KINOUCHI Hiroyuki 木内博之

Researcher Number	30241623
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 山梨大学, 大学院総合研究部, 教授 2014 – 2016: 山梨大学, 総合研究部, 教授 2011 – 2013: 山梨大学, 医学工学総合研究部, 教授 2007 – 2011: University of Yamanashi, Department of Research, Interdisciplinary Graduate School of Medicine and Engineering, Professor 2006: University of Yamanashi, Department of Research Interdisciplinary Graduate school of Medicine and Engineering, Professor, 大学院医学工学総合研究部, 教授 … More 2005: Yamanashi University, School of Medicine, Professor, 大学院・医学工学総合研究部, 教授 2003 – 2004: 秋田大学, 医学部, 助教授 1998 – 2001: 秋田大学, 医学部, 講師 1995: 東北大学, 医学部・付属病院, 助手 1994: 北海道大学, 医学部附属病院, 助手 1993 – 1994: 東北大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Neurosurgery / Cerebral neurosurgery / Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator 脳虚血 / apoptosis / cerebral ischemia / heat shock protein / 虚血性神経細胞傷害 / 脳梗塞 / 虚血性神経細胞障害 / transgenic / NMDA / HSP … More / DNA / fransfection / electroporation / PC12 / hsp60 / hsp10 / 熱ショック蛋白 / 脳虚血耐性 / アポトーシス / ATP / ミクログリア / アストロサイド / グリア細胞 / micro RNA / microRNA / 虚血耐性 / knock out / glycine / ドミナント / グルタミン酸 / アミノ酸 / mouse / マイクロダイアリーシス / グリシン / ノックアウトマウス / 興奮性アミノ酸 / 中大脳動脈閉塞 / 虚血 / cerehral ischemia / 遺伝子組み換え / トランスフェクション / hsp / transfection / HSP70 / Heat shock protein / Stress protein / Molecular chaperone / chaperonin / HSP10 / HSP60 / ストレス蛋白 / 分子シャペロン / シャペロニン / ミトコンドリアバイオジェネティクス / 脳虚血体性 / ミトコンドリアバイオジェネシス / Akt / PPARγ / JAK-STAT pathway / 神経細胞保護 / 遅発性神経細胞死 / 虚血耐性現象 / 脳血管障害 / in situ hybridization / immediate early gene / NGF / BDNF / 遅発性神経傷害 / チロジンキナーゼ受容体 / 神経栄養因子 / H波(H-wave) / 痙縮(spasticity) / 片麻痺(hemiparesis) / 治療的電気刺激(TES) / degenerate axon / Scar formadion / protease nexin-I / hirudin / Spinal cord injury / thrombin … More Except Principal Investigator SOD / アストロサイト / 脳虚血 / フリーラジカル / caspases / cytochrome c / APE / アポトーシス / 海馬CA1領域 / くも膜下出血 / free radical / c-fos / 虚血耐性現象 / ischemic tolerance / P2X7受容体 / 虚血 / 虚血耐性 / 脳卒中 / グリア細胞 / 脳虚血耐性 / 脂肪酸結合蛋白 / スーパーオキサイド / ミトコンドリア / ミトコンドリア細胞間移動 / 虚血性神経細胞障害 / 早期脳損傷 / 白質損傷 / 白質障害 / HIF1a / 破裂予測 / MRIマクロファージイメージング / 脳動脈瘤 / 数値流体力学的解析 / cerebral aneurysms / pathophysiology / macrophage / cerebral aneurysm / CFD / ischemic neuronal injury / neurogenesis / brain fatty acid bindine nrotein / 虚血性脳障害 / 虚血性神経障害 / 神経再生 / angiotensin II / angiotensin receptor / superoxide / global cerebral ischemia / アンジオテンシンII / アンジオテンシン受容体 / スーパーオキシド / 全脳虚血モデル / apoptosis / hippocampal CA1 subregion / cerebral ischemia / チトクロームC / カスパーゼ / チロクロームC / 脳虚血モデル / mouse / vasospasm / subarachnoid hemorrhage / 一酸化窒素 / ラット / マウス / 脳血管攣縮 / stress protein / brain edema / trauma / ischemia / Superoxide / ストレス蛋白 / 脳浮腫 / 外傷 / 神経保護 / ischemic preconditioning / neurovascular protection / neuroprotection / P2受容体 / グリア / グリア伝達 / 脳虚血耐性現象 / エピジェネティクス / 虚血性神経細胞傷害 / 神経細胞保護 / 神経新生 / immediate early gene / 熱ショック蛋白 / 脳血管内皮細胞 / 頭部外傷 / トランスジェニックマウス Less

