AKIZAWA Toshifumi 秋澤俊史

… Alternative Names

Akizawa Toshifumi 秋澤俊史

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Researcher Number	30202526
Other IDs
Affiliation (Current)	2025: 高知大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help	2025: 高知大学, 医学部, 特任教授 2020 – 2021: 高知大学, 医学部, 特任教授 2019: 高知大学, 教育研究部医療学系基礎医学部門, 特任教授 2012 – 2017: 摂南大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator Catalytide / 凝集性 / フラグメントペプチド / プリオンタンパク質 / アルツハイマー病治療薬 / ベーターアミロイド / In Silico / ペプチド性加水分解酵素 / Amyloid-beta / Peptide … More / ドッキングシミュレーション / Alzheimer's disease / peptide / SOD1 / 凝集性タンパク質 / コンピュータモデリング / In silico / パーキンソン病 / ALS / 酵素ペプチド / 神経変性疾患 / アルツハイマー病 / Caspase-3 / 銅 / アポトーシス / 構造変化 / チオフラビンT / CDスペクトル / 分子間相互作用 / 銅イオン / CD / 立体構造 / 凝集 / プリオンタンパク / Cu2+ / プロテアーゼ耐性 / マトリックスメタロプロテアーゼ / MT1-MMP / カラムスイッチHPLC / MT-MMP / 酵素耐性 … More Except Principal Investigator ペプチド / 神経変性疾患 / パーキンソン病 Less

パーキンソン病治療薬を目指いたαシヌクレイン凝集抑制物質による凝集阻害機構の解明
- Principal Investigator
  
  小西元美
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Setsunan University
Creation of novel Catalytide with In SilicoPrincipal Investigator
- Principal Investigator
  
  Akizawa Toshifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kochi University
Physical and chemical analyses of aggregation mechanism by using Prion fragment peptidesPrincipal Investigator
- Principal Investigator
  
  Akizawa Toshifumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
Analysis of prion protein aggregation mechanism by using that fragment peptidesPrincipal Investigator
- Principal Investigator
  
  AKIZAWA Toshifumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University

All 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration2021
- Author(s)
  Hatakawa Yusuke、Tanaka Akiko、Furubayashi Tomoyuki、Nakamura Rina、Konishi Motomi、Akizawa Toshifumi、Sakane Toshiyasu
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 10 Pages: 1673-1673
- DOI
  10.3390/pharmaceutics13101673
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22499
[Journal Article] Amyloid beta cleavage by ANA‐TA9, a synthetic peptide from the ANA/BTG3 Box A region2021
- Author(s)
  Hatakawa Yusuke、Nakamura Rina、Konishi Motomi、Sakane Toshiyasu、Tanaka Akiko、Matsuda Akira、Saito Motoaki、Akizawa Toshifumi
- Journal Title
  
  Alzheimer's & Dementia: Translational Research & Clinical Interventions
  
  Volume: 7 Issue: 1
- DOI
  10.1002/trc2.12146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22499
[Journal Article] Evaluation of the proteolytic activity of 5-mer peptides in BoxA region of Top/BTG family proteins against Amyloid-β fragment peptides2020
- Author(s)
  Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Saito Motoaki, Toshifumi Akizawa
- Journal Title
  
  Peptide Science 2019, The Japanese Peptide Society
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22499
[Journal Article] JAL-TA9 Inhibits Aggregation of Hprp180-192 through the Cleavage Reaction2020
- Author(s)
  Nakamura Rina、Konishi Motomi、Sakaguchi Yuko、Hatakawa Yusuke、Tanaka Akiko、Sakane Toshiyasu、Saito Motoaki、Akizawa Toshifumi
- Journal Title
  
  Journal of Pharmacy and Pharmacology Research
  
  Volume: 04 Issue: 02 Pages: 23-33
- DOI
  10.26502/fjppr.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22499
[Journal Article] The Novel Catalytic Peptide, A Synthetic Nona-Peptide (JAL-TA9) Derived from Tob1 Protein, Digests the Amyloid Peptide2019
- Author(s)
  Nakamura Rina, Konishi Motomi, Hatakawa Yusuke, Saito Motoaki, Akizawa Toshifumi
- Journal Title
  
