Yamazaki Hiroshi 山崎浩史

… Alternative Names

YAMAZAKI Hiroshi 山崎浩史

山崎浩史ヤキザキヒロシ

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Researcher Number	30191274
Other IDs	https://orcid.org/0000-0002-1068-4261
External Links
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2005 – 2024: 昭和薬科大学, 薬学部, 教授 2016: 昭和薬科大学, 薬物動態学研究室, 教授 2008: 昭和薬科大, 薬学部, 教授 2002 – 2004: HOKKAIDO Univ., Grad.School of Pharmaceu.Sci, Asso.Prof., 大学院・薬学研究科, 助教授 2002: Hokkaido Univ., Graduate School of, Associate Professor, 大学院・薬学研究科・代謝分析学, 助教授 1998 – 2000: 金沢大学, 薬学部, 助教授 1993 – 1996: 大阪府立公衆衛生研究所, 薬事指導部, 研究員
Review Section/Research Field	Principal Investigator Public health/Health science / Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Environmental pharmacy / 医薬分子機能学 Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Basic Section 42020:Veterinary medical science-related / Environmental pharmacy / Pathological medical chemistry … More / 応用薬理学・医療系薬学 / Biological pharmacy / Applied pharmacology / Anesthesiology/Resuscitation studies Less
Keywords	Principal Investigator CYP3A4 / P450 / 個人差 / サリドマイド / 代謝的活性化 / 薬物相互作用 / ヒト肝ミクロゾーム / 大腸菌 / チトクロームP450酵素 / CYP1A1 … More / ヒト / 不活性化 / CYP1B1 / AHR / 胎盤 / 酵素誘導 / 遺伝子多型 / リコンビナント / CYP3A5 / チトクロームb_5 / チトクロームP450 / パロキセチン / アトモキセチン / P450 2D6 / 相互作用予測 / S-ワルファリン / クマリン / アザムリン / チエニリン酸 / フラフィリン / ヒト肝細胞移植マウス / ポマリドミド / レナリドミド / 肝 / 生理学的薬物動態 / フタル酸エステル / レナリドマイド / ポマリドマイド / CYP3A / Pronofol / Voriconazole / Thalidomide / Metabolic activation / CYP2B6 / Toxicity / 奇形 / 胎仔全培養 / ヒト型モデル動物 / CYP3A7 / ヒト型モデル / Tgマウス / 胎児毒性 / TCDD / PAHs / ダイオキシン / 多環芳香族炭化水素 / drug Interaction / coexpressing system / P450 contents / Individual difference / tegafur / phenytoin / human liver microsomes / テストステロン / チトクロームb5 / NADPH-P450還元酵素 / 組換えヒトP450 / チトクロムP450 / 共発現系 / P450組成比 / テガフール / フェニトイン / ヒト肝移植マウス / P450 3A / グルタチオン付加体 / 反応性代謝物 / ヒト肝移植キメラマウス / ヒト型薬物代謝 / P450 3A4 / 薬物代謝 / 体臭 / トリメチルアミン / FMO3 / カテコールエストロジェン / エストロン / エストラジオール / CYP1A2 / エリスロマイシン / フラボドキシン / CYP2D6 / CYP2A6 / 種差 / ラット / P4501A2 / P4502B6 / P4503A4 / 6-アミノクリセン / アセチル転移酵素 … More Except Principal Investigator P450 / 薬物代謝酵素 / チトクロムP450 / 遺伝子多型 / CYP2A6 / フラビン含有酸素添加酵素 / FMO / 個人差 / 薬物相互作用 / チトクロームP450 / 薬物代謝 / トランスジェニックマウス / ゲノム / 獣医動物種 / BeWo細胞 / 肝細胞 / COX / CGH / COX-2 / cytochrome P450 / fetal toxicity / EBPα / C / p53 / 胎児毒性 / CYP3A7 / CYP3A5 / 酵素誘導 / 相互作用 / CYP3A4 / HepaRG / サリドマイド / ニコチン / 次世代シーケンサー / 遺伝子 / 毒性評価 / 連結型培養手法 / 胎盤 / 共存培養 / 胎盤細胞 / 膜透過 / レナリドマイド / 胎盤透過性 / ヒト幹細胞 / 薬学 / 培地組成 / 培養時間 / iPS / 薬物透過性 / ips細胞 / ヒト肝由来HepaＲG cells / 初代培養肝細胞 / 3次元培養法 / iPS細胞 / 培養肝細胞 / 長期間維持培地 / サイトカイン / Marmoset / チロクロムP450 / マーモセット / サル / drug oxidation / whole gene deletion / anti cancer drug / individual variation / genetic polymorphism / individualized medicine / オーダーメイド / 個別化医療 / NAT2 / カフェイン / CYP1A2 / 薬物酸化 / 全欠損変異 / 抗がん薬 / テーラーメイド / teratogenicity / animal model / humanized mice / transgenic mice / thalidomide / フェニトイン / アフラトキシンB_1 / H合成酵素 / プロスタグランジンG / 催奇形性 / 実験動物 / ヒト化マウス / microsatellite instability / genomic instability / intrahepatic cholangiocarcinoma / xanthogranulomatous cholecystitis / gall bladder cancer / biliary tract cancer / 黄色肉芽腫瘍胆襄炎 / がん遺伝子 / 症例・対照研究 / 薬剤代謝酵素 / ミクロサテライト不安定性 / マイクロサテライト不安定性 / ゲノム不安定性 / 肝内胆管がん / 黄色肉芽腫様胆嚢炎 / 胆嚢がん / 胆道がん / troglitazone / Phenotyping / transporter / genotyping / Nicotine / drug metabolizing enzyme / キノン体代謝物 / 肝障害 / 人種差 / トログリタゾン / トランスポーター / 遺伝子診断 / SNPs / transgenic mouse / gene regulation / development / サルモネラ菌 / 時期特異的発現調節 / 発現調節 / ヒト肝 / 胎児 / 転写制御 / 発生 / フラビン含有酸素添酵素 / FMO3 / フラビン含有酸素添加酵素3 / テーラーメード薬物治療 / テーラーメイド薬物治療 / 不可逆的阻害 / テーラーメード医療 / P4502D6 / HPLC / アルツハイマー治療薬 / 抗うつ薬 / アレル頻度 / P4503A422 / 抗精神薬 / CYP2D6 / 向精神薬 / ミダゾラム水酸化活性 / 促進定数 / CYP3A / GSH / ヒト型モデルマウス / 協同性 / CYP2B66 / 覚醒遅延 / CYP2B6 / プロポフォール / 麻酔学 / 寿命制御遺伝子 / 遺伝子欠損型多型 / 肺がんリスク / 煙草 / ニトロソアミン / ヒト型マウス / タバコ / 代謝的活性化 / がん Less

Functional analysis of flavin-containing monooxygenases using species differences and human polymorphisms in primary structures
- Principal Investigator
  
  清水万紀子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
獣医学での薬物代謝の研究基盤構築を目指した薬物代謝酵素の遺伝子多型の網羅的解析
- Principal Investigator
  
  宇野泰広
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kagoshima University
遺伝的多型の定量的予測のための酵素不活化ヒト肝細胞移植マウスと動態モデリング開発Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
- Principal Investigator
  
  Murayama Norie
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Roles of human cytochrome P450 1A2, 2C9, and 3A4/5 enzymes in drug oxidations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric micePrincipal Investigator
- Principal Investigator
  
  Yamazaki Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary species
- Principal Investigator
  
  Uno Yasuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kagoshima University
Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal models
- Principal Investigator
  
  Shimizu Makiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver micePrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal models
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
The functional chacterization of marmoset cytochrome P450 2C enzymes
- Principal Investigator
  
  Uehara Shotaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Evaluaion of Human Cytochrome P450 3A Enzymes in Hepatic and Placental Cells by Thalidomide and Relevance to BioactivationPrincipal Investigator
- Principal Investigator
  
  Yamazaki Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenases
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
The most suitable administration of antidepressive drug to avoid risk of side effects in patient
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450
- Principal Investigator
  
  OHTANI Hisakazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University
Thalidomide increases cytochrome P450 activity and drug metabolism in liver through direct activation of nuclear receptor CAR and PXRPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Drug interaction of thalidomide with midazolam and other compounds : heterotropic cooperativiy of human cyochrome P450
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Polymorphic drug-metabolizing enzymes of anesthetics agent propofol rekated to its infusion syndrome.
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Showa Pharmaceutical University
薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Molecular mechanism of chemical-induced toxicity in fetal liversPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa Pharmaceutical University
Basic Research for Individualized Medicine
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Molecular Mechanisms of Toxic Expression Induced by Endocrine Disruptors via AHRPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.
- Principal Investigator
  
  KAMATAKI Tetsuya, 藤田健一
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
CYP2A6のpharmacogenomics的研究
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokkaido University
Transcriptional regulation of the CYP3A7 gene specifically expressed in the human fetal liver.
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Investigation and evaluation of genetic polymorphisms of drug metabolizing
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kanazawa University
Genetic oncological and molecular epidemiological research on development and progression of the biliary tract cancer in Asia
- Principal Investigator
  
  MIWA Masanao
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Tsukuba
PREDICTION OF DRUG DISPOSITION BY HUMAN DRUG METABOLIZING ENZYMESPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  KANAZAWA UNIVERSITY
エストロジェンの代謝的活性化に関与するヒトのチトクロームP450酵素分子種の同定Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Kanazawa University
くすりの相互作用と安全性の予測を目的とした組換えヒトP450酵素の応用Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Osaka Prefectural Institute of Public Health
大腸菌に発現させたヒト薬物代謝酵素のくすりの安全性評価への応用Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Osaka Prefectural Institute of Public Health
環境化学物質の安全性評価に関わるヒト実験動物の薬物代謝酵素の種差に関する研究Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Osaka Prefectural Institute of Public Health
新しいアセチル転移酵素導入サルモネラ菌を用いた変異原性物質のDNA障害性の検出Principal Investigator
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Osaka Prefectural Institute of Public Health

[Book] Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary2022
- Author(s)
  Hiroshi Yamazaki
- Total Pages
  434
- Publisher
  Academic Press
- ISBN
  9780323911092
- Data Source
  KAKENHI-PROJECT-20K07164
[Book] OECD Environment, Health and Safety Publications Series on Testing and Assessment no. 3312021
- Author(s)
  Ryohji Takano, Norie Murayama, Kana Horiuchi, Masato Kitajima, Masatoshi Kumamoto, Fumiaki Shono, Hiroshi Yamazaki
- Total Pages
  101
- Publisher
  OECD
- Data Source
  KAKENHI-PROJECT-20K07164
[Book] OECD Environment, Health and Safety Publications Series on Testing and Assessment no. 3312021
- Author(s)
  Tomonori Miura, Hiroshi Suemizu, Masatomo Goto, Norifumi Sakai, Hiroshi Iwata, Makiko Shimizu, Hiroshi Yamazaki
- Total Pages
  101
- Publisher
  OECD
- Data Source
  KAKENHI-PROJECT-20K07164
[Book] マーモセットラボマニュアル　はじめての取扱いから研究最前線まで2018
- Author(s)
  山崎浩史他
- Total Pages
  186
- Publisher
  アドスリー
- ISBN
- Data Source
  KAKENHI-PROJECT-17K08425
[Book] Comprehensive Medicinal Chemistry III: ADME and ToxicologyYamazaki, H.Drug Metabolizing Enzyme Systems I2017
- Author(s)
  Hiroshi Yamazaki
- Total Pages
  6
- Publisher
  Elsevier
- ISBN
  9780128032008
- Data Source
  KAKENHI-PROJECT-17K08425
[Book] Advances in Medicine and Biology, vol 932016
- Author(s)
  Yamazaki, H., Chowdhury, G. and Guengerich, F.P.
- Total Pages
  8
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-26460206
[Book] Fifty Years of Cytochrome P450 Research2014
- Author(s)
  Hiroshi Yamazaki
- Total Pages
  402
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26460206
[Book] 先天代謝異常ハンドブック (トリメチルアミン尿症（魚臭症候群）)2013
- Author(s)
  山崎浩史、清水万紀子
- Total Pages
  456
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25460198
[Book] 新衛生化学・公衆衛生学2011
- Author(s)
  山崎浩史他
- Total Pages
  461
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23590200
[Book] 南江堂2007
- Author(s)
  山崎浩史, 横井毅
- Total Pages
  422
- Publisher
  製剤学改訂第5版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 中山書店2007
- Author(s)
  山崎浩史
- Publisher
  毒性物質の生体内運命「最新毒性病理学」
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 臨床薬理研究進行財団2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究「臨床薬理の進歩No.29」
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 臨床薬理研究進行財団(印刷中)2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究「臨床薬理の進歩No.29」
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 中山書店(印刷中)2007
- Author(s)
  山崎浩史
- Publisher
  毒性物質の生体内運命「最新毒性病理学」
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 日本医療薬学会会報2007
- Author(s)
  山崎浩史
- Total Pages
  93
- Publisher
  薬物治療の最適化とバイオマーカーの利用
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 製剤学改訂第5版2007
- Author(s)
  山崎浩史, 横井毅ら
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-17659038
[Book] 南江堂2007
- Author(s)
  山崎浩史, 横井毅
- Total Pages
  422
- Publisher
  製剤学改訂第5版
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 臨床中毒とゲノミクス2006
- Author(s)
  山崎浩史
- Total Pages
  6
- Publisher
  中毒研究
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 中毒研究2006
- Author(s)
  山崎浩史
- Total Pages
  6
- Publisher
  臨床中毒とゲノミクス
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 薬学教科書シリーズ2005
- Author(s)
  山崎浩史ら
- Total Pages
  10
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 薬学教科書シリーズ2005
- Author(s)
  山崎浩史ら
- Total Pages
  10
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-17659038
[Book] 「分子予防環境医学」薬物・外来異物に対する生体の代謝機構(分子予防環境医学研究会編)2003
- Author(s)
  山崎浩史ら
- Total Pages
  20
- Publisher
  本の泉社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity2024
- Author(s)
  Uno Yasuhiro、Minami Yuhki、Tsukiyama-Kohara Kyoko、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: in press Pages: 115990-115990
- DOI
  10.1016/j.bcp.2023.115990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole2024
- Author(s)
  Uno Yasuhiro、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 52 Issue: 3 Pages: 266-273
- DOI
  10.1124/dmd.123.001583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Molecular and functional characterization of flavin-containing monooxygenases (FMO1?6) in tree shrews2024
- Author(s)
  Uno Yasuhiro、Makiguchi Miaki、Ushirozako Genki、Tsukiyama-Kohara Kyoko、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
  