脳虚血および虚血耐性現象におけるミトコンドリア細胞間移動の意義の解明
- Principal Investigator
  
  吉岡秀幸
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  University of Yamanashi
New developments in the mechanism of acquisition of cerebral ischemic tolerance: intracellular molecular mechanisms and Interactions mediated by ATP receptors.Principal Investigator
- Principal Investigator
  
  Kinouchi Hiroyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  University of Yamanashi
Elucidation of mechanism of white matte injury after subarachnoid hemorrhage
- Principal Investigator
  
  YOSHIOKA Hideyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi
The roles of miRNAs in ischemic preconditioningPrincipal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi
Prediction of cerebral aneurysm rupture with MRI macrophage imaging and computational fluid dynamics
- Principal Investigator
  
  KANEMARU Kazuya
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi
Mechanisms underlying glia-mediated ischemic tolerance
- Principal Investigator
  
  KOIZUMI Schuichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi
Involvement of Nrf / ARE signaling pathway in ischemia tolerance phenomenon
- Principal Investigator
  
  YAGI Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi
Mechanisms underlying glia-mediated ischemic tolerance
- Principal Investigator
  
  KOIZUMI Schuichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi
The roles of mitochondria biogenesis on ischemic neuronal injury and tolerancePrincipal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
The roles of epigenetic mechanism in cerebral ischemic preconditioning
- Principal Investigator
  
  YOSHIOKA Hideyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
Roles of FABP and its regulating factors on neurogenesis after ischemia
- Principal Investigator
  
  SUGITA Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
Neuroprotective effects of PPARγon ischemic neuronal injuryPrincipal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
Elucidation of the mechanism of ischemic tolerance and applicationPrincipal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
The role offray acid binding protein (FABP) in hippocampal neurogenuesis
- Principal Investigator
  
  UCHIDA Mikito
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
A direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multi-enzyme systemPrincipal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Yamanashi
Candesartan Reduces Superoxide Production after Global Cerebral Ischemia
- Principal Investigator
  
  SUGAWARA Taku
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Akita University
Role of DNA repair proteins in development of the tolerance after ischemic preconditioning
- Principal Investigator
  
  SUZUKI Akira
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Akita University
The Investigation of the protective effect of hoat shock protein on neuronal deathPrincipal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Akita University
The expiession and function of molecular chaperone in the central nervous system.Principal Investigator
- Principal Investigator
  
  KINOUCHI Hiroyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  AKITA UNIVERSITY
虚血脳における神経栄養因子の誘導と興奮性細胞障害の相関について-遅発性神経障害との関連において-Principal Investigator
- Principal Investigator
  
  木内博之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
Nien9C oxiok in vasospasm folloroing experimenibl subamchnoid hemo rrhege
- Principal Investigator
  
  TOMINAGA Teiji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
ヒトSOD遺伝子導入マウスを用いた神経損傷におけるSOD保護効果の研究
- Principal Investigator
  
  YOSHIMOTO Takashi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
麻痺筋の痙縮に対する治療的刺激(TES)の定量的効果判定と適応選択Principal Investigator
- Principal Investigator
  
  木内博之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
Protection of Ischemic/Traumatic Brain Injruy in SOD-Transgenic Mouse
- Principal Investigator
  
