Kojima Naoya 小島直也

… Alternative Names

KOJIMA Naoya 小島直也

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Researcher Number	30183338
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2020 – 2022: 東海大学, 工学部, 教授 2005 – 2006: Tokai University, Future Science and Technology Joint Research Center, Professor, 未来科学技術共同研究センター, 教授 2005: 東海大学, 未来科学技術共同センター, 教授 2004: 東海大学, 工学部, 助教授 1998 – 2001: 東海大学, 工学部, 助教授 … More 1996 – 1998: 理化学研究所, 糖遺伝情報研究チーム, 研究員 1997: 理化学研究室, 糖遺伝情報研究チーム, 研究員 1996: RIKEN,Laboratory for Molecular Glycobiology, Frontier Researcher, 糖遺伝情報研究チーム, フロンティア研究員 1995: 理化学研究所, フロンティア研究システム, 研究員 1994: 理化学研究所, フロンティア研究システム・基礎化学特別研究員 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 49070:Immunology-related / Structural biochemistry / General medical chemistry / General physiology Except Principal Investigator Neurology / Functional biochemistry / Parasitology (including Sanitary zoology) / Biological Sciences
Keywords	Principal Investigator Helicobacter pylori / 糖脂質 / 糖鎖 / ポリシアル酸 / シアル酸転移酵素 / 細胞性免疫 / 貪食 / 樹状細胞 / Th1免疫応答 / オリゴマンノース被覆リポソーム … More / lactobacilli / actin / phagocytosis / mononuclear phagocyte / Intact cell wall / Liposome / マクロファージ / アクチン / 細菌細胞壁 / リポソーム / IL-12 / ファゴサイトーシス / 単核貪食細胞 / Glycolipid / Microdomain / ミクロドメイン / Bacterial adhesion / Glycosphingolipids / Human fluids / α-ヒドロキシ脂肪酸 / 人工糖タンパク質 / 人工糖脂質 / スフィンゴ糖脂質 / スルファチド / ルイスb型血液型糖鎖 / 接着 / 胃液 / Fucose / Chinese hamster Ovary Cells / Neuro2a / Neural cell adhesion molecule / Sialyltransferase / Polysialic acid / シアル酸転移酵素遺伝子 / 神経細胞接着分子(N-CAM) / CHO細胞 / フコース / 神経細胞接着因子 / Tetracycline / Neuroblastoma cells / Differentiation / Fucosyltransferase / GD3 synthase / Gangliosides / 神経細胞分化 / 糖転移酵素 / 分子生物学 / 糖転移酵素遺伝子 / テトラサイクリン / フユシルトランスフェラーゼ / 神経芽腫瘍細胞 / 分化 / GD3合成酵素 / ガングリオシド / 細胞間認識 / 糖鎖-糖鎖相互作用 / 表面プラズモン共鳴 / 細胞間相互作用 / 糖タンパク質 / 細胞接着 … More Except Principal Investigator ガングリオシド / Campylobacter jejuni / 細胞性免疫 / ワクチン / Neuro2a / テトラサイクリン / シアル酸転移酵素 / 増殖抑制 / Molecular mimicry / Lipo-oligosaccharide / Guillain-Barre syndrome / 遺伝子多型 / 分子相同性 / リポオリゴ糖 / ギラン・バレー症候群 / Neural differentiation / Differential display / GD3 synthase / フコース転移酵素 / デイファレンシャルディスプレイ / 細胞分化 / GD3合成酵素 / リポソーム / トキソプラズマ原虫 / アフリカトリパノソーマ原虫 / バベシア原虫 / 難治性原虫感染症 / リボソーム / オリゴマンノース / リーシュマニア / 感染症 / 人工糖脂質 / 神経分化 / 糖転移酵素 Less

Activation of mononuclear phagocytes by phagocytosis of carbohydrate-decorated particlesPrincipal Investigator
- Principal Investigator
  
  Kojima Naoya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokai University
難治性原虫感染症に対する細胞性免疫誘導型ワクチンシステムの評価
- Principal Investigator
  
  横山直明
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Molecular mechanism of Guillain-Barre syndrome after Campylobacter jejuni enteritis : approach from bacterial analysis
- Principal Investigator
  
  YUKI Nobuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Dokkyo Medical University
Analysis of target molecules and their effective carbohydrates for Helicobacter pyroriPrincipal Investigator
- Principal Investigator
  
  KOJIMA Naoya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokai University
人工糖脂質リポソームを用いる細胞性免疫誘導型感染症ワクチンの開発
- Principal Investigator
  
  水落次男
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Analysis of receptor carbohydrates for Helicobacter pylori from human fludsPrincipal Investigator
- Principal Investigator
  
