YOSHIDA Norimasa 吉田憲正

Researcher Number	30166962
External Links
Affiliation (based on the past Project Information) *help	2008: Kyoto Prefectural University of Medicine, 大学院・医学研究科, 講師 2003 – 2008: 京都府立医科大学, 医学研究科, 講師 2007: Kyoto Prefectural University of Medicine, Department of Molecular Gastroenterology and Hepatology, Assistant Professor 2006 – 2007: 京都府立医科大学, 医学研究科・消化器内科学, 講師
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Rehabilitation science/Welfare engineering / Gastroenterology / Risk sciences of radiation/Chemicals / Laboratory medicine
Keywords	Principal Investigator protease-activated receptor(PAR) / IL-8 / 逆流性食道炎 / NFkappaB / tryptase / trypsin / thrombin / stomach / esophagus / PAR-2 … More / NfkappaB / interleukin-8(IL-8) / 胃食道逆流症 / 食道上皮細胞 / アスピリン / サイトカイン / PAR (protease-activated receptor) / 転写因子 / トリプターゼ / トリプシン / トロンビン / 胃粘膜上皮細胞 / 食道粘膜上皮細胞 / protease-activated receptor (PAR) / 脊髄後根神経節 / NERD / 神経成長因子(NGF) / TRPV1 / サブスタンスP / 知覚過敏 / 侵害受容器 / 食道 … More Except Principal Investigator Rheumatoid arthritis / 血管内皮細胞 / 熱ショック蛋白 / 温熱療法 / Arthritis / Anti-inflammatory effect / Crohn disease / Ulcerative colitis / Inflammatory bowel disease / Carbon monoxide / 抗炎症効果 / TNBS腸炎 / 抗炎症效果 / 関節炎 / 抗炎症作用 / クローン病 / 潰瘍性大腸炎 / 炎症性腸疾患 / 一酸化炭素 / keratinocvte / genomic analysis / ultra violet / toxicology / cosmetic additives / ケラチノサイト / 遺伝子解析 / 紫外線照射 / 毒性発現 / 化粧品添加物 / anti-inflammatory action / hyperthermia / コラーゲン惹起関節炎 / 全身温熱療法 / コラーゲン惹起免疫関節炎 / 細胞接着分子 / IL-8 / 炎症性サイトカイン / 転写因子NF-kB / Anti-inflammation / Gene Chip / Alternative medicine / Heat shock protein / Hyperthermia / 滑膜細胞 / コラーゲン誘発関節炎 / 抗炎症 / サイトカイン / 関節リウマチ / Diabetes mellitus / Monolonal antibodies / Preventive Medicine / Oxidative stress / Common Disease / Biomarker / Proteome / Protein Chip / プメテオーム解析 / 糖尿病 / モノクローナル抗体 / 予防医学 / 酸化ストレス / 生活習慣病 / 疾患バイオマーカー / プロテオーム解析 / プロテインチップ Less

Role of nerve growth factor and nociceptors in the pathogenesis of gastroesophageal reflux diseasePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Norimasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
Hyperthermic treatment for early stage of rheumatoid arthritis
- Principal Investigator
  
  KOKURA Satoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Prefectural University of Medicine
Prediction of the cytotoxicity of additives in cosmetics on UV-exposed human skin keratinocytes
- Principal Investigator
  
  HANDA Osamu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto Prefectural University of Medicine
The invention of carbon monoxide inhalation system and the, utility of this system on the intestinal inflammau
- Principal Investigator
  
  TAKAGI Tomoshisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
Development of Hyperthermia Treatment for Early Stage of Rheumatoid Arthritis
- Principal Investigator
  
  NAITO Yuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Prefectural University of Medicine
Production of Oxidative Stress-Related ProteinChip and Its Evaluation on Biomarker for Common Disease
- Principal Investigator
  
  YOSHIKAWA Toshikazu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Role of protease-activated receptor in mucosal injury of upper alimentary tractPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Norimasa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] 食道粘膜への酸暴露によるTRPV1依存性神経炎症2009
- Author(s)
  吉田憲正、鎌田和浩、藤本荘太郎、鈴木隆裕、大谷りら、戸坂真子、吉川敏一、蔵本博史
- Journal Title
  
