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KINOUCHI Hiroyuki  木内 博之

ORCIDConnect your ORCID iD *help
Researcher Number 30241623
Other IDs
Affiliation (Current) 2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help 2017 – 2023: 山梨大学, 大学院総合研究部, 教授
2014 – 2016: 山梨大学, 総合研究部, 教授
2011 – 2013: 山梨大学, 医学工学総合研究部, 教授
2007 – 2011: University of Yamanashi, Department of Research, Interdisciplinary Graduate School of Medicine and Engineering, Professor
2006: University of Yamanashi, Department of Research Interdisciplinary Graduate school of Medicine and Engineering, Professor, 大学院医学工学総合研究部, 教授 … More
2005: Yamanashi University, School of Medicine, Professor, 大学院・医学工学総合研究部, 教授
2003 – 2004: 秋田大学, 医学部, 助教授
1998 – 2001: 秋田大学, 医学部, 講師
1995: 東北大学, 医学部・付属病院, 助手
1994: 北海道大学, 医学部附属病院, 助手
1993 – 1994: 東北大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Cerebral neurosurgery / Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Neurosurgery
Except Principal Investigator
Neurosurgery / Cerebral neurosurgery / Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related
Keywords
Principal Investigator
脳虚血 / apoptosis / cerebral ischemia / heat shock protein / 虚血性神経細胞傷害 / 脳梗塞 / 虚血性神経細胞障害 / transgenic / NMDA / HSP … More / DNA / fransfection / electroporation / PC12 / hsp60 / hsp10 / 熱ショック蛋白 / 脳虚血耐性 / アポトーシス / ATP / ミクログリア / アストロサイド / グリア細胞 / micro RNA / microRNA / 虚血耐性 / knock out / glycine / ドミナント / グルタミン酸 / アミノ酸 / mouse / マイクロダイアリーシス / グリシン / ノックアウトマウス / 興奮性アミノ酸 / 中大脳動脈閉塞 / 虚血 / cerehral ischemia / 遺伝子組み換え / トランスフェクション / hsp / transfection / HSP70 / Heat shock protein / Stress protein / Molecular chaperone / chaperonin / HSP10 / HSP60 / ストレス蛋白 / 分子シャペロン / シャペロニン / ミトコンドリアバイオジェネティクス / 脳虚血体性 / ミトコンドリアバイオジェネシス / Akt / PPARγ / JAK-STAT pathway / 神経細胞保護 / 遅発性神経細胞死 / 虚血耐性現象 / 脳血管障害 / in situ hybridization / immediate early gene / NGF / BDNF / 遅発性神経傷害 / チロジンキナーゼ受容体 / 神経栄養因子 / H波(H-wave) / 痙縮(spasticity) / 片麻痺(hemiparesis) / 治療的電気刺激(TES) / degenerate axon / Scar formadion / protease nexin-I / hirudin / Spinal cord injury / thrombin … More
Except Principal Investigator
SOD / アストロサイト / 脳虚血 / フリーラジカル / caspases / cytochrome c / APE / アポトーシス / 海馬CA1領域 / くも膜下出血 / free radical / c-fos / 虚血耐性現象 / ischemic tolerance / P2X7受容体 / 虚血 / 虚血耐性 / 脳卒中 / グリア細胞 / 脳虚血耐性 / 脂肪酸結合蛋白 / スーパーオキサイド / ミトコンドリア / ミトコンドリア細胞間移動 / 虚血性神経細胞障害 / 早期脳損傷 / 白質損傷 / 白質障害 / HIF1a / 破裂予測 / MRIマクロファージイメージング / 脳動脈瘤 / 数値流体力学的解析 / cerebral aneurysms / pathophysiology / macrophage / cerebral aneurysm / CFD / ischemic neuronal injury / neurogenesis / brain fatty acid bindine nrotein / 虚血性脳障害 / 虚血性神経障害 / 神経再生 / angiotensin II / angiotensin receptor / superoxide / global cerebral ischemia / アンジオテンシンII / アンジオテンシン受容体 / スーパーオキシド / 全脳虚血モデル / apoptosis / hippocampal CA1 subregion / cerebral ischemia / チトクロームC / カスパーゼ / チロクロームC / 脳虚血モデル / mouse / vasospasm / subarachnoid hemorrhage / 一酸化窒素 / ラット / マウス / 脳血管攣縮 / stress protein / brain edema / trauma / ischemia / Superoxide / ストレス蛋白 / 脳浮腫 / 外傷 / 神経保護 / ischemic preconditioning / neurovascular protection / neuroprotection / P2受容体 / グリア / グリア伝達 / 脳虚血耐性現象 / エピジェネティクス / 虚血性神経細胞傷害 / 神経細胞保護 / 神経新生 / immediate early gene / 熱ショック蛋白 / 脳血管内皮細胞 / 頭部外傷 / トランスジェニック マウス Less
  • Research Projects

