KUSUNOKI Takeshi 楠威志

… Alternative Names

Researcher Number	30248025
Other IDs
Affiliation (Current)	2019: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2019: 順天堂大学, 医学部, 教授 2008 – 2014: 順天堂大学, 医学部, 准教授 2009: Juntendo University, 医学部, 先任准教授 1995: 高知医科大学, 医学部・手術部, 助手 1993: 近畿大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 中耳真珠腫 / カテプシンL / カテプシン / 耳垢 / ヒト甲状腺 / I型コラゲナーゼ / IV型コラゲナーゼ / カテプシンB / 頭頚部腫瘍 / システインプロテアーゼ … More Except Principal Investigator 内耳 / IL-17 / コルチ器 / GJB2 / DNA microarray / 中耳粘膜肥厚 / 中耳炎 / 扁桃炎 / Brn-4 / 線維細胞 / 再生 / 内耳の再生 / 先天性難聴 / Brn-4転写因子 / 先天聾 / Gjb 遺伝子 / 優性的阻害効果 / 聴性脳幹反応検査 / 遺伝子欠失 / 電子顕微鏡 / 細胞骨格 / 柱細胞 / Deiter細胞Cx26 / Deiter細胞 / Cx26 / 難聴 / ノックアウトマウス / 蝸牛 / 内リンパ / 半規管 / アデノウイルスベクター / アデノ随伴ウイルスベクター / 聴性脳幹反応 / GJB2遺伝子 / 遺伝子導入 / ウイルスベクター / アデノウイル / アデノ随伴ウイル / Haemophilus influenzae / 中耳粘膜 / Haemophilus influenza / DNA array / 中耳炎モデル動物 / 遺伝性難聴 / ips細胞 / マウス / iPS細胞 / コンブィショナルKOマウス / コネキシン26 / 口腔咽頭科学 / Tリンパ球 / 扁桃濾胞 / 抗原提示細胞 / 扁桃腺 / 急性中耳炎 / JNK１ / JNK2 / 分子制御 / MAP kinase / 癒着性中耳炎 / JNK / 細菌性中耳炎 / CD4 / リンパ球 / 習慣性扁桃炎 / 扁桃肥大 / 病巣感染症 / CD4+ / Th17細胞 / 骨破壊 / 真珠腫性中耳炎 / 表皮細胞 / 線維芽細胞 / 副鼻腔炎 / 免疫エフェクター細胞 / 副鼻腔ポリープ由来細胞 / 免疫応答プロファイル Less

Establishment of in-vitro evaluation of sinusitis using nasal polyp-derived cellsOngoing
- Principal Investigator
  
  本間博友
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Juntendo University
pHin the external or mddle ear related a risk factor of middle ear cholesteatomaPrincipal InvestigatorOngoing
- Principal Investigator
  
  楠威志
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Juntendo University
Investigation of molecular mechanisms of middle ear cholesteatoma by the analysis of gene network involving bone destructionOngoing
- Principal Investigator
  
  春山琢男
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Juntendo University
ABC transporter of outer and middle ear related to a risk factor of middle cholesteatomaPrincipal Investigator
- Principal Investigator
  
  Kusunoki Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration
- Principal Investigator
  
  Ichihari Yukiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration
- Principal Investigator
  
  ICHIHARI Yukiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
The molecular mechanism of mucosal hypertrophy by JNK in middle ear
- Principal Investigator
  
  FURUKAWA MASAYUKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Promoter and inhibitor factors of bone destruction in human middle ear cholesteatomaPrincipal Investigator
- Principal Investigator
  
  KUSUNOKI Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
難聴遺伝子変異マウスへのiPS細胞移植による難聴レスキュウー
- Principal Investigator
  
  池田勝久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Cell therapy and gene therapy for heredity deafness with genetically modified mice
- Principal Investigator
  
  IKEDA Katuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Molecular pathogenesis of middle ear mucosal proliferation during bacterial otitis media
- Principal Investigator
  
  FURUKAWA Masayuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Brn4による間葉系幹細胞からの蝸牛線維細胞への分化誘導と難聴の再生医学への応用
- Principal Investigator
  
  中澤詠子
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Molecular basis of three-dimensional structure resolution using transgenic technology of deafness gene
- Principal Investigator
  
  IKEDA Katuhisa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
ヒト甲状腺腫瘍におけるシステインプロテアーゼとRas癌遺伝子産物に関する研究Principal Investigator
- Principal Investigator
  
  楠威志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  高知医科大学
ヒト甲状腺腫瘍におけるプロテアーゼ活性に関する研究Principal Investigator
- Principal Investigator
  
  楠威志
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kinki University

All 2018 2017 2015 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Are ATP-binding cassette transporter and earwax associated with the incidence of cholesteatoma?2018
- Author(s)
  Nakagawa H, Toyoda Y, Albrecht T, Tsukamoto M, Praetorius M , Ishikawa T, Kamiya K, Kusunoki T, Ikeda K, Serkan Sertel
- Journal Title
  