  Therapeutic Resear 30
  
  Pages: 450-453
- Data Source
  KAKENHI-PROJECT-19590729
[Journal Article] 食道粘膜への酸暴露によるTRPV1依存性神経炎症2009
- Author(s)
  吉田憲正
- Journal Title
  
  Therapeutic Research 30
  
  Pages: 450-453
- Data Source
  KAKENHI-PROJECT-19590729
[Journal Article] Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice2007
- Author(s)
  Kokura, S., Adachi, S., Manabe, E., Mizushima, K., Hattori, T., Okuda, T., Nakabe, N., Handa, O., Takagi, T., Naito, Y., Yoshida, N., Yoshikawa, T
- Journal Title
  
  Int J Hyperthermia 23
  
  Pages: 259-265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500417
[Journal Article] Hyperthermia ameliorates 2, 4, 6- Trinitrobenzene Sulphonic Acid-induced colitis in rats: the role of heat shock proteins2007
- Author(s)
  Kokura, S., Yoshida, N., Okuda, T., Nakabe, N., Sakamoto, N., Isozaki, Y., Hattori, T., Handa, O., Takagi, T., Naito, Y., Yoshikawa, T
- Journal Title
  
  Int J Hyperthermia 23
  
  Pages: 17-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500417
[Journal Article] Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells2007
- Author(s)
  Nakabe, N., Kokura, S., Shimozawa, M., Katada, K., Sakamoto, N., Ishikawa, T., Handa, O., Takagi, T., Naito, Y., Yoshida, N., Yoshikawa, T
- Journal Title
  
  Int J Hyperthermia 23
  
  Pages: 217-224
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500417
[Journal Article] Methylparaben potentiates UV-induced damage of skin keratinocytes2006
- Author(s)
  Handa, O., Kokura, S., Adachi, S., Takagi, T., Naito, Y., Tanigawa, T., Yoshida, N., Yoshikawa, T
- Journal Title
  
  Toxicology 227(1-2)
  
  Pages: 62-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510062
[Journal Article] Methylparaben potentiates UV-induced damage of skin keratinocytes.2006
- Author(s)
  半田修, 古倉聡, 足立聡子, 高木智久, 内藤裕二, 谷川徹, 吉田憲正, 吉川敏一
- Journal Title
  
  Toxicology 227巻・1-2号
  
  Pages: 62-72
- Data Source
  KAKENHI-PROJECT-18510062
[Journal Article] monoxide gas in patients with ulcerative colitis2006
- Author(s)
  Takagi, T, Naito, Y, Tsuboi, H, Isozaki, Y, Katada, K, Suzuki, H, Terao, J, Handa, O, Kokura, S, Ichikawa, H, Yoshida, N, Okuyama, Y, Yagi, K, Ueda, H, Yoshikawa, T
- Journal Title
  
  Aliment Pharmacol Ther Suppl 4
  
  Pages: 233-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590694
[Journal Article] Methylparaben potentiates UV-induced damage of skin keratinocytes2006
- Author(s)
  半田修、古倉聡、足立聡子、高木智久、内藤裕二、谷川徹、吉田憲正、吉川敏一
- Journal Title
  
  Toxicology 227巻
  
  Pages: 62-72
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510062
[Journal Article] Heme oxygenase-1 (Hsp32) is involved in the protection of small intestine by whole body mild hyperthermia from ischemia/reperfusion injury in rat.2005
- Author(s)
  Sakamoto N, Kokura S, Okuda T, Hattori T, Katada K, Isozaki Y, Nakabe N, Handa O, Takagi T, Ishikawa T, Naito Y, Yoshida N, Yoshikawa T.
- Journal Title
  
  Int J Hyperthermia. 21
  
  Pages: 603-614
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500349
[Journal Article] Trypsin activates human esophageal epithelial cells to produce inflammatory cytokines through protease-activate receptor 2.2004
- Author(s)
  Yoshida N.
- Journal Title
  
  Gastroenterol 126(4)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] Trypsin activates human esophageal epithelial cells to produce inflammatory cytokines through protease-activate receptor 2.2004
- Author(s)
  Yoshida N
- Journal Title
  
