Okuda Haruhiro 奥田晴宏

… Alternative Names

OKUDA Haruhiro 奥田晴宏

OKUDA Haruhiro Research 奥田晴宏

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Researcher Number	30160807
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 有機化学部, 客員研究員
Affiliation (based on the past Project Information) *help	2012: 国立医薬品食品衛生研究所, 副所長 2011: 国立医薬品食品衛生研究所, 薬品部, 部長 2005 – 2010: 国立医薬品食品衛生研究所, 有機化学部, 部長 1992: Tokyo College of Pharmacy, Hygienic Chemistry, Lecture, 薬学部, 構師 1990 – 1992: 東京薬科大学, 薬学部, 講師 1986 – 1988: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy Except Principal Investigator Biological pharmacy / Drug development chemistry
Keywords	Principal Investigator oxidative stress / reactive oxygen species / alkvlamine / fenfluramin / N-nitrsofenfluramine / N-nitrosocomnound / N-ニトロソ化合物 / 酸化ストレス / 活性酸素 / アルキルアミン / フェンフルラミン / N-ニトロソフェンフルラミン / N-ニトロソ化合 … More Except Principal Investigator … More 活性酸素 / 抗酸化剤 / 脂質過酸化物 / 脂肪酸ヒドロペルオキシド / 脂質過酸化 / ポリフェノール / 酸化ストレス / カテキン / Leukotriene A_4 / Glutathione peroxidase / Epoxide / Fatty acid hydroperoxide / Microsomal lipid peroxidation / Active oxygen / アフラトキシン【B_1】 / ジヒドロベンゾ〔a〕ピレン / 膜脂質アラキドン酸 / 脂質パーオキシラジカル / 肝ミクロゾームの脂質過酸化 / 変異原性エポキシド / パーオキシラジカル / 肝小胞体膜リン脂質 / 肝ミクロゾーム脂質過酸化 / エポキシドヒドロラーゼ / ロイコトリエンA_4 / グルタチオンペルオキシダーゼ / エポキシド / ミクロゾーム脂質過酸化 / 活性酵素 / chemoorevention / oxidatiye stress / reactive oxygen species / polyphenol / flavonoid / catechin / antioxidant / アポトーシス / 予防物質 / フラボノイド / Aging / Marker Substanec in Aging / Cholesterol Hydroperoxide / Phospholipid Hydroperoxide / Glutathione S-Transferase / Biomembrane / Lipid Peroxidation / Oxygen Free Radical / グルタチオントランスフェラ-ゼ / 肝細胞質 / グルタチオンペルオキシダ-ゼ / グルタチオン / 酸素フリ-ラジカル / 肝ミクロソ-ム / cDNAクローニング / グルタチオンペルオキシダーゼ活性 / 生体膜防御機構 / 過酸化脂質 / ミクロソーム / ラット肝 / 老化 / 加齢マーカー物質 / コレステロールヒドロペルオキシド / リン脂質ヒドロペルオキシド / グルタチオンS-トランスフェラーゼ / 生体膜 / 酸素フリーラジカル / レスベートロール / アルツハマー / アルツハイマー / 生活習慣病 / ビタミンE / アルツハイマー病 Less

Studies on synthetic antioxidants for prevention of oxidative stress-related diseases
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design and Synthesis of Antioxidant for a New Type of Chemopreventive Agents
- Principal Investigator
  
  KIYUOSHI Fukuhara
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygenPrincipal Investigator
- Principal Investigator
  
  OKUDA Haruhiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
A Novel Mechanism for Protecting of Biomembrane from Oxidative Disorder by Oxygen Free Radicals
- Principal Investigator
  
  WATABE Tadashi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo College of Pharmacy
Oxidation of xenobiotics by active peroxyradicals derived from lipids of hepatic endoplasmic reticulum
- Principal Investigator
  
  WATABE Tadashi Professor
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo College of Pharmacy