    (25 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (21 People)
  •  脳虚血および虚血耐性現象におけるミトコンドリア細胞間移動の意義の解明

    • Principal Investigator
      吉岡 秀幸
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      University of Yamanashi
  •  New developments in the mechanism of acquisition of cerebral ischemic tolerance: intracellular molecular mechanisms and Interactions mediated by ATP receptors.Principal Investigator

    • Principal Investigator
      Kinouchi Hiroyuki
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      University of Yamanashi
  •  Elucidation of mechanism of white matte injury after subarachnoid hemorrhage

    • Principal Investigator
      YOSHIOKA Hideyuki
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      University of Yamanashi
  •  The roles of miRNAs in ischemic preconditioningPrincipal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      University of Yamanashi
  •  Prediction of cerebral aneurysm rupture with MRI macrophage imaging and computational fluid dynamics

    • Principal Investigator
      KANEMARU Kazuya
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      University of Yamanashi
  •  Mechanisms underlying glia-mediated ischemic tolerance

    • Principal Investigator
      KOIZUMI Schuichi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      University of Yamanashi
  •  Involvement of Nrf / ARE signaling pathway in ischemia tolerance phenomenon

    • Principal Investigator
      YAGI Takashi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      University of Yamanashi
  •  Mechanisms underlying glia-mediated ischemic tolerance

    • Principal Investigator
      KOIZUMI Schuichi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      University of Yamanashi
  •  The roles of mitochondria biogenesis on ischemic neuronal injury and tolerancePrincipal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  The roles of epigenetic mechanism in cerebral ischemic preconditioning

    • Principal Investigator
      YOSHIOKA Hideyuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  Roles of FABP and its regulating factors on neurogenesis after ischemia

    • Principal Investigator
      SUGITA Masao
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  Neuroprotective effects of PPARγon ischemic neuronal injuryPrincipal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  Elucidation of the mechanism of ischemic tolerance and applicationPrincipal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  The role offray acid binding protein (FABP) in hippocampal neurogenuesis

    • Principal Investigator
      UCHIDA Mikito
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  A direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multi-enzyme systemPrincipal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      University of Yamanashi
  •  Candesartan Reduces Superoxide Production after Global Cerebral Ischemia

    • Principal Investigator
      SUGAWARA Taku
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Akita University
  •  Role of DNA repair proteins in development of the tolerance after ischemic preconditioning

    • Principal Investigator
      SUZUKI Akira
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Akita University
  •  The Investigation of the protective effect of hoat shock protein on neuronal deathPrincipal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Akita University
  •  The expiession and function of molecular chaperone in the central nervous system.Principal Investigator

    • Principal Investigator
      KINOUCHI Hiroyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      AKITA UNIVERSITY
  •  虚血脳における神経栄養因子の誘導と興奮性細胞障害の相関について-遅発性神経障害との関連において-Principal Investigator

    • Principal Investigator
      木内 博之
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Tohoku University
  •  Nien9C oxiok in vasospasm folloroing experimenibl subamchnoid hemo rrhege