  Volume: 277 Pages: 109835-109835
- DOI
  10.1016/j.cbpc.2024.109835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models2024
- Author(s)
  Uno Yasuhiro、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: in press Pages: 116124-116124
- DOI
  10.1016/j.bcp.2024.116124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan2024
- Author(s)
  Ushirozako Genki、Murayama Norie、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi、Uno Yasuhiro
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 52 Issue: 4 Pages: 305-311
- DOI
  10.1124/dmd.123.001603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans2024
- Author(s)
  Uno Yasuhiro、Yamato Osamu、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 55 Pages: 101002-101002
- DOI
  10.1016/j.dmpk.2024.101002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs2023
- Author(s)
  Uno Yasuhiro、Morikuni Saho、Shiraishi Mitsuya、Asano Atsushi、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: - Issue: 5 Pages: 637-644
- DOI
  10.1124/dmd.122.001236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers.2023
- Author(s)
  Kamimura H, Uehara S, Yoneda N, Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 53 Issue: 1 Pages: 523-535
- DOI
  10.1124/dmd.123.001481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05621, KAKENHI-PROJECT-23K06217
[Journal Article] High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4?16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database2023
- Author(s)
  Adachi Koichiro、Ohyama Katsuhiro、Tanaka Yoichi、Sato Tasuku、Murayama Norie、Shimizu Makiko、Saito Yoshiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 49 Pages: 100486-100486
- DOI
  10.1016/j.dmpk.2022.100486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164
[Journal Article] Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin.2023
- Author(s)
  Uehara S, Shimizu M, Suemizu H, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 50 Pages: 100504-100504
- DOI
  10.1016/j.dmpk.2023.100504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-23K06217
[Journal Article] Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes2023
- Author(s)
  Uno Yasuhiro、Noda Yutaro、Murayama Norie、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C
  
  Volume: 265 Pages: 109534-109534
- DOI
  10.1016/j.cbpc.2022.109534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes2023
- Author(s)
  Uno Yasuhiro、Jikuya Shiori、Noda Yutaro、Oguchi Asuka、Murayama Norie、Kawaguchi Hiroaki、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C
  
  Volume: 267 Pages: 109579-109579
- DOI
  10.1016/j.cbpc.2023.109579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A192023
- Author(s)
  Ushirozako Genki、Noda Yutaro、Murayama Norie、Kawaguchi Hiroaki、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi、Uno Yasuhiro
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: - Issue: 5 Pages: 610-617
- DOI
  10.1124/dmd.122.001152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine2022
- Author(s)
  Uno Yasuhiro、Jikuya Shiori、Noda Yutaro、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 1 Pages: 38-45
- DOI
  10.1124/dmd.121.000749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches2022
- Author(s)
 Yamada, T., Katsutani, N., Maruyama, T., Kawamura, T., Yamazaki, H., Murayama, N., Tong, W., Yamazoe, Y., and Hirose, A.
- Journal Title
 
 Food Safety
 
 Volume: 10 Issue: 3 Pages: 73-82
- DOI
 10.14252/foodsafetyfscj.D-21-00015
- ISSN
 2187-8404
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20K07139
[Journal Article] Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs2022
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Ijiri Moe、Kawaguchi Hiroaki、Asano Atsushi、Shiraishi Mitsuya、Banju Kaito、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 11 Pages: 1429-1433
- DOI
  10.1124/dmd.122.000919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Plasma concentration profiles for hepatotoxic pyrrolizidine alkaloid senkirkine in humans extrapolated from rat data sets using a simplified physiologically based pharmacokinetic model.2022
- Author(s)
  Kamiya, Y., Miura, T., Kato, A., Murayama, N., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Drug Metab Bioanal Lett
  
  Volume: 15 Issue: 1 Pages: 64-69
- DOI
  10.2174/1872312801666211220110055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Polymorphic cytochromes P450 in non-human primates2022
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Yamazaki Hiroshi
- Journal Title
  
  Advances in Pharmacology
  
  Volume: 95 Pages: 329-364
- DOI
  10.1016/bs.apha.2022.05.005
- ISBN
  9780323911092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes2022
- Author(s)
  Yamazaki Hiroshi、Shimizu Makiko
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 1 Pages: 123-129
- DOI
  10.1124/dmd.121.000742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-23K06217
[Journal Article] Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques2022
- Author(s)
  Uno Yasuhiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 42 Pages: 100431-100431
- DOI
  10.1016/j.dmpk.2021.100431
- NAID
  210000173067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes2022
- Author(s)
  Uno Yasuhiro、Ushirozako Genki、Uehara Shotaro、Murayama Norie、Fujiki Yuki、Kawaguchi Hiroaki、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 52 Issue: 7 Pages: 687-696
- DOI
  10.1080/00498254.2022.2141153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans2022
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 197 Pages: 114887-114887
- DOI
  10.1016/j.bcp.2021.114887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07164
[Journal Article] Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies2022
- Author(s)
  Daisuke Ogiya, Norie Murayama, Yusuke Kamiya, Rie Saito, Sawako Shiraiwa, Rikio Suzuki, Shinichiro Machida, Kei Tazume, Kiyoshi Ando, Hiroshi Yamazaki
- Journal Title
  
  Annals of Hematology
  
  Volume: 101 Issue: 9 Pages: 2013-2019
- DOI
  10.1007/s00277-022-04893-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17387, KAKENHI-PROJECT-20K07139
[Journal Article] Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo.2022
- Author(s)
  Uehara S, Shimizu M, Ple K, Routier S, Yoneda N, Higuchi Y, Suemizu H, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 44 Pages: 100453-100453
- DOI
  10.1016/j.dmpk.2022.100453
- NAID
  210000188903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes2022
- Author(s)
  Uno Yasuhiro、Murayama Norie、Ijiri Moe、Kawaguchi Hiroaki、Yamato Osamu、Shiraishi Mitsuya、Asano Atsushi、Teraoka Hiroki、Mizukawa Hazuki、Nakayama Shouta M.M.、Ikenaka Yoshinori、Ishizuka Mayumi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 11 Pages: 1434-1441
- DOI
  10.1124/dmd.122.000930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07139
[Journal Article] Systematic identification and characterization of cynomolgus macaque solute carrier transporters2022
- Author(s)
  Uno Yasuhiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 43 Pages: 100437-100437
- DOI
  10.1016/j.dmpk.2021.100437
- NAID
  210000172987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice2021
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shimizu Makiko、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 11 Pages: 525-530
- DOI
  10.2131/jts.46.525
- NAID
  130008110376
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects2021
- Author(s)
  Shimizu Makiko、Mizugaki Ami、Koibuchi Natsumi、Sango Haruna、Uenuma Yumi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 41 Pages: 100420-100420
- DOI
  10.1016/j.dmpk.2021.100420
- NAID
  210000186929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals2021
- Author(s)
  Kamiya Yusuke、Handa Kentaro、Miura Tomonori、Yanagi Mayu、Shigeta Kazuki、Hina Shiori、Shimizu Makiko、Kitajima Masato、Shono Fumiaki、Funatsu Kimito、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 507-513
- DOI
  10.1021/acs.chemrestox.0c00336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K07164
[Journal Article] Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques2021
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 4 Pages: 494-499
- DOI
  10.1080/00498254.2021.1874564
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07139
[Journal Article] Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources2021
- Author(s)
  Shimizu Makiko、Koibuchi Natsumi、Mizugaki Ami、Hishinuma Eiji、Saito Sakae、Hiratsuka Masahiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 38 Pages: 100387-100387
- DOI
  10.1016/j.dmpk.2021.100387
- NAID
  210000160257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats2021
- Author(s)
  Kamiya, Y. Handa, K. Miura, T. Ohori, J. Shimizu, M. Kitajima, M. Shono, F. Funatsu, K. Yamazaki, H.
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 34 Issue: 10 Pages: 2180-2183
- DOI
  10.1021/acs.chemrestox.1c00249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164
[Journal Article] Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes.2021
- Author(s)
  Nagayoshi, H., Murayama, N., Takenaka, S., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada, T.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 9 Pages: 995-1009
- DOI
  10.1080/00498254.2021.1950866
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes2021
- Author(s)
  Taniguchi-Takizawa Tomomi、Kato Nozomu、Shimizu Makiko、Kume Toshiyuki、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 40 Pages: 100412-100412
- DOI
  10.1016/j.dmpk.2021.100412
- NAID
  210000159914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 12021
- Author(s)
  Uehara Shotaro、Uno Yasuhiro、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 39 Pages: 100398-100398
- DOI
  10.1016/j.dmpk.2021.100398
- NAID
  210000169422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K06463
[Journal Article] Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2´-, 3´-, 4´-, and 6-hydroxyflavanones by human cytochrome P450 enzymes.2021
- Author(s)
  Shimada, T., Nagayoshi, H., Murayama, N., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H. ,Guengerich, F. P.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 2 Pages: 139-154
- DOI
  10.1080/00498254.2020.1836433
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations2021
- Author(s)
  Murayama, N., Yamazaki, H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 8 Pages: 371-378
- DOI
  10.2131/jts.46.371
- NAID
  130008070939
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20K07164
[Journal Article] In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice2021
- Author(s)
  Shimizu Makiko、Uehara Shotaro、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100369-100369
- DOI
  10.1016/j.dmpk.2020.11.004
- NAID
  210000164669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205, KAKENHI-PROJECT-20K06463
[Journal Article] Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans2021
- Author(s)
  Honda Shiori、Fukami Tatsuki、Hirosawa Keiya、Tsujiguchi Takuya、Zhang Yongjie、Nakano Masataka、Uehara Shotaro、Uno Yasuhiro、Yamazaki Hiroshi、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 49 Issue: 9 Pages: 718-728
- DOI
  10.1124/dmd.121.000513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants2021
- Author(s)
  Taniguchi-Takizawa Tomomi、Kato Harutoshi、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Current Drug Metabolism
  
  Volume: 22 Issue: 3 Pages: 208-214
- DOI
  10.2174/1389200221666201207195758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models2021
- Author(s)
  Miura Tomonori、Kamiya Yusuke、Uehara Shotaro、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: － Issue: 6 Pages: 1-7
- DOI
  10.1080/00498254.2021.1908643
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K07139
[Journal Article] Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.2020
- Author(s)
  .Kamiya, Y., Takaku, H., Yamada, R., Akase, C., Abe, Y., Sekiguchi, Y., Murayama, N., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H.
- Journal Title
  
  Toxicol. Rep.
  
  Volume: 149 Pages: 149-154
- DOI
  10.1016/j.toxrep.2020.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-19K16422
[Journal Article] Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver2020
- Author(s)
  Ogawa Shin-ichiro、Uehara Shotaro、Tsunenari Yoshihiko、Kawai Hiroyuki、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Issue: 7 Pages: 769-775
- DOI
  10.1080/00498254.2019.1694198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164
[Journal Article] Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets2020
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Inoue Takashi、Kawamura Shu、Murayama Norie、Nishikawa Miyu、Ikushiro Shinichi、Sasaki Erika、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 172 Pages: 113748-113748
- DOI
  10.1016/j.bcp.2019.113748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02159, KAKENHI-PROJECT-20K07139
[Journal Article] Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation2020
- Author(s)
  Dionisio Leonardo、Shimizu Makiko、Stupniki Sofia、Oyama Saki、Aztiria Eugenio、Alda Maximiliano、Yamazaki Hiroshi、Spitzmaul Guillermo
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 4 Pages: 383-388
- DOI
  10.1016/j.dmpk.2020.05.003
- NAID
  50014558612
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model2020
- Author(s)
  47.Miura T, Kamiya Y, Hina S, Kobayashi Y, Murayama N, Shimizu M, Yamazaki H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 11 Pages: 695-700
- DOI
  10.2131/jts.45.695
- NAID
  130007935150
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan2020
- Author(s)
  Uraoka Mirai、Shimizu Makiko、Kuwajima Yoshiki、Mizugaki Ami、Yokoyama Haruka、Mure Kanae、Yamazaki Hiroshi
- Journal Title
  
  Current Drug Metabolism
  
  Volume: 21 Issue: 14 Pages: 1161-1164
- DOI
  10.2174/1389200221666201009140802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205, KAKENHI-PROJECT-18H03054
[Journal Article] Different roles of human cytochrome P450 2C9 and 3A enzymes in diclofenac 4'- and 5-hydroxylations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice.2020
- Author(s)
  .Miura, T., Uehara, S., Shimizu, M., Murayama, N., Utoh, M., Suemizu, H., and Yamazaki, H.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 33 Issue: 2 Pages: 634-639
- DOI
  10.1021/acs.chemrestox.9b00446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20K07164
[Journal Article] Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques2020
- Author(s)
  Uno Yasuhiro、Mikami Takahiro、Tsukazaki Yasuko、Nakanishi Yasuharu、Murayama Norie、Ikushiro Shinichi、Tsusaki Hideshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 1 Pages: 115-121
- DOI
  10.1080/00498254.2020.1810367
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02159, KAKENHI-PROJECT-20K07139
[Journal Article] Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)2020
- Author(s)
  Shimizu Makiko、Uno Yasuhiro、Utoh Masahiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 6 Pages: 571-573
- DOI
  10.1016/j.dmpk.2020.07.001
- NAID
  50014656618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Preference for O-demethylation reactions in the oxidation of 2 -, 3 -, and 4 -methoxyflavones by human cytochrome P450 enzymes.2020
- Author(s)
  Nagayoshi, H., Murayama, N., Tsujino, M., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada, T.
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Issue: 10 Pages: 1158-1169
- DOI
  10.1080/00498254.2020.1759157
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Interleukin-1β and Tumor Necrosis Factor-α Affect Cytochrome P450 Expression in Cynomolgus Macaque Hepatocytes2020
- Author(s)
  Yasuhiro Uno , Norie Murayama , Hiroshi Yamazaki
- Journal Title
  
  Drug metabolism and pharmacokinetiks
  
  Volume: -
- NAID
  50014558606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08426
[Journal Article] Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential2020
- Author(s)
  Miura Tomonori、Shimizu Makiko、Uehara Shotaro、Yoshizawa Manae、Nakano Ayane、Yanagi Mayu、Kamiya Yusuke、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 12 Pages: 3048-3053
- DOI
  10.1021/acs.chemrestox.0c00387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model2020
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shigeta Kazuki、Yoshizawa Manae、Kamiya Yusuke、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 522-528
- DOI
  10.1021/acs.chemrestox.0c00358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate2019
- Author(s)
  Miura, T. Suemizu, H. Goto, M. Sakai, N. Iwata, H. Shimizu, M. Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 49 Issue: 5 Pages: 513-520
- DOI
  10.1080/00498254.2018.1471753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: potent inhibition by azelnidipine and manidipine2019
- Author(s)
  Noriaki Ikemura, Satoshi Yamaori, Chinatsu Kobayashi, Shinobu Kamijo, Norie Murayama, Hiroshi Yamazaki, Shigeru Ohmori
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 306 Pages: 1-9
- DOI
  10.1016/j.cbi.2019.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07063, KAKENHI-PROJECT-17K08426
[Journal Article] Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes2019
- Author(s)
  Nagayoshi, H. Murayama, N. Kakimoto, K. Tsujino, M. Takenaka, S. Katahira, J. Lim, Y. R. Kim, D. Yamazaki, H. Komori, M. Guengerich, F. P. Shimada, T.
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 6 Pages: 1268-1280
- DOI
  10.1021/acs.chemrestox.9b00078
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database.2019
- Author(s)
  Shimizu, M., Yoda, H., Nakakuki, K., Saso, A., Saito, I., Hishinuma, E., Saito, S., Hiratsuka, M., Yamazaki, H.
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 34 Issue: 5 Pages: 334-339
- DOI
  10.1016/j.dmpk.2019.06.001
- NAID
  50014558523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque.2019
- Author(s)
  Uno Y, Murayama N, Yamazaki H.
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 31 Issue: 11 Pages: 1269-1276
- DOI
  10.1021/acs.chemrestox.8b00236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08426
[Journal Article] Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity2019
- Author(s)
  Yamazaki, H. Kamiya, Y.
- Journal Title
  
  Toxicol Res
  
  Volume: 4 Issue: 4 Pages: 295-301
- DOI
  10.5487/tr.2019.35.4.295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver2019
- Author(s)
  Iwata, H. Goto, M. Sakai, N. Suemizu, H. Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 49 Issue: 11 Pages: 1311-1322
- DOI
  10.1080/00498254.2018.1564087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Novel variants and haplotypes of human flavin-containing monooxygenase 3 (FMO3) gene associated with Japanese subjects suffering from trimethylaminuria.2019
- Author(s)
  Shimizu, M., Yoda, H., Igarashi, N., Makino, M., Tokuyama, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: - Issue: 10 Pages: 1244-1250
- DOI
  10.1080/00498254.2018.1539279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Expression and metabolic activity of flavin-containing monooxygenase 1 (FMO1) in cynomolgus macaque kidney.2019
- Author(s)
  Uno Y, Shimizu M, Yoda H, Yamazaki H.
- Journal Title
  
  J.Med.Primatol.
  