  Journal of Royal Science
  
  Volume: 1 Pages: 30-35
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22499
[Journal Article] Catalytides derived from the Box A region in the ANA/BTG3 protein cleave amyloid-β fragment peptide2019
- Author(s)
  Hatakawa Yusuke、Nakamura Rina、Konishi Motomi、Sakane Toshiyasu、Saito Motoaki、Akizawa Toshifumi
- Journal Title
  
  Heliyon
  
  Volume: 5 Issue: 9 Pages: e02454-e02454
- DOI
  10.1016/j.heliyon.2019.e02454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09196, KAKENHI-PROJECT-19K22499
[Journal Article] Comparison of the catalytic activities of 5-mer synthetic peptides derived from Box A region of Tob/BTG family proteins against the amyloid-beta fragment peptides2019
- Author(s)
  Nakamura Rina、Konishi Motomi、Higashi Youichirou、Saito Motoaki、Akizawa Toshifumi
- Journal Title
  
  Integrative Molecular Medicine
  
  Volume: 6 Issue: 4 Pages: 1-4
- DOI
  10.15761/imm.1000374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22499
[Journal Article] Structure-activity relationship of 5-mer peptides derived from JAL-TA92018
- Author(s)
  Rina Nakamura, Yusuke Hatakawa, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
- Journal Title
  
  Peptide Science 2017
  
  Volume: なし Pages: 40-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] Comparison of proteolytic activity of 5-mer peptides derived from BoxA domain of Tob/BTG family proteins2018
- Author(s)
  Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
- Journal Title
  
  Peptide Science 2017
  
  Volume: なし Pages: 102-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] MMP-7 cleaves amyloid β fragment peptides and copper ion inhibits the degradation2017
- Author(s)
  Taniguchi Masanari、Matsuura Kazuki、Nakamura Rina、Kojima Aya、Konishi Motomi、Akizawa Toshifumi
- Journal Title
  
  BioMetals
  
  Volume: 30 Issue: 5 Pages: 797-807
- DOI
  10.1007/s10534-017-0048-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] THE SYNTHETIC PEPTIDE DERIVED FROM BOXA REGION IN ANA/BTG3 PROTEIN IS THE SECOND CATALYTIDE CLEAVING THE AMYLOID-β PEPTIDE2017
- Author(s)
  4.Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa
- Journal Title
  
  Peptide Science 2016
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] C-terminal Region of the hPrP Can Be the Core for the Structural Conversion and Aggregation2016
- Author(s)
  Aya Kojima, Yuko Sakaguchi, Hidenao Toyoda, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
- Journal Title
  
  Peptide Science 2015
  
  Volume: なし Pages: 217-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] STRACTURAL ANALYSIS OF THE NOVEL HYDROLASE-LIKE PEPTIDE2016
- Author(s)
  1.R. Nakamura, M. Konishi, E. Ushijima, R. Tanaka, M. Taniguchi, A. Kojima, M. Tokumasu, T. Yamamoto, T. Akizawa
- Journal Title
  
  Peptides 2016
  
  Volume: -
- Open Access
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] FINDING OF THE NOVEL HYDROLASE-LIKE PEPTIDE (JAL-TA9) DIGESTING Aβ PROTEIN2016
- Author(s)
  2.T. Akizawa, R. Nakamura, A. Kojima, M. Konishi, M. Taniguchi, M. Tokumasu, T. Yamamoto
- Journal Title
  
  Peptides 2016
  
  Volume: -
- Open Access
- Data Source
  KAKENHI-PROJECT-15K07908
[Journal Article] Intermolecular Interaction of Human Prion Protein Fragment Peptides2015
- Author(s)
  Toshifumi Akizawa, Masanari Taniguchi, Aya Kojima, Takaya Nakai, Motomi Konishi
- Journal Title
  
  Peptide Science 2014
  
  Volume: なし Pages: 169-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590066
[Journal Article] Membrane type matrix metalloproteinases degrade prion fragment peptides and are inhibited by Cu2+2014
- Author(s)
  Aya Kojima, Motomi Konishi, Toshifumi Akizawa
- Journal Title
  
  Biomolecules
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590066
[Journal Article] Prion Fragment Peptides are Digested with Membrane Type Matrix Metalloproteinases and Acquire Enzyme Resistance through Cu2+-Binding2014
- Author(s)
  Aya Kojima, Motomi Konishi, Toshifumi Akizawa
- Journal Title
  
