Sakuma Tsutomu 佐久間勉

… Alternative Names

佐久間勉サクマツトム

SAKUMA Tsutomu 佐久間勉

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Researcher Number	30250468
Other IDs
Affiliation (Current)	2025: 奥羽大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 奥羽大学, 薬学部, 教授 2011 – 2014: 富山大学, 大学院医学薬学研究部(薬学), 准教授 2008 – 2010: University of Toyama, 大学院・医学薬学研究部(薬学), 准教授 2008: 富山大学, 医学薬学研究部(薬学), 准教授 2008: 富山大学, 大学院・大学院医学薬学研究部(薬学), 准教授 … More 2007: 富山大学, 医学薬学研究部 (薬学), 准教授 2007: University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Associate Professor 2006: 富山大学, 大学院医学薬学研究部, 助教授 2003 – 2004: 富山医科薬科大学, 薬学部, 助手 2000 – 2001: 富山医科薬科大学, 薬学部, 助手 1996 – 1997: HOKKAIDO Univ., Fac.of Pharmc.Sci., Assistant Prof., 薬学部, 助手 1994 – 1995: Hokkaido Univ., Fac. Pharm. Sci., Assistant Professor, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological pharmacy / Basic Section 47060:Clinical pharmacy-related / Environmental pharmacy Except Principal Investigator Biological pharmacy / Medical pharmacy
Keywords	Principal Investigator マウス / 性差 / CYP3A41 / CYP3A44 / 薬物代謝酵素 / シトクロムP450 / 性特異性 / microRNA / 薬物代謝 / mouse … More / estrous cycle / circadian rhythm / HNF4α / 性周期 / 日内変動 / エピジェネティック / 発現調節 / CYP / 発現制御 / CYP3A / 分子生物学 / 成長ホルモン / CYP2B9 / グルココルチコイド / 肝初代培養細胞 / スフェロイド培養 / 変異原性 / 変移原性 / CYP3A7 / HITECマウス / トランスジェニックマウス / ヒト / BmNPV / 異種タンパク質発現系 / バキュロキュロウイルス / カイコ / CYP2E1 / チトクロームP450 … More Except Principal Investigator P450 / poor metabolizer / population study / CYP2A6 / polymorphism / SM-12502 / CYP3A7 / 大量発現系 / バキュロウイルス発現系 / チトクロームP450 / 代謝的活性化 / トランスジェニックマウス / CYP / coumarin / genotyping / CYP1A2 / CYP2D6 / 発がん / drugmetabolism / チトクロームP450 2A6 / チトクロームP450 2D6 / poor mtabolizer / クマリン / 遺伝子診断 / Hepatocyte / Cell expression system / p53-Knockout mouse / Transgenic mouse / Alternatives / in vitro 毒性試験 / N-アセチルトランスフェラーゼ / 薬物代謝酵素 / p53欠失マウス / アフラトキシンB_1 / 肝細胞 / 細胞発現系 / p53欠損マウス / 代替法 / bioactivation / transgenicmouse / fetus-specific / 発現調節 / 胎児特異的 / D-Penicillamine / Cyclosporin-A / Protein disulfide isomerase / Hepatitis / LEC rats / Autoimmune antibodies / カルレチクリン / プロテインジスルフィドイソメラーゼ / アルコール性肝障害 / LECラット / 薬物性肝障害 / 肝炎 / 自己免疫性抗体 / HNF3β(FoxA2) / 性ホルモン / 成長ホルモン / シトクロムP450 / CYP2B9 / シグナル伝達 / 薬物代謝 Less

薬物代謝酵素シトクロムP450の性特異的制御におけるmicroRNAの役割Principal Investigator
- Principal Investigator
  
  佐久間勉
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Ohu University
Role of epigenetic regulation on female-predominant expression of drug-metabolizing enzyme CYP3A genePrincipal Investigator
- Principal Investigator
  
  SAKUMA TSUTOMU
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Mechanisms of female-specific expression of drug-metabolizing enzyme CYP3A : comparison between human and mousePrincipal Investigator
- Principal Investigator
  
  SAKUMA Tsutomu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Sex-dependent expression mechanism of cytochrome P450 by growth hormone and a transcription factor, HNF3β or HNF4α
- Principal Investigator
  
  NEMOTO Nobuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Study of periodic change of the expression of constitutively expressing drug-metabolizing cytochrome P450 genesPrincipal Investigator
- Principal Investigator
  
