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NISHIGUCHI Tomizo  西口 富三

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… Alternative Names

KOBAYASHI Takao  西口 富三

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Researcher Number 30198452
External Links
Affiliation (based on the past Project Information) *help 2001 – 2006: Hamamatsu Univ. Sch. Of Med., Obstet. Gynecol., Assistant Prof., 医学部附属病院, 講師
2004: Hamamatsu University School of Medicine, lecturer, 医学部附属病院, 講師
2002: 浜松医科大学, 医学部付属病院, 講師
1999 – 2001: 浜松医科大学, 医学部・附属病院, 講師
1995 – 1998: 浜松医科大学, 医学部, 助手
1991: Hamamatsu Univ. Sch. of Med. Dept. of Obsl. & Gynecol. Assistant
1989 – 1991: 浜松医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology
Except Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology
Keywords
Principal Investigator
D-Dimer FDP / AT III / Coagulation Index / Clinical Index / PIVKA-11 / postpartum / PTVKA / protein S / protein C / venous thromboembolism … More / DVT / PIVKA-PC / HepG2 / HUVEC / 肥満 / APC感受性 / 血栓症 / PIVKA-II / 産褥 / PIVKA / プロテインS / プロテインC / 静脈血栓症 / anticoagulant therapy / alpha_2 antiplasmin-plasmin complex (PIC) / chronic DIC / preeclampsia / Plasminogen activator inhibitor 2(PAI2) / Plasminogen activator inhibitor 1(PAI-1) / APC-α_1AT coplex / Protein S / α_2-Antiplasmin-Plasmin complex(PIC) / Throbin-ATIII complex(TAT) / Protein C activation peptide(PCP) / proteinuria / edema / Canonical correlation analysis / Dーdimer FDP / α_2ーantiplasminーplasmin complex(PIC) / ATIII療法 / Gestosis Index(GI) / DーDimer FDP / α_2ーAntiplasminーPlasmin complex / 抗凝固療法 / DーDime FDP / α_2 antiplasminーplasmin complex(PIC) / ATIII / 慢性DIC / 妊娠中毒症 … More
Except Principal Investigator
遺伝子治療 / 癌転移抑制 / 転移 / 浸潤 / 卵巣癌 / 胎盤 / 酸素動態 / 近赤外線 / Bikunin / Gene Therapy / Ovarian Cancer / ビクニン / transabdominal monitaring / uterus / placenta / oxygenation / near-infrared spectroscopy (NIRS) / 筋赤外線 / 胎児情報 / 酸素 / 子宮収縮 / 子宮筋 / ヘモグロビン / Gene therapy / Cancer Invasion / Anti-metastatic agent / Metastasis / EPIDURAL ANESTHESIA / SYMPATHETIC NERVE / ANGIOSPASTIC SYNDROME / MR ANGIOGRAPHY / HYPERCOAGULABILITY / VASOSPASMS / PREECLAMPSIA / カテコールアミン / Shear stress / 血管攣縮 / HELLP症候群 / 子癇 / 重症妊娠中毒症 / ATIII(アンチトロビンIII) / トロンビン / カテコラミン / 左腎静脈 / 腹部交感神経節 / Angiospastic syndrome / 持続硬膜外麻酔 / 交感神経 / 内因性トロンビン / 血液凝固異常 / MR angiography / 妊娠血管攣縮症候群 / 妊娠中毒症 / metastasis / invasion / ovarian cancer / 酸素濃度 / 母体腹壁 / 胎児 Less
  • Research Projects

    (8 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (13 People)
  •  Development of non-invasive transabdominal monitoring of fetal oxygen status

    • Principal Investigator
      KANAYAMA Naohiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Investigation on the mechanism of deep vein thrombosis during postpartum periodPrincipal Investigator

    • Principal Investigator
      NISHIGUCHI Tomizo
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Instrument for measuring intrauterine oxygen metabolism using optical technique.