  Medical Hyotheses
  
  Volume: 114 Pages: 19-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10763
[Journal Article] Earwax phenotype related to risk factor of middle ear cholesteatoma.2017
- Author(s)
  Kusunoki T, Nakagawa H, Tsukamoto M, Toyoda Y, Kamiya K, Okada H, Hara S, Hatakeyama H, Furukawa M, Ikeda K
- Journal Title
  
  M J Otol
  
  Volume: 3 Pages: 1-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10763
[Journal Article] 耳垢の決定遺伝子ABCC11と耳内環境に伴う中耳真珠腫の発症リスク2017
- Author(s)
  楠　威志、岡田弘子、神谷和作、古川正幸、池田勝久
- Journal Title
  
  Otol Jpn
  
  Volume: 27 Pages: 592-592
- Data Source
  KAKENHI-PROJECT-15K10763
[Journal Article] Correlations between Cu,Zn-SOD and macrophages or MUC5AC in human eosinophilic chronic rhinosinusitis.2015
- Author(s)
  Kusunoki T, Ono N, Ikeda K.
- Journal Title
  
  J Otol Rhinol
  
  Volume: S1 Pages: 10-14
- DOI
  10.4172/2324-8785.s1-003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462694, KAKENHI-PROJECT-26861417
[Journal Article] Effectiveness of lucocorticosteroid for postoperative recurrence of nasal polyps in chronic rhinosinusitis associated with asthma.2015
- Author(s)
  Ikeda K, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Yokoi H, Kawano K.
- Journal Title
  
  J Otol Rhinol
  
  Volume: S1 Pages: 6-9
- DOI
  10.4172/2324-8785.s1-002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462694, KAKENHI-PROJECT-26861415
[Journal Article] Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma2011
- Author(s)
  Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K
- Journal Title
  
  Auris Nasus Larynx(Epub ahead of print)
  
  Pages: 1312-1319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Relationship between olfactory acuity and peak expiratory flow during postoperative follow-up in chronic rhinosinusitis associated with asthma2010
- Author(s)
  Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K
- Journal Title
  
  Ann Otol Rhinol Laryngol 119(11)
  
  Pages: 576-581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Expression of IL-17 and its role in bone destruction in human middle Ear cholesteatoma2010
- Author(s)
  Haruyama T, Furukawa M, Kusunoki T, Onoda J, Ikeda K
- Journal Title
  
  ORL
  
  Volume: 72 Pages: 325-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592168
[Journal Article] Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma.2010
- Author(s)
  Furukawa M, Kusunoki T, Onoda J, Ikeda K., Haruyama T
- Journal Title
  
  ORL J Otorhinolaryngol Relat Spec. 72(6)
  
  Pages: 325-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis.2010
- Author(s)
  Ohba S, Fujii H, Ito S, Fujimaki, M, Matsumoto F, Furukawa M, Yokoyama J, Kusunoki T, Ikeda K, Hino O
- Journal Title
  
  J Oral Pathol Med. 39(1)
  
  Pages: 74-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Eotaxin-1, -2, and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients.2009
- Author(s)
  Yao T, Kojima Y, Koyanagi A, Yokoi H, Saito T, Kawano K, Furukawa M, Kusunoki T, Ikeda K
- Journal Title
  
  Laryngoscope 119
  
  Pages: 1053-9
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis.2009
- Author(s)
  Saito T, Kusunoki T, Yao T, Kawano K, Kojima Y, Miyahara K, Onoda J, Yokoi H, Ikeda K
- Journal Title
  
  Rhinology 47
  
  Pages: 275-9
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Development of distortion product Otoacoustic emissions in C57BL/6J mice2009
- Author(s)
  Narui Y, Minekawa A, Iizuka T, Furukawa M, Kusunoki T, Koike T, Ikeda K.
- Journal Title
  
  Int J Audiol 48
  
  Pages: 576-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis.2009
- Author(s)
  Ohba S, Fujii H, Ito S, Fujimaki M, Matsumoto F, Furukawa M, Yokoyama J, Kusunoki T, Ikeda K
- Journal Title
  
  Hino O J Oral Pathol Med.
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Eotaxin-1, -2, and-3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients.2009
- Author(s)
  Yao T, Kojima Y, Koyanagi A, Yokoi H, Saito T, Kawano K, Furukawa M, Kusunoki T, Ikeda K
- Journal Title
  
  Laryngoscope. 119(6)
  
  Pages: 1053-1059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Prevention of ultrasonic coagulator-mediated mucoperiosteal flap injury and defects by using a clip manipulation in the resection of the posterior nasal nerve.2009
- Author(s)
  Ikeda K, Yokoi H, Saito T, kawano K, Yao T, Furukawa M, Kusunoki T
- Journal Title
  