  SAKUMA Tsutomu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Cyp3a遺伝子発現の性特異性を調節するホルモンの役割Principal Investigator
- Principal Investigator
  
  佐久間勉
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
新規雌性特異的マウス肝チトクロームP450(CYP3A41)の発現調節機構の解析Principal Investigator
- Principal Investigator
  
  佐久間勉
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
チトクロームP450の生体内機能を直接的に証明する新しいアプローチPrincipal Investigator
- Principal Investigator
  
  佐久間勉
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
カイコを利用したヒトチトクロームP450大量発現系の確立Principal Investigator
- Principal Investigator
  
  佐久間勉
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Pharmacogenetics of drug metabolizing enzymes
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Analysis of human fetus-specific cytochrome P450 : Evaluation of its function (s) by using transgenic mice and estimation of regulation mechnism (S).
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
DEVELOPMENT OF NOVEL ALTERNATIVE METHODS FOR THE PREDICTION OF DRUG METABOLISM IN HUMANS
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Can the Occurence of Autoantibody to Protein Disulfide Isomerase be a Marker for the Development of Hepatitis?
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

All 2022 2021 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.2014
- Author(s)
  Zhou Y., Tanaka T., Sugiyama N., Yokoyama S., Kawasaki Y., Sakuma T., Ishihama Y., Saiki I., and Sakurai H.
- Journal Title
  
  FEBS Letters
  
  Volume: 588 Issue: 1 Pages: 131-137
- DOI
  10.1016/j.febslet.2013.11.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071, KAKENHI-PROJECT-23590172, KAKENHI-PUBLICLY-24116513, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017, KAKENHI-PROJECT-24659348, KAKENHI-PROJECT-24700971
[Journal Article] Modulations of cytochrome P450 expression in diabetic mice by berberine2012
- Author(s)
  Chatuphonprasert W., Nemoto N., Sakuma T., and Jarukamjorn K.
- Journal Title
  
  Chem. Biol. Interact.
  
  Volume: 196 Issue: 1-2 Pages: 23-29
- DOI
  10.1016/j.cbi.2012.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590172
[Journal Article] Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes2011
- Author(s)
  Kondo S., Chatuphonprasert W., Jaruchotikamol A., Sakuma T., Nemoto N.
- Journal Title
  
  Toxicology 280
  
  Pages: 18-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Modified expression of aryl hydrocarbon receptor-related genes by deoxymiroestrol, a phytoestrogen, in mouse hepatocytes in primary culture2011
- Author(s)
  Udomsuk L., Jarukamjorn K., Putalun W., Sakuma T., Kawasaki Y., Nemoto N
- Journal Title
  
  Journal of Ethnopharmacology
  
  Volume: 137 Issue: 1 Pages: 902-908
- DOI
  10.1016/j.jep.2011.06.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590172
[Journal Article] Hepatocyte nuclear factor 4 alpha regulates expression of the mouse female-specific Cyp3a41 gene in the liver.2011
- Author(s)
  Bhadhprasit W., Sakuma T., Kawasaki Y., Nemoto N.
- Journal Title
  
  Drug Metab. Dispos. 39
  
  Pages: 490-497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Hepatocyte nuclear factor 4 alpha regulates expression of the mouse female-specific Cyp3a41 gene in the liver2011
- Author(s)
  Bhadhprasit W., Sakuma T., Kawasaki Y., Nemoto N
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Issue: 3 Pages: 490-497
- DOI
  10.1124/dmd.110.035980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590172
[Journal Article] Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver.2010
- Author(s)
  Jarukamjorn K., Kondo S., Chatuphonprasert W., Sakuma T., Kawasaki Y., Nemoto N.
- Journal Title
  
  Eur.J.Pharm.Sci. 39
  
  Pages: 394-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Potent modification of inducible CYP1A1 expression by flavonoids.2010
- Author(s)
  Chatuphonprasert W., Kondo S., Jarukamjorn K., Kawasaki Y., Sakuma T., Nemoto N.
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 1698-1703
- NAID
  130000402364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Regulatory xenobiotic responsive elements in the distal 5'-flanking region of the mouse Cypla2 gene required for transcriptional activation by 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.2010
- Author(s)
  Kawasaki Y., Sakuma T., Goto Y., Nemoto N.
- Journal Title
  