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013
- Author(s)
  Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 52 Issue: 2 Pages: 133-138
- DOI
  10.3164/jcbn.12-118
- NAID
  130004466706
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-24590397
[Journal Article] A New Approach to Characterization of Insulin Derived from Different Species Using 1H-NMR Coupled with Multivariate Analysis2012
- Author(s)
  A. Ohno, T. Kawanishi, H. Okuda, K. Fukuhara, K.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 3 Pages: 320-324
- DOI
  10.1248/cpb.60.320
- NAID
  130001852416
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 4 Pages: 1793-1796
- DOI
  10.1016/j.bmcl.2011.11.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
[Journal Article] A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity2011
- Author(s)
  K. Fukuhara, A. Ohno, Y. Ando, T. Yamoto, H. Okuda
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 4 Pages: 399-406
- DOI
  10.2133/dmpk.DMPK-11-RG-005
- NAID
  130004463199
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Synthesis and enhanced radical scavenging activity of a conformationally constrained epigallocatechin analogue2011
- Author(s)
  K. Imai, I. Nakanishi, A. Anzai, T. Ozawa, N. Miyata, S. Urano, H. Okuda, A. Nakamura, K. Fukuhara
- Journal Title
  
  Chem. Lett.
  
  Volume: 40 Issue: 12 Pages: 1417-1419
- DOI
  10.1246/cl.2011.1417
- NAID
  10030221524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-23590064
[Journal Article] Characterization of Tea Cultivated at Four Different Altitudes Using 1H NMR Analysis Coupled with Multivariate Statistics2011
- Author(s)
  A. Ohno, K. Oka, C. Sakuma, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Agric. Food Chem
  
  Volume: 59 Issue: 10 Pages: 5181-5187
- DOI
  10.1021/jf200204y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Complete NMR analysis of oxytocin in phosphate buffer2010
- Author(s)
  A. Ohno, N. Kawasaki, K. Fukuahra, H. Okuda, T. Yamaguchi
- Journal Title
  
  Magn. Reson. Chem
  
  Volume: 48 Issue: 2 Pages: 168-172
- DOI
  10.1002/mrc.2557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Intramolecular base-accelerated radicalscavenging reaction of a planar catechin derivative having a lysine moiety2009
- Author(s)
  K. Fukuahra, I. Nakanishi, K. Ohkubo, Y. Obara, A. Tada, K. Imai, A. Ohno, A. Nakamura, T. Ozawa, S. Urano, S. Saito, S. Fukuzumi, K. Anzai, N. Miyata, H. Okuda
- Journal Title
  
  Chem. Comm.
  
  Issue: 41 Pages: 6180-6182
- DOI
  10.1039/b913714a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative having a lysine moiety2009
- Author(s)
  K.Fukuahra, I.Nakanishi, K.Ohkubo, Y.Obara, A.Tada, K.Imai, A.Ohno, A.Nakamura, T.Ozawa, S.Urano, S.Saito, S.Fukuzumi, K.Anzai, N.Miyata, H.Okuda
- Journal Title
  
  Chem.Comm.
  
  Pages: 6180-6182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Novel Ninhydrin adduct of catechin with potent antioxidative activity2009
- Author(s)
  K.Fukuhara, A.Ohno, I.Nakanishi, K.Imai, A.Nakamura, K.Anzai, N.Miyata, H.Okuda
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 6989-6992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Enhanced Radical-Scavenging Activity of Naturally-Oriented Artepillin C Derivatives2008
- Author(s)
  S. Manda, I. Nakanishi, K. Ohkubo, Y. Uto, T. Kawashima. K. Fukuhara, H. Okuda, H. Hori, T. Ozawa, N. Ikota, S. Fukuzumi, K. Anzai
- Journal Title
  
  Chem. Commun.
  
  Pages: 626-628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Enhanced Radical-Scavenging Activity of Naturally-Oriented Artepillin C Derivatives2008
- Author(s)
  S. Manda, I. Nakanishi, K. Ohkubo, Y. Uto, T. Kawashima, K. Fukuhara, H. Okuda, H. Hori, T. Ozawa, N. Ikota, S. Fukuzumi, K. Anzai
- Journal Title
  
  Chem. Commumn.
  