  YOSHIMOTO Takashi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tohoku University
Thrombin抑制による神経外傷治療の研究Principal Investigator
- Principal Investigator
  
  木内博之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University

All 2023 2022 2021 2015 2014 2012 2005 2003 Other

All Journal Article Presentation Book

[Book] Heat shock protein familyと脳虚血病態. 日本臨床最新臨床脳卒中学(上)―最新の診断と治療―2014
- Author(s)
  吉岡秀幸、木内博之
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-24592119
[Book] 脳虚血のニューロサイエンス. 脳神経外科診療プラクティス１. 脳血管障害の急性期マネジメント2014
- Author(s)
  吉岡秀幸、木内博之
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-24592119
[Book] 脳虚血のニューロサイエンス.清水宏明編:脳神経外科診療プラクティス.脳血管障害の急性期マネージメント2014
- Author(s)
  吉岡秀幸、木内博之
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-23592088
[Journal Article] STAT3 induces hypoxic preconditioning against oxidative stress in neural stem cells2023
- Author(s)
  Norito Fukuda, Hideyuki Yoshioka, Takuma Wakai, Toru Tateoka, Koji Hashimoto, Kazuya Kanemaru, Hiroyuki Kinouchi
- Journal Title
  
  Conditioning Medicine
  
  Volume: 6 Pages: 138-146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09386
[Journal Article] Neuroprotective roles of HAX-1 in ischemic neuronal injury2021
- Author(s)
  Xin Sui, Hideyuki Yoshioka, Yuichiro Fukumoto, Kazuya Kanemaru, Hiroyuki Kinouchi
- Journal Title
  
  Experimental Neurology
  
  Volume: 339 Pages: 113642-113642
- DOI
  10.1016/j.expneurol.2021.113642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09386
[Journal Article] Astrocyte-Mediated Ischemic Tolerance2015
- Author(s)
  Yuri Hirayama, Yuri Ikeda-Matsuo, Shoji Notomi, Hiroshi Enaida, Hiroyuki Kinouchi, Schuichi Koizumi
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 35(9) Issue: 9 Pages: 3794-3805
- DOI
  10.1523/jneurosci.4218-14.2015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670622, KAKENHI-PROJECT-15K15524
[Journal Article] Candesartan reduces superoxide production after global cerebral ischemia.2005
- Author(s)
  Sugawara T, Kinouchi H, Oda M, Shoji H, Omae T, Mizoi K
- Journal Title
  
  Neuroreport 16
  
  Pages: 325-328
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591507
[Journal Article] Cerebral ischemia and knockout animals2003
- Author(s)
  Sugawara T, Kinouchi H, Oda M, Shoji H, Omae T, Mizoi K
- Journal Title
  
  Molecular cerebrovascular disease 2
  
  Pages: 99-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591507
[Journal Article] 脳虚血とノックアウトモデル2003
- Author(s)
  菅原卓, 木内博之, 溝井和夫
- Journal Title
  