    • Principal Investigator
      TOMINAGA Teiji
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Tohoku University
  •  ヒトSOD遺伝子導入マウスを用いた神経損傷におけるSOD保護効果の研究

    • Principal Investigator
      YOSHIMOTO Takashi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Tohoku University
  •  麻痺筋の痙縮に対する治療的刺激(TES)の定量的効果判定と適応選択Principal Investigator

    • Principal Investigator
      木内 博之
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Tohoku University
  •  Protection of Ischemic/Traumatic Brain Injruy in SOD-Transgenic Mouse

    • Principal Investigator
      YOSHIMOTO Takashi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tohoku University
  •  Thrombin抑制による神経外傷治療の研究Principal Investigator

    • Principal Investigator
      木内 博之
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Tohoku University

All 2023 2022 2021 2015 2014 2012 2005 2003 Other

All Journal Article Presentation Book

  • [Book] Heat shock protein familyと脳虚血病態. 日本臨床 最新臨床脳卒中学(上)―最新の診断と治療―2014

    • Author(s)
      吉岡秀幸、木内博之
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-24592119
  • [Book] 脳虚血のニューロサイエンス. 脳神経外科診療プラクティス1. 脳血管障害の急性期マネジメント2014

    • Author(s)
      吉岡秀幸、木内博之
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-24592119
  • [Book] 脳虚血のニューロサイエンス.清水宏明編:脳神経外科診療プラクティス.脳血管障害の急性期マネージメント2014

    • Author(s)
      吉岡秀幸、木内博之
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-23592088
  • [Journal Article] STAT3 induces hypoxic preconditioning against oxidative stress in neural stem cells2023

    • Author(s)
      Norito Fukuda, Hideyuki Yoshioka, Takuma Wakai, Toru Tateoka, Koji Hashimoto, Kazuya Kanemaru, Hiroyuki Kinouchi
    • Journal Title

      Conditioning Medicine

      Volume: 6 Pages: 138-146

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09386
  • [Journal Article] Neuroprotective roles of HAX-1 in ischemic neuronal injury2021

    • Author(s)
      Xin Sui, Hideyuki Yoshioka, Yuichiro Fukumoto, Kazuya Kanemaru, Hiroyuki Kinouchi
    • Journal Title

      Experimental Neurology

      Volume: 339 Pages: 113642-113642

    • DOI

      10.1016/j.expneurol.2021.113642

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09386
  • [Journal Article] Astrocyte-Mediated Ischemic Tolerance2015

    • Author(s)
      Yuri Hirayama, Yuri Ikeda-Matsuo, Shoji Notomi, Hiroshi Enaida, Hiroyuki Kinouchi, Schuichi Koizumi
    • Journal Title

      Journal of Neuroscience

      Volume: 35(9) Issue: 9 Pages: 3794-3805

    • DOI

      10.1523/jneurosci.4218-14.2015

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670622, KAKENHI-PROJECT-15K15524
  • [Journal Article] Candesartan reduces superoxide production after global cerebral ischemia.2005

    • Author(s)
      Sugawara T, Kinouchi H, Oda M, Shoji H, Omae T, Mizoi K
    • Journal Title

      Neuroreport 16

      Pages: 325-328

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591507
  • [Journal Article] Cerebral ischemia and knockout animals2003

    • Author(s)
      Sugawara T, Kinouchi H, Oda M, Shoji H, Omae T, Mizoi K
    • Journal Title

      Molecular cerebrovascular disease 2

      Pages: 99-105

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591507
  • [Journal Article] 脳虚血とノックアウトモデル2003

    • Author(s)
      菅原卓, 木内博之, 溝井和夫
    • Journal Title

      分子脳血管病 2

      Pages: 99-105

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591507
  • [Presentation] Microglia initiated Astrocyte-Mediated Ischemic Tolerance2023