  Pages: 626-628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, H Okuda, et. al.
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of MethyI Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K.Fukuhara, I.Nakanishi, A.Matsuoka, T.Matsumura, S.Honda, M.Hayashi, T.Ozawa, N.Miyata, S.Saito, N.Ikota, H.Okuda
- Journal Title
  
  Chem.Res.Toxicol. 21
  
  Pages: 282-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Present State of New Chiral Drug Development and Review in Japan2008
- Author(s)
  R. Shimazawa, N. Nagai, S. Toyoshima, H. Okuda
- Journal Title
  
  J. Health Sci. 54
  
  Pages: 23-29
- NAID
  110006570799
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 21 Issue: 2 Pages: 282-287
- DOI
  10.1021/tx7003008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K. Fukuhara, S. Oikawa, N. Hakota, Y. Sakai, Y. Hiraku. T. Shoda, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Involvement of Electron Transfer in the Radical-Scavenging Reaction of Resveratrol2007
- Author(s)
  I. Nakanishi, T. Shimada, K. Ohkubo, T. Shimizu, S.Urano, H. Okuda, N. Miyata, T. Ozawa, K. Anzai, S. Fukuzumi, N. Ikota, K. Fukuhara
- Journal Title
  
  Chem. Lett. 36
  
  Pages: 1276-1277
- NAID
  10019962015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] involvement of Electron Transfer in Radical-Scavenging Reaction of Resveratrol2007
- Author(s)
  I. Nakanishi, T. Shimada, K. Ohkuboo, T. Shimizu, S. Urano. H. Okuda, N. Miyata, T. Ozawa, K. Anzai, S. Fukuzumi, N. Ikota, K. Fukubara
- Journal Title
  
  Chem. Lett. 36
  
  Pages: 1276-1277
- NAID
  10019962015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K. Fukuhara, S. Oikawa, N. Hakota, Y. Sakai, Y. Hiraku, T. Shoda, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Structural basis for DNA cleaving-activity of resveratrol in the presence of Cu(II)2006
- Author(s)
  K. Fukuhara, M. Nagakawa, I. Nakanishi, K. Ohkubo, K. Imai, S. Urano, S. Fukuzumi, T. Ozawa, N. Ikota, M. Mochizuki, N. Miyata, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 1437-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Design and synthesis of α-glucosidase inhibitor having DNA cleaving activity2006
- Author(s)
  W. Hakamata, E. Yamamoto, M. Muroi, M. Mochizuki, M. Kurihara, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Appl. Glycosci 53
  
  Pages: 255-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Structural Basis for DNA Cleaving-Activity of Resveratrol om the Presence of Cu(II)2006
- Author(s)
  H.Okuda, K.Fukuhara et al.
- Journal Title
  
  Bioorg.Medi.Chem. 14
  
  Pages: 1437-1443
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Design and synthesis of α-glucosidase inhibitor having DNA cleaving activity2006
- Author(s)
  W. Hakamata, E. Yamamoto, M. Muroi, M. Mochizuki, M. Kurihara, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Appl. Glycosci 53
  
  Pages: 255-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] N-linked oligosaccharide processing enzymes as molecular targets for drug discovery2006
- Author(s)
  W. Hakamata, M. Muroi, T. Nishio, T. Oku, A. Takatsuki, H. Osada, K. Fukahara, H. Okuda, M. Kurihara
- Journal Title
  
  J. Appl. Glycosci 53
  
  Pages: 149-154
- NAID
  10016802897
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Planar catechin analogues with alkyl side chains, as a potent antioxidant and an α-glucosidase inhibitor2006
- Author(s)
  W. Hakamata, I. Nakanishi, Y. Masuda, T. Shimizu, H. Higuchi, Y. Nakamura, T. Oku, S. Saito, S. Urano, T. Ozawa, N. Ikota, N. Miyata, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Am. Chem. Soc 128
  
