HAYASHI Kazuhiko 林一彦

… Alternative Names

林一彦ハヤシカズヒコ

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Researcher Number	30180962
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2021 – 2023: 鳥取大学, 医学部, 特任教授 2019 – 2020: 鳥取大学, 医学部, 特任教員 2011 – 2018: 鳥取大学, 医学部, 教授 2003 – 2005: Tottori University, Molecular Pathology, Professor, 医学部, 教授 2004: 国立大学法人鳥取大学, 医学部, 教授 … More 2001 – 2002: OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE AND DENTISTRY, ASSOCIATE PROFESSOR, 大学院・医歯学総合研究科, 助教授 1999 – 2000: Medical School, Okayama University, Associate Professor, 医学部, 助教授 1997 – 1998: 岡山大学, 医学部, 講師 1993 – 1994: 岡山大学, 医学部, 講師 1990 – 1991: 岡山大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Human pathology / Experimental pathology Except Principal Investigator Human pathology / Experimental pathology / Basic Section 49020:Human pathology-related / Human pathology
Keywords	Principal Investigator EBV / T-cell / Herpesvirus papio / LPD / HVP / 血球貪食症候群 / ウサギ / うさぎ / Rabbit / 血球貧食症候群 … More / シグナル伝達系 / ポリオーマウイルス / メルケル細胞癌 / 病理学 / ランゲルハンス組織球症 / トリプトファン代謝経路 / NOTCHシグナル伝達経路 / Mismatch Repair (MMR) / ヒストンH3K27me3 / エピジェネティクス / 腫瘍微小環境 / メルケル細胞ポリオーマウイルス / Hemophagocytic Syndrome / LPDs / hemophagocytic syndrome / 治療 / LYMPHOCRYPTOVIRUS / ANIMAL MODEL / MONKEY / HEMOPHAGOCYTIC SYNDROME / RABBIT / MALIGNANT LYMPHOMA / EBウイルス / ヘルペスウイルス / 悪性リンパ腫 / EVウイルス / lymphocryptovirus / 動物モデル / サル / リンパ腫 / 新規ウイルス検出法 / 免疫グロブリン / CK20陰性 / 増殖マーカー / 顎骨腫瘍 / 口腔腫瘍 / 予後 / 接着因子 / 遺伝子変異 / がん遺伝子 / EBNA-2遺伝子欠損型のEBV / ワクチン / EBNA2遺伝子欠損型EBV / ウサギモデル / EBVの感染モデル / HTLV-II / simian leukocyte / rabbit / malignant lymphoma / 合成ペプチド / モノクローナル抗体 / HTLV-〓 … More Except Principal Investigator cDNA microarray / tissue microarray / LOH / methylation / SHP1 / lymphoma / leukemia / EBウイルス / 成人T細胞白血病 / HTLVーI / RNA修飾 / METTL3 / RNA-seq / メルケル細胞ポリオーマウイルス / メルケル細胞癌 / 自己反応性B細胞 / TRAbアイソタイプ / TRAb / AID / 女性ホルモン / TSHレセプター抗体（TRAb） / Epstein-Barrウイルス(EBV) / TSHレセプター抗体 (TRAb) / Epstein-Barr ウイルス (EBV) / 活性化誘導シチジンデアミナーゼ (AID) / IgG4 / IgM / 自己免疫疾患 / バセドウ病 / 抗体産生 / 再活性化 / Epstein-Barr virus (EBV) / gene scilencing / gene silencing / Herpesvirus / Viral carcinogenesis / Animal model / Lymphocyte / Malignant lymphoma / Epstein-Barr virus / リンパ節炎 / LMP1 / p53 / 家兎実験モデル / サルEBウイルス関連ヘルペスウイルス / ヘルペスウイルス / ウイルス発癌 / 動物モデル / リンパ球 / 悪性リンパ腫 / Epstein-Barrウイルス / 試験管内発癌 / 多段階発癌 / 化学発癌剤 / HAM / 組織培養 / 神経組織 / レトロウイルス / ミエロパチ- Less

エピトランスクリプトーム解析によるメルケル細胞癌の病態機構解明
- Principal Investigator
  
  松下倫子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Tottori University
EBV reactivation-induced autoantibody production and management of Graves' disease
- Principal Investigator
  
  NAGATA Keiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tottori University
Establishment of MCPyV-infection experimental system and the therapy base on the carcinogenesis of MCPyV-positive Merkel cell carcinomaPrincipal Investigator
- Principal Investigator
  
  HAYASHI Kazuhiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tottori University
Analysis on the differences of tumorigenesis between MCPyV-positive and -negative Merkel cell carcinomas and its application to therapyPrincipal Investigator
- Principal Investigator
  
  Hayashi Kazuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tottori University
Pathological analysis of chronic active EBV-infection rabbit model with hemophagocytosisPrincipal Investigator
- Principal Investigator
  
  HAYASHI Kazuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tottori University
The first animal model for "Hit and Run" theory of oncogenesis by EBV related virusPrincipal Investigator
- Principal Investigator
  
  HAYASHI Kazuhiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National University Corporation Tottori University
Molecular Pathological analyses of aberrant expression of the proteintyrosine phosphatase SHP1 gene in terms of lymphomagenesis/leukemogenesis.
- Principal Investigator
  
  OKA Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  OKAYAMA UNIVERSITY
Pathological analyses and therapeutic trials of animal model of EB virus-related fatal hemophagocytic syndromePrincipal Investigator
- Principal Investigator
  
  HAYASHI Kazuhiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tottori University
  Okayama University
ANIMAL MODEL FOR HUMAN EB VIRUS-RELATED TUMOR: PATHOGENESIS OF RABBIT LYMPHOMA INDUCED BY SIMIAN EBV-RELATED VIRUSPrincipal Investigator
- Principal Investigator
  
  HAYASHI Kazuhiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  OKAYAMA UNIVERSITY
Participation of Epstein-Barr virus in the pathogenesis of malignant lymphoma
- Principal Investigator
  
  AKAGI Tadaath
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Okayama University
HTLV-II型ウイルス産生株を用いたHTLV関連疾患の動物モデル作製の試みPrincipal Investigator
- Principal Investigator
  
  林一彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Okayama University
合成ペプチドを用いたHTLV-II型に特異な抗体作製とその中和活性の検討Principal Investigator
- Principal Investigator
  
  林一彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Okayama University
成人T細胞白血病のin vitro多段階発癌モデルの作成
- Principal Investigator
  
  赤木忠厚
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Okayama University
HAMの発症病理:培養神経組織を使用したウイルス学的並びに免疫学的研究
- Principal Investigator
  
  AKAGI Tadaath
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Okayama University

