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Toya Yoshiyuki  戸谷 義幸

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TOYA Yoshiyuki  戸谷 義幸

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Researcher Number 30237143
Other IDs
Affiliation (Current) 2025: 横浜市立大学, 医学研究科, 客員教授
Affiliation (based on the past Project Information) *help 2013 – 2018: 横浜市立大学, 附属病院, 准教授
2006: 横浜市立大学, 大学附属病院, 準教授
2005 – 2006: 横浜市立大学, 附属病院, 準教授
2004: 横浜市立大学, 附属病院, 助教授
2003 – 2004: Yokohama City University, Internal Medicine II, Associated Professer, 医学部附属病院, 助教授 … More
2002 – 2004: 横浜市立大学, 医学部附属病院, 講師
2001: 横浜市立大学, 医学部・附属病院, 講師
1999 – 2000: 横浜市立大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Metabolomics
Except Principal Investigator
Circulatory organs internal medicine / Biological Sciences / Kidney internal medicine / Metabolomics / Functional biochemistry / General internal medicine(including psychosomatic medicine)
Keywords
Principal Investigator
gene transfer / type 2 diabetes / glycogen / caveolin / insulin resistance / インスリン / 遺伝子治療 / ノックアウトマウス / 糖尿病 / グリコーゲン … More / カベオリン / インスリン抵抗性 / phosphatase / insulin receptor / insulin / 遺伝子導入 / インスリン感受性 / チロシンフォスファターゼ / インスリン受容体 / knockout mouse / skeletal muscle / insulin signal / 骨格筋 / インスリン刺激伝達系 … More
Except Principal Investigator
レニン・アンジオテンシン系 / アデニル酸シクラーゼ / カベオリン / eNOS / 動脈硬化 / ACE / cAMP / ノックアウト / インシュリン / カルシウム / 褐色細胞腫 / ニコチン受容体 / 増殖シグナル / 腎臓内科学 / 人工透析学 / アフェレーシス / 脂質異常症 / 閉塞性動脈硬化症 / Nephrin / Renin-angiotensin system / Nephropathy / Diabetes / ネフリン / 腎症 / 糖尿病 / ahterosclerosis / renin-angiotensin system / caveolin / 血管内皮 / レニンアンジオテンシン系 / カベリオン / NOS / 血管平滑筋 / ACE inhibitor / nitric oxide / angiotensin I / angiotensin II / angiotensin (1-7) / 前腕抵抗血管 / 一酸化窒素 / アンジオテンシン(1-7) / 本態性高血圧 / アンジオテンシン変換酵素 / アンジオテンシンII / ブラジキニン / ACE阻害素 / 一酸化窒素(NO) / アンジオテンシンI / アンジオランシンII / アンジオテンシン1-7 / sucrose gradient centrifugation / G protein / transgenic mice / cardiac subtype / subtype / catecholamine / adenylyl cyclase / 分子生物学 / ショ糖密度勾配遠心法 / G蛋白 / 遺伝子操作動物 / 心臓型 / サブタイプ / CAMP / カテコラミン / 生体分子 / トランスレーショナルリサーチ / 循環器・高血圧 / 生理活性 / シグナル伝達 / 受容体 Less
  • Research Projects

    (10 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (18 People)
  •  LDL cholesterol apheresis treatment for arteriosclerosis without hypercholesterolemia

    • Principal Investigator
      Masato Ohsawa
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Yokohama City University
  •  Receptor-based modulation of cardiovascular disease in the process of aging

    • Principal Investigator
      KANAOKA Tomohiko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Yokohama City University
  •  The gene transfer of caveolin improves metabolism in diabetic micePrincipal Investigator

    • Principal Investigator
      TOYA Yoshiyuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  がん細胞の増殖とカベオリン

    • Principal Investigator
      石川 義弘
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  Regulatory roles of podocyte slit membrane associated molecules in cell polarity in diabetes nephropathy

    • Principal Investigator
      UMEMURA Satoshi, 木原 実
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  がん細胞の増殖とカベオリン

    • Principal Investigator
      ISHIKAWA Yoshihiro
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  The lack of caveolin-3, muscle-specific subtype of caveolin, leeds to the development of insulin resistancePrincipal Investigator

    • Principal Investigator
      TOYA Yoshiyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  The role of caveolin in pathogenesis of arteriosclerosis

    • Principal Investigator
      KIHARA Minoru
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Yokohama City University
  •  SIGNIFICANCE OF THE MULTIPLICITY OF ADENYLYL CYCLASE

    • Principal Investigator
      ISHIKAWA Yoshihiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional biochemistry
    • Research Institution
      YOKOHAMACITY UNIVERSITY SCHOOL OF MEDICINE
  •  Vascular effects of angiotensin (1-7) and its contribution to the effect of the cardiovascular drugs

    • Principal Investigator
      UEDA Shinichiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Yokohama City University