    • Author(s)
      舘岡達、吉岡秀幸、若井卓馬、橋本幸治、福田憲人、小泉修一、木内博之
    • Organizer
      Brain and Brain Pet 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03769
  • [Presentation] アストロサイト誘導性虚血耐性現象におけるミクログリアの役割2022

    • Author(s)
      舘岡達、吉岡秀幸、若井卓馬、橋本幸治、福田憲人、小泉修一、木内博之
    • Organizer
      Stroke 2022
    • Data Source
      KAKENHI-PROJECT-19H03769
  • [Presentation] アストロサイト誘導性虚血耐性現象におけるミクログリアの役割2022

    • Author(s)
      舘岡達、吉岡秀幸、若井卓馬、橋本幸治、福田憲人、小泉修一、木内博之
    • Organizer
      Stroke 2022
    • Data Source
      KAKENHI-PROJECT-20K09386
  • [Presentation] Role of Brain Type Fatty Acid Binding Protein in the Transient Brain Ischemia2012

    • Author(s)
      Tatsuya Kato, Hideyuki Yoshioka, Yuji Owada, Masao Sugita, Takashi Yagi, Takuma Wakai, and Hiroyuki Kinouchi
    • Organizer
      XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function & IXth International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Chicago
    • Year and Date
      2012-07-02
    • Data Source
      KAKENHI-PROJECT-21591834
  • [Presentation] 脳虚血における神経細胞障害および保護機構の解明にむけて2012

    • Author(s)
      木内博之、吉岡秀幸、八木貴、堀越徹
    • Organizer
      山梨大学国立精神・神経医療研究センター合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-12-04
    • Data Source
      KAKENHI-PROJECT-23592088
  • [Presentation] 一過性前脳虚血におけるHax-1の発現変化

    • Author(s)
      吉岡秀幸、八木貴、若井卓馬、福元雄一郎、金丸和也、Pak H Chan、木内博之
    • Organizer
      第26回日本脳循環代謝学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Data Source
      KAKENHI-PROJECT-24592119
  • [Presentation] The Roles of Hax-1 after Transient Forebrain Ischemia in Mice

    • Author(s)
      Hideyuki Yoshioka, Takashi Yagi, Takuma Wakai, Yuichiro Fukumoto, Kazuya Kanemaru, Pak H. Chan, Hiroyuki Kinouchi
    • Organizer
      Brain 2015
    • Place of Presentation
      Vancouver (Canada)
    • Year and Date
      2015-06-27 – 2015-06-30
    • Data Source
      KAKENHI-PROJECT-24592119
  • [Presentation] The Role of PARL and HtrA2 in Striatal Neuronal Injury after Transient Global Cerebral Ischemia

    • Author(s)
      吉岡秀幸、嘉津政隆、坂田洋之、岡見修哉、若井卓馬、木内博之、Pak H Chan
    • Organizer
      第15回日本分子脳神経外科学会
    • Place of Presentation
      大手門パルズ(山形県・山形)
    • Year and Date
      2014-09-14 – 2014-09-15
    • Data Source
      KAKENHI-PROJECT-24592119
  • 1.  YOSHIOKA Hideyuki (20402076)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 12 results
  • 2.  TOMINAGA Teiji (00217548)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  SUGITA Masao (70235886)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  YAGI Takashi (90345702)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  KOIZUMI Schuichi (10280752)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 6.  SUGAWARA Taku (80241660)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 7.  YOSHIMOTO Takashi (50091765)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KATO Ichiro (50250741)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SHINOZAKI Youichi (10443772)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  SHIGETOMI Eiji (00631061)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  ITOH Hideaki (80168369)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  橋本 幸治 (10644792)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  SHIBATA Keisuke (50580411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SUZUKI Akira (10311573)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  UCHIDA Mikito (30313795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KANEMARU Kazuya (80402080)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HIRAYAMA Yuri (30732804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  高橋 和彦 (10113581)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  若井 卓馬 (30456446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  CHAN Pak h.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MURAYAMA Hiroaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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