[Book] 臨床で使える！甲状腺疾患診療のテキスト【電子版付】2019
- Author(s)
  長田佳子・林一彦：深田修司（編）
- Total Pages
  352
- Publisher
  日本医事新報社
- ISBN
  9784784972920
- Data Source
  KAKENHI-PROJECT-17K08694
[Journal Article] Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma2023
- Author(s)
  Iwasaki Takeshi、Hayashi Kazuhiko、Matsushita Michiko、Nonaka Daisuke、Matsumoto Takamasa、Taniguchi Midori、Kuwamoto Satoshi、Umekita Yoshihisa、Oda Yoshinao
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13114-13114
- DOI
  10.1038/s41598-023-40050-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15406, KAKENHI-PROJECT-21K06885
[Journal Article] Epstein?Barr Virus Reactivation-Induced Immunoglobulin Production: Significance on Autoimmunity2020
- Author(s)
  Nagata Keiko、Hayashi Kazuhiko
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 12 Pages: 1875-1875
- DOI
  10.3390/microorganisms8121875
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07374, KAKENHI-PROJECT-17K08694
[Journal Article] Subclinical Epstein-Barr virus primary infection and lytic reactivation induce thyrotropin receptor autoantibodies2019
- Author(s)
  Tamoto N, Nagata K, Hara S, Nakayama Y, Kuwamoto S, Matsushita M, Kato M, Hayashi K
- Journal Title
  
  Viral Immunology
  
  Volume: 32 Issue: 9 Pages: 362-369
- DOI
  10.1089/vim.2019.0086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08694, KAKENHI-PROJECT-18K06183
[Journal Article] Decreased H3K27me3 Expression is Associated With Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma, Especially Combined With Cutaneous Squamous Cell Carcinoma2019
- Author(s)
  Michiko Matsushita, Takeshi Iwasaki, Lusi Oka Wardhani, Satoshi Kuwamoto, Daisuke Nonaka, Keiko Nagata, Masako Kato , Yukisato Kitamura , Kazuhiko Hayashi
- Journal Title
  
  Anticancer Res.
  
  Volume: 39 Issue: 10 Pages: 5573-5579
- DOI
  10.21873/anticanres.13751
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720, KAKENHI-PROJECT-17K15644
[Journal Article] Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with MCPyV status and prognosis in Merkel cell carcinoma2019
- Author(s)
  Lusi Oka Wardhani, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Daisuke Nonaka, , Keiko Nagat, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
- Journal Title
  
  Hum Pathol
  
  Volume: 84 Pages: 52-61
- DOI
  10.1016/j.humpath.2018.09.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Journal Article] Expression of Notch 3 and Jagged 1 Is Associated With Merkel Cell Polyomavirus Status and Prognosis in Merkel Cell Carcinoma.2019
- Author(s)
  Wardhani LO, Matsushita M, Kuwamoto S, Nonaka D, Nagata K, Kato M, Kitamura Y, Hayashi K
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 1 Pages: 319-329
- DOI
  10.21873/anticanres.13114
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15644, KAKENHI-PROJECT-17K08720
[Journal Article] High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls2019
- Author(s)
  Hara S, Nagata K, Nakayama Y, Higaki K, Matsushita M, Kuwamoto S, Kato M, Hayashi K
- Journal Title
  
  Yonago Acta Medica
  
  Volume: 62 Issue: 2 Pages: 240-243
- DOI
  10.33160/yam.2019.06.010
- NAID
  130007665218
- ISSN
  0513-5710, 1346-8049
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08694, KAKENHI-PROJECT-18K06183
[Journal Article] Estradiol Affects Epstein-Barr Virus Reactivation-Induced Thyrotropin Receptor Antibody and Immunoglobulin Production in Graves' Disease Patients and Healthy Controls.2018
- Author(s)
  Hara S, Nagata K, Kumata K, Matsushita M, Kuwamoto S, Kato M, Hayashi K.
- Journal Title
  
  Viral Immunology
  
  Volume: 31 (7) Issue: 7 Pages: 486-491
- DOI
  10.1089/vim.2018.0032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08694
[Journal Article] Epstein-Barr Virus Lytic Reactivation Induces IgG4 Production by Host B Lymphocytes in Graves' Disease Patients and Controls: A Subset of Graves' Disease Is an IgG4-Related Disease-Like Condition.2018
- Author(s)
  Nagata K, Hara S, Nakayama Y, Higaki K, Sugihara H, Kuwamoto S, Matsushita M, Kato M, Tanio S, Ishiguro K, Hayashi K.
- Journal Title
  
  Viral Immunoogy
  
  Volume: 31 (8) Issue: 8 Pages: 540-547
- DOI
  10.1089/vim.2018.0042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08694, KAKENHI-PROJECT-18K06183
[Journal Article] Merkel cell polyomavirus and Langerhans cell neoplasm.2018
- Author(s)
  Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F.
- Journal Title
  
  Cell Commun Signal.
  
  Volume: 16(1) Issue: 1 Pages: 49-49
- DOI
  10.1186/s12964-018-0261-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08667, KAKENHI-PROJECT-17K08720, KAKENHI-PROJECT-17K08743, KAKENHI-PROJECT-17K09927, KAKENHI-PROJECT-17K10245, KAKENHI-PROJECT-16K10915, KAKENHI-PROJECT-16K19612
[Journal Article] 感染性疾患の病理、Merkel細胞癌とMerkel細胞ポリオーマウイルス2018
- Author(s)
  桑本　聡史、松下倫子、林　一彦
- Journal Title
  
  病理と臨床
  
  Volume: 36 Pages: 179-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08720
[Journal Article] Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma.2017
- Author(s)
  Kuromi T, Matsushita M, Iwasaki T, Nonaka D, Kuwamoto S, Nagata K, Kato M, Akizuki G, Kitamura Y, Hayashi K
- Journal Title
  
  Hum Pathol
  
  Volume: 69:8-14 Pages: 8-14
- DOI
  10.1016/j.humpath.2017.05.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Journal Article] Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas.2017
- Author(s)
  Matsushita M, Iwasaki T, Nonaka D, Kuwamoto S, Nagata K, Kato M, Kitamura Y, Hayashi K
- Journal Title
  
  Yonago Acta Med
  
  Volume: 60(3): Pages: 145-153
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Journal Article] Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers.2017
- Author(s)
  Mohri T, Nagata K, Kuwamoto S, Matsushita M, Sugihara H, Kato M, Horie Y, Murakami I, Hayashi K.
- Journal Title
  
  Oncol Lett.
  
  Volume: 13 (6) Issue: 6 Pages: 4133-4140
- DOI
  10.3892/ol.2017.5978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08694, KAKENHI-PROJECT-17K08720
[Journal Article] Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas.2017
- Author(s)
  Matsushita M, Iwasaki T, Nonaka D, Kuwamoto S, Nagata K, Kato M, Kitamura Y, Hayashi K.
- Journal Title
  
  Yonago Acta Med.
  