  Drug Metab.Dispos. 38
  
  Pages: 1640-1643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Alteration of acetaminophen-induced cytotoxicity in mouse hepatocytes during primary culture.2009
- Author(s)
  Jaruchotikamol A, Takase A, Ito S, Kawasaki Y., Kondo S, Sakuma T., Nemoto N.
- Journal Title
  
  J.Health Sci. 55
  
  Pages: 767-776
- NAID
  130000127965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Sex differences of drug-metabolizing enzyme : female predominant expression of human and mouse cytochrome P450 3A isoforms2009
- Author(s)
  Sakuma T, et al.
- Journal Title
  
  J.Health Sci. 55
  
  Pages: 325-337
- NAID
  130000127906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Conjugates of p-hydroxymethamphetamine and 4-hydroxy-3-methoxymethamphetamine in blood obtained from methamphetamine and 3, 4-methylenedioxymethamphetamine users : analysis by LC-MS-MS.2008
- Author(s)
  Shima N., Katagi M., Kamata H., Zaitsu K., Kamata T., Miki A., Tsuchihashi H., Sakuma T., Nemoto N.
- Journal Title
  
  Forensic Toxicol. 26
  
  Pages: 58-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene.2008
- Author(s)
  Hashita T., Sakuma T., Akada M., Nakajima A., Yamahara H., Ito S., Takesako H., Nemoto N.
- Journal Title
  
  Drug Metab.Dispos. 36
  
  Pages: 1080-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female- specific mouse Cyp3a44 gene expression2008
- Author(s)
  Tsutomu, Sakuma, Wattanaporn, Bhadhprasit, Tadahiro, Hashita, Nobuo, Nemoto
- Journal Title
  
  Drug Metabolism and Disposition 36
  
  Pages: 878-884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression2008
- Author(s)
  Sakuma T, Bhadhprasit W, Hashita T, and Nemoto N.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene2008
- Author(s)
  Hashita T., Sakuma T., Akada M., Nakajima A., Yamahara H., Ito S., Takesako H., and Nemoto N.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 1080-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression2008
- Author(s)
  Sakuma T., et. al.
- Journal Title
  
  Drug Metabolism and Disposition 36
  
  Pages: 878-884
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression2008
- Author(s)
  Sakuma T., Bhadhprasit W., Hashita T., Nemoto N
- Journal Title
  
  Drug Metab. Dispos. . 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression.2008
- Author(s)
  Sakuma T., Bhadhprasit W., Hashita T., Nemoto N.
- Journal Title
  
  Drug Metab.Dispos. 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression2008
- Author(s)
  Sakuma, T., et al.
- Journal Title
  
  Drug Metab. Dispos. 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene.2008
- Author(s)
  Hashita T., Sakuma T., Akada M., Nakajima A., Yamahara H., Ito S., Takesako H., Nemoto N.
- Journal Title
  
  Drug Metab. Dispos. 35
  
  Pages: 1080-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes2008
- Author(s)
  Jaruchotikamol A., Jarukamjorn K, Sirisangtrakul W, Sakuma T, Kawasaki Y, and Nemoto N
- Journal Title
  
  Toxicol. Appl. Pharmacol 224
  
  Pages: 156-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W., Sakuma T., Hatakeyama N., Fuwa M., Kitajima K., Nemoto N.
- Journal Title
  
  Drug Metab Dispos 35
  
  Pages: 1880-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W, Sakuma T, Hatakeyama N, Fuwa M, Kitajima K, and Nemoto N.
- Journal Title
  
  Drug Metab. Dispos 35
  
  Pages: 1880-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Strong synergistic induction of CYP1A1 expression by androgra-pholide plus typical CYP1A inducers in mouse hepatocytes2007
- Author(s)
  Jaruchotikamol A., Jarukamjorn K., Sirisangtrakul W., Sakuma T., Kawasaki Y., Nemoto N.
- Journal Title
  
  Toxicol. Appl. Pharmacol 224
  
  Pages: 156-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Direct determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine,the main metabolite of MDMA,in human urine2007
- Author(s)
  Shima N., Kamata H., Katagi M., Tsuchihashi H., Sakuma T., Nemoto N.
- Journal Title
  
  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci 857
  
  Pages: 123-129
- NAID
  10025808869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female- predominant expression by glucocorticoid hormone2007
- Author(s)
  Wattanaporn, Bhadhprasit, Tsutomu, Sakuma, Nobuyuki, Hatakeyama, Masahiro, Fuwa, Kaori, Kitajima, Nobuo, Nemoto
- Journal Title
  