  KOJIMA Naoya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  TOKAI UNIVERSITY
糖鎖-糖鎖間の相互作用に基づく細胞間認識と情報伝達に関する研究Principal Investigator
- Principal Investigator
  
  小島直也
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokai University
Analysis of two types of sialytransferases involved in polysialic acid synthesisPrincipal Investigator
- Principal Investigator
  
  KOJIMA Naoya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokai University
増殖抑制誘導能をもつ糖転移酵素遺伝子の解析
- Principal Investigator
  
  辻崇一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
ガングリオシド依存性神経系分化過程での遺伝子発現とその制御機構の解析
- Principal Investigator
  
  辻崇一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
Molecular analysis of neural differentiation induced by glycosyltransferase
- Principal Investigator
  
  TSUJI Shuichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research (RIKEN)
増殖抑制誘導能を持つ糖転移酵素遺伝子の解析
- Principal Investigator
  
  TSUJI Shuichi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
Induction of differentiation of neural cells by remodeling of ganglioside synthesis and expressionPrincipal Investigator
- Principal Investigator
  
  KOJIMA Naoya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research (RIKEN)
糖鎖間相互作用に基づく細胞間認識機構Principal Investigator
- Principal Investigator
  
  小島直也
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2021 2020 2007 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] Wall teichoic acid-dependent phagocytosis of intact cell walls of Lactiplantibacillus plantarum elicits IL-12 secretion from macrophages2022
- Author(s)
  Kojima Naoya、Kojima Shohei、Hosokawa Shin、Oda Yoshiki、Zenke Daisuke、Toura Yuta、Onohara Emi、Yokota Shin-ichi、Nagaoka Masato、Kuroda Yasuhiro
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 13 Pages: 986396-986396
- DOI
  10.3389/fmicb.2022.986396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03488, KAKENHI-PROJECT-20K07542
[Journal Article] Importance of particle size of oligomannose-coated liposomes for induction of Th1 immunity2021
- Author(s)
  Matsuoka Yuko、Onohara Emi、Kojima Naoya、Kuroda Yasuhiro
- Journal Title
  
  International Immunopharmacology
  
  Volume: 99 Pages: 108068-108068
- DOI
  10.1016/j.intimp.2021.108068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07542
[Journal Article] Preliminary evaluation of oligomannose-coated liposome vaccines against lethal protozoan infections in mice.2007
- Author(s)
  Kuboki, N., Tiwaanthagorn, W., Takagi, H., Nakayama, T., Xuan, X., Inoue, N., Igarashi, I., Tsujimura, K., Ikehara, Y., Kojima, N., Yokoyama, N.
- Journal Title
  
  J.Protozool.Res. (印刷中)
- NAID
  130007747168
- Data Source
  KAKENHI-PROJECT-17659120
[Journal Article] Intraperitoneal Immunization With Oligomannose-Coated Liposome-Entrapped Soluble Leishmanial Antigen Induces Antigen-Specific T-helper Type 1 Immune Response in BALB/c Mice Through Uptake by Peritoneal Macrophages.2007
- Author(s)
  Shimizu, Y., Takagi, H., Nakayama, T., Yamakami, K., Tadakuma, T., Yokoyama, N., Kojima, N.
- Journal Title
  
  Parasit.Immunol. 29
  
  Pages: 229-239
- Data Source
  KAKENHI-PROJECT-17659120
[Journal Article] Efficacy of dipalmitoylphosphatidylcholine liposome against African trypanosomes.2006
- Author(s)
  Kuboki, N., Yokoyama, N., Kojima N, Sakurai, T., Inoue, N., Sugimoto, C.
- Journal Title
  
  J.Parasitol. 92
  
  Pages: 389-393
- Data Source
  KAKENHI-PROJECT-17659120
[Journal Article] EFFICACY OF DIPALMITOYLPHOSPHATIDYLCHOLINE LIPOSOME AGAINST AFRICAN TRYPANOSOMES.2006
- Author(s)
  KUBOKI, N., YOKOYAMA, N., KOJIMA, N., (他三名)
- Journal Title
  
  J.PARACYTOL (In press)
- Data Source
  KAKENHI-PROJECT-16570101
[Journal Article] Histochemical Expression of Siloglycoconjugates in Carcinoma of the Papilla of Vater.2005
- Author(s)
  Tang W, Guo Q, Usuda M, Kokudo N, Seyama Y, Minagawa M, Sugawara Y, Nakata, M., Kojima, N., Makuuchi, M
- Journal Title
  
  Hepato-Gastroenterology 52
  
  Pages: 67-71
- Data Source
  KAKENHI-PROJECT-16570101
[Journal Article] Novel Role of the Ras Cascade in Memory B Cell Response2005
- Author(s)
  Takahasi, Y., Inamine, A., Hoshimoto, S., Haraguchi, S., Yoshizawa, E., Kojima, N., Abe, R., Takemori, T
- Journal Title
  