  Volume: 60 (3) Pages: 145-153
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08694
[Journal Article] Immunoglobulin Production Induced by EBV Reactivation: Underlying Mechanisms of Autoimmune Diseases Including Graves' Disease2017
- Author(s)
  Nagata K, Hayashi K
- Journal Title
  
  Journal of Basic & Clinical Medicine
  
  Volume: 6 (2) Pages: 4-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08694
[Journal Article] Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease2017
- Author(s)
  Nagata, K. Kumata, K. Nakayama, Y. Satoh, Y. Sugihara, H. Hara, S. Matsushita, M. Kuwamoto, S. Kato, M. Murakami, I. Hayashi, K.
- Journal Title
  
  Viral Immunol
  
  Volume: 30 Issue: 3 Pages: 240-249
- DOI
  10.1089/vim.2016.0179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06896, KAKENHI-PROJECT-17K08694, KAKENHI-PROJECT-17K08720
[Journal Article] Comment on 'Cytokeratin 20-negative Merkel cell carcinoma is infrequently associated with the Merkel cell polyomavirus'.2016
- Author(s)
  Iwasaki T, Matsushita M, Nonaka D, Murakami I, Hayashi K.
- Journal Title
  
  Mod Pathol.
  
  Volume: 29 Issue: 1 Pages: 89-90
- DOI
  10.1038/modpathol.2015.69
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-26860238
[Journal Article] Thyrotropin receptor antibody (TRAb)-IgM levels are markedly higher than TRAb-IgG levels in Graves’ disease patients and controls, and TRAb-IgM production is related to EBV reactivation.2016
- Author(s)
  K Kumata, K Nagata, M Matsushita, S Kuwamoto, M Kato, I Murakami, S Fukata, K Hayashi
- Journal Title
  
  Viral Immunol.
  
  Volume: 29 Issue: 8 Pages: 459-463
- DOI
  10.1089/vim.2016.0043
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-26460451
[Journal Article] Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.2016
- Author(s)
  Takeshi Iwasaki, Michiko Matsushita, Daisuke Nonaka, Keiko Nagata, Masako Kato, Satoshi Kuwamoto, Ichiro Murakami, Kazuhiko Hayashi
- Journal Title
  
  Hum Pathol
  
  Volume: 48 Pages: 1-8
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Journal Article] Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.2016
- Author(s)
  Iwasaki T, Matsushita M, Nonaka D, Nagata K, Kato M, Kuwamoto S, Murakami I, Hayashi K
- Journal Title
  
  Hum Pathol.
  
  Volume: 48 Pages: 1-8
- DOI
  10.1016/j.humpath.2015.09.030
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-26860238
[Journal Article] Multiple Skin Cancers in a Renal Transplant Recipient: A Patient Report with Analyses of Human Papillomavirus and Human Polyomavirus Infection.2015
- Author(s)
  Kaneda T, Matsushita M, Iwasaki T, Ishiguro N, Koide T, Hayashi K, Kitamura Y.
- Journal Title
  
  Yonago Acta Med.
  
  Volume: 58 Pages: 145-150
- NAID
  120005663723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460433
[Journal Article] Establishment of a Langerhans cell histiocytosis lesion cell line with dermal dendritic cell characteristics.2015
- Author(s)
  Murakami I, Gogusev J, Jaubert F, Matsushita M, Hayashi K, Miura I, Tanaka T, Oka T, Yoshino T.
- Journal Title
  
  Oncol Rep.
  
  Volume: 33 Issue: 1 Pages: 171-8
- DOI
  10.3892/or.2014.3567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-26460451
[Journal Article] Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis2015
- Author(s)
  Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Nagata K, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
- Journal Title
  
  Cell Commun Signal
  
  Volume: 13 Issue: 1 Pages: 13-13
- DOI
  10.1186/s12964-015-0092-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461606, KAKENHI-PROJECT-26460451, KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-25460437, KAKENHI-PROJECT-15K19053
[Journal Article] Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.2015
- Author(s)
  Iwasaki T, Matsushita M, Nonaka D, Kuwamoto S, Kato M, Murakami I, Nagata K, Nakajima H, Sano S, Hayashi K.
- Journal Title
  
  Hum Pathol.
  
  Volume: 46 Issue: 2 Pages: 210-6
- DOI
  10.1016/j.humpath.2014.07.025
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-25461671
[Journal Article] Acute-phase ITIH4 levels distinguish multi-system from single-system Langerhans cell histiocytosis via plasma peptidomics2015
- Author(s)
  Murakami I, Oh Y, Morimoto A, Sano H, Kanzaki S, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Nagata K, Hayashi K, Imashuku S, Gogusev J, Jaubert F, Oka T, Yoshino T.
- Journal Title
  
  Clin Proteomics.
  
  Volume: 12 Issue: 1 Pages: 16-16
- DOI
  10.1186/s12014-015-9089-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-26460451, KAKENHI-PROJECT-25460437, KAKENHI-PROJECT-25461606
[Journal Article] Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms.2015
- Author(s)
  Tanio S, Matsushita M, Kuwamoto S, Horie Y, Kodani I, Murakami I, Ryoke K, Hayashi K.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 3 Pages: 1301-1306
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460433
[Journal Article] Phosphohistone-H3 (PHH3) is prognostic relevant in Merkel cell carcinomas but Merkel cell polyomavirus is a more powerful prognostic factor than AJCC clinical stage, PHH3, Ki-67 or mitotic indices.2015
- Author(s)
  Iwasaki T, Matsushita M, Nonaka D, Kato M, Nagata K, Murakami I, Hayashi K.
- Journal Title
  
  Pathol Int. 2015 Aug;65(8):404-9. doi: 10.1111/pin.12305.
  