  Biomolecules 2014
  
  Volume: 4 Issue: 2 Pages: 510-526
- DOI
  10.3390/biom4020510
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590066
[Patent] アミロイドβの凝集抑制剤、アミロイドβ凝集疾患用医薬組成物、及びその用途2020
- Inventor(s)
  秋澤俊史、齊藤源顕、東洋一郎、中村里菜
- Industrial Property Rights Holder
  秋澤俊史、齊藤源顕、東洋一郎、中村里菜
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-167404
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K22499
[Patent] NOVEL PEPTIDE2017
- Inventor(s)
  T. Yamamoto and T. Akizawa
- Industrial Property Rights Holder
  OIST
- Industrial Property Rights Type
  特許
- Filing Date
  2017-01-06
- Overseas
- Data Source
  KAKENHI-PROJECT-15K07908
[Patent] 加水分解活性を示す新規ペプチドおよびその用途2017
- Inventor(s)
  T. Yamamoto and T. Akizawa
- Industrial Property Rights Holder
  OIST
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-068496
- Filing Date
  2017-03-31
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Alzheimer's model mouse を用いた 9 残基酵素ペプチド JAL-TA9 脳内投与の効果2021
- Author(s)
  中村里菜、小西　元美、新武　享明、東　洋一郎、齊藤　源顕、秋澤　俊史
- Organizer
  第 20 回 KMS Research Meeting
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Tau を標的としたアルツハイマー病治療薬の開発-Tau 凝集の核となるペプチドの同定と凝集抑制ペプチドのスクリーニング-2021
- Author(s)
  谷口大樹、坂田大輔、中村里菜、齊藤源顕、秋澤俊史
- Organizer
  第 21 回 KMS リサーチミーティング
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Effects of 9-Mer Catalytide, JAL-TA9 to APP Knock-in Mice through the Single Direction Dose into Hippocampus2021
- Author(s)
  R. Nakamura, Y. Higashi, T. Aratake, M. Konishi, M. Saito, T. Akizawa
- Organizer
  International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] パーキンソン病 (PD) 治療薬開発に向けたシーズペプチドの同定2021
- Author(s)
  中村里菜、小西元美、齊藤源顕、秋澤俊史
- Organizer
  第 21 回 KMS リサーチミーティング
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] SOD1 を標的とした ALS の根本的治療薬の開発-SOD1 凝集の核となるペプチドの同定と凝集抑制ペプチドのスクリーニング-2021
- Author(s)
  坂田大輔、谷口大樹、中村里菜、齊藤源顕、秋澤俊史
- Organizer
  第 21 回 KMS リサーチミーティング
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Effects of 9-Mer Catalytide, JAL-TA9 to APP Knock-in Mice through the Single Direction Dose into Hippocampus2021
- Author(s)
  Rina Nakmaura, Youichirou Higashi, Takaaki Aratake, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa
- Organizer
  International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Catalytide improves the cognitive deficits by injecting into the CA1 of hippocampus in Alzheimer's disease model mice2020
- Author(s)
  Rina Nakamura, Youichirou Higashi, Takaaki Aratake, Motomi Konishi, Yusuke Hatakawa, Motoaki Saito, Toshifumi Akizawa
- Organizer
  Cold Spring Haver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Alzheimer's model mouse を用いた 9 残基酵素ペプチド JAL-TA9 脳内投与の効果2020
- Author(s)
  中村　里菜、小西　元美、新武　享明、東　洋一郎、齊藤　源顕、秋澤　俊史
- Organizer
  第 39 回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Evaluation of the proteolytic activity of 5-mer peptides in BoxA region of Top/BTG family proteins against Amyloid-β fragment peptides2019
- Author(s)
  Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Saito Motoaki, Toshifumi Akizawa
- Organizer
  第 56 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] 5 残基 Catalytide (RHGSG) とAβ1-20 とのドッキングシュミレーション2019
- Author(s)
  山本隆幸、小西元美、中村里菜、秋澤俊史
- Organizer
  第 32 回　バイオメディカル分析科学シンポジウム (BMAS)
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] 5 残基 Catalytide (RYGSG) とAβ11-29 とのドッキングシュミレーション2019
- Author(s)
  大西航平、小西元美、中村里菜、秋澤俊史
- Organizer
  第 32 回　バイオメディカル分析科学シンポジウム (BMAS)
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Tob/BTG ファミリータンパク質 BoxA 領域由来フラグメントペプチドの加水分解酵素2019
- Author(s)
  中村里菜、小西元美、齊藤源顕、秋澤俊史
- Organizer
  病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] Creating the novel proteolytic peptide (Catalytide) extracting from protein enzyme2019
- Author(s)
  Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Saito Motoaki, Toshifumi Akizawa
- Organizer