  Pages: 6524-6525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Planar catechin analogues with alkyl side chains, as a potent antioxidant and an α-glucosidase inhibitor2006
- Author(s)
  W. Hakamata, I. Nakanishi, Y. Masuda, T. Shimizu, H. Higuchi, Y. Nakamura, T. Oku, S. Saito, S. Urano, T. Ozawa, N. Ikota, N. Miyata, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Am. Chem. Soc. 128
  
  Pages: 6524-6525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] N-linked oligosaccharide processing enzymes as molecular targets for drug discovery2006
- Author(s)
  W. Hakamata, M. Muroi, T. Nishio, T. Oku, A. Takatsuki, H. Osada, K. Fukuhara, H. Okuda, M. Kurihara
- Journal Title
  
  J. App. Glycosci 53
  
  Pages: 149-154
- NAID
  10016802897
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Structural basis for DNA cleaving-activity of resveratorl in the presence of Cu(II)2006
- Author(s)
  K. Fukuhara, M. Nagakawa, I. Nakanishi, K. Ohkubo, K. Imai, S. Urano. S. Fukuzumi, T. Ozawa, N. Ikota, M. Mochizuki, N. Miyata, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 1437-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-Oxide by an NADH Analogue, Org.2005
- Author(s)
  Nakanishi, C. Nishizawa, K. Ohkubo, K. Takeshita, K. Suzuki, T. Ozawa, S. M. Hecht, M. Tanno, S. Sueyoshi, N. Miyata, H. Okuda, S. Fukuzumi, N. Ikota, K. Fukuhara
- Journal Title
  
  Biomol. Chem 3
  
  Pages: 3263-3265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-Oxide by an NADH Analogue2005
- Author(s)
  H.Okuda, K.Fukuhara et al.
- Journal Title
  
  Org.Biomol.Chem 3
  
  Pages: 3263-3265
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Electron-Tansfer Mechanism in Radical-Scavenging Reactions by a Vitamin E Model in a Protic Medium, Org.2005
- Author(s)
  I. Nakanishi, T. Kawashima, K. Ohkubo, H. Kanazawa, K. Inami, M. Mochizuki, K. Fukuhara, H. Okuda, T. Ozawa, S. Itoh, S. Fukuzumi, N. Ikota
- Journal Title
  
  Biomol. Chem 3
  
  Pages: 626-629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-Oxide by an NADH Analogue, Org.2005
- Author(s)
  Nakanishi, C. Nishizawa, K. Ohkubo, K. Takeshita, K. Suzuki, T. Ozawa, S. M. Hecht, M. Tanno, S. Sueyoshi, N. Miyata, H. Okuda, S. Fukuzumi, N. Ikota, K. Fukuhara
- Journal Title
  
  Biomol. Chem 3
  
  Pages: 3263-3265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Eclectron-Tansfer Mechanism in Radical-Scavenging Reactions by a Vitamin E Model in Protic Medium2005
- Author(s)
  I. Nakanishi, T. Kawashima, K. Ohkubo, H. Kanazawa, K. Inami, M. Mochizuki, K. Fukubara, H. Okuda, T. Ozawa, S. Itoh, S. Fukuzumi, N. Ikota
- Journal Title
  
  Org. Biomol. Chem 3
  
  Pages: 626-629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Electron-Tansfer Mechanism in Radical-Scavenging Reactions by a Vitamin E Model in a Protic Medium2005
- Author(s)
  H.Okuda, K.Fukuhara et al.
- Journal Title
  
  Org.Biomol.Chem. 3
  
  Pages: 626-629
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Characterization of tea cultivated at four different altitudes using 1H NMR analysis coupled with multivariate statistics
- Author(s)
  A.Ohno, K.Oka, C.Sakuma, H.Okuda, K.Fukuhara
- Journal Title
  