  Volume: 65 Issue: 8 Pages: 404-409
- DOI
  10.1111/pin.12305
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Journal Article] Immunoglobulin expressions are only associated with MCPyV-positive Merkel cell carcinomas but not with MCPyV-negative ones: comparison of prognosis.2014
- Author(s)
  Murakami I, Takata K, Matsushita M, Nonaka D, Iwasaki T, Kuwamoto S, Kato M, Mohri T, Nagata K, Kitamura Y, Yoshino T, Hayashi K.
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 38 Issue: 12 Pages: 1627-1635
- DOI
  10.1097/pas.0000000000000279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790350, KAKENHI-PROJECT-26460433
[Journal Article] A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV).2014
- Author(s)
  Matsushita M, Nonaka D, Iwasaki T, Kuwamoto S, Murakami I, Kato M, Nagata K, Kitamura Y, Hayashi K.
- Journal Title
  
  Diagn Pathol
  
  Volume: 9 Issue: 1 Pages: 65-65
- DOI
  10.1186/1746-1596-9-65
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500420, KAKENHI-PROJECT-26460433, KAKENHI-PROJECT-26860238
[Journal Article] Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caaucasian type MCPyVs: genetic variability and phyllogeeny of MCPyV genomes oobtained from Japanese MCPyV-infected MCCs2014
- Author(s)
  Matsushita M,Iwasaki T, Kuwamoto S, Kato M, Nagata K, Murakami I, Kitamura Y, Hayashi K
- Journal Title
  
  Virus Genes
  
  Volume: 48 Issue: 2 Pages: 233-242
- DOI
  10.1007/s11262-013-1023-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500420, KAKENHI-PROJECT-26460433
[Journal Article] High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues.2014
- Author(s)
  Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Nakamoto S, Yamakawa M, Nakamine H, Takata K, Oka T, Yoshino T.
- Journal Title
  
  Infect Agent Cancer
  
  Volume: 9 Issue: 1 Pages: 15-15
- DOI
  10.1186/1750-9378-9-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500420, KAKENHI-PROJECT-25460437, KAKENHI-PROJECT-25460451, KAKENHI-PROJECT-26460433
[Journal Article] Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis.2014
- Author(s)
  Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
- Journal Title
  
  Hum Pathol.
  
  Volume: 45 Issue: 1 Pages: 119-126
- DOI
  10.1016/j.humpath.2013.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590426, KAKENHI-PROJECT-25461606, KAKENHI-PROJECT-26293078, KAKENHI-PROJECT-26460433
[Journal Article] EBNA-2-deleted Epstein–Barr virus from P3HR-1 can infect rabbits with lower efficiency than prototype Epstein–Barr virus from B95-82013
- Author(s)
  Hitoshi Sano, Keiko Nagata, Kaoru Kato, Kyousuke Kanai, Kiyoshige Yamamoto, Keisuke Okuno, Satoshi Kuwamoto, Hiromi Higaki-Mori, Hirotsugu Sugihara, Masako Kato, Ichiro Murakami, Susumu Kanzaki, and Kazuhiko Hayashi
- Journal Title
  
  Intervirology
  
  Volume: 56: Pages: 114-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] EBウイルスと甲状腺疾患成人病と生活習慣病2013
- Author(s)
  長田佳子,林一彦
- Volume
  43
- Pages
  1103-1107
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] EBウイルスと甲状腺疾患2013
- Author(s)
  長田　佳子、林　一彦
- Journal Title
  
  成人病と生活習慣病
  
  Volume: ４３巻９号 Pages: 1103-1107
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] Synthetic Peptides of Epstein-Barr Virus-major envelope glycoprotein-350/220 Do Not Prevent Infection in a Rabbit Epstein-Barr Virus Infection Model2012
- Author(s)
  Kaoru Kato, Hitoshi Sano, Keiko Nagata, Hirotsugu Sugihara, Kyosuke Kanai, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Kazuhiko Hayashi
- Journal Title
  
  J Vaccine & Vaccination
  
  Volume: 4 Pages: 2157-2160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] In Vitro EBV infection Model of Rabbit Lymphocytes from Peripheral Blood or Spleen.2011
- Author(s)
  Kyosuke Kanai1,4, Kaoru Kato1,2, Hitoshi Sano1,3, Keiko Nagata1, Keisuke Okuno1,3,Satoshi Kuwamoto1, Hiromi Higaki1, Hirotsugu Sugihara1, Masako　Kato1, Ichiro Murakami1, Kazuhiko Hayashi1
- Journal Title
  
  Intervirology
  
  Volume: 54 Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] A rabbit model for primary and lifelong persistent Epstein-Barr virus infection.2011
- Author(s)
  K Hayashi, K Takashima, K Okuno, K. Kato, S Sano, H Sugihara, M Kato, I Murakami K, K Nagata
- Journal Title
  
  Virchows Arch
  
  Volume: 459（Suppl 1)
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] In Vitro EBV infection Model of Rabbit Lymphocytes from Peripheral Blood or Spleen2011
- Author(s)
  Kyosuke Kanai, Kaoru Kato, Hitoshi, Sano, Keiko Nagata, Keisuke Okuno, Satoshi Kuwamoto, Hiromi Higaki, Hirotsugu Sugihara, Masako Kato, Ichiro Murakami, Kazuhiko Hayashi
- Journal Title
  
  Intervirology
  
  Volume: 54 Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] A rabbit model for primary and lifelong persistent Epstein-Barr virus infection2011
- Author(s)
  Hayashi K, K Takashima, K Okuno, K. Kato, S Sano, H Sugihara, M Kato, I Murakami K, K Nagata
- Journal Title
  
  Virchows Arch
  
  Volume: 459(Suppl 1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590463
[Journal Article] EBV-Associated Diseases in Humans and their Animal In Vivo Models : Part22005
- Author(s)
  Kazuhiko Hayashi
- Journal Title
  
  Yonago Acta medica 48・2
  
  Pages: 41-56
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] EBV-Associated Diseases in Humans and their Animal In Vivo Models : Part 22005
- Author(s)
  Kazuhiko Hayashi
- Journal Title
  
  Yonago Acta Medica 48・2
  
  Pages: 41-56
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] EBV-Associated Diseases in Humans and their Animal In Vivo Models : Part22005
- Author(s)
  Hayashi K
- Journal Title
  
  Yonago Acta medica 48-2
  
  Pages: 41-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] Characterization of Rabbit Model for Epstein-Barr Virus-associated Lymphoproliferative Disease with Hemophagocytic Syndrome and its Therapeutic trials2005
- Author(s)
  Hayashi K
- Journal Title
  
  Virchows Archiv 447・2
  
  Pages: 209-210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] Characterization of Rabbit Model for Epstein-Barr Virus-associated Lymphoproliferative Disease with Hemophagocytic Syndrome and its therapeutic trials2005
- Author(s)
  Hayashi K
- Journal Title
  
  Virchows Archiv 447-2
  
  Pages: 209-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] EBV-Associated Diseases in Humans and their Animal In Vivo Models : Part12005
- Author(s)
  Hayashi K
- Journal Title
  
  Yonago Acta medica 48-1
  
  Pages: 1-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] EBV-Associated Diseases in Humans and their Animal In Vivo Models : Part 12005
- Author(s)
  Kazuhiko Hayashi
- Journal Title
  
  Yonago Acta Medica 48・1
  
  Pages: 1-6
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] Characterization of Rabbit Model for Epstein-Barr Virus-associated Lymphoproliferative Disease with Hemophagocytic Syndrome and its therapeutic trials2005
- Author(s)
  Hayashi K et al.
- Journal Title
  