All 2017 2015 2014 2013 2006 2004 Other

All Journal Article Presentation

  • [Journal Article] ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice2017

    • Author(s)
      Wakui H, Ohki K, Azushima K, Uneda K, Haku S, Kobayashi R, Haruhara K, Kinguchi S, Matsuda M, Ohsawa M, Maeda A, Minegishi S, Ishigami T, Toya Y, Yamashita A, Umemura S, Tamura K
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 3 Pages: 676-676

    • DOI

      10.3390/ijms18030676

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19536, KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-15K09293, KAKENHI-PROJECT-16K19558
  • [Journal Article] Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin2017

    • Author(s)
      Uneda Kazushi、Wakui Hiromichi、Maeda Akinobu、Azushima Kengo、Kobayashi Ryu、Haku Sona、Ohki Kohji、Haruhara Kotaro、Kinguchi Sho、Matsuda Miyuki、Ohsawa Masato、Minegishi Shintaro、Ishigami Tomoaki、Toya Yoshiyuki、Atobe Yoshitoshi、Yamashita Akio、Umemura Satoshi、Tamura Kouichi
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 8

    • DOI

      10.1161/jaha.117.006120

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-15K09293
  • [Journal Article] Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: a multicenter, randomized, parallel-group controlled trial.2015

    • Author(s)
      Azushima K, Tamura K, Haku S, Wakui H, Kanaoka T, Ohsawa M, Uneda K, Kobayashi R, Ohki K, Dejima T, Maeda A, Hashimoto T, Oshikawa J, Kobayashi Y, Nomura K, Azushima C, Takeshita Y, Fujino R, Uchida K, Shibuya K, Ando D, Tokita Y, Fujikawa T, Toya Y, Umemura S.
    • Journal Title

      Atherosclerosis.

      Volume: 240 Issue: 1 Pages: 297-304

    • DOI

      10.1016/j.atherosclerosis.2015.01.025

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09293, KAKENHI-PROJECT-26893218, KAKENHI-PROJECT-25460906
  • [Journal Article] Effects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia.2015

    • Author(s)
      Ohsawa M, Tamura K, Wakui H, Kanaoka T, Azushima K, Uneda K, Haku S, Kobayashi R, Ohki K, Haruhara K, Kinguchi S, Toya Y, Umemura S.
    • Journal Title

      Lipids Health Dis.

      Volume: 14 Issue: 1 Pages: 161-161

    • DOI

      10.1186/s12944-015-0164-5

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09293, KAKENHI-PROJECT-15K19536, KAKENHI-PROJECT-25460906
  • [Journal Article] Effects of single pill-based combination therapy of amlodipine and atorvastatin on within-visit blood pressure variability and parameters of renal and vascular function in hypertensive patients with chronic kidney disease.2014

    • Author(s)
      Azushima K, Uneda K, Tamura K, Wakui H, Ohsawa M, Kobayashi R, Dejima T, Kanaoka T, Maeda A, Toya Y, Umemura S.
    • Journal Title

      Biomed Res Int.

      Volume: 2014 Pages: 437087-437087

    • DOI

      10.1155/2014/437087

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591233, KAKENHI-PROJECT-25460906
  • [Journal Article] Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity.2013

    • Author(s)
      Maeda A, Tamura K, Wakui H, Dejima T, Ohsawa M, Azushima K, Kanaoka T, Uneda K, Matsuda M, Yamashita A, Miyazaki N, Yatsu K, Hirawa N, Toya Y, Umemura S.
    • Journal Title

      J Am Heart Assoc.

      Volume: 2(4) Issue: 4

    • DOI

      10.1161/jaha.113.000312

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-21115004, KAKENHI-PROJECT-23687025, KAKENHI-PROJECT-24790950, KAKENHI-PROJECT-25460906
  • [Journal Article] Addition of aliskiren to Angiotensin receptor blocker improves ambulatory blood pressure profile and cardiorenal function better than addition of benazepril in chronic kidney disease2013

    • Author(s)
      Ohsawa M, Wakui H, et al
    • Journal Title

      Int J Mol Sci

      Volume: 14(8) Issue: 8 Pages: 15361-75

    • DOI

      10.3390/ijms140815361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790950, KAKENHI-PROJECT-24890189, KAKENHI-PROJECT-25460906
  • [Journal Article] Umemura S.L/N-type calcium channel blocker cilnidipine added to renin-angiotensin inhibition improves ambulatory blood pressure profile and suppresses cardiac hypertrophy in hypertension with chronic kidney disease2013

    • Author(s)
      Kanaoka T, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kobayashi R, Fujikawa T, Tsurumi-Ikeya Y, Maeda A, Yanagi M, Toya Y
    • Journal Title

      Int J Mol Sci

      Volume: 14 Issue: 8 Pages: 16866-16881

    • DOI

      10.3390/ijms140816866

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890189, KAKENHI-PROJECT-25460906
  • [Journal Article] Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension.2013

    • Author(s)
      Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, Umemura S.
    • Journal Title

      Kidney Int.