  11th General Meeting of the International Proteolysis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] フラグメントペプチドを用いた Tob/BTG ファミリータンパク質 BoxA ドメインの機能解析2019
- Author(s)
  中村里菜、小西元美、齊藤源顕、秋澤俊史
- Organizer
  第 32 回　バイオメディカル分析科学シンポジウム (BMAS)
- Data Source
  KAKENHI-PROJECT-19K22499
[Presentation] ヒトプリオンタンパク質C-端由来ペプチドhPrP180-192 の凝集性に対する１アミノ酸変異の影響2018
- Author(s)
  坂口裕子、中村里菜、幡川祐資、谷口将済、小西元美、秋澤俊史、津田正博、豊田英尚
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] In silicoによるβアミロイドペプチドを加水分解する5残基Catalytideの立体構造2018
- Author(s)
  小西元美、中村里菜、佐々木輝、幡川祐資、谷口将済、秋澤俊史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Catalytides are the attractive hydrolase-peptide for the strategic development of new drugs for neurotoxic diseases prevention and treatment2017
- Author(s)
  Toshifumi Akizawa, Rina Nakamura, Yusuke Hatakawa, Masanari Taniguchi, Motomi Konishi
- Organizer
  10 th GENERAL MEETING OF THE INTERNATIONAL PROTEOLYSIS SOCIETY
- Invited
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ANA/BTG3 由来酵素ペプチド (Catalytide) のアミロイド-β 切断活性2017
- Author(s)
  幡川祐資、中村里菜、小西元美、谷口将済、徳増美穂、山本雅、秋澤俊史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ヒトプリオンタンパク質C 末端由来ペプチドの凝集性とCu2+の影響2017
- Author(s)
  坂口裕子、中村里菜、幡川祐資、谷口将済、小西元美、小嶋絢、豊田英尚、秋澤俊史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Tob1 タンパク質由来のCatalytide の活性構造2017
- Author(s)
  小西元美、中村里菜、幡川祐資、谷口将済、牛島恵美梨、田中龍一郎、山本雅、秋澤俊史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Catalytide のβ-アミロイドペプチドに対する結合性2017
- Author(s)
  谷口将済、中村里菜、西口杏奈、幡川祐資、小西元美、秋澤俊史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] The Development of the novel 5-Mer Catlytide cleaving Amyloid beta peptide2017
- Author(s)
  Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Masanari Taniguchi, Toshifumi Akizawa
- Organizer
  10 th GENERAL MEETING OF THE INTERNATIONAL PROTEOLYSIS SOCIETY
- Invited
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ANA タンパク質の Box A 由来フラグメントペプチドはアミロイドβを分解する2016
- Author(s)
  幡川祐資、中村里菜、小嶋絢、谷口将済、小西元美、山本雅、秋澤俊史
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] 酵素活性をもつペプチドの CD による二次構造解析2016
- Author(s)
  小西元美、中村里菜、小嶋絢、谷口将済、山本雅、秋澤俊史
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] THE SYNTHETIC PEPTIDE DERIVED FROM BOXA REGION IN ANA/BTG3 PROTEIN IS THE SECOND CATALYTIDE CLEAVING THE AMYLOID-β PEPTIDE2016
- Author(s)
  Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Catalytide と β-アミロイドペプチドとの結合2016
- Author(s)
  谷口将済、中村里菜、西口杏奈、幡川祐資、小西元美、秋澤俊史
- Organizer
  第5回新アミノ酸分析研究会
- Place of Presentation
  東京
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Chemical and Physical Properties of the Novel Serine Protease-Like Peptide Digesting Amyloid-Beta Protein2016
- Author(s)
  Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Emiri Ushijina, Ryuichiro Tanaka, Aya Kojima, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa
- Organizer
  14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress
- Place of Presentation
  Taipei
- Year and Date
  2016-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ペプチド性酵とβ-アミロイドペプチドとの結合性2016
- Author(s)
  谷口将済、中村里菜、西口杏奈、幡川祐資、小嶋絢、小西元美、徳増美穂、山本雅、秋澤俊史
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ANA/BTG3 由来 Catalytide のアミロイド-β 切断活性2016
- Author(s)
  幡川祐資、中村里菜、谷口将済、小西元美、山本雅2、秋澤俊史演題名：ANA/BTG3 由来 Catalytide のアミロイド-β 切断活性
- Organizer
  第5回新アミノ酸分析研究会
- Place of Presentation
  東京
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] STRACTURAL ANALYSIS OF THE NOVEL HYDROLASE-LIKE PEPTIDE2016
- Author(s)
  R. Nakamura, M. Konishi, E. Ushijima, R. Tanaka, M. Taniguchi, A. Kojima, M. Tokumasu, T. Yamamoto, T. Akizawa
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  Germany-Leipzig
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] FINDING OF THE NOVEL HYDROLASE-LIKE PEPTIDE (JAL-TA9) DIGESTING Aβ PROTEIN2016
- Author(s)
  T. Akizawa, R. Nakamura, A. Kojima, M. Konishi, M. Taniguchi, M. Tokumasu, T. Yamamoto