  Virchows Archiv 447・2
  
  Pages: 209-210
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] EBV-Associated Diseases in Humans and their Animal In Vivo Models : Part12005
- Author(s)
  Kazuhiko Hayashi
- Journal Title
  
  Yonago Acta medica 48・1
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] Induction and Prevention of Virus-associated Malignant Lymphoma by Serial Transmission of EBV-related Virus from Cynomolgus by Blood Transfusion in Rabbits2004
- Author(s)
  Koirala TR, Hayashi K. et al.
- Journal Title
  
  Acta Medica Okayama 58・2
  
  Pages: 67-74
- NAID
  120002311969
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] Induction and prevention of virus-associated malignant lymphoma by serial transmission of EBV-related virus from cynomolgus by blood transfusion in rabbits.2004
- Author(s)
  Koirala T.R., Hayashi K., K., Ohara N., Oka T., Yamada M et al.
- Journal Title
  
  Acta.Med.Okayama 58
  
  Pages: 67-74
- NAID
  120002311969
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells.2004
- Author(s)
  Matsumoto MY., Matsuo H., Oka T., Fukudome T., Hayashi K., Shiraishi H., Motomura M., Shibuya N., Ayabe H.
- Journal Title
  
  J.Neuroimmunol. 150
  
  Pages: 80-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines.2004
- Author(s)
  Jin Z., Tereamoto N., Hayashi K., Liu Y.X., Jin G., Oka T., Takahashi K., Yoshino T., Akagi T.
- Journal Title
  
  Anticancer Res. 24
  
  Pages: 691-698
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines.2004
- Author(s)
  Jin Z., Tereamoto N., Hayashi K., Liu Y.X., Jin G., Oka T., Takahashi
- Journal Title
  
  Anticancer Res. 24
  
  Pages: 691-698
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Human placenta feeder layers support undifferentiated growth of primate embryonic stem cells.2004
- Author(s)
  Miyamoto K, Hayashi K et al.
- Journal Title
  
  Stem Cells 22・4
  
  Pages: 433-440
- Data Source
  KAKENHI-PROJECT-16590314
[Journal Article] Induction and prevention of virus-associated malignant lymphoma by serial transmission of EBV-related virus from cynomolgus by blood transfusion in rabbits.2004
- Author(s)
  Koirala T.R., Hayashi K., Jin Z., Onoda S., Tanaka T., Oda W., Ichimura K., Ohara N., Oka T., Yamada M, Yoshino T.
- Journal Title
  
  Acta.Med.Okayama 58(2)
  
  Pages: 67-74
- NAID
  120002311969
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Therapeutic trial for a rabbit model of EBV-associated hemophagocytic syndrome (HPS) : Effects of vidarabine or CHOP, and development of Herpersvirus papio (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease.2003
- Author(s)
  Hayashi K., Joko H., Koirala T.R., Onoda S, Jin S.J., Munemasa M., Ohara N., Oda W., Tanaka T., Oka T., Kondo E., Yoshino T, Takahashi K., Yamada M., Akagi T.
- Journal Title
  
  Histol Histopathol 18
  
  Pages: 1155-1166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Activated proliferation of B-cell lymphomas/leukemias with the sHP1 gene silencing by aberrant CpG methylation2003
- Author(s)
  Maho Koyama, Takashi Oka, Mamoru Ouchida, Yoko Nakatani, Ritsuo Nishiuchi, Tadashi Yoshino, Kazuhiko Hayashi, Tadaatsu Akagi, Yoshiki Seino
- Journal Title
  
  Lab Invest. 83(12)
  
  Pages: 1849-1858
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Rabbit model for human EBV-associated hemophagocytic syndrome(HPS).2003
- Author(s)
  Hayashi K., Jin Z., Onoda S, Joko H., Teramoto N., Ohara N., Oda W., Tanaka T., Liu YX., Koirala R., Oka T., Kondo E., Yoshino T., Takahashi K., Akagi T.
- Journal Title
  
  Amer.J.Pathol 162
  
  Pages: 1721-1736
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Therapeutic trial far a rabbit model of EBV-associated hemophagocytic syndrome (HPS) : Effects of vidarabine or CHOP, and development of Herpersvirus paplo (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease.2003
- Author(s)
  Hayashi K., Tanaka T., Oka T., Kondo E., Yamada M., Akagi T et al.
- Journal Title
  
  Histol Histopathol 18
  
  Pages: 1155-1166
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Rabbit model for human EBV-associated hemophagocytic syndrome (HPS).2003
- Author(s)
  Hayashi K., Oka T., et al.
- Journal Title
  
  Amer.J.Pathol 162
  
  Pages: 1721-1736
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Rabbit model for human EBV-associated hemophagocytic syndrome (HPS).2003
- Author(s)
  Hayashi K., Oka T, Kondo E., Yoshino T., Takahashi K., et al.
- Journal Title
  
  Amer.J.Pathol 162
  
  Pages: 1721-1736
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Activated Proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation2003
- Author(s)
  Maho Koyama, Takashi Oka, Kazuhiko Hayashi, Yoshiki Seino et al.
- Journal Title
  
  Lab Invest. 83
  
  Pages: 1849-1858
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590302
[Journal Article] Therapeutic trial for a rabbit model of EBV-associated hemophagocytic syndrome (HPS) : Effects of vidarabine or CHOP, and development of Herpersvirus papio.2003
- Author(s)
  Hayashi K., Oka T., et al.
- Journal Title
  
