KOBARI Masao 小針雅男

Researcher Number	30170369
External Links
Affiliation (based on the past Project Information) *help	1998: 東北大学, 医学部, 助教授 1997: Tohoku University, School of Medicine, Lecturer, 医学部, 講師 1996: 東北大学, 医学部・附属病院, 講師 1994: Tohoku Univer School of Medicine, Assistant Professor, 医学部, 講師 1992 – 1994: 東北大学, 医学部・附属病院, 講師 … More 1993: 東北大学, 医学部・付属病院, 講師 1993: Tohoku University School of Medicine First Department of Surgery Lecturer, 医学部附属病院, 講師 1992: 東北大学, 医学部付属病院, 講師 1988 – 1991: 東北大学, 医学部附属病院, 講師 1988: 東北大学, 医学部附属病院, 講師 1986 – 1987: Tohoku University School of Medicine, assistant, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Digestive surgery Except Principal Investigator Digestive surgery / Experimental pathology / General surgery
Keywords	Principal Investigator 膵癌 / pancreatic cancer / targeting chemotherapy / DUSP6 / FISH / 5FU / gene therapy / 遺伝子治療 / NK / LAK … More / mono-clonal antibody / liposome / targetin g chemotherapy / モノクローナル抗体 / リポソーム / 補助化学療法 / ヒト膵癌培養細胞 / モノクロ-ナル抗体 / 制癌剤封入リポソ-ム / microsatellite instability / tumor suppressor gene / prognosis / loss of heterozygosity / genetics / 治療抵抗性 / DNAミスマッチ修復 / 遺伝子異常 / 遺伝子診療 / 発癌メカニズム / ING1 / p33 / p73 / TP53 / LOH / 悪性腫瘍 / 癌抑制遺伝子 / マイクロサテライト不安定性 / 予後 / ヘテロ接合性の消失 / 遺伝子 / 膵臓がん / flt 1 / soluble VEGF receptor / angiogenesis / uracil phosphoribosyl transferase / UPRT遺伝子 / 変異型アデノウィルスベクター / 増殖型アテツウイルス / UPRT,CD, / UPRT / アデイウイルス / P53遺伝子 / 癌 / ハイブリッド型リポソームベクター / fltJ / 可溶性VEGF受容体 / 血管新生 / urasyl phospholiposyl transterare / tumor vaccine / transfection efficiency / immunogene therapy / suicede gene / カチオニックリボソーム / 腫瘍ワクチン / 遺伝子導入効率 / 遺伝子免疫療法 / 自殺遺伝子 / Basement Membrare Proteirs / Liver Metastasis / Adoptite Immunorlorapy / Pancreatic Cancer / 膵癌肝転移 / LAK細胞 / Kupffer細胞 / Kupffer細飽 / 基底膜蛋白 / 肝転移 / 養子免疫療法 … More Except Principal Investigator IL-12 / 膵癌 / 血管新生 / Th1 / 肝転移 / pancreatic cancer / angiogenesis / LFA-1 / ICAM-1 / LAK / NK活性 / リポソーム / 18q / 17p / 12q / 6q / 癌抑制遺伝子 / VEGF / gene therapy / 遺伝子治療 / Th2 / フィブロネクチン / Th2バランス / adoptive immunotherapy / NK / human pancreatic cancer cells / liver metastasis / 人膵癌培養細胞 / BRM / ヌードマウス肝転移モデル / EBvirus / 単クロ-ン抗体 / ヌ-ドマウス肝転移モデル / 人膵癌細胞 / 養子免疫 / LAK活性 / 膵癌細胞 / liposome / sousitinty to anti-tumor drugs / platelet aggregation inhibition / fibrorectin / NK activity / pahcreatic liver metastasis / プロスタグランジン / targeting chemotherapy / 抗癌剤感受性 / 血小板凝集阻害 / Liposome / EB viruo transform B Cell line / Monoclonal antibody / Auti-tumor chemosensitivity / Pancreatic cancer / EB virusトランスフォームB細胞 / 制癌剤感受性試験 / ヌードマウス移植膵癌 / 人膵癌培養細胞株 / 融合細胞 / 人癌培養細胞株 / EBvirusトランスフォームB細胞 / 単クローン抗体 / 抗癌剤感受性試験 / endometrial cancer / PTEN / SMAD4 / Adenovirus vector / DUSP6遺伝子 / DNAミスマッチ修復異常 / 遺伝子導入 / アデノウィルスベクター / 子宮内膜癌 / PTEN遺伝子 / SMAD4遺伝子 / アデノウイルスベクター / tumor suppressor gene / FISH / CGH / LOH / 染色体異常 / 遺伝子異常 / 早期診断 / 診療システム / E-selectin / matrix metalloproteinase / microenvironment / 腫瘍 / TNP-470 / αvβ3 / Eセレクテン / E セレクチン / マトリックス・メタロプロテネース / 局所環境 / cancer / gene gun / 抗腫瘍療法 / 遺伝子統 / P53 / 細胞死 / 腫瘍免疫 / BAI-1 / 抗腫瘍免疫 / 腫瘍血管新生 / 癌 / 癌の遺伝子治療 / 遺伝子銃 / anti IL-12 antibody / Islet transplantation / IL-12,p40遺伝子 / 抗IL-12抗体 / 膵ラ島移植 / Extracellular Matrix / Organic Matrix / Chronic Pancreatitis / Pancreatic Stone / 膵石有機基質 / 細胞接着因子 / 慢性膵炎 / 膵石症 / Th2 balance / islet transplantation / hybrid pancreas / xenograft transplantation / growth factor / costimulatory signal / セルロース / 膵移植 / ラ島移植 / ハイブリッド型人工膵 / ラ氏島移植 / ハイブリッド型人工膵臓 / 持続動注療法 / 膵酵素阻害剤 / 重症膵炎 Less