  Drug Metabolism and Disposition 35
  
  Pages: 1880-1885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by gluco-corticoid hormone2007
- Author(s)
  Bhadhprasit W., Sakuma T., et. al.
- Journal Title
  
  Drug Metabolism and Disposition 35
  
  Pages: 15-162
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver2006
- Author(s)
  Kanokwan, Jarukamjorn, Tsutomu, Sakuma, Atika, Jaruchotikamol, Yukako, Ishino, Miki, Oguro, Nobuo, Nemoto
- Journal Title
  
  Toxicology 219
  
  Pages: 97-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver2006
- Author(s)
  Jarukamjorn K., Sakuma T., et. al.
- Journal Title
  
  Toxicology 219
  
  Pages: 97-105
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver2006
- Author(s)
  Jarukamjorn K, Sakuma T. et al.
- Journal Title
  
  Toxicology 219
  
  Pages: 97-105
- Data Source
  KAKENHI-PROJECT-18590136
[Journal Article] Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones2004
- Author(s)
  Tsutomu Sakuma
- Journal Title
  
  Biochemical and Biophysical Research Communications 323
  
  Pages: 776-781
- Data Source
  KAKENHI-PROJECT-15790090
[Presentation] 核内受容体HNF4α、VDR及びPPARγのリン酸化による調節2022
- Author(s)
  佐久間勉、渡邊葵、加茂桃佳、猪越遥、永井春菜、吉田捷吾、池上沙耶茄
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19K07228
[Presentation] 核内受容体DBDの保存されたセリン・スレオニン残基のリン酸化影響2021
- Author(s)
  佐久間勉、渡邊葵、永井春菜、吉田捷吾、池上沙耶茄、大和田望実、奥村雄太、加茂桃佳、猪越遥
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07228
[Presentation] マウスCyp1a2遺伝子のフェノバルビタール型誘導剤による発現調節機構の解析2014
- Author(s)
  佐久間勉、河崎優希、古野幸美、後藤雄真、茂木優治、根本信雄、櫻井宏明
- Organizer
  日本薬学会北陸支部第126回例会
- Place of Presentation
  石川県金沢市
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] 高度に保存されているDBD内スレオニンのリン酸化による核内受容体の活性調節2013
- Author(s)
  佐久間勉，谷翔太，手賀悠真，進藤佐和子，根岸正彦，河崎優希，根本信雄，櫻井宏明
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] 高度に保存されたスレオニンのリン酸化を介したPPARの活性調節機構2013
- Author(s)
  谷翔太，佐久間勉，手賀悠真，進藤佐和子，根岸正彦，梅嵜雅人，河崎優希，根本信雄，櫻井宏明
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] 成長ホルモンおよびグルココルチコイドホルモンによるマウスCyp3a遺伝子発現の比較解析2012
- Author(s)
  佐久間勉，栗本夕夏，松井友理恵，池松怜美，宅間祐太朗，河崎優希，根本信雄，櫻井宏明
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] Regulatory elements for transcriptional activation of the mouse Cyp1a2 gene by constitutive androstane receptor-ligand2012
- Author(s)
  Kawasaki Y., Furuno Y., Goto Y., Sakuma T., Sakurai H., and Nemoto N.
- Organizer
  50TH Anniversary Symposium on Cytochrome P450 in Fukuoka
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] Periodic fluctuation of Cyp3a gene expression in the mouse liver2011
- Author(s)
  Tsutomu Sakuma, Satomi Ikematsu, Yuka Kurimoto, Yuki Kawasaki, Nobuo Nemoto
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] マウス全CYP3A分子種のmRNA発現量の比較解析2011
- Author(s)
  栗本夕夏, 佐久間勉, 宅間祐太郎, 池松怜美, 河崎優希, 櫻井宏明, 根本信雄
- Organizer
  日本薬学会北陸支部第123回例会
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-23590172
[Presentation] Role of hepatocyte nuclear factor 4 alpha and chromatin structure in the regulation of female-specific Cyp3a41 gene expression2010
- Author(s)
  Tsutomu Sakuma, et al.
- Organizer
  18th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] マウスCyp3a41遺伝子構造とHNF4αによる性特異的発現2010
- Author(s)
  佐久間勉, 池松怜美, Bhadhprasit Wattanaporn, 河崎優希, 根本信雄
- Organizer
  日本薬学会北陸支部第122回例会
- Place of Presentation
  金沢
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Regulatory XREs in distal 5'-flanking region of the mouse Cypla2 gene for transcriptional activation by 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.2010
- Author(s)
  Kawasaki Y., Yuma Goto, Sakuma T., Nemoto N.
- Organizer
  18th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] メスマウス肝でのCyp3a41遺伝子発現におけるクロマチン構造とHNF4αの役割2010
- Author(s)
  佐久間勉, 池松怜美, Bhadhprasit Wattanaporn, 河崎優希, 近藤佐千子, 根本信雄
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Role of hepatocyte nuclear factor 4 alpha and chromatin structure in the regulation of female-specific Cyp3a41 gene expression.2010
- Author(s)
  Sakuma T., Bhadhprasit W., Kawasaki Y., Nemoto N.
- Organizer
  18th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Cyp3a41遺伝子メス特異的発現の調節機構2010
- Author(s)