  Histol Histopathol 18
  
  Pages: 1155-1166
- Data Source
  KAKENHI-PROJECT-15590302
[Presentation] RNAscopeを用いたメルケル細胞癌の組織切片上でのMCPyV検出の有用性2023
- Author(s)
  松下倫子, 林一彦, 岩崎健, 桑本聡史
- Organizer
  第112回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06885
[Presentation] メルケル細胞癌におけるFOXP3、TIGIT/CD155経路の異常発現と臨床病態の解明2023
- Author(s)
  岩崎健, 林一彦, 松下倫子, 松本崇雅, 宮本拓海, 大石智恵美, 桑本聡史, 梅北善久, 小田義直
- Organizer
  第112回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06885
[Presentation] RNAscopeを用いたメルケル細胞癌の組織切片上でのMCPyV検出の有用性2023
- Author(s)
  松下倫子、林一彦、岩崎健、桑本聡史
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06885
[Presentation] TRAbs induced by Epstein-Barr virus reactivation injure thyroid follicular epithelial cells2021
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi, Yukio Satoh, Mitsuhiko Osaki, Satoshi Kuwamoto, Junichiro Miake, Yoshinori Ichihara, Tatsuya Sawano, Kazuhiko Matsuzawa, Takeshi Imamura
- Organizer
  第110回　日本病理学会　総会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] Thyrotropin receptor antibodies (TRAbs) induced by Epstein-Barr virus reactivation: Significance on Graves’ disease2021
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi, Yukio Satoh, Mitsuhiko Osaki, Junichiro Miake, Yoshinori Ichihara, Tatsuya Sawano, Yuhang Zhou, Agung Kurniawan Priyono, Kazuhiko Matsuzawa, Takeshi Imamura
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] TRAb-IgM induced by Epstein-Barr virus reactivation: significance in Graves' disease2020
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi, Keisuke Kumata, Sayuri Hara, Satoshi Kuwamoto, Yoshihisa Umekita
- Organizer
  第109回　日本病理学会　総会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] Association of mismatch repair proteins with Merkel cell polyomavirus status and prognosis in Merkel cell carcinoma2019
- Author(s)
  Lusi Oka Wardhani, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Daisuke Nonaka, Keiko Nagata, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
- Organizer
  31st European Congress of Pathology, Nice, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] Cytotoxicity of Epstein-Barr Virus Reactivation-Induced TRAb-IgM to Thyrocytes2019
- Author(s)
  Keiko Nagata, Mitsuhiko Osaki, Yukio Satoh, Sayuri Hara, Satoshi Kuwamoto, Michiko Matsushita, Masako Kato, Kazuhiko Hayashi
- Organizer
  ENDO 2019（米国内分泌学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] The expression of Notch signaling pathway in Merkel cell carcinoma2019
- Author(s)
  Michiko Matsushita, Lusi Oka Wardhani, Takeshi Iwasaki, Satoshi Kuwamoto, Daisuke Nonaka, Keiko Nagata, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
- Organizer
  31st European Congress of Pathology, Nice, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] EBウイルス再活性化によって誘導されたTSHレセプター抗体による甲状腺濾胞上皮障害 An injury to the thyroid follicular epithelium by TRAbs induced by EBV reactivation2019
- Author(s)
  長田佳子、尾崎充彦、佐藤幸夫、原　小百合、桑本聡史、松下倫子、加藤雅子、林一彦
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] メルケル細胞癌の腫瘍細胞と腫瘍微小環境におけるIDO1/TDO2-AhR経路の発現は予後と相関する2019
- Author(s)
  松下倫子、ルシオカワードダーニ、岩崎健、桑本聡史、野中大輔、長田佳子、加藤雅子、北村幸郷、林一彦
- Organizer
  第108回日本病理学会総会、東京
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] Significance of Epstein-Barr Virus Reactivation-Induced Antibodies to Autoimmune Diseases: Relevance to Graves’ disease2019
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi
- Organizer
  第48回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] メルケル細胞ポリオーマウイルス陰性のメルケル細胞癌では、ヒストンH3K27me3修飾が低下する2018
- Author(s)
  松下倫子、岩崎健、桑本聡史、野中大輔、長田佳子、加藤雅子、北村幸郷、林一彦
- Organizer
  第107回日本病理学会総会、札幌、2018
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] The Role of the Immunoglobulins Produced by Epstein-Barr Virus Reactivation-Induced Pathway in Autoimmune Reaction2018
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi
- Organizer
  第47回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] バセドウ病患者および健常者のPBMCでは潜伏しているEBウイルス再活性化によってIgG4産生が誘導される2018
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi
- Organizer
  第107回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] バセドウ病患者および健常者の末梢血単核球では、潜伏しているEBウイルスの再活性化によってIgG4産生が誘導される2018
- Author(s)
  長田佳子、原　小百合、中山祐二、檜垣克美、杉原弘貢、桑本聡史、松下倫子、加藤雅子、林　一彦
- Organizer
  第11回　IgG4研究会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] The histone modification H3K27me3 is reduced in MCPyV-negative Merkel cell carcinomas.2018
- Author(s)
  Matsushita M, Iwasaki T, Kuwamoto S, Lusi Oka Wardhani, Nonaka D, Nagata K, Kato M, Kitamura Y, Hayashi K.
- Organizer
  30th European Congress of Pathology, Bilbao, Spain, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] EB virus reactivation induces IgG4 production from B cells in Graves’ disease patients and controls2018
- Author(s)
  Keiko Nagata, Sayuri Hara, Yuji Nakayama, Katsumi Higaki, Hirotsugu Sugihara, Satoshi Kuwamoto, Michiko Matsushita, Masako Kato, Kazuhiko Hayashi
- Organizer
  第107回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] The expressions of IDO1 and TDO2 in tumor cells and their tumor microenvironment are associated with MCPyV status and prognosis in Merkel Cell Carcinomas2018
- Author(s)
  Lusi Oka Wardhani, Matsushita M, Iwasaki T, Kuwamoto S, Nonaka D, Nagata K, Kato M, Kitamura Y, Hayashi K.
- Organizer
  30th European Congress of Pathology, Bilbao, Spain, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] Association of Hedgehog signal expression with MCPyV infection and outcome in Merkel cell carcinoma.2017
- Author(s)
  Matsushita M, Kuromi T, Iwasaki T, Kuwamoto S, Nonaka D, Nagata K, Kato M, Kitamura Y, Hayashi K.
- Organizer
  29th European Congress of Pathology, Amsterdam, Netherlands
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] メルケル細胞癌におけるSWI/SNF複合体の発現異常とその意義に関する検討2017
- Author(s)
  松下倫子、桑本聡史、岩崎健、野中大輔、長田佳子、加藤雅子、村上一郎、北村幸郷、林一彦
- Organizer
  第106回日本病理学会総会、東京、2017
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] バセドウ病継続観察例における刺激性および阻害型TSHレセプター抗体価の変動2017
- Author(s)
  長田佳子、熊田圭祐、原　小百合、松下倫子、桑本聡史、加藤雅子、村上一郎、林　一彦
- Organizer
  題106回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] Association of Hedgehog signal expression with MCPyV infection and outcome in Merkel cell carcinoma.2017
- Author(s)
  Matsushita M, Kuromi T, Iwasaki T, Kuwamoto S, Nonaka D, Nagata K, Kato M, Kitamura Y, Hayashi K
- Organizer
  29th European Congress of Pathology, Amsterdam, Netherlands, 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] ImmunoglobulinG4 production is induced by reactivation of Epstein-Barr virus persistent in B lymphocytes from Graves’ disease patients and controls2017
- Author(s)
  Keiko Nagata, Kazuhiko Hayashi
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] Altered expression of SWI/SNF complex and its significance in Merkel cell carcinoma.2017
- Author(s)
  Matsushita M, Kuwamoto S, Iwasaki T, Nonaka D, Nagata K, Kato M, Kitamura Y, Hayashi K
- Organizer
  29th European Congress of Pathology, Amsterdam, Netherlands, 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] Expression of NEAT1 is significantly higher in MCPyV-positive MCC than MCPyV-negative one.2017
- Author(s)
  秋月源、今村亮俊、山田俊理、水谷玲菜、松下倫子、長田佳子、桑本聡史、加藤雅子、秋光信佳、林一彦
- Organizer
  第106回日本病理学会総会、東京、2017
- Data Source
  KAKENHI-PROJECT-17K08720
[Presentation] バセドウ病患者と健常者においてEpstein-Barr virusの再活性化に関連した抗体産生ではIgG4の産生も起こる2017
- Author(s)
  長田佳子、熊田圭祐、原小百合、桑本聡史、松下倫子、加藤雅子、林　一彦
- Organizer
  第14回　EBV研究会
- Data Source
  KAKENHI-PROJECT-17K08694
[Presentation] メルケル細胞癌におけるJAK-STAT経路活性化とMCPyVおよび予後との関係2016
- Author(s)
  松下倫子、岩崎健、野中大輔、桑本聡史、長田佳子、加藤雅子、北村幸郷、林　一彦
- Organizer
  第105回病理学会総会
- Place of Presentation
  仙台国際センター、（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] The relations of JAK-STAT signaling expressions to MCPyV-infection and outcome in Merkel cell carcinoma.2016
- Author(s)