Establishment of novel efficient methods for pancreatic cancer patients based on genetic abnormality.
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku Uniersity
Adjuvant gene therapy for pancreatic cancer using hybrid type liposome vectorPrincipal Investigator
- Principal Investigator
  
  SUNAMURA Makoto, 小針雅男
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Towards establishment of gene therapy for human pancreatic and endometrial cancers
- Principal Investigator
  
  HORII Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
Establishment of efficient treatment strategies for the pancreatic cancer based on its molecular characteristicsPrincipal Investigator
- Principal Investigator
  
  FURUKAWA Toru, 小針雅男
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Gene therapy for cancer using the gone gun system
- Principal Investigator
  
  SUNAMURA Makoto
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Tohoku University
A Study of an anti-angiogenic thcropy targetting integrins expressed on angiogenesis endotherial cells
- Principal Investigator
  
  SUNAMURA Makoto, 江川新一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Suicide gene therapy and tumor specific CTL activated by B7 gene transfected tumor cells against pancretic cancer.Principal Investigator
- Principal Investigator
  
  KOBARI Masao
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Prolongation of Islet allograft by transfection of IL-12, p40 gene into Islet
- Principal Investigator
  
  SUNAMURA Makoto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
PATHOGENESIS OF PANCREATIC SOTONE : STUDIES ON THE ORGANIC MATRIX OF HUMAN PANCREATIC STONES.
- Principal Investigator
  
  TAKEDA Kazunori
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  TOHOKU UNIVERSITY
The treatment for diabetes mellitus after surgery using artificial hybrid pancreas
- Principal Investigator
  
  MATUNO Seiki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
The Role of Immure Cells in Liver Metastasis of Paucreatic CariromaPrincipal Investigator
- Principal Investigator
  
  KOBARI Masao
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
生体防御能増強による重症膵炎の治療ートリプシン・インヒビタ-持続動注療法の開発
- Principal Investigator
  
  TAKEDA Kazunori
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Combined modality therapy for pancreatic cancer by targeting chemotherapy and LAK adoptive immunotherapy
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  1988 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
THE STUDY OF TARGETING CHEMOTHERAPY USING ANTIBODY-CONJUGATED LIPOSOME AGAINST PANCREATIC CANCERPrincipal Investigator
- Principal Investigator
  
  KOBARI Masao
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  TOHOKU UNIVERSITY
Research for mechanism clarification and prevention of micro-liub-mitastasis in pahcreatic cancer
- Principal Investigator
  
  SEIKI Matsuho, 宮川菊雄
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  TOHOKU UNIVERSITY
Research for the establishment of combined modality therapy including targeting chemotherapy for cancer of the pancreas.
- Principal Investigator
  
  SATO Toshio
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  TOHOKU UNIVERSITY

All 2000 1999 1998

All Journal Article

[Journal Article] Effect of intraportal adoptive immunotherapy on liver metastases after resection of pancreatic cancer.2000
- Author(s)
  Kobari M.
- Journal Title
  
  Br.J.Surg. 87
  
  Pages: 43-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Effect of intraportal adoptive immunotherapy on liver metastases after resection of pancreatic cancer.2000
- Author(s)
  Kobari, M., Egawa, S., Shibuya, K., Sunamura, M., Saitoh, K., Matsuno, S.
- Journal Title
  
  Br.J.Surg. 87
  
  Pages: 43-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes : differences in clinical characteristics and surgical management.1999
- Author(s)
  Kobari, M.et al.
- Journal Title
  
  Archives, of Surgery 134
  
  Pages: 1131-1136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10557116
[Journal Article] Controlling tumor angiogenesis and metastasis of C26 murin colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.1999
- Author(s)
  Lozonschi L., Sunamura M., Kobari M., Egawa S., Ding L., Matsuno S.
- Journal Title
  
  Cancer Res. 59
  
  Pages: 1252-1258
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes1999
- Author(s)
  Kobari, M.
- Journal Title
  
  Arch.Surg. 134
  
  Pages: 1131-1136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes : differences in clinical characteristics and surgical management.1999
- Author(s)
  Kobari, M., et al.
- Journal Title
  