  Rhinology. 47(1)
  
  Pages: 45-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Role of Interleukin-17A in the Eosinophil Accumulation and Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps Associated with Asthma.2009
- Author(s)
  Saitoh T, Kusunoki T, Yao T, Kawano K, Kojima Y, Miyahara K, Onoda J, Yokoi H, Ikeda K
- Journal Title
  
  Int Arch Allergy Immunol 151
  
  Pages: 8-16
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Development of distortion product otoacoustic emissions in C57BL/6J mice.2009
- Author(s)
  Narui Y, Minekawa A, Iizuka T, Furukawa M, Kusunoki T, Koike T, Ikeda K
- Journal Title
  
  Int J Audiol. 48(8)
  
  Pages: 576-581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Development of distortion product Otoacoustic emissions in C57BL/6J mice.2009
- Author(s)
  Narui Y, Minekawa A, Iizuka T, Furukawa M, Kusunoki T, Koike T, Ikeda K
- Journal Title
  
  Int J Audiol 48
  
  Pages: 576-81
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Postnasal development of the organ of Corti in dominant-negative Gjb2 transgenic mice.2008
- Author(s)
  Inoshita A, Iizuka T, Okamura HO, Minekawa A, Kojima K, Furukawa M, Kusunoki T, Ikeda K
- Journal Title
  
  Neuroscience. 156(4)
  
  Pages: 1039-1047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Clinical effectiveness of ototopical application of mupirocin ointment in methicillin-resistant Staphylococcus aureus otorrhea.2008
- Author(s)
  Furukawa M, Minekawa A, Haruyama T, Narui Y, Sugita G, Sugita R, Kusunoki T, Ikeda K
- Journal Title
  
  Otol Neurotol. 29(5)
  
  Pages: 676-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591992
[Journal Article] Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice2008
- Author(s)
  Inoshita A, Iizuka T, Okamura HO, Minekawa A, Kojima K, Furukawa M, Kusunoki T, Ikeda K
- Journal Title
  
  Neuroscience 156
  
  Pages: 1039-1047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea2008
- Author(s)
  Iizuka T, Kanzaki S, Mochizuki H, Inoshita A, Narui Y, Furukawa M, Kusunoki T, Saji M, Ogawa K, Ikeda K
- Journal Title
  
  Hum Gene Ther 19
  
  Pages: 384-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390445
[Presentation] 耳垢の決定遺伝子ABCC11と耳内環境に伴う中耳真珠腫の発症リスク2017
- Author(s)
  楠　威志
- Organizer
  第27回日本耳科学会
- Data Source
  KAKENHI-PROJECT-15K10763
[Presentation] Cathepsin L, RANKL and those inhibitors in human middle ear Cholesteatoma2010
- Author(s)
  Kusunoki T
- Organizer
  The 13 th Korea-Japan Joint Meeting of Otorhino-laryngology-Head and Neck Surgery
- Place of Presentation
  ソウル
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-21592168
[Presentation] Cathepsin L, its inhibitor inhuman otitis memia2009
- Author(s)
  KusunokiT
- Organizer
  6th ExtraordinaryInternational Sympsium on Recent Advancesiin Otitis Media
- Place of Presentation
  ソウル
- Year and Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21592168
[Presentation] Cathepsin L and its inhibitor in human otitis media2009
- Author(s)
  楠威志
- Organizer
  6th Extraordinary internatinal symposium on recent advances in otitis media
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21592168

1. IKEDA Katuhisa (70159614)

# of Collaborated Projects: 10 results

# of Collaborated Products: 20 results
2. HURUKAWA Masayuki (20359524)

# of Collaborated Projects: 8 results

# of Collaborated Products: 14 results
3. KAMIYA Kazusaku (10374159)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. YOKOI Hidenori (80317487)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. ICHIHARI Yukiko (30327803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 中川大 (40397039)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 豊田優 (80650340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. MINOWA Osamu (00181967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOIKE Takuji (10282097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KAKEHATA Seiji (90261619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATTUMOTO Fumihiko (70445584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KASAI Misato (70549279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中澤詠子 (60245751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 春山琢男 (80549270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 本間博友 (90433771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小野倫嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUSUNOKI Takeshi 楠 威志

楠 威志 クスノキ タケシ

Research Projects

Research Products

Co-Researchers

Establishment of in-vitro evaluation of sinusitis using nasal polyp-derived cellsOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

pHin the external or mddle ear related a risk factor of middle ear cholesteatomaPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of molecular mechanisms of middle ear cholesteatoma by the analysis of gene network involving bone destructionOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ABC transporter of outer and middle ear related to a risk factor of middle cholesteatomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Promoter and inhibitor factors of bone destruction in human middle ear cholesteatomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト甲状腺腫瘍におけるシステインプロテアーゼとRas癌遺伝子産物に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

KUSUNOKI Takeshi 楠威志

楠威志クスノキタケシ