  Michiko Matsushita, Takeshi Iwasaki, Daisuke Nonaka, Satoshi Kuwamoto, Keiko Nagata, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
- Organizer
  28th European Congress of Patholgy
- Place of Presentation
  Cologne, Germany
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] Expression of a long non-coding RNA NEAT1 is significantly higher in MCPyV-positive Merkel cell carcinomas than MCPyV-negative ones.2016
- Author(s)
  Gen Akizuki, Katsutoshi Imamura, Toshimichi Yamada, Aiko Sato, Rena Mizutani, Michiko Matsushita, Takeshi Iwasaki, Daisuke Nonaka, Satoshi Kuwamoto, Keiko Nagata, Masako Kato, Nobuyoshi Akimitsu, Kazuhiko Hayashi
- Organizer
  European Congress of Patholgy
- Place of Presentation
  Cologne, Germany
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] Biphasic production of immunoglobulin from EBV reactivated PBMCs in Graves’ disease patients and controls2016
- Author(s)
  Keiko Nagata, Keisuke Kumata, Yuji Nakayama, Yukio Satoh, Michiko Matsushita, Ichiro Murakami, Satoshi Kuwamoto, Masako Kato, Hirotsugu Sugihara, Kazuhiko Hayashi
- Organizer
  28th European Congress of Patholgy
- Place of Presentation
  Cologne, Germany
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] メルケル細胞癌におけるHedgehog signal発現とMCPyV感染および予後との関連2016
- Author(s)
  黒見晃行、松下倫子, 岩崎健、野中大輔、桑本聡史、長田佳子、加藤雅子、北村幸郷、林　一彦
- Organizer
  第105回病理学会総会
- Place of Presentation
  仙台国際センター、（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] Activation-induced deaminase (AID) gene expressions in Merkel cell carcinomas.by immunohistochemical and molecular analysis2015
- Author(s)
  Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Daisuke Nonaka, Keiko Nagata, Ichiro Murakami, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
- Organizer
  27th European Congress of Pathology
- Place of Presentation
  Belgrade, Serbia,
- Year and Date
  2015-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] 多変量解析によるメルケル細胞癌の予後予測因子の検討2015
- Author(s)
  桑本聡史、松下倫子、野中大輔、岩崎健、村上一郎、加藤雅子、林一彦
- Organizer
  第１０4回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] Higher CADM1 expression and lower MAL expression in Merkel cell carcinomas (MCCs) are associated with MCPyV-negative MCCs and unfavorable outcome2015
- Author(s)
  Takeshi Iwasaki, Michiko Matsushita, Daisuke Nonaka, Ichiro Murakami, Masako Kato, Satoshi Kuwamoto, Keiko Nagata, Kazuhiko Hayashi
- Organizer
  27th European Congress of Pathology
- Place of Presentation
  Belgrade, Serbia,
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] Epstein-Barr virus reactivation stimulates the expression of activation-induced cytidine deaminase in PBMCs from Graves’ disease patients and healthy controls2015
- Author(s)
  Keiko Nagata, Yuji Nakayama, Yukio Satoh, Keisuke Kumata, Michiko Matsushita, Shunsuke Tanio, Ichiro Murakami, Satoshi Kuwamoto, Masako Kato, Hirotsugu Sugihara, Kazuhiko Hayashi
- Organizer
  27th European Congress of Pathology
- Place of Presentation
  Belgrade, Serbia
- Year and Date
  2015-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] EBV関連遺伝子mRNA発現の定量法の検討2013
- Author(s)
  越智　万梨華、長田佳子、松下倫子、佐藤幸夫、林　一彦
- Organizer
  第１０回　EBウイルス研究会
- Place of Presentation
  キャンパスプラザ京都
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] EBV関連遺伝子mRNA発現の定量法の検討2013
- Author(s)
  越智万梨華、長田佳子、松下倫子、佐藤幸夫、林一彦
- Organizer
  第10会EBウイルス研究会
- Place of Presentation
  キャンパスプラザ京都
- Year and Date
  2013-07-12
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] バセドウ病患者の末梢血には、表面グロブリンとしてTSHレセプター抗体を持ち、EBウイルスに感染したBリンパ球が存在する2013
- Author(s)
  長田佳子、檜垣克美、中山祐二、宮内裕美、桐谷唯、越智万梨華、金井亨輔、難波栄二、木村宏、林一彦
- Organizer
  第１０回　EBウイルス研究会
- Place of Presentation
  キャンパスプラザ京都
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] EBウイルス感染B細胞株の再活性化後期におけるEBERとgp350/ 220の局在:72A1抗体を用いたP3HR-1細胞株の蛍光染色2012
- Author(s)
  長田佳子、檜垣克美、中山祐二、金井亨輔、桐谷唯、佐野仁志、加藤郁、木村宏、西蓮寺剛、林一彦
- Organizer
  日本ウイルス学会
- Place of Presentation
  大阪国際会議場(大阪府
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] バセドウ病患者の末梢血におけるEBV loadの検討2012
- Author(s)
  桐谷唯、長田佳子、木村宏、石黒清介、佐野仁志、加藤郁、林一彦
- Organizer
  第9会EBウイルス研究会
- Place of Presentation
  米子市文化ホール(鳥取県)
- Year and Date
  2012-07-06
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] バセドウ病患者の末梢血におけるEBV loadの検討2012
- Author(s)
  桐谷唯、長田佳子、木村宏、石黒清介、佐野仁志、加藤郁、林一彦
- Organizer
  第９会EBウイルス研究会
- Place of Presentation
  米子市文化ホール（鳥取県）
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] EBウイルス感染B細胞株の再活性化後期におけるEBERとgp350/ 220の局在：72A1抗体を用いたP3HR-1細胞株の蛍光染色2012
- Author(s)
  長田佳子、檜垣克美、中山祐二、金井亨輔、桐谷　唯、佐野仁志、加藤　郁、木村　宏、西蓮寺　剛、林　一彦
- Organizer
  日本ウイルス学会
- Place of Presentation
  大阪国際会議場（大阪府）
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] P3HR-1株産生EBVの経鼻投与におけるEBウイルス感染ウサギの解析2011
- Author(s)
  佐野仁志、金井亨輔*、加藤郁、長田佳子、林一彦
- Organizer
  第8回EBウイルス研究会
- Place of Presentation
  大阪大学大学院　銀杏会館（大阪）
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] P3HR-1株産生EBVの経鼻投与におけるEBウイルス感染ウサギの解析2011
- Author(s)
  佐野仁志、金井亨輔、加藤郁、長田佳子、林一彦
- Organizer
  第8回EBウイルス研究会
- Place of Presentation
  大阪大学大学院銀杏会館(大阪)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] A rabbit model for primary and lifelong persistent Epstein-Barr virus infection.2011
- Author(s)
  K Hayashi, K Takashima, K Okuno, K. Kato, S Sano, H Sugihara, M Kato, I Murakami K, K Nagata
- Organizer
  23rd European Congress of Pathology
- Place of Presentation
  Helsinki Exhibition & Convention Centre, Helsinki, Finland
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] A rabbit model for primary and lifelong persistent Epstein-Barr virus infection2011
- Author(s)
  Hayashi K, K Takashima, K Okuno, K. Kato, S Sano, H Sugihara, M Kato, I Murakami K, K Nagata
- Organizer
  23rd European Congress of Pathology
- Place of Presentation
  Helsinki Exhibition & Convention Centre, Helsinki, Finland
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-23590463
[Presentation] Expressions of p63 or/and its isoform, p40, are not correlated with the prognosis of Japanese and British patients with Merkel cell carcinoma
- Author(s)
  Michiko Matsushita, Satoshi Kuwamoto, Daisuke Nonaka, Takeshi Iwasaki, Keiko Nagata, Ichiro Murakami, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
- Organizer
  26th European Congress of Pathology
- Place of Presentation
  ExCel, London, UK
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] TRAbs production induced by Epstein-Barr virus reactivation in cultured-PBMCs from Graves’ disease patients and healthy controls
- Author(s)
  Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Hiromi Miyauchi, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Takeshi Iwasaki, Hiroshi Kimura, Kazuhiko Hayashi
- Organizer
  26th European Congress of Pathology
- Place of Presentation
  ExCel, London, UK
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] Comparative analysis of B cell-related marker and immunoglobulin expressions between MCPyV-positive and MCPyV-negative Merkel cell carcinomas
- Author(s)
  Kazuhiko Hayashi, Daisuke Nonaka, Michiko Matsushita, Katsuyoshi Takata, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yukisato Kitamura, Tadashi Yoshino, Ichiro Murakami
- Organizer
  26th European Congress of Pathology
- Place of Presentation
  ExCel, London, UK
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] メルケル細胞癌におけるp63及びp40の発現と生物学的悪性度との相関に関する検討
- Author(s)
  松下倫子、桑本聡史、野中大輔、岩崎健、村上一郎、加藤雅子、北村幸郷、林一彦
- Organizer
  日本病理学会
- Place of Presentation
  広島市、広島国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26460433
[Presentation] メルケル細胞癌のポリオーマウイルス(MCPyV)陽性群と陰性群におけるB細胞関連因子と免疫グロブリン発現の比較検討
- Author(s)
  Kazuhiko Hayashi, Daisuke Nonaka, Michiko Matsushita, Katsuyoshi Takata, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yukisato Kitamura, Tadashi Yoshino, Ichiro Murakami
- Organizer
  日本ウイルス学会
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26460433

