NAKAE Hideaki 中江英明

… Alternative Names

Researcher Number	30227730
External Links
Affiliation (based on the past Project Information) *help	2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 2007 – 2011: The University of Tokushima, Institute of Health Biosciences, Graduate School, Associate professor 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教授 2004 – 2005: The University of Tokushima, Institute of Health Biosciences of Tokushima Graduate School, Department of Conservative Dentistry, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 2000 – 2003: Univ.of Tokushima, Conserv.Dent., Assistant professor, 歯学部, 助教授 … More
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontal dentistry Except Principal Investigator Conservative dentistry / Conservative dentistry / Periodontal dentistry
Keywords	Principal Investigator claudin / 線維芽細胞 / 上皮細胞 / IL-8 / tight junction / クローディン / 共培養 / 歯周病関連細菌 / RT-PCR / ICAM-1 … More Except Principal Investigator バイオフィルム / 歯髄炎 / 免疫染色 / 歯周炎 / マクロファージ / リンパ球 / 接着分子 / 象牙細管 / 根尖性歯周炎 / 細菌 / 遺伝子発現 / シグナル伝達 / 歯周ポケット内細菌 / 歯周病関連細菌 / 感染根管 / 難治性根尖性歯周炎 / Immunohistology / 線維芽細胞 / MCP-1 / MMP-1 / Macrophage / MIP-3α / CCR6 / ケモカイン / pulpitis / chemokine / histon-like protein / Porphyromonas gingivalis / biofilm / suicide vector / anaerobic system / antibody / Woodruff assay / 象牙質齲蝕 / 齲蝕原性細菌 / クオラムセンシング / 根面齲蝕 / ミュータンス菌 / 再石灰化 / カテキン / 象牙細管侵入細菌 / 歯髄応答 / 自然免疫 / 病原体特異的分子パターン / パターン認識受容体 / 茶カテキン / 自然免疫機構 / 歯内療法学 / 電磁・高周波 / 骨芽細胞 / 成長因子 / 歯内療法 / マイクロアレイ / オステオポンティン / アドレノメデュリン / 抗菌ペプチド / 診断方法 / 活動期病変 / 線形判別分析 / 歯肉溝浸出液 / 歯肉縁下プラ-ク / 歯肉溝滲出液 / Diagnostic method / Periodontitis / Periodontal disease activity / Linear discriminant analysis / Subgingival plaque / Gingival crevicular fluid / プラーク細菌 / ヒト歯周ポケット / 局在性 / 免疫組織学的検索 / 細菌レクチン / B細胞マイトジェン / 付着因子 / 免疫組織学 / 微細形態学 / Periodontal disease-associated bacteria / Plaque bacteria / Human periodontal pocket / Localization / Immunohistological observation / Bacterial lectin / B cell mitogen / 口腔内細菌 / 根管壁 / 根尖病巣 / 根管拡大 / 根尖部 / 局在 / 歯根部象牙細管 / 侵入 / Infected root canal / Dentinal tubules / Bacteria / Pulpal wall / Periapical lesion / Canal enlargement / う蝕関連細菌 / cyclooxygenase-2 / シクロオキシゲナーゼ-2 / Caries-associated bacteria / Pulpitis / Fibroblast / Cyclooxygenase-2 / 根尖孔外 / 歯根部象牙質 / 免疫組織 / 走査型電子顕微鏡 / 根管治療 / 根尖孔 / apical periodontitis / extra-radical area / bacteria / root dentin / immunohistology / SEM / refractory apical periodontitis / infected root canal treatment / 内皮細胞 / ケモカインレセプター / RT-PCR / ELISA / Streptococcus mutans / IL-1β / TNF-α / CD45RO / macrophage / endothelial cell / lymphocyte / chemokine receptor / サイトカイン / 細菌関連物質 / 細菌由来物質 / 白血球 / cytokine / bacteria-related products / fibroblast / periodontal disease / GST融合蛋白 / histon-like prote / 薬剤耐性遺伝子 / GST fused protein / 歯周病 / 動脈硬化症 / 細菌感染 / 炎症 / 免疫応 / 炎症性サイトカイン / スカベンジャーレセプター / Periodontal Disease / Atherosclerosis / Periodontopathogen / Bacterial Infection / Inflammation / Gene_Expression / Immune Reaction Less

