
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells2005
- Author(s)
  橋本修
- Journal Title
  
  Eur J Pharmacol 517
  
  Pages: 11-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] COPDにおいて肺血管リモデリングが発生する機序2005
- Author(s)
  橋本修
- Journal Title
  
  日本医事新報 42222
  
  Pages: 102-103
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] COPDの診断 2.COPDの鑑別診断 1)炎症マーカー2005
- Author(s)
  橋本修
- Journal Title
  
  化学療法の領域21 56
  
  Pages: 56-67
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells.2005
- Author(s)
  Kumasawa F, Hashimoto S, Onose A, Jibiki I, Mizumura K, Matsumoto K, Maruoka S, Gon Y, Kobayashi T, Takahashi N, Ichijo H, Horie T.
- Journal Title
  
  Eur J Pharmacol. 517(1-2)
  
  Pages: 11-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide -induced apoptosis in human pulmonary vascular endothelial cells.2004
- Author(s)
  橋本修
- Journal Title
  
  Crit Care Med 31812)
  
  Pages: 2776-2781
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] COPDを診断しよう2004
- Author(s)
  橋本修
- Journal Title
  
  Medical Practice 21(8)
  
  Pages: 1490-1490
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Asthma controlの再評価とtotal asthma control2004
- Author(s)
  橋本修
- Journal Title
  
  COPD FRONTIER 3(3)
  
  Pages: 83-87
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] 薬物療法のシンポが生んだ診断治療概念のup-to-date。COPD2004
- Author(s)
  橋本修
- Journal Title
  
  COPD FRONTIER 3(1)
  
  Pages: 72-77
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] Interferon-β attenuates bleomycin-induced pulmonary fibrosis by decreasing levels of thrombos pondin.2004
- Author(s)
  橋本修
- Journal Title
  
  Am J Respir Cell Mol Biol 32(3)
  
  Pages: 93-98
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] A 20 inhibits toll-like receptor 2 and 4-mediated interleukin-8 synthesis in airway epithelial cells2004
- Author(s)
  橋本修
- Journal Title
  
  Am J Respir Cell Mol Biol 31
  
  Pages: 330-336
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] A 20 inhibits toll-like receptor 2 and 4-mediated interleukin-8 synthesis in airway epithelial cells.2004
- Author(s)
  Gon Y, Asai Y, Hashimoto S, Mizumura K, Jibiki I, Mchino T, Ra C, Horie T
- Journal Title
  
  Am J Respir Cell Mol Biol. 31
  
  Pages: 330-336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] Interferon-β attenuates bleomycin-induced pulmonary fibrosis by decreasing levels of thrombospondin.2004
- Author(s)
  Azuma A, Li YJ, Abe S, Usuki J, Matsuda K, Henmi S, Miyauchi Y, Ueda K, Izawa A, Sone S, Hashimoto S, Kudoh S.
- Journal Title
  
  Am J Respir Cell Mol Biol 32
  
  Pages: 93-98
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] 肺疾患とtoll-like receptor2004
- Author(s)
  橋本修
- Journal Title
  
  呼吸と循環 52(8)
  
  Pages: 811-817
- NAID
  40020000088
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] COPD治療のup-to-date2004
- Author(s)
  橋本修
- Journal Title
  
  呼吸と循環 52(12)
  
  Pages: 2311-1239
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] ASK1 regulates influenza virus infection-induced apoptotic cell death.2003
- Author(s)
  橋本修
- Journal Title
  
  Biochem Biophys Res Commun. 307(4)
  
  Pages: 870-876
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] 気管上皮細胞による微生物監視機構2003
- Author(s)
  橋本修
- Journal Title
  
  呼吸と循環 51(2)
  
  Pages: 153-158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260
[Journal Article] ASK1 regulates influenza virus infection-induced apoptotic cell death.2003
- Author(s)
  Maruoka S, Hashimoto S, Gon Y, Nishitoh H, Takeshita I, Asai Y, Mizumura K, Shimizu K, Ichijo H, Horie T
- Journal Title
  
  Biochem Biophys Res Commun. 307(4)
  
  Pages: 870-876
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] ASK1 regulates influenza virus infection-induced apoptotic cell death.2003
- Author(s)
  橋本修
- Journal Title
  