  J.Agri.Food Chem. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen induced hepatotoxicity
- Author(s)
  K.Fukuhara, A.Ohno, Y.Ando, T.Yamato, H.Okuda
- Journal Title
  
  Drug.Metab.Pharm. in press.
- NAID
  130004463199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Patent] フラバノール誘導体‐アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ 蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔,大野彰子,奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-20390038
[Patent] フラバノール誘導体-アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔, 大野彰子, 奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2011-183246
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 金属イオン存在下におけるヒドロキノン類のラジカル消去反応2008
- Author(s)
  中西郁夫, 大久保敬, 福原潔, 奥田晴宏, 安西和紀
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ブラジル産プロポリスに含まれるフェノール性抗酸化物質およびその誘導体のラジカル消去活性2008
- Author(s)
  中西郁夫, 大久保敬, 奥田晴宏, 福原潔, 安西和紀
- Organizer
  第41回酸化反応討論会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ラジカル消去活性の増強と遺伝毒性の軽減を目的としたレスベラトロールの誘導化2008
- Author(s)
  福原潔, 中西郁夫, 宮田直樹, 奥田晴宏
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 天然抗酸化物質の生合成前駆体およびその類縁体のラジカル消去活性2008
- Author(s)
  中西郁夫, 宇都義浩, 大久保敬, 福原潔, 奥田晴宏
- Organizer
  第8回AOB(Antioxidant Biofactor)研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 放射線防護剤を指向した分子内に塩基性部位を有する新規ビタミンE誘導体の開発2008
- Author(s)
  中西郁夫, 乳井美奈子, 福原潔, 奥田晴宏, 安西和紀
- Organizer
  日本環境変異原学会第37回大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] エピカテキンの抗酸化作用の増強を目的とした立体構造固定化2008
- Author(s)
  今井耕平, 中西郁夫, 奥田晴宏, 福原潔
- Organizer
  日本環境変異原学会第37回大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ヒドロキノン類によるラジカル消去速度に及ぼす金属イオンの効果2008
- Author(s)
  中西郁夫, 宇都義浩, 福原潔, 奥田晴宏, 安西和紀
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Structure-Activity Relationships in the Radical-scavenging Reaction of Polyphenolic Flavones, Oxgen Club of Californai 2008 World Congress, California2008
- Author(s)
  I. Kahanishi, K. Ohkubo, K. Miyazaki, S. Urano, H. Okuda, N. Ikota, K. Anzai, S. Fukuzumi, T. Ozawa, K. Fukuhara
- Place of Presentation
  USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Intramolecular Base-Accelerated Radical-Scavenging Reaction of a Planar Catechin Derivative having a Lysine Moiety, 14th Annual Meeting of the Society for Free Radical Biology and Medicine(Sfrbm), Washington, D. C.2007
- Author(s)
  K. Fukuhara, I. Nakanishi, M. Obara, K. Ohbubo, T. Kawashima, T. Ozawa, N. Ikota, K. Anzai, S. Fukuzumi, N. Miyata, S. Saito, H. Okuda
- Place of Presentation
  USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] DNA cleaving activity of nitroimidazole under photoirradiation2007
- Author(s)
  T. Shoda, K. Miura, Y. Sakai, S. Saito, H. Okuda, K. Fukahara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygen2007
- Author(s)
  K. Fukuhara, A. Ishikawa, W. Hakamata, S. Saito, H. Okuda
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygen2007
- Author(s)
  K. Fukuhara, A. Ishikawa, W. Hakamata, S. Saito, H. Okuda
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Effect of Methyl Substitution of Antioxidative Properties and Genotoxicity of Resveratrol, International Conference on Food Factors for Health Promotion(ICoFF2007)2007
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Ozawa, N. Miyata, N. Ikota, H. Okuda
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Enhanced radical-scavenging activities of methyl resveratrol, Annual Meeting of SFRR Japan2007
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Ozawa, N. Ikota N. Miyata, H. Okuda
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Electron-Transfer Mechanism in the Radical-Scavenging Reaction of Resveratrol, 14th Annual Meeting of the Society for Free Radical Biology and Medicin(SFRBM), Washington, D. C.2007
- Author(s)
  I. Nakanishi, T. Shimada, K. Ohkubo, S. Manda, S. Urano, H. Okuda, n. Miyata, t. Ozawa K. Anzai, S. Fukuzumi, N. Ikota, K. Fukuhara
- Place of Presentation
  USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] DNA cleaving activity of nitroimidazole under photoirradiation2007
- Author(s)
  T. Shoda, K. Miura, Y. Sakai, S. Saito, H. Okuda, K. Fukuhara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Enhanced radical-scavenging activities of planar catechin derivatives having Lysine Moiety, 128th Annual Meeting of the Phamaceutical Society of Japan2006
- Author(s)
  K. Fukuhara, I. Nakanishi, K. Okubo, N. Fukai, T. Ozawa, N. Miyata, S. Urano, S. Fukuzami, K. Anzai, H. Okuda
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Involvement of Electron Transfer in the Radical-Scavenging Reaction of Resveratrol128th Annual Meeting of the Pharmaceutical Society of Japan2006
- Author(s)
  I. Nakanishi, T. Shimada, K. Okubo, S. Manda, T. shimizu, S. Urano, H. Okuda, N. Miyata, T.Ozawa K. Anzai, S. Fukuzami, N. Ikota, K. Fukuhara
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2006
- Author(s)
  K. Fukuhara, N. Hakota, S. Oikawa, Y. Hiraku, Y. Sakai, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Organizer
  126th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2006
- Author(s)
  K. Fukuhara, N. Hakota, S. Oikawa, Y. Hiraku, Y. Sakai, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Organizer
  126th Annual Meeting of the Phamnaceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Enhanced radical-scavenging activities of planar catechin derivatives having alkyl side chains2005
- Author(s)
  K. Fukuhara, I. Nakanishi, T. Kawashima, H. Yakumaru, H. Kanazawa, H. Okuda, K. Ohkubo, T. Ozawa, S. Fukuzumi, N. Ikota
- Organizer
  Pacifichem 2005
- Place of Presentation
  Honolulu, Hawaii, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033