  Volume: 48 Issue: 1 Pages: 51-53
- DOI
  10.1111/jmp.12385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques.2019
- Author(s)
  Uno, Y., Shimizu, M., Yoda, H., Origuchi, Y., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Pharmacokinet.,
  
  Volume: 34 Issue: 1 Pages: 104-109
- DOI
  10.1016/j.dmpk.2018.09.001
- NAID
  50014558505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Steady-state human pharmacokinetics of monobutyl phthalate predicted by physiologically based pharmacokinetic modeling using single-dose data from humanized-liver mice orally administered with dibutyl phthalate2019
- Author(s)
  Miura, T. Uehara, S. Mizuno, S. Yoshizawa, M. Murayama, N. Kamiya, Y. Shimizu, M. Suemizu, H. Yamazaki, H.
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 2 Pages: 333-340
- DOI
  10.1021/acs.chemrestox.8b00361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone2018
- Author(s)
  Kakimoto Kensaku、Murayama Norie、Takenaka Shigeo、Nagayoshi Haruna、Lim Young-Ran、Kim Vitchan、Kim Donghak、Yamazaki Hiroshi、Komori Masayuki、Guengerich F. Peter、Shimada Tsutomu
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Issue: 2 Pages: 1-12
- DOI
  10.1080/00498254.2018.1426133
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07770, KAKENHI-PROJECT-16K09119, KAKENHI-PROJECT-17K08426
[Journal Article] Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies2018
- Author(s)
  Shimura, K., Ishii, Y., Takada, M., Uno, Y., Utoh, M., Iwasaki, K., and Yamazaki, H.
- Journal Title
  
  Biopharm. Drug Dispos.
  
  Volume: 39 Issue: 2 Pages: 115-121
- DOI
  10.1002/bdd.2115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA2018
- Author(s)
  Murayama Norie、Suemizu Hiroshi、Uehara Shotaro、Kusama Takashi、Mitsui Marina、Kamiya Yusuke、Shimizu Makiko、Guengerich F. Peter、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 6 Pages: 369-375
- DOI
  10.2131/jts.43.369
- NAID
  130007384441
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques.2018
- Author(s)
  Uno, Y., Takahira, R., Murayama, N., Ishii, Y., Ikenaka, Y., Ishizuka, M., Yamazaki, H., and Ikushiro, S.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 155 Pages: 172-181
- DOI
  10.1016/j.bcp.2018.06.027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426, KAKENHI-PROJECT-18H04132, KAKENHI-PROJECT-18H02159, KAKENHI-PROJECT-17K20038
[Journal Article] Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice2018
- Author(s)
 Shimizu, M., Suemizu, H., Mizuno, S., Kusama, T., Miura, T., Uehara, S., and Yamazaki, H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 43 Issue: 6 Pages: 387-393
- DOI
 10.2131/jts.43.387
- NAID
 130007384444
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08380
[Journal Article] Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks2018
- Author(s)
  Ｍｕｒａｙａｍａ　Ｎ，　ａｎｄ　Ｙａｍａｚａｋｉ　ｈ．
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 4 Pages: 241-245
- DOI
  10.2131/jts.43.241
- NAID
  130006627486
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426, KAKENHI-PROJECT-17K08425
[Journal Article] Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure.2018
- Author(s)
  Suemizu, H., Kawai, K., Murayama, N., Nakamura, M., and Yamazaki, H.
- Journal Title
  
  Pest Manag.Sci.
  
  Volume: 74 Issue: 6 Pages: 1424-1430
- DOI
  10.1002/ps.4825
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426
[Journal Article] Strong induction of cytochrome P450 1A/3A, but not P450 2B, in cultured hepatocytes from common marmosets and cynomolgus monkeys by typical human P450 inducing agents.2017
- Author(s)
  Uehara, S., Uno, Y., Suzuki, T., Inoue, T., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Lett.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage2017
- Author(s)
  Wani Tasaduq H.、Chakrabarty Anindita、Shibata Norio、Yamazaki Hiroshi、Guengerich F. Peter、Chowdhury Goutam
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 30 Issue: 8 Pages: 1622-1628
- DOI
  10.1021/acs.chemrestox.7b00127
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines.2017
- Author(s)
  Uehara, S., Yuki, Y., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 4 Pages: 342-347
- DOI
  10.1080/00498254.2017.1321811
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity2017
- Author(s)
  Murayama Norie、Kazuki Yasuhiro、Satoh Daisuke、Arata Kazuya、Harada Tasuku、Shibata Norio、Guengerich F. Peter、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 3 Pages: 343-348
- DOI
  10.2131/jts.42.343
- NAID
  130006865647
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Differences in toxicological and pharmacological responses mediated by polymorphic cytochromes P450 and related drug-metabolizing enzymes.2017
- Author(s)
  Yamazaki, H.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 30 Issue: 1 Pages: 53-60
- DOI
  10.1021/acs.chemrestox.6b00286
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206, KAKENHI-PROJECT-17K08425
[Journal Article] Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase.2017
- Author(s)
  Uehara, S., Shimizu, M., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 45 Issue: 5 Pages: 497-500
- DOI
  10.1124/dmd.117.075184
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-16K08380
[Journal Article] Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues.2017
- Author(s)
  Uehara, S., Uno, Y., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 7 Pages: 553-561
- DOI
  10.1080/00498254.2016.1206673
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Cloning and expression of a novel catechol-O-methyltransferase in common marmosets2017
- Author(s)
 Uehara, S., Uno, Y., Inoue, T., Sasaki, E. and Yamazaki H.
- Journal Title
 
 Journal of Veterinary Medical Science
 
 Volume: 79 Issue: 2 Pages: 267-272
- DOI
 10.1292/jvms.16-0459
- NAID
 130005316105
- ISSN
 0916-7250, 1347-7439
- Language
 English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
 KAKENHI-PROJECT-15K18934
[Journal Article] Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model2017
- Author(s)
 Shimizu M, Yamazaki H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 42 Issue: 4 Pages: 485-490
- DOI
 10.2131/jts.42.485
- NAID
 130005765918
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08380
[Journal Article] Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity2017
- Author(s)
  Murayama, N., Kazuki, Y., Satoh, D., Arata, K., Harada, T., Shibata, N., Guengerich, F. P., and Yamazaki, H
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 42
- NAID
  130006865647
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.2017
- Author(s)
  Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 10 Pages: 844-848
- DOI
  10.1080/00498254.2016.1247218
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380, KAKENHI-PROJECT-17K08425
[Journal Article] Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone.2017
- Author(s)
  Uehara, S., Uno, Y., Nakanishi, K., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 45 Issue: 5 Pages: 457-467
- DOI
  10.1124/dmd.116.074898
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice.2017
- Author(s)
  Yamazaki-Nishioka M, Shimizu M, Suemizu H, Nishiwaki M, Mitsui M, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 2 Pages: 117-123
- DOI
  10.1080/00498254.2017.1288280
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.2016
- Author(s)
  Uehara, S., Kawano, M., Murayama, N., Uno, Y., Utoh, M., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 120 Pages: 56-62
- DOI
  10.1016/j.bcp.2016.09.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Individual differences in metabolic clearance of S-warfarin efficiently mediated by polymorphic marmoset cytochrome P450 2C19 in livers.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] A new marmoset P450 4F12 enzyme expressed in small intestines and livers efficiently metabolizes an anti-histaminic drug ebastine.2016
- Author(s)
  Uehara, S., Uno, Y., Yuki, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus).2016
- Author(s)
  Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 2 Pages: 163-168
- DOI
  10.3109/00498254.2015.1057270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Okamoto, E., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Assessment of protein binding of 5-hydroxythalidomide bioactivated in humanized mice with human P450 3A-chromosome or hepatocytes by two-dimensional electrophoresis/accelerator mass spectrometry2016
- Author(s)
  Yamazaki, H., Suemizu, H., Kazuki, Y., Oofusa, K., Kuribayashi, S., Shimizu, M., Ninomiya, S., Horie, T., Shibata, N., and Guengerich, F. P.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 29 Issue: 12 Pages: 1279-1281
- DOI
  10.1021/acs.chemrestox.6b00136
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome P450 1A1, 1A2, and 1B1.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 44 Issue: 1 Pages: 8-15
- DOI
  10.1124/dmd.115.067561
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Utility of non-human primates in drug development: comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes.2016
- Author(s)
  Uehara, S., Uno, Y., and Yamazaki, H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 121 Pages: 1-7
- DOI
  10.1016/j.bcp.2016.06.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.2016
- Author(s)
  Kazuki Y, Akita M, Kobayashi K, Osaki M, Satoh D, Ohta R, Abe S, Takehara S, Kazuki K, Yamazaki H, Kamataki T, Oshimura M.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 21419-21419
- DOI
  10.1038/srep21419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04285, KAKENHI-PROJECT-26460206
[Journal Article] Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets.2016
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Suzuki, T., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 7 Pages: 573-578
- DOI
  10.3109/00498254.2015.1096980
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.2016
- Author(s)
  Iwasaki, K., Kitsugi, Y., Ikeda, K., Yoshikawa, T., Hosaka, S., Uehara, S., Uno, Y., Utoh, M., and Yamazaki, H.
- Journal Title
  
  Biopharm. Drug Dispos.
  
  Volume: 37 Issue: 6 Pages: 379-383
- DOI
  10.1002/bdd.2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.2015
- Author(s)
  Taniguchi-Takizawa T, Shimizu M, Kume T, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 30 Issue: 1 Pages: 64-69
- DOI
  10.1016/j.dmpk.2014.09.006
- NAID
  50014415981
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Simulation of human plasma concentrations of thalidomide and primary 5-hydroxylated metabolites explored with pharmacokinetic data in humanized TK-NOG mice2015
- Author(s)
  Nishiyama, S., Suemizu, H., Shibata, N., Guengerich, F. P., and Yamazaki, H.
- Journal Title
  
  Chem. Res.Toxicol.
  
  Volume: 28 Issue: 11 Pages: 2088-2090
- DOI
  10.1021/acs.chemrestox.5b00381
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 5 Pages: 735-742
- DOI
  10.1124/dmd.115.063594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-25460198
[Journal Article] Regioselective hydroxylation of steroid hormones by human cytochromes P450.2015
- Author(s)
  Niwa T, Murayama N, Imagawa Y, Yamazaki H.
- Journal Title
  
  Drug Metab Rev.
  
  Volume: 13 Pages: 1-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Substrate selectivities and catalytic activities of marmoset liver cytochrome P450 2A6 differed from those of human P450 2A6.2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 7 Pages: 969-976
- DOI
  10.1124/dmd.115.063909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Human HepaRG Cells can be Cultured in Hanging-Drop Plates for Cytochrome P450 Induction and Function Assays.2015
- Author(s)
  Murayama N, Usui T, Slawny N, Chesne; C, Yamazaki H.
- Journal Title
  
  Drug Metab Lett
  
  Volume: 42 Issue: 9 Pages: 111-112
- DOI
  10.1124/dmd.114.059220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria2015
- Author(s)
  Shimizu M, Origuchi Y, Ikuma M, Mitsuhashi N, Yamazaki H.
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 5 Pages: 89-93
- DOI
  10.1016/j.ymgmr.2015.10.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver2015
- Author(s)
  Yamazaki,H.; Kuribayashi,S.; Inoue,T.; Honda,T.; Tateno,C.; Oofusa,K.; Ninomiya,S.; Ikeda,T.; Izumi,T.; Horie,T.
- Journal Title
  
  Toxicol.Res.
  
  Volume: 4 Issue: 1 Pages: 106-111
- DOI
  10.1039/c4tx00068d
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling2015
- Author(s)
  Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 12 Pages: 1049-1055
- DOI
  10.3109/00498254.2016.1147102
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206, KAKENHI-PROJECT-15K18934
[Journal Article] Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients.2015
- Author(s)
  Fukami K, Yamagishi S, Sakai K, Kaida Y, Yokoro M, Ueda S, Wada Y, Takeuchi M, Shimizu M, Yamazaki H, Okuda S.
- Journal Title
  
  J. Cardiovasc. Pharmacol.
  
  Volume: 65. Issue: 3 Pages: 289-295
- DOI
  10.1097/fjc.0000000000000197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25282029, KAKENHI-PROJECT-26860487, KAKENHI-PROJECT-25460198
[Journal Article] Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays2015
- Author(s)
  Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H
- Journal Title
  
  Drug Metab.Lett.
  
  Volume: 28 Issue: 1 Pages: 268-278
- DOI
  10.2174/1872312809666150119104806
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole.2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 10 Pages: 1408-1416
- DOI
  10.1124/dmd.115.066100
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan.2015
- Author(s)
  Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 45 Issue: 9 Pages: 757-765
- DOI
  10.3109/00498254.2015.1019595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934
[Journal Article] Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.2015
- Author(s)
  Shimizu M, Shiraishi A, Sato A, Nagashima S, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 30 Issue: 1 Pages: 70-74
- DOI
  10.1016/j.dmpk.2014.09.008
- NAID
  50014415982
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients.2015
- Author(s)
  Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 93 Issue: 1 Pages: 104-109
- DOI
  10.1016/j.bcp.2014.11.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling2015
- Author(s)
  Miyaguchi,T.; Suemizu,H.; Shimizu,M.; Shida,S.; Nishiyama,S.; Takano,R.; Murayama,N.; Yamazaki,H.
- Journal Title
  
  Regul.Toxicol.Pharmacol.
  