  Gastroenterol 126(4)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats2004
- Author(s)
  Tomatsuri N, Yoshida N, Yoshikawa T, et al.
- Journal Title
  
  Int J Mol Med 13
  
  Pages: 105-109
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390178
[Journal Article] 炎症性疾患とProtease-activated receptor(PAR)2004
- Author(s)
  吉田憲正
- Journal Title
  
  医薬の門 44(1)
  
  Pages: 21-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] PAR2を介した食道上皮細胞からのIL-8産生と食道粘膜の炎症2004
- Author(s)
  吉田憲正
- Journal Title
  
  日薬理誌 124
  
  Pages: 93-94
- NAID
  10018622103
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease.2004
- Author(s)
  Yoshida N.
- Journal Title
  
  Scand J Gastroenterol 39
  
  Pages: 816-822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] 炎症性疾患とProtease-activated receptor (PAR)2004
- Author(s)
  吉田憲正
- Journal Title
  
  医薬の門 44(1)
  
  Pages: 21-25
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] Anoxia/reoxygenation down-regulates the expression of E-cadherin in human colon cancer cell lines2004
- Author(s)
  Kokura S, Yoshida N, Yoshikawa T, et al.
- Journal Title
  
  Cancer Lett 211
  
  Pages: 79-87
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390178
[Journal Article] Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease2003
- Author(s)
  Yoshida N
- Journal Title
  
  Scand J Gastoenterol 39
  
  Pages: 816-822
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] 食道粘膜防御機構の破綻と食道粘膜の炎症2003
- Author(s)
  吉田憲正
- Journal Title
  
  診断と治療 91(1)
  
  Pages: 2103-2110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590672
[Journal Article] Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells
- Author(s)
  Nakabe;Kokura, Shimozawa;Katada, Sakamoto;Ishikawa, Handa;Takagi, Naito;Yoshida, Yoshikawa
- Journal Title
  