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  Germany-Leipzig
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] 酵素活性をもつペプチドのコンフォメーション解析2016
- Author(s)
  牛島恵美梨、小西元美、中村里菜、田中龍一郎、谷口将済、秋澤俊史
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Tob1 タンパク質由来の Catalytide の立体構造2016
- Author(s)
  小西元美、中村里菜、幡川祐資、谷口将済、田中龍一朗、秋澤俊史
- Organizer
  第5回新アミノ酸分析研究会
- Place of Presentation
  東京
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] アミロイドβを分解する低分子ペプチドの発見2016
- Author(s)
  中村里菜、小嶋絢、小西元美、谷口将済、牛島恵美梨、田中龍一郎、徳増美穂、山本雅、秋澤俊史
- Organizer
  21回病態プロテアーゼ学会
- Place of Presentation
  大阪
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ヒトプリオンタンパク質（hPrP）C-末端領域由来フラグメントペプチドの構造変化と分子間相互作用の検討2016
- Author(s)
  坂口裕子、小嶋絢、豊田英尚、谷口将済、小西元美、秋澤俊史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ヒトプリオンタンパク質由来フラグメントペプチドのSH-SY5Y細胞への影響2016
- Author(s)
  大藤敏男、小嶋絢、坂口裕子、豊田英尚、谷口将済、小西元美、秋澤俊史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] THE NOVEL FINFING OF SERINE PROTEASE-LIKE PEPTIDE2016
- Author(s)
  Rina Nakamura, Aya Kojima, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Catalytideの発見2016
- Author(s)
  秋澤俊史、中村里菜、幡川祐資、谷口将済、小西元美、小嶋絢　徳増美穂、山本雅
- Organizer
  第5回新アミノ酸分析研究会
- Place of Presentation
  東京
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] Discover of the Novel Serine Protease-like Peptide digesting Amyloid-Beta Protein2016
- Author(s)
  Toshifumi Akizawa, Rina Nakamura, Aya Kojima, Motomi Konishi, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto
- Organizer
  14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress
- Place of Presentation
  Taipei
- Year and Date
  2016-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] 合成フラグメントペプチドを用いたヒトプリオンタンパク質（PrP）C-末端領域の性質解2015
- Author(s)
  小嶋絢、坂口裕子、永井裕子、豊田英尚、谷口将済、小西元美、秋澤俊史
- Organizer
  第28回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎県長崎市
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] C-terminal region of the hPrP can be the core for the structual conversion and the aggregation2015
- Author(s)
  Aya Kojima, Yuko Sakaguchi, Hidenao Toyoda, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川県平塚市
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K07908
[Presentation] ヒトプリオンタンパク質由来フラグメントペプチドhPrP150-159の結合部位の検討2014
- Author(s)
  廣瀬玲子、中井貴也、小嶋絢、豊田英尚、谷口将済、小西元美、秋澤俊史
- Organizer
  第31回関西地区ペプチドセミナー
- Place of Presentation
  神戸
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] ペプチド固定化担体を用いたhPrP由来フラグメントペプチド間の結合性の検討2014
- Author(s)
  廣瀬玲子、中井貴也、小嶋絢、豊田英尚、谷口将済、小西元美、秋澤俊史
- Organizer
  第64回日本薬学会近畿支部総会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] INTERMOLECULAR INTERACTION OF HUMAN PRION FRAGMENT PEPTIDES
- Author(s)
  Toshifumi Akizawa, Masanari Taniguchi, Aya Kojima, Takaya Nakai, Motomi Konishi
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] ヒトプリオンタンパク質由来フラグメントペプチド間の結合性の検討
- Author(s)
  中井貴也、廣瀬玲子、小嶋絢、谷口将済、小西元美、秋澤俊史
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] Metal binding ability and structure analysis of the synthetic fragment peptides originating from human prion protein
- Author(s)
  Toshifumi Akizawa, Aya Kojima, Reiko Hirose, Motomi Konishi
- Organizer
  The 23rd Symposium on Role of Metals in Biological Reactios, Biology and Medicine
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] 凝集性タンパク質の酵素分解と耐性獲得機序の解明におけるフラグメントペプチドの有用性について
- Author(s)
  秋澤俊史
- Organizer
  BMAS
- Place of Presentation
  東京
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] STRUCTURAL ANALYSIS OF PRION FRAGMENT PEPTIDES BY CIRCULAR DICHROISM ANALYSIS
- Author(s)
  Toshifumi Akizawa, Aya Kojima, Motomi Konishi
- Organizer
  33rd European Peptide Synposium
- Place of Presentation
  ソフィア
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24590066
[Presentation] hPrP由来フラグメントペプチドhPrP150-159に対する結合部位の検索
- Author(s)
  廣瀬玲子、中井貴也、小嶋絢、豊田英尚、谷口将済、小西元美、秋澤俊史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590066