1. AKAGI Tadaath (20136386)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. YOSHINO Tadashi (70183704)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. OKA Takashi (50160651)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. OHARA Nobuya (90325100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMADA Masao (40166731)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 宮本寛治 (80036459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KONDO Eisaku (30252951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OUCHIDA Mamoru (80213635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. SAIRENJI Takeshi (10117351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HORIE Yasushi (60229226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGATA Keiko (50304209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 田浩淙 (70226364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高橋聖之 (90101815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 松下倫子 (70642198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. TAKAHATA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KATO Shinsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. MORIMOTO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 長田桂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 22 results
19. 高田尚良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 加藤雅子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
21. 岩崎健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 横山淳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 村上一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 中山祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAYASHI Kazuhiko 林 一彦

林 一彦 ハヤシ カズヒコ

Research Projects

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Co-Researchers

エピトランスクリプトーム解析によるメルケル細胞癌の病態機構解明

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Review Section

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EBV reactivation-induced autoantibody production and management of Graves' disease

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Establishment of MCPyV-infection experimental system and the therapy base on the carcinogenesis of MCPyV-positive Merkel cell carcinomaPrincipal Investigator

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Analysis on the differences of tumorigenesis between MCPyV-positive and -negative Merkel cell carcinomas and its application to therapyPrincipal Investigator

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Pathological analysis of chronic active EBV-infection rabbit model with hemophagocytosisPrincipal Investigator

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The first animal model for "Hit and Run" theory of oncogenesis by EBV related virusPrincipal Investigator

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Molecular Pathological analyses of aberrant expression of the proteintyrosine phosphatase SHP1 gene in terms of lymphomagenesis/leukemogenesis.

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Pathological analyses and therapeutic trials of animal model of EB virus-related fatal hemophagocytic syndromePrincipal Investigator

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ANIMAL MODEL FOR HUMAN EB VIRUS-RELATED TUMOR: PATHOGENESIS OF RABBIT LYMPHOMA INDUCED BY SIMIAN EBV-RELATED VIRUSPrincipal Investigator

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Participation of Epstein-Barr virus in the pathogenesis of malignant lymphoma

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HTLV-II型ウイルス産生株を用いたHTLV関連疾患の動物モデル作製の試みPrincipal Investigator

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合成ペプチドを用いたHTLV-II型に特異な抗体作製とその中和活性の検討Principal Investigator

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成人T細胞白血病のin vitro多段階発癌モデルの作成

Principal Investigator

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HAYASHI Kazuhiko 林一彦

林一彦ハヤシカズヒコ

[Book] 臨床で使える！甲状腺疾患診療のテキスト【電子版付】2019