  Volume: 72 Issue: 1 Pages: 71-76
- DOI
  10.1016/j.yrtph.2015.03.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing.2014
- Author(s)
  Shimizu M, Iwano S, Uno Y, Uehara S, Inoue T, Murayama N, Onodera J, Sasaki E, Yamazaki H.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 6 Pages: e100936-e100936
- DOI
  10.1371/journal.pone.0100936
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine.2014
- Author(s)
  Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., Yamazaki, H.
- Journal Title
  
  Clin.Kidney J.,
  
  Volume: 7 Issue: 3 Pages: 329-329
- DOI
  10.1093/ckj/sfu045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes2014
- Author(s)
  Suemizu,H.; Sota,S.; Kuronuma,M..; Shimizu,M.; Yamazaki,H.
- Journal Title
  
  Regul.Toxicol.Pharmacol.
  
  Volume: 70 Issue: 2 Pages: 468-473
- DOI
  10.1016/j.yrtph.2014.08.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.2014
- Author(s)
  Yamazaki M, Shimizu M, Uno Y, Yamazaki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 90 Issue: 2 Pages: 159-165
- DOI
  10.1016/j.bcp.2014.04.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes p4502014
- Author(s)
  Yajima K, Uno Y, Murayama N, Uehara S, Shimizu M, Nakamura C, Iwasaki K, Utoh M, Yamazaki H
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 5 Pages: 867-871
- DOI
  10.1124/dmd.113.056804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] 261. Chowdhury G, Shibata N, Yamazaki H., and Guengerich FP. Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analog of thalidomide2014
- Author(s)
  Chowdhury G, Shibata N, Yamazaki H., and Guengerich FP.
- Journal Title
  
  Chem. Res.Toxicol.
  
  Volume: 27 Issue: 1 Pages: 146-157
- DOI
  10.1021/tx4004215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-26460206
[Journal Article] The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice2014
- Author(s)
  Higuchi, Y., Kawai, K., Yamazaki, H., Nakamura, M., Bree, F., Guillouzo, C., and Suemizu, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 27 Issue: 2 Pages: 146-157
- DOI
  10.3109/00498254.2013.836257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24700439
[Journal Article] Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.2014
- Author(s)
  Shimizu M, Allerston CK, Shephard EA, Yamazaki H, Phillips IR.
- Journal Title
  
  Br J Clin Pharmacol.
  
  Volume: 77 Issue: 5 Pages: 839-851
- DOI
  10.1111/bcp.12240
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor2014
- Author(s)
  Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol
  
  Volume: 27 Issue: 2 Pages: 304-307
- DOI
  10.1021/tx4004374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211, KAKENHI-PROJECT-26460206
[Journal Article] CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes2013
- Author(s)
  Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H
- Journal Title
  
  J Toxicol Sci.
  
  Volume: 38 Pages: 349-354
- NAID
  10031158900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes2013
- Author(s)
 Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F. P., and Yamazaki, H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 38 Issue: 3 Pages: 349-354
- DOI
 10.2131/jts.38.349
- NAID
 10031158900
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23590200
[Journal Article] Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A62013
- Author(s)
  Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 26 Issue: 4 Pages: 529-537
- DOI
  10.1021/tx3004906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque2013
- Author(s)
  Uno Y, Murayama N, Kunori M, Yamazaki H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 9 Pages: 1621-1625
- DOI
  10.1124/dmd.113.052977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.2013
- Author(s)
  Uno, Y., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 85 Issue: 12 Pages: 1837-1847
- DOI
  10.1016/j.bcp.2013.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline2013
- Author(s)
  Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K, Yamazaki H
- Journal Title
  
  Xenobiotica
  
  Volume: 43 Issue: 12 Pages: 1037-1042
- DOI
  10.3109/00498254.2013.793874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Effects of ADH1C, ALDH2, and CYP2A6 polymorphisms on individual risk of tobacco-related lung cancer in male Japanese smokers.2013
- Author(s)
  Shimizu, M., Ishii, Y., Okubo, M., Kunitoh, H., Kamataki, T., and Yamazaki, H.
- Journal Title
  
  J.Cancer Ther
  
  Volume: 4 Issue: 08 Pages: 28-35
- DOI
  10.4236/jct.2013.48a005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities.2013
- Author(s)
  Yamazaki, H. and Shimizu, M.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 85 Issue: 11 Pages: 1588-1593
- DOI
  10.1016/j.bcp.2013.03.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque2013
- Author(s)
  Uno Y, Murayama N, Kunori M, Yamazaki H
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 86 Issue: 5 Pages: 679-690
- DOI
  10.1016/j.bcp.2013.06.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling2013
- Author(s)
  Tsukada, A., Suemizu, H., Murayama, N., Takano, R., Shimizu, M., Nakamura, M., and Yamazaki, H
- Journal Title
  
  Regul.Toxicol.Pharmacol
  
  Volume: 65 Issue: 3 Pages: 316-324
- DOI
  10.1016/j.yrtph.2013.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] Clinical Evidence of Pharmacokinetic Changes in Thalidomide Therapy2013
- Author(s)
  Nakamura K, Matsuzawa N, Ohmori S, Ando Y, Yamazaki H, Matsunaga T
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 28 Issue: 1 Pages: 38-43
- DOI
  10.2133/dmpk.DMPK-12-RV-089
- NAID
  130004463295
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028, KAKENHI-PROJECT-23590200
[Journal Article] In vivo drug interactions of the teratogen thalidomide with midazolam: Heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice2013
- Author(s)
  Yamazaki, H., Suemizu, H., Murayama, N., Utoh, M., Shibata, N., Nakamura, M., and Guengerich, F. P.
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 26 Issue: 3 Pages: 486-489
- DOI
  10.1021/tx400008g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs.2012
- Author(s)
  Mogi M, Toda A, Iwasaki K, Kusumoto S, Takehara H, Shimizu M, Murayama N, Izumi H, Utoh M, Yamazaki H.
- Journal Title
  
  J Toxicol Sci.
  
  Volume: 37 Pages: 1157-116
- NAID
  10031126020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs2012
- Author(s)
  Mogi, M., Toda, A., Iwasaki, K., Kusumoto, S., Takahara, H., Shimizu, M., Murayama, N., Izumi, H., Utoh, M., and Yamazaki, H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 37 Issue: 6 Pages: 1157-1164
- DOI
  10.2131/jts.37.1157
- NAID
  130004447016
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] CYP2C76 Non-synonymous Variants in Cynomolgus and Rhesus Macaques2012
- Author(s)
 Uehara S, Murayama N, Yamazaki H, Uno Y
- Journal Title
 
 Drug Metabolism and Pharmacokinetics
 
 Volume: 27 Issue: 3 Pages: 344-348
- DOI
 10.2133/dmpk.DMPK-11-NT-118
- NAID
 130004463249
- ISSN
 1347-4367, 1880-0920
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-24590211
[Journal Article] In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-hydroxythalidomide in humanized TK-NOG mice2012
- Author(s)
  Yamazaki, H., Suemizu, H., Shimizu, M., Igaya, S., Shibata, N., Nakamura, N., Chowdhury, G., and Guengerich, F.P
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 25 Issue: 2 Pages: 274-276
- DOI
  10.1021/tx300009j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles.2012
- Author(s)
  Okubo, M., Murayama, N., Miura, J., Shimizu, M., and Yamazakik, H
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 413 Issue: 19-20 Pages: 1675-1677
- DOI
  10.1016/j.cca.2012.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition2012
- Author(s)
  Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 26 Issue: 4 Pages: 517-523
- DOI
  10.1021/tx300492j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Different metabolites of human hepatotoxic pyrazolopyrimidine derivative 5-n-butyl-pyrazolo[1,5-a]pyrimidine produced by human, rat, and monkey cytochrome P450 1A2 and liver microsomes2012
- Author(s)
  Kuribayashi, S., Uno, Y., Naito, S., and Yamazaki, H
- Journal Title
  
  Basic Clin.Pharmacol.Toxicol
  
  Volume: 110 Issue: 4 Pages: 405-408
- DOI
  10.1111/j.1742-7843.2011.00823.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation2012
- Author(s)
  Hosoi, Y., Uno, Y., Murayama, N., Fujino, H., Shukuya, M., Iwasaki, K., Shimizu, M., Utoh, M., and Yamazaki, H.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 84 Issue: 12 Pages: 1691-1695
- DOI
  10.1016/j.bcp.2012.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG2011
- Author(s)
  Yamazaki, H., Suemizu, H.(8名・2番目)
- Journal Title
  
  Mice Chem Res Toxicol
  
  Volume: 24 Issue: 3 Pages: 287-289
- DOI
  10.1021/tx200005g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240042, KAKENHI-PROJECT-21390030, KAKENHI-PROJECT-21590177, KAKENHI-PUBLICLY-22106515, KAKENHI-PROJECT-23590200
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., and Yamazaki, H
- Journal Title
  
  Drug Metab. Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual Differences in Pharmacokinetics and Pharmacodynamics of Anesthetic Agent Propofol with Regard to CYP2B6 and UGT1A9 Genotype and Patient Age2011
- Author(s)
  Kansaku, F, Kumai, T., Sasaki, K., Yukozuka, M., Shimizu, M., Tateda, T., Murayama, N., Kobayashi, S., Yamazaki, H.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 5 Pages: 532-537
- DOI
  10.2133/dmpk.DMPK-11-RG-039
- NAID
  130004463217
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23790200
[Journal Article] Species d ifference between cynomolgus monkeys and humans on cytochromes P450 2D and 3A-dependent drug oxidation activities in liver microsomes2011
- Author(s)
  Emoto, C., Iwasaki, K., Koizumi, R., Utoh, M., Murayama, N., Uno Y., and Yamazaki, H
- Journal Title
  
  J. Health Sci
  
  Volume: 57 Pages: 164-170
- NAID
  130000663115
- URL
  http://dx.doi.org/10.1248/jhs.57.164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Species difference between cynomolgus monkeys and humans on cytochromes P450 2D and 3A-dependent drug oxidation activities in liver microsomes.2011
- Author(s)
  Emoto, C., Iwasaki, K., Koizumi, R., Utoh, M., Murayama, N., Uno Y., Yamazaki, H.
- Journal Title
  
  J.Health Sci.
  
  Volume: 57 Pages: 164-170
- NAID
  130000663115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Mechanism-based inhibition of cytochrome P450 (CYP) 2A6 by chalepensin in recombinant systems, in human liver microsomes and mice in vivo2011
- Author(s)
  Ueng, Y.-F., Chen, C.-C., Chung, Y.-T, Liu, T.-Y., Chang, Y.-P., Lo, W.-S., Murayama, N., Yamazaki, H., Soucek, P., Chau, G.-Y., Chi, C.-W., Chen, R.-M., Li D.T.
- Journal Title
  
  Brit.J.Pharmacol.
  
  Volume: 163 Issue: 6 Pages: 1250-1262
- DOI
  10.1111/j.1476-5381.2011.01341.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23590200
[Journal Article] Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.2011
- Author(s)
  Akiyoshi, T.Saito, T., Murase, S., Miyazaki, M.Murayama, N.Yamazaki, H., Guengerich, F.P., Nakamura, K., Yamamoto, K., Ohtani, H
- Journal Title
  
  Drug Metab.Dispos.
  
  Volume: 39 Pages: 74-728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] CYP2G2, pseudogenized in human, is expressed in nasal mucosa of cynomolgus monkey and encodes a functional drug-metabolizing2011
- Author(s)
  Uno Y, Uehara, S., Murayama, N., Yamazaki, H.
- Journal Title
  
  Drug Metab.Dispos.
  
  Volume: 39 Issue: 4 Pages: 717-723
- DOI
  10.1124/dmd.110.036574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age2011
- Author(s)
  Kansaku F, Kumai T, Sasaki K, Yokozuka M, Shimizu M, Tateda T, Murayama N, Kobayashi S, Yamazaki H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 26 Pages: 532-7
- NAID
  130004463217
- URL
  http://dx.doi.org/10.2133/dmpk.DMPK-11-RG-039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system2011
- Author(s)
  Nakamura, K., Mizutani, R., Sanbe, A., Enosawa, S., Kasahara, M., Nakagawa, A., Ejiri, Y., Murayama, N., Miyamoto, Y., Torii, T., Kusakawa, S., Yamauchi, J., Fukuda, M., Yamazaki, H., and Tanoue. A
- Journal Title
  
  J. Biosci. Bioeng
  
  Volume: 111 Pages: 78-84
- NAID
  110008440354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Sorafenib and sunitinib, two anti-cancer drugs, inhibit CYP3A4-and activate CYP3A5-mediated midazolam 1' hydroxylation2011
- Author(s)
  Sugiyama, M., Fujita, K., Murayama, N., Akiyama, Y., Yamazaki, H., and Sasaki, Y
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Issue: 5 Pages: 757-762
- DOI
  10.1124/dmd.110.037853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants2011
- Author(s)
  Akiyoshi, T. Saito, T., Murase, S., Miyazaki, M. Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K., and Ohtani, H
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Issue: 4 Pages: 724-728
- DOI
  10.1124/dmd.110.036780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23590200
[Journal Article] Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system.2011
- Author(s)
  Nakamura, K., Mizutani, R., Sanbe, A., Enosawa, S., Kasahara, M., Nakagawa, A., Ejiri, Y., Murayama, N., Miyamoto, Y., Torii, T., Kusakawa, S., Yamauchi, J., Fukuda, M., Yamazaki, H., Tanoue.A.
- Journal Title
  
  J.Biosci.Bioeng
  
  Volume: 111 Pages: 78-84
- NAID
  110008440354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition2011
- Author(s)
  Niwa T, Murayama N, Yamazaki H
- Journal Title
  
  Curr Drug Metab
  
  Volume: 12 Pages: 412-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Immunochemical detection of cytoclirome P450 enzymes in liver microsomes of 27 cynomolgus monkeys2011
- Author(s)
  Uehara, S., Murayama, N., Nakanishi, Y., Zeldin, D.C., Yamazaki, H., Uno, Y.
- Journal Title
  
  J.Pharmacol.Exp.Ther
  
  Volume: 339 Issue: 2 Pages: 654-661
- DOI
  10.1124/jpet.111.185009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Stereoselectivity of human cytochrome p450 in metabolic and inhibitory activities2011
- Author(s)
  Niwa T, Murayama N, Yamazaki H
- Journal Title
  
  Curr Drug Metab
  
  Volume: 12 Pages: 549-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice.2010
- Author(s)
  Yamazaki, H., Suemizu, H., Igaya, S., Shimizu, M., Shibata, N., Nakamura, M., Chowdhury, G., Guengerich, F.P.
- Journal Title
  
  Chem.Res.ToxicoL
  
  Volume: 24 Pages: 287-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate2010
- Author(s)
  Chowdhury, G., Murayama, N., Okada, Y., Uno, Y., Shimizu, M., Shibata, N., Guengerich, F. P., and Yamazaki, H
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 23 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans2010
- Author(s)
  Iwasaki, K., Murayama, N., Koizumi, R., Uno, Y., Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. (印刷中)
- NAID
  10027583437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.2010
- Author(s)
  Chowdhury, G.., Murayama, N., Okada, Y., Uno, Y., Shimizu, M., Shibata, N., Guengerich, F.P., Yamazaki, H.
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 23 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives2010
- Author(s)
  Shimada, T., Tanaka, K., Takenaka, T., Murayama, N., Martin, M. V., Foroozesh, M. K. Yamazaki, H., Guengerich, F. P, and Komori. M
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 23 Issue: 12 Pages: 1921-1935
- DOI
  10.1021/tx100286d
- NAID
  130004639911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Blood concentrations of 1, 4-dioxane in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling.2010
- Author(s)
  Takano, R., Murayama, N., Horiuchi, K., Kitajima, M., Shono F., Yamazaki, H..
- Journal Title
  
  J.Health Sci.
  