歯周病変に発現するクローディンとケモカインによる歯周病原因子の上皮透過性制御機構Principal Investigator
- Principal Investigator
  
  中江英明
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Study of the effects of adrenomedullin upon oral biofilm formation
- Principal Investigator
  
  OZAKI Kazumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Endodontic therapeutic application of electro-magnetic wave irradiation for refractory periapical periodontitis and periapical biofilm
- Principal Investigator
  
  YUMOTO Hiromichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Development of the diagnosis and treatment of root caries on its pathosis and pathogenesis
- Principal Investigator
  
  MATSUO Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Study of quorum-sensing system of invading bacteria in dentinal caries
- Principal Investigator
  
  OZAKI Kazumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Clarification of the mechanism of periodontitis-initiated/accelerated atheroacleicsis and identification of its causal components
- Principal Investigator
  
  YUMOTO Hiromichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Analysis of the mechanisms that claudins expressed in periodontal diseased epithelium regulate the permeability of gingival epitheliumPrincipal Investigator
- Principal Investigator
  
  NAKAD Hideaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Analysis of the role of pulp fibroblasts on lymphocytes infiltration in pulpitis
- Principal Investigator
  
  FUJINAKA Keiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Analysis of the genes and proteins that regulate both formation of biofilm and transmission of drug resistance in periodontal disease
- Principal Investigator
  
  SHIBUTANI Takuya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Analysis of gingival epithelial cells and fibroblast using three-dimensional culture system mimic to periodontal pocketsPrincipal Investigator
- Principal Investigator
  
  NAKAE Hideaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Study on the role of chemokines in the infiltration of inflammatory cells in dental pulp tissue destruction
- Principal Investigator
  
  NAKANISHI Tadashi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
A histological investigation into the actual conditions of infected regions of apices of the teeth with apical periodontitis
- Principal Investigator
  
  MATSUO Takashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Analysis of the relationship between the invasion of dental caries-associated bacteria and the host response of dental pulp in human carious teeth with pulp exposure
- Principal Investigator
  
  NAKANISHI Tadashi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima, School of Dentistry
Bacterial Invasion of Infected Canals and Root Dentin of Human Teeth and Analysis of the Host-parasite Interaction at the Apex. - Elucidation of Pathogenesis of Refractory Cases-.
- Principal Investigator
  
  MATSUO Takashi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Analysis of the interaction between periodontopathic bacteria and junctional epithelial cells using in situ (RT-) PCRPrincipal Investigator
- Principal Investigator
  
  NAKAE Hideaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
ヒト歯周炎における炎症浸潤細胞の接着機構の研究
- Principal Investigator
  
  MATSUO Takashi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Localization of periodontal disease-associated bacteria in human periodontal pockets and its relationship to tissue destruction
- Principal Investigator
  
  EBISU Shigeyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Tokushima University
Studies on diagnostic methods for measurement of periodontal disease activity
- Principal Investigator
  
  EBISU Shigeyuki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Tokushima University

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article

[Journal Article] Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1 β-stimulated human gingival fibroblast2012
- Author(s)
  Hosokawa Y, et al
- Journal Title
  
  Human Immunology
  
  Volume: 73 Pages: 26-30
- DOI
  10.1016/j.humimm.2011.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J08021, KAKENHI-PROJECT-22592122, KAKENHI-PROJECT-23593064, KAKENHI-PROJECT-23792479
[Journal Article] Tumor necrosis factor-like weak inducer of apoptosis increases CC chemokine ligand 20 production in interleukin 1β-stimulated human gingival fibroblasts2012
- Author(s)
  Hosokawa Y, et al.
- Journal Title
  
  Human Immunology
  
  Volume: 73 Pages: 470-473
- DOI
  10.1016/j.humimm.2012.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J08021, KAKENHI-PROJECT-22592122, KAKENHI-PROJECT-23792479
[Journal Article] Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts.2011
- Author(s)
  Hosokawa Y, et al
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 11 Pages: 670-674
- DOI
  10.1016/j.intimp.2011.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J08021, KAKENHI-PROJECT-22592122, KAKENHI-PROJECT-23390435, KAKENHI-PROJECT-23593064, KAKENHI-PROJECT-23792479
[Journal Article] Oncostatin M synergistically induces CXCL10 and ICAM-1 expression in IL-1β-stimulated-human gingival fibroblasts2010
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T
- Journal Title
  