  International Journal of Hyperthermia (in press)
- Data Source
  KAKENHI-PROJECT-18500417
[Presentation] 食道粘膜の知覚過敏2009
- Author(s)
  吉田憲正
- Organizer
  炎症とTRPVl, 日本消化管学会
- Place of Presentation
  東京
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] 食道粘膜の知覚過敏、炎症とTRPV12009
- Author(s)
  吉田憲正
- Organizer
  日本消化管学会
- Place of Presentation
  東京
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] Role of TRPVl expression associated with nerve growth factor in the esophageal viscoral sonsitivity2009
- Author(s)
  Kamada K, Yoshida N, Suzuki T, Kishimoto E, Handa O, Yoshikawa T.
- Organizer
  日本消化管学会
- Place of Presentation
  東京
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] TRPVlを介した食道粘膜内の神経炎症2008
- Author(s)
  鈴木隆裕、吉田憲正、吉川敏一
- Organizer
  第26回Cytoprotectio研究会
- Place of Presentation
  京都
- Year and Date
  2008-03-14
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] 食道粘膜への酸暴露はNGF/TRPV1/substance Pを増加させる2008
- Author(s)
  吉田憲正、鈴木隆裕、鎌田和浩、大谷りら、戸坂真子、吉川敏一、蔵本博史
- Organizer
  日本神経消化器病学会
- Place of Presentation
  東京
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] ラット食道への酸曝露によるTRPV1を介した神経炎症2008
- Author(s)
  鈴木隆裕、吉田憲正, 他
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] TRPVl expression associated with nerve growth factor mediates the esophageal visceral hypersensitivity2008
- Author(s)
  Suzuki T, Yoshida N, Mizushima K, Kamada K, Handa O. Takagi T, Kokura S, Ichikawa H, Naito Y, Kttramoto il, Yoshikawa T.
- Organizer
  109th Annual meeting of the American Gastroenterological Association
- Place of Presentation
  San Diego
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19590729
[Presentation] UV potentiates cytotoxicity of additives in cosmetics on human skin keratinocytes2007
- Author(s)
  Osamu, Handa, Satoshi, Kokura, Katsura, Mizushima, Satomi, Akagiri, Tomohisa, Takagi, Yuji, Naito, Norimasa, Yoshida, Toshikazu, Yoshikawa
- Organizer
  8th World Congress on Inflammation
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2007-06-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510062
[Presentation] Intracolonic administration of carbon monoxide amel-iorates on trinitrobenzene sulfonic acid- induced colitis in rats2007
- Author(s)
  Tomohisa, Takagi, Yuji, Naito, Toshimitsu, Okuda, Katsura, Mizushima, Tetsuya, Okayama, Ikuhiro, Hirata, Tatsushi, Omatsu, Takahiro, Suzuki, Hisato, Tsuboi, Hitomi, Okada, Osamu, Handa, Satoshi, Kokura, Hiroshi, Ichikawa, Norimasa, Yoshida, Toshikazu, Yoshikawa
- Organizer
  8th World Congress on Inflammation
- Place of Presentation
  Copenhagen, Denmark
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590694
[Presentation] Vitamin E ameliorates methylparaben/ultraviolet-induced cytotoxicity on skin keratinocytes2007
- Author(s)
  Osamu, Handa, Satoshi, Kokura, Satomi, Akagiri, Tomohisa, Takagi, Yuji, Naito, Norimasa, Yoshida, Toshikazu, Yoshikawa
- Organizer
  18th annual meeting of Japanese society of vitamin E research
- Place of Presentation
  Nagasaki, Japan
- Year and Date
  2007-01-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510062
[Presentation] Effect of whole body hyperthermia for the early stage of rheumatoid arthritis-2006
- Author(s)
  Inoue, M., Kokura, S., Nakabe, N., Takagi, T., Mizushima, K., Adachi, S., Handa, O., Manabe, E., Naito, Y., Yoshida, N., Yoshikawa, T
- Organizer
  The 4th Asian Congress of Hyperthermic Oncology &The 23rd Japanese Congress of Hyperthermic Oncology
- Place of Presentation
  Nara
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500417
[Presentation] Cytotoxic effect of cosmetic additives on ultraviolet exposed Skin keratinocytes2006
- Author(s)
  Osamu, Handa, Satoshi, Kokura, Katsura, Mizushima, Tomohisa, Takagi, Hiroshi, Ichikawa, Yuji, Naito, Toru, Tanigawa, Norimasa, Yoshida, Toshikazu, Yoshikawa
- Organizer
  30th annual meeting of Japanese Society for Lipid peroxidation and Free Radical Research
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2006-10-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510062

1. YOSHIKAWA Toshikazu (90158410)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. NAITO Yuji (00305575)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
3. KOKURA Satoshi (80347442)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
4. KURAMOT Hiroshi (30153373)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. TAKAGI Tomohisa (70405257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. HANDA Osamu (90381970)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
7. ICHIKAWA Hiroshi (60336732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKANO Hirohisa (60281698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIDA Norimasa 吉田 憲正

Research Projects

Research Products

Co-Researchers

Role of nerve growth factor and nociceptors in the pathogenesis of gastroesophageal reflux diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hyperthermic treatment for early stage of rheumatoid arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of the cytotoxicity of additives in cosmetics on UV-exposed human skin keratinocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The invention of carbon monoxide inhalation system and the, utility of this system on the intestinal inflammau

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Hyperthermia Treatment for Early Stage of Rheumatoid Arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production of Oxidative Stress-Related ProteinChip and Its Evaluation on Biomarker for Common Disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of protease-activated receptor in mucosal injury of upper alimentary tractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 食道粘膜への酸暴露によるTRPV1依存性神経炎症2009

Author(s)

Journal Title

Data Source

[Journal Article] 食道粘膜への酸暴露によるTRPV1依存性神経炎症2009

Author(s)

Journal Title

Data Source

[Journal Article] Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hyperthermia ameliorates 2, 4, 6- Trinitrobenzene Sulphonic Acid-induced colitis in rats: the role of heat shock proteins2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Methylparaben potentiates UV-induced damage of skin keratinocytes2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Methylparaben potentiates UV-induced damage of skin keratinocytes.2006

Author(s)

Journal Title

Data Source

[Journal Article] monoxide gas in patients with ulcerative colitis2006

Author(s)

YOSHIDA Norimasa 吉田憲正