  Volume: 56 Pages: 557-565
- NAID
  130000425091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling2010
- Author(s)
  Takano R, Murayama N, Horiuchi K, Kitajima M, Kumamoto M, Shono F, Yamazaki H
- Journal Title
  
  Regul Toxicol Pharmacol
  
  Volume: 58 Pages: 252-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity : A structure-function relationship study2009
- Author(s)
  Shimada, T., Tanaka, K.Takenaka, S.Foroozesh, M.K., Murayama, N., Yamazaki, H., Guengerich, F.P., Komori, M.Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol. 22
  
  Pages: 1325-1333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems2009
- Author(s)
  Emoto, C., Murayama, N., Wakiya, S., Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett.t. 3
  
  Pages: 207-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug discovery stage: The impact of plasma and microsomal binding2009
- Author(s)
  Chie Emoto, Norie Murayama Rostami-Hodjegan, A. and Hiroshi Yamazaki
- Journal Title
  
  Xenobiotica 39
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug discovery stage : The impact of plasma and microsomal binding2009
- Author(s)
  Emoto, C., Murayama, N. Rostami-Hodjegan, A., Yamazaki, H
- Journal Title
  
  Xenobiotica 39
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies2009
- Author(s)
  Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., Yamazaki, H
- Journal Title
  
  Drug Metab.Pharmacokinet. 24
  
  Pages: 404-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P4502009
- Author(s)
  Niwa, T., Murayama, N., Yamazaki, H.
- Journal Title
  
  Curr.Drug Metab. 10
  
  Pages: 700-712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug discovery stage : The impact of plasma and microsomal binding2009
- Author(s)
  Emoto, C., Murayama, N.Rostami-Hodjegan, A., Yamazaki, H.
- Journal Title
  
  Xenobiotica 39
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual differences in toxicological response caused by a diversity of chemicals:Observations in Japan2008
- Author(s)
  Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol. 21
  
  Pages: 3-4
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A52008
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., and Yamazaki.H
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Individual differences in toxicological response caused by a diversity of chemicals : Observations in Japan2008
- Author(s)
  Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol 21
  
  Pages: 3-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A52008
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., and Yamazaki, H
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene(FMO3)2008
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M.Shepherd, E.A.Yamazaki, H.and Phillips, I.R.
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in Inhibiting catalytic activity2008
- Author(s)
  Shimada, T. Murayama, N., Tanaka, K., Takenaka, S., Imai, Y., Hopkins, E., Foroozesh, M. K., Al worth, W. L., Yamazaki, H., Guengerich, F. P, Komori, M
- Journal Title
  
  Chem. Res Toxicol 21
  
  Pages: 2313-2323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Heterotropic cooperativity in oxidation mediated by cytochrome P4502008
- Author(s)
  Niwa, T., Murayama, N., and Yamazaki, H
- Journal Title
  
  Curr.Drug Metab. 9
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH- cyto- chrome P450 reductase2008
- Author(s)
  Chie Emoto, Norie Murayama, and Hiroshi Yamazaki
- Journal Title
  
  Drug Metab.Lett., 2
  
  Pages: 190-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase3 gene(FMO3)2008
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M., Shephard, E.A., Yamazaki, H. and Phillips, I.R.
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Individual differences in toxicological response caused by adiversity of chemicals: Observations in Japan2008
- Author(s)
  Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol. 21
  
  Pages: 3-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A52008
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., and Yamazaki, H
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase.2008
- Author(s)
  Emoto, C., Murayama, N., Yamazaki, H.
- Journal Title
  
  Drug Metab. Lett. 2
  
  Pages: 190-192
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Disparity in holo/apoprotein ratios of different standards used for immunoquantification of hepatic cytochrome P450 enzymes2007
- Author(s)
  Perrett, H., F., Barter, Z.E., Jones, B.C., Yamazaki. H., Tucker, G.T., Rostami-Hodjegan, A
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 1733-1736
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Genein a Japanese Cohort2007
- Author(s)
  Shimizu, M.Tomioka, S., Murayama, N.and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3 (FMO3) on N-and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S.Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effects of propofol analogs on glucuronidation of propofol,an anesthetic drug,by human live rmicrosomes2007
- Author(s)
  Shirmizu, M., Matsumoto, Y., and Yamazaki, H.
- Journal Title
  
  Drug Metab.Left, 1
  
  Pages: 77-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R. and Yamazaki, H.
- Journal Title
  
  BMC.Med.Genet. 8
  
  Pages: 2-2
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort2007
- Author(s)
  Shimizu, M.Tbmioka, S., Murayama, N. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- NAID
  10018733032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3) on N- and S-oxygenation activities2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., and Guengerich, F.P.
- Journal Title
  
  Chem.Res.Toxicol. 20
  
  Pages: 489-496
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., Guengerich, F.P
- Journal Title
  
  Chem. Res. Toxicol., 20
  
  Pages: 489-496
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 37
  
  Pages: 717-724
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effects of propofol analogs on glucuronidation of propofol,an anesthetic drug,by human liver microsomes2007
- Author(s)
  Shimizu, M., Matsumoto, Y., and Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett 1
  
  Pages: 77-79
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3) on N- and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.2007
- Author(s)
  Yamazaki H, Fujita H, Gunji T, Zhang Z, Kamataki T, Cashman JR, Shimizu, M
- Journal Title
  
  Mol.Genet.Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite for mation from voriconazole,a new anti-fungal agent,in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol. 73
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1,1A2,and 1B1 by polycyclic aromatic inhibitors2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., and Guengerich, F.P
- Journal Title
  
  Chem.Res.Toxicol. 20
  
  Pages: 489-496
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Genetic polymorphism of bile acid CoA:amino acid N-acyltransferase in Japanese in dividuals.2007
- Author(s)
  Tougou, K., Fukuda, T., Ito, T., Yamazaki, H., and Azuma, J.
- Journal Title
  
  Drug Metab Pharmacokinet. 22
  
  Pages: 125-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., Yamazaki, H
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population2007
- Author(s)
  Yamazaki H, Fujita H, Gunji T, Zhang Z, Kamataki T, Cashman JR, Shimizu, M
- Journal Title
  
  Mol.Genet.Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R., Yamazaki, H
- Journal Title
  
  BMC.Med.Genet
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Disparity in holo/apoprotein ratios of different standards used for immunoquantification of hepatic cytochrome P450 enzymes.2007
- Author(s)
  Perrett, H.F., Barter, Z.E.., Jones, B.C.Yamazaki, H., Tucker, G.T., and Rostami-Hodjegan, A.
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 1733-1736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite for mation from voriconazole,a new anti-fungal agent,in human liver microsomes.2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol. 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Transient trimethylaminuria related to menstruation.2007
- Author(s)
  Shirmizu, M., Cashman, J.R.and Yamazaki, H.
- Journal Title
  
  BMC.Med.Genet. 8
  
  Pages: 2-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3)on N- and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1,1A2,and IBl by polycyclic aromatic inhibitors.2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki.H., and Guengerich, F.P.
- Journal Title
  
  Chem.Res.Toxicol. 20
  
  Pages: 489-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R. and Yamazaki, H.
- Journal Title
  
  BMC.Med.Genet 8
  
  Pages: 2-2
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Genetic polymorphism of bile acid CoA : amino acid N-acyltransferase in Japanese individuals2007
- Author(s)
  Tougou, K., Fukuda, T., Ito, T., Yamazaki, H., Azuma, J
- Journal Title
  
  Drug Metab Pharmacokinet 22
  
  Pages: 125-128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Transient trimethylaminuria related to menstruation.2007
- Author(s)
  Shimizu, M., Cashman, J.R., Yamazaki, H.
- Journal Title
  
  BMC Med Genet. 8
  
  Pages: 2-2
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort2007
- Author(s)
  Shimizu, M., Tomioka, S., Murayama, N. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- NAID
  10018733032
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole,a new anti-fungal agent,in humanlive rmicrosomes.2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Genotoxic activation of the environmental pollutant 3-nitrobenzanthrone by human cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains2007
- Author(s)
  Oda, Y., Watanabe, T., Yamazaki. H., Hirayama, T
- Journal Title
  
  Genes and Environment 29
  
  Pages: 146-152
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene(FMO3)2007
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M., Shephard, E.A., Yamazaki, H., Phillips, I.R
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] lnvolvement of human cytochrome P450 2B6 in the ω-and 4-hydroxylation of the anesthetic agent propofol.2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Disparity in holo/apoprotein ratios of different standards used for immunoqu antification of hepatic cytochrome P450 enzymes2007
- Author(s)
  Perrett, H.F., Barter, Z.E., Jones, B.C., Yamazaki, H., Tucker, G.T., and Rostami-Hodjegan, A.
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 1733-1736
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., Guengerich, F.P
- Journal Title
  
  Chem.Res.Toxicol 20
  
  Pages: 489-496
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Genotoxic activation of the environmental pollutant 3-nitrobenzanthrone by human cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains2007
- Author(s)
  Oda, Y., Watanabe, T., Yamazaki, H., and Hirayama, T.
- Journal Title
  
  Genes and Environment 29
  
  Pages: 146-152
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes2007
- Author(s)
  Shimizu, M., Matsumoto, Y., Yamazaki, H
- Journal Title
  
  Drug Metab.Lett 1
  
  Pages: 77-79
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Involvement of human cytochrome P450 2B6 in the □-and 4-hydroxylation of the a nesthetic agent propofol.2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations.2007
- Author(s)
  Yamazaki H. et al.
- Journal Title
  
  Xenobiotica 36(12)
  
  Pages: 1201-1209
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., Yamazaki, H
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3)on N-and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S.Murayama, N., Zhang, J., Cashman, J.R.and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Genetic polymorphism of bile acid CoA:amino acid N-acyitransferase in Japanese in dividuals2007
- Author(s)
  Tougou, K., Fukuda, T., Ito, T., Yamazaki, H., and Azuma, J.
- Journal Title
  
  Drug Metab Pharmacokinet. 22
  
  Pages: 125-128
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais2006
- Author(s)
  Peamkrasatam S, Sriwatanakul K, Kiyotani K, Fujieda M, Yamazaki H, Kamataki T and Yoovathaworn K
- Journal Title
  
  Drug Metab Pharmacokinet 21
  
  Pages: 475-484
- NAID
  10018658956
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl2006
- Author(s)
  Nakajima, M., Itoh, M., Sakai, H., Fukami, T., Katoh, M., Yamazaki, H., Kadlubar, F.F., Imaoka, S., Funae, Y. and Yokoi, T
- Journal Title
  
  Int.J.Cancer 117
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol2006
- Author(s)
  Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M., Murayama, N., Drug Metab.Dispos.
- Journal Title
  
  Drug Metab. Dispos 34
  
  Pages: 1803-1805
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.2006
- Author(s)
  Peamkrasatam S, Siwatanakul K, Kiyotani K, Fujieda M, Yamazaki H, Kamataki T, Yoovathaworn K
- Journal Title
  
  Drug Metab Pharmacokinet 21
  
  Pages: 475-484
- NAID
  10018658956
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] High-performance liquid chromatographic assay for carboplatin in ultrafiltered plasma combined with hyperbaric oxygenation.2006
- Author(s)
  Yamazaki H. et al.
- Journal Title
  
  Drug Metab Pharmacokinet. 21(5)
  
  Pages: 429-431
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FM03) gene responsible for trimethylaminuria in a Japanese population.2006
- Author(s)
  Yamazaki H. et al.
- Journal Title
  
  Mol Genet Metab. 90(1)
  
  Pages: 58-63
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.2006
- Author(s)
  Nakajima, M., Itoh, M., Sakai, H., Fukami, T., Katoh, M., Yamazaki, H., Kadlubar, F.F., Imaoka, S., Funae, Y., Yokoi, T
- Journal Title
  
  Int. J. Cancer 117
  
  Pages: 2520-2526
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol2006
- Author(s)
  Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M. and Murayama, N. Drug Metab.Dispos.
- Journal Title
  
  Drug Metab.Dispos 34
  
  Pages: 1803-1805
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Mild trimethylaminuria observed in a Japanese cohort with liver damage.2005
- Author(s)
  Yamazaki, H. et al.
- Journal Title
  
  Am. J. Med. 118(7)
  
  Pages: 803-805
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Mild trimethylaminuria observed in a Japanese cohort with liver damage.2005
- Author(s)
  Yamazaki, H, et al.
- Journal Title
  
  Am.J.Med. 118(7)
  
  Pages: 803-805
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Mild trimethylaminuria observed in a Japanese cohort with liver damage.2005
- Author(s)
  Yamazaki, H. et al.
- Journal Title
  
  Am. J. Med. 118
  
  Pages: 803-805
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Mild trimethylaminuria observed in a Japanese cohort with liver damage.2005
- Author(s)
  Yamazaki, H.et al.
- Journal Title
  
  Am.J.Med. 118
  
  Pages: 803-805
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients2004
- Author(s)
  Yamazaki, H., et al.
- Journal Title
  
  Life Sci 74
  
  Pages: 2739-2747
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Establishment of ten strains of genetically engineered salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004
- Author(s)
  Yamazaki, Y., et al.
- Journal Title
  
  Mutat.Res. 562
  
  Pages: 151-162
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.2004
- Author(s)
  Yamazaki, H, et al.
- Journal Title
  
  Life Sci. 74(22)
  
  Pages: 2739-2747
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.2004
- Author(s)
  Hiroshi Yamazaki et al.
- Journal Title
  
  Life Sci. 74 2
  
  Pages: 2739-2747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390040
[Journal Article] Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004
- Author(s)
  Yoshiyuki Yamazaki et al.
- Journal Title
  
  Mutat.Res. 562
  
  Pages: 151-162
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390040
[Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients2004
- Author(s)
  Hiroshi Yamazaki et al.
- Journal Title
  
  Life Sci. 74
  
  Pages: 2739-2747
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390040
[Journal Article] Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004
- Author(s)
  Yamazaki, Y. et al.
- Journal Title
  
  Mutat. Res. 562(1-2)
  
  Pages: 151-162
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004
- Author(s)
  Yamazaki, Y, et al.
- Journal Title
  
  Mutat.Res. 562(1-2)
  
  Pages: 151-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients2004
- Author(s)
  Hiroshi Yamazaki et al.
- Journal Title
  
  Life Sci. 74(22)
  