  佐久間勉, Bhadhprasit Wattanaporn, 河崎優希, 近藤佐千子, 根本信雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] グルココルチコイドによるCyp3a41遺伝子の発現調節機構:Glucocoeticoid receptorおよびHepatocyte nuclear factor-4αの役割2009
- Author(s)
  Bhadhprasit Wattanaporn, 佐久間勉, 河崎優希, 根本信雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] 12のXを含むCyp1a2遺伝子の5'上流域による3-MC並びに2,3,7,8-TCDD誘導性マウスCyp1a2遺伝子転写調節2009
- Author(s)
  河崎優希, 佐久間勉, 根本信雄
- Organizer
  第81回日本生化学会大会・第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メス優位に発現するマウスCyp3a41遺伝子転写過程におけるHNF4αの役割2008
- Author(s)
  根本信雄, 古澤裕之, 上野真一, 佐久間勉
- Organizer
  第15回肝細胞研究
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] マウスCyp3a41の性特異的発現におけるHNF4αの役割2008
- Author(s)
  古澤之裕, 佐久間勉, 上野真一, Bhadhprasit Wattanaporn, 坡下真大, 根本信雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] メス優位に発現するマウスCyp3a41遺伝子転写過程におけるHNF4αの役割2008
- Author(s)
  根本信雄, 古澤裕之,上野真一, 佐久間勉
- Organizer
  第15回肝細胞研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] メス優位に発現するマウスCyp3a41遺伝子転写過程におけるHNF4αの役割2008
- Author(s)
  根本信雄, 古澤裕之, 上野真一, 佐久間勉
- Organizer
  第15回肝細胞研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Glucocorticoid-mediated induction of mouse Cyp3a41 gene expression ; involvement of glucocorticoid receptor and hepatocyte nuclear factor 4 alpha2008
- Author(s)
  Bhadhprasit Wattanaporn, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Glucocorticoid-mediated induction of mouse Cyp3a41 gene expression ; involve-ment of glucocorticoid receptor and hepatocyte nuclear factor 4 alpha2008
- Author(s)
  Wattanaporn Bhadhprasit, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Cypla2遺伝子5'上流域による3-メチルコラントレン並びに2, 3, 7, 8-TCDD誘導性マウスCypla2遺伝子転写調節2008
- Author(s)
  河崎優希, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] アンドログラフォリドによる3-メチルコラントレン誘導性CYP1A1遺伝子ファミリー発現の促進と性差2008
- Author(s)
  近藤佐千子, Kanokwan Jarukamjorn, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] グルココルチコイドによるCyp3a41遺伝子の調節機構:C/EBPの役割2008
- Author(s)
  Bhadhprasit Wattanaporn, 佐久間勉, 赤田真美, 根本信雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Glucocorticoid-mediated induction of mouse Cyp3a41 gene expression ; involvement of glucocorticoid receptor and hepatocyte nuclear factor 4 alpha2008
- Author(s)
  Wattanaporn Bhadhprasit^*, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] グルココルチコイドによるCyp3a41遺伝子の調節機構 : C/EBPの役割2008
- Author(s)
  Wattanaporn Bhadhprasit, 佐久間勉, 赤田真美, 根本信雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] 12のXREを含むCypla2遺伝子の5'上流域による3-MC並びに2, 3, 7, 8-TCDD誘導性マウスCypla2遺伝子転写調節.2008
- Author(s)
  河崎優希, 佐久間勉, 根本信雄
- Organizer
  第81回日本生化学会大会・第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Wattanaporn Bhadhprasit and Nobuo Nemoto: Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers2007
- Author(s)
  Tsutomu, Sakuma
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Role of HNF4 alpha in regulation mechanism for constitutive expression of female-specific mouse Cyp3a41 gene in livers2007
- Author(s)
  Yukihiro, Furusawa, Tsutomu, Sakuma, Wattanaporn, Bhadhprasit, Tadahiro, Hashita, Kimiko, Miyauchi, Kaoru, Abe, Yasuyuki, Mukai, Nobuo, Nemoto
- Organizer
  117th meeting of the Hokuriku-branch of the Pharmaceutical Society of Japan
- Place of Presentation
  Kanazawa
- Year and Date
  2007-11-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers2007
- Author(s)
  Sakuma T., et. al.,
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Role of HNF4 alpha in constitutive expression of Cyp3a41 gene in female mouse livers2007
- Author(s)
  Yukihiro, Furusawa, Tsutomu, Sakuma, Shin-ichi, Ueno, Wattanaporn, Bhadhprasit, Tadahiro, Hashita, Kaoru, Abe, Nobuo, Nemoto
- Organizer
  BMB2007
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse Cyp3a44 gene expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W., Sakuma T., et. al.
- Organizer
  8th Intemational ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] マウスメス特異的Cyp3a41遺伝子の常在的発現機構のHNF4αの役割2007
- Author(s)
  古澤之裕, 佐久間勉, ペットパラシットワッタナポン, 坡下真大, 宮内希弥子, 阿部かおる, 向井恭行, 根本信雄
- Organizer
  日本薬学会北陸支部第117回例会
- Place of Presentation
  金沢
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Cyp2b9 遺伝子の性依存的転写活性における調節領域の同定2007