    • Principal Investigator
      KANAYAMA Naohiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Gene Therapy for Ovarian Cancer by Bikunin

    • Principal Investigator
      KOBAYASHI Hiroshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Anti-metastatic gene therapy by human amniotic fluid-derived bikunin

    • Principal Investigator
      KOBAYASHI Hiroshi
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hamamatsu University School of Medicine
  •  STUDY ON THE PATHOPHYSIOLOGY OF PREECLAMPSIA : THE MECHANISM OF VASOSPASMS

    • Principal Investigator
      KOBAYASHI Takao
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      HAMAMATSU UNIVERSITY SCHOOL OF MEDECINE
  •  Production and characterization of newly developed anti-metastatic agents

    • Principal Investigator
      KOBAYASHI Hiroshi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      HAMAMATSU UNIV.SCH.OF MED.
  •  A study of coagulation and fibrinolysis abnormalities in preeclamptic patients.Principal Investigator

    • Principal Investigator
      KOBAYASHI Takao, KOBAYASHI Takao
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hamamatsu University School of Medicine

All 2007 2005 2004 2002

All Journal Article

  • [Journal Article] Sugimura M, Sumimoto K, Kanayama N : Measurement of placental oxygenation by transabdominal near-infrared spectroscopy2007

    • Author(s)
      Kawamura T, Kakogawa J, Takeuchi Y, Takani S, Kimura S, Nishiguchi T.
    • Journal Title

      Am J Perinatol 24(3)

      Pages: 161-166

    • Data Source
      KAKENHI-PROJECT-18390445
  • [Journal Article] Congenital blood coagulation factor XIII deficiency a nd successful deliveries : A review of the literature2007

    • Author(s)
      Asahina T, Kobayashi T, Takeuchi K, Katayama T, Kanayama N
    • Journal Title

      Obstet Gynecol Surv 62(4)

      Pages: 255-260

    • Data Source
      KAKENHI-PROJECT-18390445
  • [Journal Article] Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.2005

    • Author(s)
      Takei Y, Mizukami H, Saga Y, Kobayashi H, Suzuki M, Matsushita T, Ozawa K, Suzuki M.
    • Journal Title

      Int J Cancer. 113(1)

      Pages: 54-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor-alpha and interleukin-1beta in macrophages.2005

    • Author(s)
      Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      J.Infect.Dis. 191

      Pages: 930-938

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.2005

    • Author(s)
      Takei Y, Mizukami H, Saga Y, Kobayashi H, Suzuki M, Matsushita T, Ozawa K, Suzuki M.
    • Journal Title

      Int J Cancer. 113

      Pages: 54-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer a Cell Invasion by Blocking Urokinase Upregulation.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      Clin.Exp.Metastasis 21

      Pages: 159-166

    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer.2004

    • Author(s)
      Yoshiko Tanaka, Hiroshi Kobayashi, Mika Suzuki, Naohiro Kanayama, Mitsuaki Suzuki, Toshihiko Terao.
    • Journal Title

      Gynecologic Oncology 94(3)

      Pages: 725-734

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] 妊娠産褥期における母体血中PIVKA II値の推移2004

    • Author(s)
      西口富三
    • Journal Title

      日本産婦人科・新生児血液学会誌 14.1

      Pages: 65-66

    • NAID

      10019221146

    • Data Source
      KAKENHI-PROJECT-16591653
  • [Journal Article] Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.2004

    • Author(s)
      Kobayashi H, Yagyu T, Inagaki K, Kondo T, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      Cancer. 100(4)

      Pages: 869-877

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages.2004

    • Author(s)
      Matsuzaki H, Kobayashi H, Yagyu T, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      Clin.Diag.Lab.Immunol. 11

      Pages: 1140-1147

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      Cancer 100

      Pages: 869-877

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Inhibition of Tumor Invasion by Genomic Downregulation of Matriptase Through Suppression of Activation of Receptor-bound Pro-Urokinase.2004

    • Author(s)
      Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin C-Y, Dickson RB, Terao T.
    • Journal Title

      J.Biol.Chem. 279(15)

      Pages: 14899-14908

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model.2004

    • Author(s)
      Kobayashi H, Fukuda Y, Yoshida R, Kanada Y, Nishiyama S, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      Int.J.Cancer. 112