  Pages: 2739-2747
- Data Source
  KAKENHI-PROJECT-15390040
[Journal Article] Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004
- Author(s)
  Yoshiyuki Yamazaki et al.
- Journal Title
  
  Mutat.Res. 562(1-2)
  
  Pages: 151-162
- Data Source
  KAKENHI-PROJECT-15390040
[Journal Article] Two novel haplotypes of CYP2D6 gene in a Japanese population.2003
- Author(s)
  Yamazaki, H. et al.
- Journal Title
  
  Drug Metabol.Pharmacokinet. 18(4)
  
  Pages: 269-271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Two novel haplotypes of CYP2D6 gene in a Japanese population.2003
- Author(s)
  Yamazaki, H, et al.
- Journal Title
  
  Drug Metab. Pharmacokinet. 18(4)
  
  Pages: 269-271
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] Comparison of kinetic 2008. parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Species and individual differences of drug oxygenations mediated by polymorphic human cytochrome P450 enzymes2023
- Author(s)
  Hiroshi Yamazaki
- Organizer
  The 10th International Congress of Asian Society of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06217
[Presentation] イヌ肝チトクロムP450 3A酵素が触媒する典型的なヒト選択的基質に対する酸化酵素活性の個体差2023
- Author(s)
  野田優太朗、村山典恵、森國紗帆、宇野泰広、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] イヌ、ブタ、カニクイザルにおけるチトクロムP450の同定・解析2023
- Author(s)
  宇野泰広，山崎浩史
- Organizer
  第50回日本毒性学会学術年会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] Identification and characterization of tree shrew CYP2Cs2023
- Author(s)
  Yasuhiro Uno, Yuhki Minami, Genki Ushirozako, Kyoko Kohara, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] Model Selection for Drug Oxygenations Mediated by Polymorphic Human Enzymes2023
- Author(s)
  Hiroshi Yamazaki
- Organizer
  2023 international joint meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06217
[Presentation] Species Specificity and Selection of Animal Models for Drug Oxygenations Mediated by Polymorphic Human Enzymes2023
- Author(s)
  Hiroshi Yamazaki
- Organizer
  7th Asia Pacific Regional International Society of Study of Xenobiotics (ISSX) meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] 簡易生理学的薬物動態モデルによるチトクロム P450 3A4/5 遺伝子多型患者でのアトルバスタチンおよびカルバマゼピン血中動態予測2023
- Author(s)
  佐藤翼、安達昂一郎、村山典恵、清水万紀子、田中庸一、斎藤嘉朗、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] イヌ、ブタ、ツパイおよびヒトチトクロムP450 2B分子種の薬物酸化酵素活性2023
- Author(s)
  村山典恵、藤木有樹、後迫玄城、野田優太朗、上原正太郎、宇野泰広、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] Identification and characterization of tree shrew CYP2Ds2023
- Author(s)
  Genki Ushirozako, Norie Murayama, Kyoko Kohara, Hiroshi Yamazaki, and Yasuhiro Uno
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] Cytochrome P450 2C21 and 2C41 functionally metabolize warfarin and omeprazole in dogs2023
- Author(s)
  Norie Murayama, Saho Morikuni, Yasuhiro Uno, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] シトクロムP450 2D6遺伝子多型を考慮したアトモキセチンおよびその4-水酸化体と脱メチル体代謝物のヒト体内動態予測2023
- Author(s)
  清水万紀子、上原正太郎、大山勝宏、田中庸一、齋藤嘉朗、末水洋志、吉田　さやか、山崎浩史
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06217
[Presentation] Characterization of tree shrew CYP2A13 in comparison with human, dog and pig CYP2As2022
- Author(s)
  Yasuhiro Uno, Genki Ushirozako, Yutaro Noda, Kyoko Kohara, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] 物質のヒト体内動態を規定する生理学的薬物動態モデル重要パラメータの予測と消化管吸収性推定の精緻化2022
- Author(s)
  神矢佑輔、佐藤翼、森國紗帆、内海正義、三浦智徳、村山典恵、清水万紀子、半田健太郎、北島正人、庄野文章、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] サリドマイドのヒト型酸化的代謝物のウサギでの生成: 奇形のないラットとの比較2022
- Author(s)
  山崎浩史
- Organizer
  第49回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] ツパイCYP2A13の同定と解析2022
- Author(s)
  後迫玄城、村山典恵、小原恭子、山崎浩史、宇野泰広
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] 物質のヒト体内動態を規定する生理学的薬物動態モデル重要パラメータの予測と消化管吸収性推定の精緻化2022
- Author(s)
  神矢佑輔、佐藤翼、森國紗帆、内海正義、三浦智徳、村山典恵、清水万紀子、半田健太郎、北島正人、庄野文章、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] イヌ肝と小腸に発現するチトクロム4503A分子種の同定とそれらの機能解析2022
- Author(s)
  村山典恵、野田優太朗、軸屋志織、宇野泰広、山崎浩史現するチトクロム4503A分子種の同定とそれらの機能解析
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] イヌ肝と小腸に発現するチトクロムP450 3A分子種の同定とそれらの機能解析2022
- Author(s)
  村山典恵、野田優太朗、軸屋志織、宇野泰広、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] 東北メディカル・メガバンク統合データベースより見出した新規フラビン含有モノオキシゲナーゼ3 遺伝子変異の酵素機能に及ぼす影響2022
- Author(s)
  清水万紀子、巻口美晶、中村友里愛、菱沼英史、齋藤さかえ、平塚真弘、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] 小型非ヒト霊長類マーモセット薬物代謝特徴把握からヒト型動態を考える2022
- Author(s)
  山崎浩史
- Organizer
  JSSX-APDD合同ワークショップ(第六回)
- Invited
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] データ駆動型生理学的薬物動態モデルを用いる化学物質の体内濃度予測2022
- Author(s)
  山崎浩史
- Organizer
  日本動物実験代替法学会第35回大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] カニクイザルにおける薬物代謝酵素の同定・解析2021
- Author(s)
  宇野泰広，山崎浩史
- Organizer
  第48回日本毒性学会学術年会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] 創薬候補品のpH依存的N-酸化反応に対するフラビン含有酸素添加酵素の寄与予測2021
- Author(s)
  谷口　友美、加藤　望、加藤　晴敏、久米　俊行、清水万紀子、山崎　浩史
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] Primary oxidative metabolites of Thalidomide in rat and humanized-liver mouse pharmacokinetics2021
- Author(s)
  Hiroshi Yamazaki, Shotaro Uehara, Makiko Shimizu, Hiroshi Suemizu
- Organizer
  24th North American ISSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] カニクイザルにおける薬物代謝酵素の同定・解析2021
- Author(s)
  宇野泰広、山崎浩史
- Organizer
  第48回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] 創薬候補品のpH依存的N-酸化反応に対するフラビン含有酸素添加酵素の寄与予測2021
- Author(s)
  谷口　友美、加藤　望、加藤　晴敏、久米　俊行、清水万紀子、山崎　浩史
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] Systematic identification and characterization of flavin-containing monooxygenases in cats, dogs, and pigs2021
- Author(s)
  Yasuhiro Uno, Makiko Shimizu, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第36年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] Prediction of metabolic fates of food chemicals for risk assessment2021
- Author(s)
  Hiroshi Yamazaki
- Organizer
  2021 International Workshop for Non-animals Approaches in Food Sector
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] CYP2C19の代謝キネティクスにおける*23変異アレルの影響とその基質間差の要因2021
- Author(s)
  渡辺大智、粟田祐作、秋好健志、関博行、今岡鮎子、村山典恵、山崎浩史、下地みゆき、中村克徳、大谷壽一
- Organizer
  医療薬学フォーラム
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] フラビン含有酸素添加酵素が関わる薬物体内動態の個人差と相互作用2021
- Author(s)
  清水万紀子、山崎浩史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] ネコ、イヌ、ブタにおけるフラビン含有モノオキシゲナーゼの同定・解析2021
- Author(s)
  宇野泰広、清水万紀子、小川友里衣、藤井優哉、山崎浩史
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] 日常生活下日本人の動脈硬化症指標とチトクロム P450 2A6 遺伝子型の関連2020
- Author(s)
  清水万紀子、水垣亜美、浦岡未来、桑島愛生、牟礼佳苗、山崎浩史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] AI-SHIPSにおける生理学的薬物動態（PBPK）モデルを用いた一般化学物質の臓器内濃度予測手法開発の現状2020
- Author(s)
  山崎浩史
- Organizer
  CBI学会2020年大会シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] Hepatic and renal concentrations of general chemicals estimated after virtual oral administrations extrapolated using simple physiologically based pharmacokinetic models and rat plasma data2020
- Author(s)
  Hiroshi Yamazaki and Makiko Shimizu
- Organizer
  SOT 59th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] 化学物質の予測物性値を用いる生理学的薬物動態(PBPK)モデルを活用するヒト臓器中濃度推移と毒性予測2020
- Author(s)
  山崎浩史
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] アルプラゾラムと口キソプ口フェンの誤飲が疑われた1歳児における薬物動態分析2020
- Author(s)
  田中敏博，清水万紀子，山崎浩史
- Organizer
  第41回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] 一般化学物質の経口吸収過程を含む簡素な生理学的薬物動態モデルを活用する体内動態評価2020
- Author(s)
  山崎浩史
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] Hepatic concentrations of chemicals after virtual oral administrations extrapolated using rat plasma data and simple physiologically based pharmacokinetic models2019
- Author(s)
  Hiroshi Yamazaki, Makiko Shimizu
- Organizer
  SOT 58th Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Functional and Molecular Characterization of UDP-glucuronosyltransferase 1A Enzymes in Common Marmosets2019
- Author(s)
  Norie Murayama, Shotaro Uehara, Shu Kawamura, Miyu Nishikawa, Shinichi Ikushiro, Yasuhiro Uno, and Hiroshi Yamazaki
- Organizer
  第34回日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] 肝毒性予測のため薬物動態モデル2019
- Author(s)
  山崎浩史、北島正人、清水万紀子
- Organizer
  第46回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Drug interactions mediated by flavin-containing monooxygenase in humanized-liver mice2019
- Author(s)
  Makiko Shimizu, Shotaro Uehara, Hiroshi Suemizu, Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] Message from the JSSX president : Current topics in societal impact of physiologically based kinetic modeling in cutting-edge sciences2019
- Author(s)
  Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第34回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] 肝毒性予測のため薬物動態モデル2019
- Author(s)
  山崎浩史、北島正人、清水万紀子
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] Roles of human Cytochrome P450 enzymes in drug oxidation: Comparison of in vitro and in vivo system results2019
- Author(s)
  Hiroshi Yamazaki and Norie Murayama
- Organizer
  21th International Conference on Cytochrome P450
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] リスク評価のための一般化学物質の体内運命予測2019
- Author(s)
  山崎浩史
- Organizer
  日本動物実験代替法学会第32回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Genetic Polymorphisms of Flavin-containing Monooxygenase 3 Gene in Japanese Cohorts2018
- Author(s)
  Makiko Shimizu, Komei Nakakuki, Hiromi Yoda, Masahiro Hiratsuka, and Hiroshi Yamazaki
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Human plasma and urinary metabolic profiles of trimethylamine and its N-oxide extrapolated using humanized-liver mice and simple physiologically based pharmacokinetic models2018
- Author(s)
  Hiroshi Yamazaki, Hiroshi Suemizu, and Makiko Shimizu
- Organizer
  SOT 57th Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Human drug metabolism and disposition in humanized-liver mice and non-human primate models2018
- Author(s)
  Hiroshi Yamazaki
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Human plasma and urinary metabolic profiles of trimethylamine and its N-oxide extrapolated using humanized-liver mice and simple physiologically based pharmacokinetic models2018
- Author(s)
  Hiroshi Yamazaki, Hiroshi Suemizu, and Makiko Shimizu
- Organizer
  SOT 57th Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] 生理学的薬物動態 (PBPK) モデルを活用する化学物質の体内動態評価技術2018
- Author(s)
  山崎浩史
- Organizer
  CBI学会2018年大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] 東北メディカル・メガバンク統合データベースより見出された新規フラビン含有モノオキシゲナーゼ3 遺伝子変異の組換え酵素を用いた機能解析2018
- Author(s)
  中莖昂明、清水万紀子、菱沼英史、平塚真弘、山崎浩史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Cytochrome P450 3A Enzyme-dependent Thalidomide Toxicity and Inducibility in Cultured Human Placental Cells2018
- Author(s)
  Norie Murayama, F. Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] Metabolic profile of 14C-diisononyl phthalate using pharmacokinetic modelling and chimeric mouse with humanized-liver2018
- Author(s)
  Hiroshi Yamazaki
- Organizer
  International Scientific Meeting of Plasticisers and Science, State of the Art
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] A physiologically based pharmacokinetic model to predict chemical concentrations in livers after virtual oral doses2018
- Author(s)
  Hiroshi Yamazaki
- Organizer
  Tokyo AI-SHIPS International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Mutations of flavin-containing monooxygenase 3 (FMO3) gene in Japanese cohorts2018
- Author(s)
  Makiko Shimizu, Komei Nakakuki, Hiromi Yoda, Masahiro Hiratsuka, and Hiroshi Yamazaki
- Organizer
  22nd North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Activities of UDP-glucuronosyltransferase 1A/2B Enzymes in Marmoset Liver Microsomes: Comparison with Cynomolgus Macaques and Humans2018
- Author(s)
  Norie Murayama, Shotaro Uehara, Yu Ishii, Shunsuke Onozeki, Shu Kawamura, Shinichi Ikushiro, Yasuhiro Uno, Hiroshi Yamazaki
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] マーモセット、カニクイザルおよびヒト肝によるメトプロロール酸化的代謝の比較2017
- Author(s)
  石井さくら、上原正太郎、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット、カニクイザルおよびヒト肝および小腸P450酵素によるテルフェナジンの酸化的代謝2017
- Author(s)
  結城友香子、上原正太郎、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] ヒト肝細胞移植マウスの薬物血中濃度および生理学的薬物動態モデルを組み合わせたヒト薬物血中濃度推移予測2017
- Author(s)
  三井満里奈、清水万紀子、山崎美穂、末水洋志、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県、仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] 日本人トリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3変異型酵素の触媒機能2017
- Author(s)
  清水万紀子、依田紘美、五十嵐成美、武井まどか、中莖昂明、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県、仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Human drug metabolism in humanized-liver mice and non-human primate models2017
- Author(s)
  Hiroshi Yamazaki
- Organizer
  0th International Conference on Cytochrome P450
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] 新規マーモセットP450 2F 酵素の同定および機能解析2017
- Author(s)
  上原正太郎、大塩徹、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセットP450 3A 酵素の臓器分布および薬物酸化酵素活性：ヒトP450 3Aとの類似性2017
- Author(s)
  上原正太郎、中西一志、石井さくら、宇野泰広、井上貴史、佐々木えりか、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県　仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] TK-NOGマウスおよび各種動物モデルを利用したPBPKモデリングによるヒト動態予測2017
- Author(s)
  山崎浩史
- Organizer
  第24回HAB研究機構学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Metabolic Profiles of Benzydamine in Humanized-liver Mice2017
- Author(s)
  Makiko Shimizu, Hiroshi Suemizu, and Hiroshi Yamazaki
- Organizer
  21st North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] マーモセットおよびカニクイザル小腸P450酵素によるエバスチン酸化的代謝2016
- Author(s)
  上原正太郎, 結城友香子, 宇野泰広, 井上貴史, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Comparison of drug oxidations in humans, primates, and rodents2016
- Author(s)
  Hiroshi Yamazaki
- Organizer
  13th Meeting of the Asia Pacific Federation of Pharmacologists （Bangkok)）
- Place of Presentation
  Barkley Hotel (Bangkok, Thai）
- Year and Date
  2016-02-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] ヒト肝細胞移植マウスおよびマーモセット生理学的薬物動態モデルを活用したチトクロムP450カクテル基質のヒト血中濃度推移予測2016
- Author(s)
  清水万紀子, 三井満里奈, 河野未来, 上原正太郎, 宇野泰広, 鵜藤雅裕, 井上貴史, 佐々木えりか, 末水洋志, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Pharmacokinetics of efavirenz after intravenous and oral administration of efavirenz to genotyped cynomolgus monkeys.2016
- Author(s)
  Kazuhide Iwasaki, Yusuke Kitsugi, Kanami Ikeda, Takahiro Yoshikawa, Shotaro Uehara, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan（Korea）
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] フラビン含有酸素添加酵素およびチトクロム P450 の共通基質ベンジダミンのヒト肝移植マウスを用いた in vivo 血中動態予測2016
- Author(s)
  清水万紀子、末水洋志、三井満里奈、山崎美穂、山崎浩史
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子コンベンションセンター (鳥取県　米子市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Combining mice with humanized liver, mass spectrometry, and physiologically-based pharmacokinetic modeling2016
- Author(s)
  Hiroshi Yamazaki
- Organizer
  The 31st JSSX Annual Meeting
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] 新規マーモセットP450 2J酵素の同定および機能解析2016
- Author(s)
  上原正太郎, 岡本絵里子, 宇野泰広, 井上貴史, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Human and monkey P450 metabolism for human-specific metabolite formation2016
- Author(s)
  Hiroshi Yamazaki:
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  釜山、韓国
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] マーモセットあるいはカニクイザル肝細胞を用いた薬物暴露によるチトクロムP450誘導の評価2016
- Author(s)
  鈴木貴子, 上原正太郎, 村山典恵, 宇野泰広, 矢島加奈子, 鵜藤雅裕, 井上貴史, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット肝のワルファリン酸化的代謝の立体選択性2016
- Author(s)
  河野未来, 上原正太郎, 石井さくら, 宇野泰広, 井上貴史, 鵜藤雅裕, 佐々木えりか, 山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Drug Oxidations Mediated by Polymorphic Flavin-Containing Monooxygenase2016
- Author(s)
  Shimizu, M., and Yamazaki, H.
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  USA, California, UC Davis Conference Centre
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] 日本人におけるトリメチルアミン尿症の原因となる新規フラビン含有モノオキシゲナーゼ3遺伝子変異の解析2016
- Author(s)
  徳山瑛美、清水万紀子、牧野美紀、梶谷綾、渡邊碧、山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Activation of thalidomide to reactive metabolites by autoinduced human cytochrome P450 3A enzymes with substrate cooperativity2016
- Author(s)
  Hiroshi Yamazaki, Makiko Shimizu
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Davis, California, USA
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Identification and characterization of cytochrome P450 4F enzymes in marmosets.2016
- Author(s)
  Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan（Korea）
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] 日本人におけるトリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3ハプロタイプの解析2016
- Author(s)
  牧野美紀、清水万紀子、徳山瑛美、梶谷綾、渡邊碧、山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Cytochrome P450-dependent warfarin and caffeine metabolism in marmosets, monkeys, and humans.2015
- Author(s)
  Hiroshi Yamazaki, Shotaro Uehara, Yasuhiro Uno, and Erika Sasaki
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Hilton Orlando Bonnet Creek (Orlando, USA）
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] Molecular cloning, expression and functional characterization of marmoset cytochrome P450 2A6.2015
- Author(s)
  Shotaro Uehara, Yasuhiro Uno, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  国立オリンピック記念青少年総合センター(東京都・代々木)
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] ヒト薬物動態予測を目指したサル、マーモセットとヒト肝細胞移植マウスの活用研究2015
- Author(s)
  山崎浩史
- Organizer
  第38回薬物動態談話会年会 (浜松）
- Place of Presentation
  アクトシティホテル（浜松市）
- Year and Date
  2015-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] マーモセット肝のワルファリン代謝の解析2015
- Author(s)
  河野未来, 上原正太郎, 宇野泰広, 鵜藤雅裕, 佐々木えりか、山崎浩史
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県・船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] 日本人のトリメチルアミン尿症に関する大規模調査2015
- Author(s)
  千葉布季子、清水万紀子、牧野美紀、三觜菜々子、友田沙也加、山崎浩史
- Organizer
  第69回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  川崎、聖マリアンナ医科大学
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] ヒトと実験動物との代謝の種差2015
- Author(s)
  山崎浩史
- Organizer
  第42回日本毒性学会年会（金沢）
- Place of Presentation
  金沢日航ホテル（釜沢市）
- Year and Date
  2015-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Flavin-containing monooxygenase 3: Individual differences and drug interactions2015
- Author(s)
  Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  30th JSSX Annual Meeting
- Place of Presentation
  東京、江戸川区民センター
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Mutations of flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria2015
- Author(s)
  Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  東京、国立オリンピック記念青少年総合センター
- Year and Date
  2015-06-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人トリメチルアミン尿症の大規模詳細調査2015
- Author(s)
  千葉布季子、清水万紀子、徳山瑛美、牧野美紀、山崎浩史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸　（兵庫県）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Comparison of drug oxidations in humans, primates, and rodents2015
- Author(s)
  Hiroshi Yamazaki
- Organizer
  2015 JSSX / KAPS Joint Session, 30th JSSX Annual Meetign (Tokyo)
- Place of Presentation
  江戸川区民センター（東京）
- Year and Date
  2015-11-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Cytochrome P450-dependent xenobiotic metabolism in marmosets2015
- Author(s)
  Shotaro Uehara, Hiroshi Yamazaki
- Organizer
  2nd Symposium of SPU Innovative Project for Pharmaceutical Analyses of Covalent Modification in Biomolecules
- Place of Presentation
  昭和薬科大学(東京都・町田市)
- Year and Date
  2015-08-31
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] マーモセット肝のカフェイン代謝経路の解析2015
- Author(s)
  鈴木貴子, 上原正太郎, 宇野泰広, 鵜藤雅裕, 佐々木えりか, 山崎浩史
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県・船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K18934
[Presentation] 日本人のトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3遺伝子変異の解析2014
- Author(s)
  伊熊鞠佳、清水万紀子、三觜菜々子、友田沙也加、山崎浩史
- Organizer
  第68回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  聖マリアンナ医科大学（神奈川県川崎市）
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Genetic polymorphisms in flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population2014
- Author(s)
  Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  19th North American ISSX / 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco Union Square Hotel（サンフランシスコ、米国）