1. FUKUHARA Kiyoshi (70189968)

# of Collaborated Projects: 3 results

# of Collaborated Products: 49 results
2. UMEMURA Takashi (50185071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SYODA Takuji (60435708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. WATABE Tadashi (00057316)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HIRATSUKA Akira (20165179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHNO Akiko (70356236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. OGURA Kenichiro (10185564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Okuda Haruhiro 奥田 晴宏

OKUDA Haruhiro 奥田 晴宏

OKUDA Haruhiro Research 奥田 晴宏

Research Projects

Research Products

Co-Researchers

Studies on synthetic antioxidants for prevention of oxidative stress-related diseases

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Design and Synthesis of Antioxidant for a New Type of Chemopreventive Agents

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Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygenPrincipal Investigator

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A Novel Mechanism for Protecting of Biomembrane from Oxidative Disorder by Oxygen Free Radicals

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Oxidation of xenobiotics by active peroxyradicals derived from lipids of hepatic endoplasmic reticulum

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[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013

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[Journal Article] A New Approach to Characterization of Insulin Derived from Different Species Using 1H-NMR Coupled with Multivariate Analysis2012

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[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012

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[Journal Article] A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity2011

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[Journal Article] Synthesis and enhanced radical scavenging activity of a conformationally constrained epigallocatechin analogue2011

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[Journal Article] Characterization of Tea Cultivated at Four Different Altitudes Using 1H NMR Analysis Coupled with Multivariate Statistics2011

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[Journal Article] Complete NMR analysis of oxytocin in phosphate buffer2010

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Okuda Haruhiro 奥田晴宏

OKUDA Haruhiro 奥田晴宏

OKUDA Haruhiro Research 奥田晴宏