1. KONISHI Motomi (20229446)

# of Collaborated Projects: 3 results

# of Collaborated Products: 44 results
2. 谷口将済 (50710696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 34 results
3. 中村里菜 (70868629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 齋藤源顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIZAWA Toshifumi 秋澤 俊史

Akizawa Toshifumi 秋澤 俊史

Research Projects

Research Products

Co-Researchers

パーキンソン病治療薬を目指いたαシヌクレイン凝集抑制物質による凝集阻害機構の解明

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Creation of novel Catalytide with In SilicoPrincipal Investigator

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Physical and chemical analyses of aggregation mechanism by using Prion fragment peptidesPrincipal Investigator

Principal Investigator

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Analysis of prion protein aggregation mechanism by using that fragment peptidesPrincipal Investigator

Principal Investigator

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[Journal Article] Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration2021

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[Journal Article] Amyloid beta cleavage by ANA‐TA9, a synthetic peptide from the ANA/BTG3 Box A region2021

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[Journal Article] Evaluation of the proteolytic activity of 5-mer peptides in BoxA region of Top/BTG family proteins against Amyloid-β fragment peptides2020

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[Journal Article] JAL-TA9 Inhibits Aggregation of Hprp180-192 through the Cleavage Reaction2020

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[Journal Article] The Novel Catalytic Peptide, A Synthetic Nona-Peptide (JAL-TA9) Derived from Tob1 Protein, Digests the Amyloid Peptide2019

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[Journal Article] Catalytides derived from the Box A region in the ANA/BTG3 protein cleave amyloid-β fragment peptide2019

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[Journal Article] Comparison of the catalytic activities of 5-mer synthetic peptides derived from Box A region of Tob/BTG family proteins against the amyloid-beta fragment peptides2019

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[Journal Article] Structure-activity relationship of 5-mer peptides derived from JAL-TA92018

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[Journal Article] Comparison of proteolytic activity of 5-mer peptides derived from BoxA domain of Tob/BTG family proteins2018

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[Journal Article] MMP-7 cleaves amyloid β fragment peptides and copper ion inhibits the degradation2017

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[Journal Article] THE SYNTHETIC PEPTIDE DERIVED FROM BOXA REGION IN ANA/BTG3 PROTEIN IS THE SECOND CATALYTIDE CLEAVING THE AMYLOID-β PEPTIDE2017

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[Journal Article] C-terminal Region of the hPrP Can Be the Core for the Structural Conversion and Aggregation2016

AKIZAWA Toshifumi 秋澤俊史

Akizawa Toshifumi 秋澤俊史