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人集団から見出されたトリメチルアミン尿症の原因となるフラビン含有酸素添加酵素3遺伝子多型2014
- Author(s)
  清水万紀子、折口裕美、伊熊鞠佳、三觜菜々子、友田沙也加、山崎浩史
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  愛媛看護研修センター（愛媛）
- Year and Date
  2014-12-04
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] サリドマイドは核内レセプターを介してヒト肝薬物代謝酵素を誘導する2014
- Author(s)
  村山典恵、矢島加奈子、Christophe Chesné、Rene Houtman、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学　黒髪キャンパス、他　（熊本市）
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] 抗うつ薬ミルタザピンの代謝消失に影響を与える因子2014
- Author(s)
  大久保真穂、村山典恵、三浦淳、千葉泰二、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学　黒髪キャンパス、他　（熊本市）
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] レボカルニチン投与時の透析患者におけるトリメチルアミンおよび N-酸化体の体内運命の検討2014
- Author(s)
  小泉綾乃、若林あかり、清水万紀子、小篠榮、山崎浩史
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学（東京都）
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] ヒト及びサル肝P450に認められるワルファリン代謝の立体選択性2013
- Author(s)
  村山典恵、宇野泰広、細井祥生、岩崎一秀、清水万紀子、鵜藤雅裕、山崎浩史
- Organizer
  日本学学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] P450 Based DDI and Clinical Significance: Genotyping and Phenotyping2013
- Author(s)
  Hiroshi Yamazaki
- Organizer
  4th Joint Workshop of the International Society for the Study of Xenobiotics (ISSX) and the Chinese Society for the Study of Xenobiotics (CSSX)
- Place of Presentation
  河南大学, Henan, China
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Acrylonitrile concentrations hypothetically modeled in humans2013
- Author(s)
  Hiroshi Yamazaki
- Organizer
  13th International Congress of Toxicology
- Place of Presentation
  COEX in Seoul, Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] DRUG OXIDATIONS AND INTERACTIONS MEDIATED BY MOKEY AND HUMAN CYTOCHROME P450 ENZYEMS2013
- Author(s)
  Hiroshi Yamazaki
- Organizer
  18th International Conference on Cytochrome P450 ~Biochemistry, Biophysics, Biotechnology~
- Place of Presentation
  Washington University, Seatle, WA, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Comparison of Estimates of “Normal” Exposure through Diet to Internal Dosimetry Generated at NOEL and LOEL Doses in Animal Toxicity Studies2013
- Author(s)
  Hiroshi Yamazaki
- Organizer
  ICCA-LRI and NCATS Workshop
- Place of Presentation
  La Posada de Santa, Santa Fe, NM, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] P4503A4タンパク発現量および薬物代謝酵素活性におよぼすCYP3A4:22遺伝子多型の影響2013
- Author(s)
  大久保真穂、村山典恵、清水万紀子、山崎浩史
- Organizer
  日本学学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Function of Thalidomide for Potential Inducer of Drug Metabolizing Enzymes in Human Livers2013
- Author(s)
  Norie Murayama, Hiroshi Suemizu, Kanako Yajima, Masahiro Utoh, Masato Nakamura, and Hiroshi Yamazaki
- Organizer
  28th JSSX Annual Metting
- Place of Presentation
  タワーホール船堀　（江戸川区）
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Function of Thalidomide for Potential Inducer of Drug Metabolizing Enzymes in Human Livers2013
- Author(s)
  Norie Murayama, Hiroshi Suemizu, Kanako Yajima, Masahiro Utoh, Christiane Guguen-Guillouzo, Christophe Chesné, René Houtman, Rinie van Beuningen, Norio Shibata, Masato Nakamura, and Hiroshi Yamazaki
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Westin Harbour Castle Hotel (Tronto, Canada)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Induction of cytochrome P450 3A enzymes by thalidomide in human hepatic cells2012
- Author(s)
  Norie Murayama, Kanako Yajima Masahiro Utho, and Hiroshi Yamazaki
- Organizer
  JSSX
- Place of Presentation
  タワーホール船堀(千葉)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] チオカルバメート系除草剤モリネートの代謝消失における種差の検討2012
- Author(s)
  村山典恵、山下真直、塚田藍、高野良治、末水洋志、中村雅登、清水万紀子、山崎浩史
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌市・北海道大学・高等教育推進機構
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] チオカルバメート系除草剤モリネートの代謝消失における種差の検討2012
- Author(s)
  村山典恵、山下真直、塚田藍、末水洋志、中村雅登、高野良治、清水万紀子、山崎浩史
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Utility of Microminipig for in vitro and in vivo drug metabolizing activities2012
- Author(s)
  Hiroshi Yamazaki
- Organizer
  第85回日本薬理学会年会(招待講演)
- Place of Presentation
  京都国際会議場　（京都市）
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Drug Metabolism In Human Hepatoma Cell Line System with Differentiated HepaRG Cryopresorved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
  JSSX
- Place of Presentation
  広島市・国際会議場
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Drug interactions of thalidomide with midazolam in human hepatoma cell line system with differentiated HepaRG cryopreserved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, and Hiroshi Yamazaki
- Organizer
  17 th North American regional ISSX meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2011-10-18
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 肝試料画分を考慮した化学物質のヒト生理学的薬物動態モデルの精緻化2011
- Author(s)
  村山典恵、國兼絵里子、塚田藍、高野良治、北島正人、清水万紀子、池田敏彦、山崎浩史
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Reactive metabolite formation from thalidomide mediated by human cytochrome P450 3A enzymes and in chimeric mice with humanized liver2011
- Author(s)
  Hiroshi Yamazaki
- Organizer
  17th International Conference on Cytochrome P450 ~Biochemistry, Biophysics, Biotechnology~(招待講演)
- Place of Presentation
  Manchester大学（Manchester, UK)
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] 正常動物を用いたヒト薬物代謝予測-ミニブタおよびサルの有用性2011
- Author(s)
  山崎浩史
- Organizer
  第58回日本実験動物学会総会(招待講演)
- Place of Presentation
  江戸川区民センター（東京都）
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Human Drug metabolites and interactions mediated by polymorphic drug-metabolizing enzymes2011
- Author(s)
  Hiroshi Yamazaki
- Organizer
  The 26th JSSX Annual Meeting(招待講演)
- Place of Presentation
  広島国際会議場　（広島市）
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] 肝試料画分を考慮した化学物質のヒト生理学的薬物動態モデルの精緻化2011
- Author(s)
  村山典恵、國兼絵里子、塚田藍、高野良治、北島正人、清水万紀子、山崎浩史
- Organizer
  日本薬学会第131年会
- Place of Presentation
  要旨集上にて発表
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Drug Interaction of Thalidomide with Midazolam in Human Hepatoma Cell Line System with Differentiated HepaRG Cryopreserved2011
- Author(s)
 Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
 17^<th> Notth America ISSX Meeting
- Place of Presentation
 Atranta, USA, Hotel Hirtone
- Year and Date
 2011-10-17
- Data Source
 KAKENHI-PROJECT-21590177
[Presentation] Drug metabolism in human hepatomacell line system with differentiated HepaRG cryopreserved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, and Hiroshi Yamazaki
- Organizer
  26th JSSX Annual Meeting
- Place of Presentation
  広島
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] トキシコキネティクス、特に薬物代謝酵素特性の面からみたマイクロミニピッグ2011
- Author(s)
  山崎浩史
- Organizer
  第38回日本トキシコロジー学会学術年会(招待講演)
- Place of Presentation
  横浜国際会議場 (横浜市）
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] P450を介した相互作用2011
- Author(s)
  山崎浩史
- Organizer
  第32回日本臨床薬理学会年会(招待講演)
- Place of Presentation
  アクトシティ浜松市（浜松市）
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] OLINDAを用いた放射線内部被ばく評価2011
- Author(s)
  山崎浩史
- Organizer
  第3回医薬品開発支援機構（APDD) シンポジウム－我が国における14C-MD臨床試験の実施手順　-　NEDOプロジェクトの成果を踏まえて　-(招待講演)
- Place of Presentation
  慶應義塾大学薬学部　（東京都）
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol in patients genotyped for CYP2B6 and UGT1A92010
- Author(s)
  Hiroshi Yamazaki, Toshio Kumai, Kuniharu Sasaki, Makito Yokozuka, Makiko Shimizu, Tadashi Tateda, Norie Murayama and Shinichi Kobayashi
- Organizer
  ISSX Workshop on Genetic Polymorphisms in Drug Disposition
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2010-04-11
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] ヒトと実験動物間で認められる薬物代謝酵素機能の種差2010
- Author(s)
  村山典恵, 今村裕樹, 大久保真穂, 國兼絵里子, 松本史彦, 小野瀬優維, 佐々木国玄, 清水万紀子, 山崎浩史
- Organizer
  日本薬学会第130回総会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] An improved method to assess internal radiation exposure in humans using in vivo and in vitro animal pharmacokinetic data2010
- Author(s)
  Toshihiko Ikeda, Norie Murayama and Hiroshi Yamazaki
- Organizer
  25th JSSX Annual Meeting
- Place of Presentation
  埼玉
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Impact of genetic polymorphism of the CYP3A5 appeared in the metabolism of and inhibition by voriconazoke in a Japanese population2009
- Author(s)
  村山典恵, 清水万紀子, 山崎浩史
- Organizer
  日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Remarked properties of human cytochrome P450 1A2 and 3A5 in function and cooperativity for drug development2009
- Author(s)
  山崎浩史
- Organizer
  16th International Conference on Cytochrome P450 ～Biochemistry, Biophysics, Biotechnology～
- Place of Presentation
  沖縄
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Impact of cytochrome p450 3A5 expression in human livers on drug interactions of anti-fungal agents with midazolam2009
- Author(s)
  村山典恵, 中本美那子, 清水万紀子, 山崎浩史
- Organizer
  16th International Conference on Cytochrome P450 ～Biochemistry, Biophysics, Biotechnology～
- Place of Presentation
  沖縄
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] アゾール系抗真菌薬の阻害効果とCYP3A5遺伝子多型との関連性2009
- Author(s)
  村山典恵、中本実那子、岡田雄介、清水万紀子、山崎浩史
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] ヒト肝におけるフラビン含有モノオキシゲナーゼ3発現量の個人差の解析2008
- Author(s)
  永島里美, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, a Dimitrios Zonios, b Makiko Shimizu, a John Bennett, b Norie Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharm aceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2008
- Author(s)
  Hiroshi, Yamazaki, Node, Murayama, Naoko, Imai, Takahisa, Nakane, Makiko, Shimizu
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, ^a Dimitrios Zonios, ^b Makiko Shimizu, ^a John Bennett, ^b Norie Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharm aceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi, Yamazaki, Dimitrios, Zonios, Makiko, Shimizu, John, Bennett, Node, Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences The 4th US-Japan Joint Conference
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 全身性麻酔薬プロポフォールの酸化的代謝における個人差2008
- Author(s)
  中本実那子、村山典恵、神作文康、柏田雅也、簑島正樹、清水万紀子、山崎浩史
- Organizer
  第29回日本臨床薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] レポーターアッセイを用いたFMO3遺伝子の転写調節機構2008
- Author(s)
  清水万紀子, 永島里美, 村山典恵, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  村山典恵, 柳田千裕, 清水万紀子, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Inhibitory effects of thalidomide on human liver microsomal Cytochrome P450-mediated drug oxidation activities2008
- Author(s)
  Norie, Murayama, Chihiro, Yanagida, Makiko, Shimizu, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 抗真菌薬ボリコナゾールの酸化的代謝物生成の個人差について2008
- Author(s)
  山崎浩史, 清水万紀子, 村山典恵
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロムP450による全身性麻酔薬プロポフォールの代謝について2008
- Author(s)
  中本実那子, 村山典恵, 簑島正樹, 清水万紀子, 山崎浩史
- Organizer
  医療薬学フォーラム2008
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] "Micromini" Pigs as a Possible New Animal Model For Humans in Non-Clinical Study2008
- Author(s)
 Norie Murayama, Naoki Kaneko, Kana Horiuchi, Makiko Shimizu, Katzuhiko Ito, and Hiroshi Yamazaki
- Organizer
 23^<rd> JSSX Annual Meeting
- Place of Presentation
 熊本
- Data Source
 KAKENHI-PROJECT-19591819
[Presentation] Individual differences of levels of voriconazole and its oxidative metabolites in patients2008
- Author(s)
  Node, Murayama, Dimitrios, Zonios, Makiko, Shimizu, John, Bennett, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES O FOXIDATIVEME TABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, ^a DimitriosZonios, ^b MakikoShimizu, ^a JohnBennett, ^b NorieMurayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  永島里美, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  目本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  村山典恵、柳田千裕、清水万紀子、山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] ヒト肝チトクロムP450による全身麻酔薬プロポフォールの代謝について2008
- Author(s)
  中本実那子、村山典恵、簑島正樹、清水万紀子、山崎浩史
- Organizer
  医療薬学フォーラム2008 第16回クリニカルファーマシーシンポジウム
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Analysis of transcriptional regulation of the human flavin-containing monooxygenase 3(FMO3) gene using the reporter assay Individual differences of flavin-containing monooxygenase S(FMO3) expression levels in human livers2008
- Author(s)
  Makiko, Shimizu, Satomi, Nagashima, Norie, Murayama, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] アゾール系抗真菌薬の薬物酸化的代謝に及ぼす影響2008
- Author(s)
  中本実那子、村山典恵、清水万紀子、山崎浩史
- Organizer
  第56回聖マリアンナ医学会学術集会
- Place of Presentation
  川崎
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3(FMO3) Associatedwith Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Oxygenation Activities of the Flavin-Containing Monooxygenase 3(FMO3) Variants Found in Japanese2007
- Author(s)
  Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 日本人におけるCYP2C19^*17の頻度とCYP2C19代謝活性に及ぼす影響2007
- Author(s)
  杉本勝良, 宇野司, 山崎浩史, 立石智則
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  栃木
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Three novel single nucleotide polymorphisms of the flavin-containing monooxygenase 3(FMO3) gene in a Japanese population2007
- Author(s)
  Hiroshi, Yamazaki, Makiko, Shimizu
- Organizer
  127th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Genetic polymorphism of the flavin-containing monooxygenase 3(FMO3) associated with trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko, Shimizu, Satomi, Nagashima, Node, Murayama, Hiroshi, Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama , Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Omega-and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Metabolic pathway of anesthesic drug propofol in human liver microsomes2007
- Author(s)
  Node, Murayama, Masaki, Minoshima, Naoko, Imai, Makiko, Shimizu, Hiroshi, Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2007
- Author(s)
  Hiroshi Yamazaki, Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 全身性プロポフォールの覚醒遅延に関するヒト肝薬物代謝酵素の検討2007
- Author(s)
  村山典恵、簑島正樹、今井直子、清水万紀子、山崎浩史
- Organizer
  第127会日本薬学年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Omega- and 4-Hydroxylation of theAnesthetic Agent Propofol Catalyzed by HumanLiver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2007
- Author(s)
  Hiroshi Yamazaki, Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3(FMO3)Associated with Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Rat Cytochrome P450 2C11 Involved in Oxidation of Anesthetic Drug Propofol and Deactivated by Propofol in Liver Microsomes2006
- Author(s)
  Hiroshi, Yamazaki, Makiko, Shimizu, Takashi, Nagashima, Masaki, Minoshima, Node, Murayama
- Organizer
  21st JSSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] レボカルニチン投与時の透析患者におけるトリメチルアミンおよびN-酸化体の体内動態の検討
- Author(s)
  小泉綾乃、清水万紀子、若林あかり、村山典恵、小篠榮、山崎浩史
- Organizer
  第66回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  聖マリアンナ医科大学　(神奈川県川崎市)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] マイクロミニピッグ肝薬物代謝酵素活性のヒトとの比較
- Author(s)
  山崎浩史
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] 抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差
- Author(s)
  大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也、清水万紀子、秋元洋一、後藤晶子、○山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学,兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] 成長に伴う薬物酸化酵素フラビン含有モノオキシゲナーゼの個人変動
- Author(s)
  清水万紀子、山崎浩史
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2013
- Place of Presentation
  熊本大学薬学部（熊本）
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Reactive metabolite formation of drugs by human P450s in chimeric mice with humanized liver
- Author(s)
  Hiroshi Yamazaki
- Organizer
  19th Notrh American ISSX/ 29th JSSX Annual Meeting
- Place of Presentation
  Hilton San Francisco Union Square Hotel (San Fransico, USA)
- Year and Date
  2014-10-19 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in aJapanese population
- Author(s)
  Makiko Shimizu, Elizabeth Shephard, IAN Phillips, Hiroshi Yamazaki
- Organizer
  ICCP450
- Place of Presentation
  The University of Washington（シアトル、米国）
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Species, Ethnic, and Individual Differences in Human Drug-metabolizing Cytochrome P450 Enzymes
- Author(s)
  Hiroshi Yamazaki
- Organizer
  50th Anniversary Symposium on Cytochrome P450
- Place of Presentation
  九州大学医学部（福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Polymorphic human flavin-containing monooxygenase 3 (FMO3)-mediated drug interactions
- Author(s)
  Makiko Shimizu and Hiroshi Yamazaki
- Organizer
  SOT 53rd Annual Meeting and ToxExpo
- Place of Presentation
  West and North Buildings at the Phoenix Convention Center (Phoenix, USA)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 抗精神病薬リスペリドン投与日本人患者における血漿中薬物濃度の個人差
- Author(s)
  ○大久保真穂1、村山典恵1、森田翔子1、森亜沙美1、倉林優貴1、秋元洋一2、後藤晶子2、山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学,兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] ヒトフラビン含有酸素添加酵素3が関与する薬物相互作用
- Author(s)
  清水万紀子、佐藤歩、石井有紀、白石有紗、村山典恵、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館　(熊本県)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] レボカルニチンを使う透析患者さんの体臭を科学する－個の医療－
- Author(s)
  山崎浩史
- Organizer
  医療薬学フォーラム2014
- Place of Presentation
  東京ビックサイト　（東京都）
- Year and Date
  2014-06-24 – 2014-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Drug Metabolism in Chimeric Mice with Humanized Liver
- Author(s)
  Hiroshi Yamazaki
- Organizer
  The North Jersey ACS Drug Metabolism Discussion Group, 2012 Spring Symposium
- Place of Presentation
  Crowne Plaza Hotel Somerset-Bridgewater, Somerset, New Jersey , USA,
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Human Drug metabolites bioactivated by cytochrome P450 enzymes
- Author(s)
  Hiroshi Yamazaki
- Organizer
  The 27th JSSX Annual Meeting
- Place of Presentation
  江戸川区民センター（江戸川区）
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] Metabolic activation and fate of xenobiotics determined by polymorphic drug-metabolizing enzymes
- Author(s)
  Hiroshi Yamazaki
- Organizer
  19th Notrh American ISSX/ 29th JSSX Annual Meeting
- Place of Presentation
  Hilton San Francisco Union Square Hotel (San Fransico, USA)
- Year and Date
  2014-10-19 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Effects of CYP2D6 and CYP3A5 genotypes and co-administrated drugs on the metabolic clearance of antidepressant mirtazapine
- Author(s)
  ○Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba and Hiroshi Yamazaki
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco, San Francisco, California, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Roles of Auto-Induction of Human P450 3A Enzymes Involved in The Teratogenicity of Thalidomide
- Author(s)
  ○Norie Murayama, Hiroshi Suemizu , Christophe Chesné, Norio Shibata,F. Peter Guengerich, Hiroshi Yamazaki
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco, San Francisco, California, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Flavin-containing monooxygenase 3 (FMO3) genotype and phenotype in a Japanes e cohort
- Author(s)
  Makiko Shimizu, Elizabeth Shephard, Ian R. Phillips, Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀　(千葉県)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人トリメチルアミン尿症の一因となるフラビン含有酸素添加酵素3遺伝子多型
- Author(s)
  清水万紀子、加瀬愛幸、石井有紀、山崎美穂、山崎浩史
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京国際フォーラム　(東京都)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] ヒト肝試料を活用した薬物代謝研究
- Author(s)
  山崎浩史
- Organizer
  第33回日本臨床薬理学会年会
- Place of Presentation
  沖縄コンベンションセンター（宜野湾市）
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] mpact of human drug-metabolizing enzymes in drug development
- Author(s)
  Hiroshi Yamazaki
- Organizer
  2013 JSSX / KPS Joint Session, Korean Pharmacetical Society
- Place of Presentation
  Osong Medical Innovation Foudation CV Center, Osong, Chungchungbuk-do, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23590200
[Presentation] 医薬品開発におけるヒト代謝物研究の役割
- Author(s)
  山崎浩史
- Organizer
  第41回日本毒性学会年会
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] サリドマイドによるヒトP450酵素自己誘導機構の要因
- Author(s)
  ○村山典恵、矢島加奈子、柴田哲男、鵜藤雅裕、山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学、兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211