  J Cell Biochem
  
  Volume: 111 Pages: 40-48
- DOI
  10.1002/jcb.22648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592122
[Journal Article] Proinflammatory effects of muramyldipeptide on human gingival fibroblasts2010
- Author(s)
  Hosokawa I., Hosokawa Y., Ozaki K., Yumoto H., Nakae H., Matsuo T
- Journal Title
  
  J Periodontal Res
  
  Volume: 45 Pages: 193-199
- DOI
  10.1111/j.1600-0765.2009.01217.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592122
[Journal Article] Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts2010
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K.Nakanishi T., Nakae H., Matsuo T
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 54 (Suppl 2)
- DOI
  10.1002/mnfr.200900549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592122
[Journal Article] TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts2010
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T
- Journal Title
  
  Mol Immunol
  
  Volume: 47 Pages: 666-670
- DOI
  10.1016/j.molimm.2009.10.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592122
[Journal Article] Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts2010
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakanishi T., Nakae H., Matsuo T
- Journal Title
  
  J Nutr Biochem
  
  Volume: 21 Pages: 659-664
- DOI
  10.1016/j.jnutbio.2009.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592122
[Journal Article] Human gingival fibroblasts express functional chemokine receptor CXCR62009
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T.
- Journal Title
  
  Clin Exp Immunol 156
  
  Pages: 413-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592204
[Journal Article] Cytokines differentially regulate CXCL10 production by IFN-gamma or TNF-alpha stimulated-human gingival fibroblasts2009
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T.
- Journal Title
  
  J Periodontal Res 44
  
  Pages: 225-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592204
[Journal Article] CC-Chemokine Ligand 17 in periodontal diseases : expression in diseased tissues and production by human gingival fibroblasts2008
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T.
- Journal Title
  
  J Periodontal Res 43
  
  Pages: 471-477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592204
[Journal Article] Adrenomedullin suppresses tumor necrosis factor alpha-induced CXC chemokine ligand 10 production by human gingival fibroblasts2008
- Author(s)
  Hosokawa I., Hosokawa Y., Ozaki K., Nakae H., Matsuo T.
- Journal Title
  
  Clin Exp Immunol 152
  
  Pages: 568-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592204
[Journal Article] CXC chemokine ligand 16 in periodontal diseases : expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts2007
- Author(s)
  Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T.
- Journal Title
  
  Clin Exp Immunol 149
  
  Pages: 146-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592204
[Journal Article] Proinflammatory effects of muramyldipeptide on human gingivaI fibroblasts
- Author(s)
  Hosokawa I., Hosokawa Y., Ozaki K., Yumoto H., Nakae H., Matsuo T.
- Journal Title
  
  J Periodontal Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592204

1. OZAKI Kazumi (90214121)

# of Collaborated Projects: 8 results

# of Collaborated Products: 14 results
2. MATSUO Takashi (30173800)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
3. YUMOTO Hiromichi (60284303)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
4. NAKANISHI Tadashi (00217770)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
5. SUGE Toshiyuki (60243713)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. TAKAHASHI Kanako (80403715)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. HOSOKAWA Yoshitaka (90346601)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
8. FUJINAKA Keiko (00294710)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. EBISU Shigeyuki (50116000)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. YOSHIYAMA Masahiro (10201071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. YOSHIDA Yoshiko (20243727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. KAWASAKI Akiko (60294708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. SHIMIZU Hirotoshi (70294709)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. NOIRI Yuichiro (50218286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SHINOHARA Chihiro (50332820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIBUTANI Takuya (20363153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. URAYAMA Akihisa (40304539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAKAMATSU Natsuko (90403716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAE Hideaki 中江 英明

中江 英明 ナカエ ヒデアキ

Research Projects

Research Products

Co-Researchers

歯周病変に発現するクローディンとケモカインによる歯周病原因子の上皮透過性制御機構Principal Investigator

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Analysis of the mechanisms that claudins expressed in periodontal diseased epithelium regulate the permeability of gingival epitheliumPrincipal Investigator

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Analysis of gingival epithelial cells and fibroblast using three-dimensional culture system mimic to periodontal pocketsPrincipal Investigator

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Analysis of the interaction between periodontopathic bacteria and junctional epithelial cells using in situ (RT-) PCRPrincipal Investigator

Principal Investigator

NAKAE Hideaki 中江英明

中江英明ナカエヒデアキ