  Immunity 23
  
  Pages: 127-138
- Data Source
  KAKENHI-PROJECT-16570101
[Journal Article] Efficacy of dipalmitoylphosphatidylcholine liposome against African trypanosomes.
- Author(s)
  Kuboki, N., Yokoyama N., Kojima N, Sakurai, I., Inoue, N., Sugimoto, C.
- Journal Title
  
  J.Parasitology (印刷中)
- Data Source
  KAKENHI-PROJECT-17659120
[Patent] 特許2005
- Inventor(s)
  小島直也, 池原譲, 辻村邦夫
- Industrial Property Rights Holder
  東海大学, 愛知県
- Industrial Property Number
  2005-094380
- Filing Date
  2005-03-29
- Data Source
  KAKENHI-PROJECT-16570101
[Patent] 特許2005
- Inventor(s)
  小島直也, 池原譲, 辻村邦夫
- Industrial Property Rights Holder
  東海大学, 愛知県
- Industrial Property Number
  2005-094380
- Filing Date
  2005-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570101
[Presentation] L. plantarum の Intact cell walls (ICWs) によるマクロファージの活性化2022
- Author(s)
  小島直也,横田伸一,長岡正人, 小田慶喜, 黒田泰弘
- Organizer
  第41回糖質学会年会
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] Recognition of Cell Wall Teichoic Acids Displayed on Intact Cell Walls of L. plantarum by Murine Macrophages Leads to IL-12 Secretion2022
- Author(s)
  Kojima Naoya, Touura Yuta, Onohara Emi
- Organizer
  10th Annual Meeting of the International Cytokine & Interferon Society (Cytokine 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] Lactobacillus plantarumの細胞壁テイコ酸に依存したファゴサイトーシスによるマクロファージの活性化2021
- Author(s)
  細川　伸、小島匠平、横田伸一、小島直也、黒田泰弘
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] Induction of IL-12 from murine macrophages by intact particulate cell wall of Lactobacillus plantarum through cell wall teichoic acid-dependent phagocytosis2021
- Author(s)
  Shin Hosokawa, Naoya Kojima
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] OMLによる細胞性免疫誘導には糖鎖依存的なファゴサイトーシスによるOMLの取り込みが必要である2021
- Author(s)
  小野原えみ、松岡祐子、小島直也、黒田泰弘
- Organizer
  第94回日本生化学会大会,
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] Carbohydrate dependent phagocytosis of oligomannose-coated liposomes induces IL-12 production from mononuclear phagocytes2021
- Author(s)
  Naoya Kojima, Yuko Matsuoka, Yasuhiro Kuroda
- Organizer
  16th International Meeting of Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] Lactobacillus plantarumの細胞壁テイコ酸に依存したファゴサイトーシスによるマクロファージの活性化2021
- Author(s)
  細川　伸、小島匠平、横田伸一、小島直也、黒田泰弘
- Organizer
  日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-20K07542
[Presentation] オリゴマンノース被覆リポソーム（OML）による細胞生免疫誘導にはリポソーム粒子の大きさが重要である2020
- Author(s)
  小島直也
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07542

1. TSUJI Shuichi (90124677)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TAKASHIMA Shou (00300880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YUKI Nobuhiro (60285913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MASUDA Michiaki (80199702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉田雪子 (90271543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 水落次男 (90133149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横山直明 (80301802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 井上昇 (10271751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. HONG Liu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. LIU Hong

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOKOTA Shin-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐藤豊孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kojima Naoya 小島 直也

KOJIMA Naoya 小島 直也

Research Projects

Research Products

Co-Researchers

Activation of mononuclear phagocytes by phagocytosis of carbohydrate-decorated particlesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性原虫感染症に対する細胞性免疫誘導型ワクチンシステムの評価

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of Guillain-Barre syndrome after Campylobacter jejuni enteritis : approach from bacterial analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of target molecules and their effective carbohydrates for Helicobacter pyroriPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

人工糖脂質リポソームを用いる細胞性免疫誘導型感染症ワクチンの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of receptor carbohydrates for Helicobacter pylori from human fludsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖鎖-糖鎖間の相互作用に基づく細胞間認識と情報伝達に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of two types of sialytransferases involved in polysialic acid synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

増殖抑制誘導能をもつ糖転移酵素遺伝子の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ガングリオシド依存性神経系分化過程での遺伝子発現とその制御機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular analysis of neural differentiation induced by glycosyltransferase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

増殖抑制誘導能を持つ糖転移酵素遺伝子の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Induction of differentiation of neural cells by remodeling of ganglioside synthesis and expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖鎖間相互作用に基づく細胞間認識機構Principal Investigator

Kojima Naoya 小島直也

KOJIMA Naoya 小島直也