1. MURAYAMA Norie (90219949)

# of Collaborated Projects: 16 results

# of Collaborated Products: 165 results
2. SHIMIZU Makiko (90307075)

# of Collaborated Projects: 16 results

# of Collaborated Products: 181 results
3. KAMATAKI Tetsuya (00009177)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
4. Uno Yasuhiro (90372276)

# of Collaborated Projects: 5 results

# of Collaborated Products: 66 results
5. 藤田健一 (60281820)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 有吉範高 (00243957)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. YOKOI Tsuyoshi (70135226)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAKAJIMA Miki (70266162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. FUJIEDA Masaki (00344474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 高橋芳樹 (80292019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 岩野俊介 (80374560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. OHTANI Hisakazu (70262029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAMOTO Koujirou (70174787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. AKIYOSHI Takeshi (50399143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MIWA Masanao (20012750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TODOROKI Takeshi (70114105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. UCHIDA Kazuhiko (90211078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Uehara Shotaro (10733123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 37 results
19. 青山隆彦 (70384633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIMADA Noriaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HONJO Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SUEMIZU Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. TAKEUCHI Masayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. KAZUKI Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 生城真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 西川美宇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 山折大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 竹中重雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 神矢佑輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 上田忠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 扇屋大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamazaki Hiroshi 山崎 浩史

YAMAZAKI Hiroshi 山崎 浩史

山崎 浩史 ヤキザキ ヒロシ

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遺伝的多型の定量的予測のための酵素不活化ヒト肝細胞移植マウスと動態モデリング開発Principal Investigator

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Roles of human cytochrome P450 1A2, 2C9, and 3A4/5 enzymes in drug oxidations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric micePrincipal Investigator

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Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver micePrincipal Investigator

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Evaluaion of Human Cytochrome P450 3A Enzymes in Hepatic and Placental Cells by Thalidomide and Relevance to BioactivationPrincipal Investigator

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Yamazaki Hiroshi 山崎浩史

YAMAZAKI Hiroshi 山崎浩史

山崎浩史ヤキザキヒロシ