- Author(s)
  坡下真大, 中島明日香, 赤田真美, 佐久間勉, 根本信雄
- Organizer
  日本薬学会127 年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers2007
- Author(s)
  Sakuma T., Bhadhprasit W., et. al.
- Organizer
  8th Intemational ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse Cyp3a44 gene expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W., Sakuma T., et. al.
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] 表面汚染モニタリングのための拭き取り効率の検討.2007
- Author(s)
  Sakuma T., Bhadhprasit W., Nemoto N, :
- Organizer
  日本放射線安全管理学会第6回学術大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Involvement of glucoconicoid receptor and pregnane X receptor in theregulation of mouse Cyp3a44 gene expression by glucocor-ticoid hormone.2007
- Author(s)
  Bhadhprasit W., Sakuma T., Nemoto N.
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] マウスメス特異的Cyp3a41遺伝子の常在的発現機構のHNF4αの役割2007
- Author(s)
  古澤之裕, 佐久間勉, 他
- Organizer
  日本薬学会北陸支部第117回例会
- Place of Presentation
  金沢
- Year and Date
  2007-11-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] メスマウス肝臓におけるCyp3a41遺伝子の常在的発現に対するHNF4αの役割2007
- Author(s)
  古澤之裕, 佐久間勉, 他
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] メスマウス肝臓におけるCyp3a41遺伝子の常在的発現に対するHNF4αの役割2007
- Author(s)
  古澤之裕, 佐久間勉, 上野真一, ペットパラシットワッタナポン, 坡下真大, 阿部かおる, 根本信雄
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス特異的Cyp3a 遺伝子の発現調節2007
- Author(s)
  佐久間勉, Bhadhprasit W, 根本信雄
- Organizer
  第5回ながの遺伝子発現調節研究会
- Place of Presentation
  諏訪
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers.2007
- Author(s)
  Sakuma T., Bhadhprasit W., Nemoto N
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers2007
- Author(s)
  Sakuma T, Bhadhprasit W, and Nemoto N
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス肝臓における Cyp3a41遺伝子の常在的発現に対するHNF4αの役割.2007
- Author(s)
  古澤之裕, 佐久間勉, 上野真一, ペットパラシットワッタナポン, 坡下真大, 阿部かおる, 根本信雄
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse Cyp3a44 gene expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W, Sakuma T, and Nemoto N
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス特異的Cyp3a遺伝子の発現調節2007
- Author(s)
  佐久間勉, 他
- Organizer
  第5回ながの遺伝子発現調節研究会
- Place of Presentation
  諏訪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Wattanaporn Bhadhprasit, Nobuo Nemoto: Gene regulation of female mouse -specific Cyp3a genes2007
- Author(s)
  Tsutomu, Sakuma
- Organizer
  5th Nagano gene regulation meeting
- Place of Presentation
  Suwa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Regulation of Cyp3a41 and Cyp3a44 gene expression mediated by glucocorticoid receptor2006
- Author(s)
  Wattanaporn, Bhadhprasit, Tsutomu, Sakuma, Masahiro, Fuwa, Shin-ichi, Ueno, Kaori, Kitajima, Nobuo, Nemoto
- Organizer
  21th JSSX meeting
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Regulation of Cyp3a41 and Cyp3a44 gene expression mediated by gluco corticoid receptor2006
- Author(s)
  Bhadhprasit W., Sakuma T., et. al.
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] マウス肝シトクロムP450遺伝子発現の成長ホルモンによる影響2006
- Author(s)
  佐久間勉, 他
- Organizer
  日本薬学会第126年会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Regulation of female mouse-specific Cyp3a genes by growth hormone and glucocorticoid hormone2006
- Author(s)
  Tsutomu, Sakuma, Wattanaporn, Bhadhprasit, Kaori, Kitajima, Nobuo, Nemoto
- Organizer
  4th Nagano gene regulation meeting
- Place of Presentation
  Matsumoto
- Year and Date
  2006-11-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] Effects of growth hormone treatment on the expression of Cyp genes in mouse livers2006
- Author(s)
  Tsutomu, Sakuma, Kanokwan, Jarukamjorn, Atika, Jaruchotikamol, Yukako, Ishino, Miki, Oguro, Nobuo Nemoto
- Organizer
  126th annual meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] メスマウス特異的Cyp3a遺伝子の成長ホルモンおよびグルココルチコイドホルモンによる調節2006
- Author(s)
  佐久間勉, 他
- Organizer
  第4回ながの遺伝子発現調節研究会
- Place of Presentation
  松本
- Year and Date
  2006-11-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590136
[Presentation] マウスCyp1a2遺伝子フェノバルビタール型誘導剤応答領域の解析
- Author(s)
  佐久間勉、河崎優希、古野幸美、後藤雄真、茂木優治、根本信雄、櫻井宏明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-23590172