      Volume: 86(3) Issue: 3 Pages: 570-81

    • DOI

      10.1038/ki.2014.95

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-21115004, KAKENHI-PLANNED-22136009, KAKENHI-PROJECT-24390200, KAKENHI-PROJECT-24591233, KAKENHI-PROJECT-24890189, KAKENHI-PROJECT-25460906, KAKENHI-PROJECT-25670131
  • [Journal Article] Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity.2013

    • Author(s)
      Azushima K, Tamura K, Wakui H, Maeda A, Ohsawa M, Uneda K, Kobayashi R, Kanaoka T, Dejima T, Fujikawa T, Yamashita A, Toya Y, Umemura S.
    • Journal Title

      PLoS One.

      Volume: 8(10) Issue: 10 Pages: e75560-e75560

    • DOI

      10.1371/journal.pone.0075560

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-21115004, KAKENHI-PROJECT-23687025, KAKENHI-PROJECT-24591233, KAKENHI-PROJECT-24790950, KAKENHI-PROJECT-25460906
  • [Journal Article] Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.2013

    • Author(s)
      Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Uneda K, Haku S, Tsurumi-Ikeya Y, Toya Y, Maeshima Y, Yamashita A, Umemura S.
    • Journal Title

      J Biol Chem.

      Volume: 288(26) Issue: 26 Pages: 19238-49

    • DOI

      10.1074/jbc.m113.451054

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-21115004, KAKENHI-PROJECT-23591193, KAKENHI-PROJECT-24591233, KAKENHI-PROJECT-24790950, KAKENHI-PROJECT-24890189, KAKENHI-PROJECT-25460906
  • [Journal Article] Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules2006

    • Author(s)
      Thurumi Y, Toya Y et al.
    • Journal Title

      Kidney International 69

      Pages: 488-494

    • Data Source
      KAKENHI-PROJECT-17590943
  • [Journal Article] Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells2006

    • Author(s)
      Hashimoto T, Toya Y et al.
    • Journal Title

      Arterioscler Thromb Vase Biol 26(掲載予定(電子版に掲載中))

      Pages: 1267-1272

    • Data Source
      KAKENHI-PROJECT-17590943
  • [Journal Article] Insulin resistance in skeletal muscles of caveolin-3-null mice2004

    • Author(s)
      Oshikawa, Jin, Otsu, Koji, Toya, Yoshiyuki, Tsunematsu, Takashi, Hankins, Raleigh, Kawabe, Jun-ichi, Minamisawa, Susumu, Umemura, Satoshi, Hagiwara Yasuko, Ishikawa, Yoshihiro
    • Journal Title

      Proc Natl Acad Sci USA vol.101 no.34

      Pages: 12670-12675

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590951
  • [Presentation] CKDにおける24時間自由行動下血圧測定(ABPM)による血圧・心拍関連指標と腎機能障害増悪との関連についての研究2013

    • Author(s)
      金岡知彦,田村功一,藤川哲也,戸谷義幸,梅村 敏
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Data Source
      KAKENHI-PROJECT-25460906
  • [Presentation] ENHANCEMENT OF ANGIOTENSIN II TYPE 1 RECEPTOR ASSOCIATED PROTEIN SUPPRESSES VASCULAR REMODELING AND OXIDATIVE STRESS IN ANGIOTENSIN II-MEDIATED HYPERTENSION.

    • Author(s)
      Wakui H, Tamura K, Kobayashi R, Uneda K, Azushima K, Ohsawa M, Dejima T, Tsurumi-Ikeya Y, Kanaoka T, Maeda A, Ishigami T, Hirawa N, Toya Y, Yabana M, Umemura S.
    • Organizer
      The Joint Meeting of the European Society of Hypertension (ESH, 24th) and International Society of Hypertension (ISH, 25th)
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2014-06-13 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-25460906
  • [Presentation] Single Pill-Based Combination Therapy with Amlodipine and Atorvastatin Improves Renal and Vascular Function and Clinic Blood Pressure Variability in Hypertension with Chronic Kidney Disease.

    • Author(s)
      Tamura K, Azushima K, Uneda K, Wakui H, Ohsawa M, Kobayashi R, Ohki K, Azuma K, Dejima T, Kanaoka T, Toya Y, Umemura S.
    • Organizer
      American Society of Nephrology (ASN) Kidney Week 2014
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-25460906
  • 1.  ISHIKAWA Yoshihiro (40305470)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 2.  UMEMURA Satoshi (00128589)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TAMURA Kouichi (40285143)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 4.  KIHARA Minoru (60177904)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  南沢 享 (40257332)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KANAOKA Tomohiko (70551258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  GOSHIMA Yoshiro (00153750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KITAMURA Hitoshi (20094302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  UEDA Shinichiro (80285105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  GOTO Eiji (30153753)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  HASHIMOTO Tatsuo (20363806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Masato Ohsawa (60733433)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  岩坪 耕策 (90363796)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  堀 英明 (30117759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  常松 尚志 (70347300)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  涌井 広道 (10587330)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  IKEYA Yuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  山下 暁朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results

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