  分子脳血管病 2
  
  Pages: 99-105
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591507
[Presentation] Microglia initiated Astrocyte-Mediated Ischemic Tolerance2023
- Author(s)
  舘岡達、吉岡秀幸、若井卓馬、橋本幸治、福田憲人、小泉修一、木内博之
- Organizer
  Brain and Brain Pet 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03769
[Presentation] アストロサイト誘導性虚血耐性現象におけるミクログリアの役割2022
- Author(s)
  舘岡達、吉岡秀幸、若井卓馬、橋本幸治、福田憲人、小泉修一、木内博之
- Organizer
  Stroke 2022
- Data Source
  KAKENHI-PROJECT-19H03769
[Presentation] アストロサイト誘導性虚血耐性現象におけるミクログリアの役割2022
- Author(s)
  舘岡達、吉岡秀幸、若井卓馬、橋本幸治、福田憲人、小泉修一、木内博之
- Organizer
  Stroke 2022
- Data Source
  KAKENHI-PROJECT-20K09386
[Presentation] Role of Brain Type Fatty Acid Binding Protein in the Transient Brain Ischemia2012
- Author(s)
  Tatsuya Kato, Hideyuki Yoshioka, Yuji Owada, Masao Sugita, Takashi Yagi, Takuma Wakai, and Hiroyuki Kinouchi
- Organizer
  XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function & IXth International Conference on Quantification of Brain Function with PET
- Place of Presentation
  Chicago
- Year and Date
  2012-07-02
- Data Source
  KAKENHI-PROJECT-21591834
[Presentation] 脳虚血における神経細胞障害および保護機構の解明にむけて2012
- Author(s)
  木内博之、吉岡秀幸、八木貴、堀越徹
- Organizer
  山梨大学国立精神・神経医療研究センター合同シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-12-04
- Data Source
  KAKENHI-PROJECT-23592088
[Presentation] 一過性前脳虚血におけるHax-1の発現変化
- Author(s)
  吉岡秀幸、八木貴、若井卓馬、福元雄一郎、金丸和也、Pak H Chan、木内博之
- Organizer
  第26回日本脳循環代謝学会総会
- Place of Presentation
  岡山コンベンションセンター（岡山県・岡山）
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24592119
[Presentation] The Roles of Hax-1 after Transient Forebrain Ischemia in Mice
- Author(s)
  Hideyuki Yoshioka, Takashi Yagi, Takuma Wakai, Yuichiro Fukumoto, Kazuya Kanemaru, Pak H. Chan, Hiroyuki Kinouchi
- Organizer
  Brain 2015
- Place of Presentation
  Vancouver (Canada)
- Year and Date
  2015-06-27 – 2015-06-30
- Data Source
  KAKENHI-PROJECT-24592119
[Presentation] The Role of PARL and HtrA2 in Striatal Neuronal Injury after Transient Global Cerebral Ischemia
- Author(s)
  吉岡秀幸、嘉津政隆、坂田洋之、岡見修哉、若井卓馬、木内博之、Pak H Chan
- Organizer
  第15回日本分子脳神経外科学会
- Place of Presentation
  大手門パルズ（山形県・山形）
- Year and Date
  2014-09-14 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-24592119

1. YOSHIOKA Hideyuki (20402076)

# of Collaborated Projects: 8 results

# of Collaborated Products: 12 results
2. TOMINAGA Teiji (00217548)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SUGITA Masao (70235886)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. YAGI Takashi (90345702)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. KOIZUMI Schuichi (10280752)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. SUGAWARA Taku (80241660)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. YOSHIMOTO Takashi (50091765)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KATO Ichiro (50250741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SHINOZAKI Youichi (10443772)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SHIGETOMI Eiji (00631061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. ITOH Hideaki (80168369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 橋本幸治 (10644792)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. SHIBATA Keisuke (50580411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUZUKI Akira (10311573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. UCHIDA Mikito (30313795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KANEMARU Kazuya (80402080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HIRAYAMA Yuri (30732804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 高橋和彦 (10113581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 若井卓馬 (30456446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. CHAN Pak h.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MURAYAMA Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KINOUCHI Hiroyuki 木内 博之

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New developments in the mechanism of acquisition of cerebral ischemic tolerance: intracellular molecular mechanisms and Interactions mediated by ATP receptors.Principal Investigator

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The roles of miRNAs in ischemic preconditioningPrincipal Investigator

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The roles of mitochondria biogenesis on ischemic neuronal injury and tolerancePrincipal Investigator

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Neuroprotective effects of PPARγon ischemic neuronal injuryPrincipal Investigator

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Elucidation of the mechanism of ischemic tolerance and applicationPrincipal Investigator

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Research Institution

A direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multi-enzyme systemPrincipal Investigator

KINOUCHI Hiroyuki 木内博之