  Arch Surg 134
  
  Pages: 1131-1136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557116
[Journal Article] Controlling tumor angiogenesis and metastasis of C26 murin colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.1999
- Author(s)
  Lozonschi L., Sunamura M., Kobari M., Egawa S., Ding L., Matsuno S.
- Journal Title
  
  Cancer Res. 59
  
  Pages: 1252-1258
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557026
[Journal Article] Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.1999
- Author(s)
  Abe, T., Makino, N., Furukawa.T., Ouyang, H., Kimura, M., Yatsuoka T., Yokoyama, T., Inoue, H., Fukushige, S., Hoshi, M., Hayashi, Y., Sunamura, M., Kobari, M., Matsuno, S., Horii, A.
- Journal Title
  
  Genes Chromosomes Cancer 25
  
  Pages: 60-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557026
[Journal Article] Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes.1999
- Author(s)
  Kobari, M., Egawa, S., Shibuya K., Shimamura, H., Sunamura, M., Takeda, K., Matsuno, S.
- Journal Title
  
  Arch.Surg. 134
  
  Pages: 1131-1136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.1999
- Author(s)
  Yatsuoka, T., Furukawa, T., Abe, T., Yokoyama, T., Sunamura, M., Kobari, M., Matsuno, S., Horii, A.
- Journal Title
  
  Int.J.Panc. 25
  
  Pages: 97-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557026
[Journal Article] Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.1999
- Author(s)
  Yatsuoka, T., Furukawa, T., Abe, T., Yokoyama, T., Sunamura, M., Kobari, M., Matsuno, S., Horii, A.
- Journal Title
  
  Int.J.Panc. 25
  
  Pages: 97-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.1999
- Author(s)
  Abe, T., Makino, N., Furukawa, T, Ouyang, H., Kimura, M., Yatsuoka, T., Yokoyama, T., Inoue, H., Fukushige, S., Hoshi, M., Hayashi, Y., Sunamura, M., Kobari, M., Matsuno, S., Horii.A.
- Journal Title
  
  Genes Chromosomes Cancer 25
  
  Pages: 60-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Loss of chromosome 18q is an early event in pancreatic ductal tumorigenesis.1998
- Author(s)
  Fukushige, S., Furukawa, T., Satoh, K., Sunamura, M., Kobari.M., Koizumi, M., Horii, A.
- Journal Title
  
  Cancer Res. 58
  
  Pages: 4222-4226
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557026
[Journal Article] Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer.1998
- Author(s)
  Kimura, M., Furukawa, T., Abe, T., Yatsuoka, T., Youssef, E.M., Yokoyama, T., Ouyang, H., Ohnishi, Y., Sunamura, M., Kobari, M., Matsuno, S., Horii, A.
- Journal Title
  
  Cancer Res. 58
  
  Pages: 2456-2460
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557026
[Journal Article] Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.1998
- Author(s)
  Furukawa, T., Yatsuoka, T., Youssef, E.M., Abe, T., Yokoyama, T., Fukushige, S., Soeda, E., Hoshi, M., Hayashi, Y., Sunamura, M., Kobari, M., Horii, A.
- Journal Title
  
  Cytogenet.Cell Genet. 82
  
  Pages: 156-159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557026

1. SUNAMURA Makoto (10201584)

# of Collaborated Projects: 14 results

# of Collaborated Products: 11 results
2. TAKEDA Kazunori (20171639)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. MATUNO Seiki (80004737)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. SIBUYA Kazuhiko (70260429)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. FURUKAWA Toru (30282122)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
6. AKAISHI Satoshi (70202504)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NAKAMURA Ryuji (40201678)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. EGAWA Shin-ichi (00270679)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. HORII Akira (40249983)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
10. SHIIDA Kenichi (90196345)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SHIMAMURA Hiromune (70312585)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MIYASHITA Eiji (00133059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. MIYAGAWA Kikuo (10124629)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 角川陽一郎 (60221173)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 久野弘武 (30181093)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. AMIKURA Katsumi (10231995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HAMADA Hirofumi (00189614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SATO Masaaki (30111371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUKUSHIGE Shinichi (90192723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. YAJIMA Akira (80004993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SATO Toshio (80004571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TACHIBANA Takehiko (50076973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高橋道長 (60206852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SAKATA Tsuneaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. HISANO Hirotake

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KAQUNORI Takeda

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 澁谷和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KOBARI Masao 小針 雅男

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Adjuvant gene therapy for pancreatic cancer using hybrid type liposome vectorPrincipal Investigator

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Establishment of efficient treatment strategies for the pancreatic cancer based on its molecular characteristicsPrincipal Investigator

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Suicide gene therapy and tumor specific CTL activated by B7 gene transfected tumor cells against pancretic cancer.Principal Investigator

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The Role of Immure Cells in Liver Metastasis of Paucreatic CariromaPrincipal Investigator

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THE STUDY OF TARGETING CHEMOTHERAPY USING ANTIBODY-CONJUGATED LIPOSOME AGAINST PANCREATIC CANCERPrincipal Investigator

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KOBARI Masao 小針雅男