  Biochem Biophys Res Commun 307(4)
  
  Pages: 870-876
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] Role of mitogen-activated protein kinases in influenza virus induction of prostaglandin E2 from arachidonic acid in bronchial epithelial cells.2003
- Author(s)
  Mizumura K, Hashimoto S, Maruoka S, Gon Y, Kitamura N, Matsumoto K, Hayashi S, Shimizu K, Horie T
- Journal Title
  
  Clin Exp Allergy. 33(9)
  
  Pages: 1244-1251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] Role of mitogen-activated protein kinases in influenza virus induction of prostaglandin E2 from arachidonic acid in bronchial epithelial cells.2003
- Author(s)
  橋本修
- Journal Title
  
  Clin Exp Allergy 33(9)
  
  Pages: 1244-1251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells.2003
- Author(s)
  Machine T, Hashimoto S, Maruoka S, Gon Y, Shinichi H, Nishitoh H, Ichijo H, Horie T
- Journal Title
  
  Crit Care Med. 31(12)
  
  Pages: 2776-2781
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570568
[Journal Article] Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.2003
- Author(s)
  橋本修
- Journal Title
  
  J Cell Physiol 206
  
  Pages: 363-370
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390260

1. HORIE Takashi (60090081)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. SHIMIZU Kazufumi (50004677)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. KAMEI Satoshi (40142509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKAYAMA Tomohiro (00339334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MORITA Akihiko (80547117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SASAKI Hidenao (80281806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ARAKI Nobuo (70151157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. AZUMA Arata (10184194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KUDOH Shoji (40256912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KABAYASHI Tomoko (10343576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 権寧博 (80339316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

HASHIMOTO Shu 橋本 修

Research Projects

Research Products

Co-Researchers

Development of personalized treatment based on polymorphism of drug-metabolizing enzyme gene in tuberculous meningitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular and genetic mechanism in the pathogenesis of COPD and bronchial asthmaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of signaling molecules in the pathogenesis of COPD and bronchial asthmaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research in Mechanisms of Action Regarding Inhibitory Effects of Interferon-γ and -β in Intracellular Signal Transduction.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism in the production of airway inflammation caused by influenza virus infection : role of mitogen-activated protein kinase in bronchial epitheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the intracellular signals regulating hyperosmolarity-and cooling-induced cytokine expression in bronchial epithelium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 酸化ストレスナビゲーター基礎編 細胞応答制御第III章細胞応答制御B.各種細胞の応答5.気道上皮細胞2005

Author(s)

Total Pages

Publisher

Data Source

[Book] 酸化ストレスナビゲーター基礎編 細胞応答制御第III章細胞応答制御B.各種細胞の応答5.軌道上皮細胞2005

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] Mitogen-activated protein kinase in airway inflammation, in Proceedings of the 24^<th> Symposium of the Collegium Internationale Allergologium, Ring J, Bienenstock J and Togisas AG.Ed.Hogrefe2004

Author(s)

Total Pages

Publisher

Data Source

[Book] Mitogen-activated protein kinase in airway inflammation, in Proceedings of the 24^<th> Symposium of the Collegium Internationale Allergologium, Ring J, Bienenstock J and Togisas AG. Ed. Hogrefe2004

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] COPDのマネージメント2004

Author(s)

Total Pages

Publisher

Data Source

[Book] 病態生理のトピックス.6.細胞内刺激伝達系。SIRSの病態と治療2003

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] An inhibitory effect of A20 on NF-kB activation in airway epithelium upon influenza virus infection2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] An inhibitory effect of A20 on NE-kB activation in airway epithelium upon influenza virus infection.2006

Author(s)

HASHIMOTO Shu 橋本修

[Book] 酸化ストレスナビゲーター基礎編細胞応答制御第III章細胞応答制御B.各種細胞の応答5.気道上皮細胞2005

[Book] 酸化ストレスナビゲーター基礎編細胞応答制御第III章細胞応答制御B.各種細胞の応答5.軌道上皮細胞2005

[Journal Article] 症例とQ&Aで学ぶガイドラインに基づく喘息診療運動誘発性喘息2005