      Pages: 519-524

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Bikunin Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in Mouse Model of Ovarian Cancer.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      Int.J.Cancer 110

      Pages: 134-139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Bikunin Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in Mouse Model of Ovarian Cancer.2004

    • Author(s)
      Kobayashi H, Yagyu T, Inagaki K, Kondo T, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      Int.J.Cancer 110(1)

      Pages: 134-139

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      Int.J.Cancer 112

      Pages: 519-524

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Transforming growth factor-beta 1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells.2004

    • Author(s)
      Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      J Biol Chem. 279(10)

      Pages: 8567-8576

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Genetic down-regulation of phosphoinositide-3-kinase by Bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      J Biol Chem. 279

      Pages: 6371-6379

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis.2004

    • Author(s)
      Tanaka Y, Kobayashi H, Suzuki M, Hirashima Y, Kanayama N, Terao T.
    • Journal Title

      Int J Cancer. 109(3)

      Pages: 336-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer Cell Invasion by Blocking Urokinase Upregulation.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      Clin.Exp.Metastasis 21

      Pages: 159-166

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.2004

    • Author(s)
      Kobayashi H, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      Clin Exp Metastasis. 21(2)

      Pages: 159-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Genetic down-regulation of phosphoinositide-3-kinase by Bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.2004

    • Author(s)
      Kobayashi H, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      J Biol Chem. 279(8)

      Pages: 6371-6379

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-β and subsequently suppresses TGF-β signalings.2004

    • Author(s)
      Tatsuo Yagyu, Hiroshi Kobayashi, Kiyoshi Wakahara, Hidenori Matsuzaki, Toshiharu Kondo, Noriyuki Kurita, Hideo Sekino, Kiyokazu Inagaki, Mika Suzuki, Naohiro Kanayama, Toshihiko Terao.
    • Journal Title

      FEBS Lett. 576

      Pages: 408-416

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.2004

    • Author(s)
      Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      J Cell Biochem. 93(3)

      Pages: 437-453

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI)-ITI target genes in mouse ovary identified by microarray analysis.2004

    • Author(s)
      Suzuki M, Kobayashi H, Tanaka Y, Kanayama N, Terao T.
    • Journal Title

      J.Endocrinol. 183

      Pages: 29-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer Cell Invasion by Blocking Urokinase Upregulation.2004

    • Author(s)
      Kobayashi H, Suzuki M, Kanayama N, Terao T.
    • Journal Title

      Clin.Exp.Metastasis 21(2)

      Pages: 159-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571553
  • [Journal Article] Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWo.2004

    • Author(s)
      Iwaki T, Matsuura T, Sugimura M, Kobayashi T, Kanayama N.
    • Journal Title

      Gynecol Obstet Invest 57

      Pages: 196-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370529
  • [Journal Article] Increased expression of vascular endothelial growth factor in placentas of p57^<Kip2> null embryos.2002

    • Author(s)
      Matsuura T, Takahashi K, Nakayama K, Kobayashi T, Choi-Miura N, Tomita M, Kanayama N.
    • Journal Title

      FEBS Lett. 532

      Pages: 283-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370529
  • [Journal Article] Deficiency in p57^<Kip2> expression induces preeclampsia-like symptoms in mice.2002

    • Author(s)
      Kanayama N, Takahashi K, Matsuura T, Sugimura M, Kobayashi T, Moniwa N, Tomita M, Nakayama K
    • Journal Title

      Mol Hum Reprod 8

      Pages: 1129-1135

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370529
  • 1.  KANAYAMA Naohiro (70204550)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 2.  SUGIMURA Motoi (30273189)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  SUMIMOTO Kazuhiro (30126817)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  KOBAYASHI Hiroshi (40178330)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 23 results
  • 5.  KOBAYASHI Takao (20107808)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TERAO Toshihiko (60022852)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SUZUKI Mitsuaki (50110870)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 8.  茂庭 將彦 (00230053)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TOKUNAGA Naoki (20283369)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OOI Hidekazu (10283368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  河村 隆一 (90397422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  竹内 欽哉 (80362193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  須床 和恵 (40343199)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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