1. YOKOI Tsuyoshi (70135226)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KAMATAKI Tetsuya (00009177)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. NAKAYAMA Kazuo (20261323)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KAWASAKI Yuki (30432107)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
5. NEMOTO Nobuo (10085631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 47 results
6. 澤田稔 (30215917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 伊東進 (70223154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤田健一 (60281820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 櫻井宏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 済木育夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakuma Tsutomu 佐久間 勉

佐久間 勉 サクマ ツトム

SAKUMA Tsutomu 佐久間 勉

Research Projects

Research Products

Co-Researchers

薬物代謝酵素シトクロムP450の性特異的制御におけるmicroRNAの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of epigenetic regulation on female-predominant expression of drug-metabolizing enzyme CYP3A genePrincipal Investigator

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Mechanisms of female-specific expression of drug-metabolizing enzyme CYP3A : comparison between human and mousePrincipal Investigator

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Sex-dependent expression mechanism of cytochrome P450 by growth hormone and a transcription factor, HNF3β or HNF4α

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Study of periodic change of the expression of constitutively expressing drug-metabolizing cytochrome P450 genesPrincipal Investigator

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Cyp3a遺伝子発現の性特異性を調節するホルモンの役割Principal Investigator

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新規雌性特異的マウス肝チトクロームP450(CYP3A41)の発現調節機構の解析Principal Investigator

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チトクロームP450の生体内機能を直接的に証明する新しいアプローチPrincipal Investigator

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カイコを利用したヒトチトクロームP450大量発現系の確立Principal Investigator

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Pharmacogenetics of drug metabolizing enzymes

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Analysis of human fetus-specific cytochrome P450 : Evaluation of its function (s) by using transgenic mice and estimation of regulation mechnism (S).

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DEVELOPMENT OF NOVEL ALTERNATIVE METHODS FOR THE PREDICTION OF DRUG METABOLISM IN HUMANS

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Can the Occurence of Autoantibody to Protein Disulfide Isomerase be a Marker for the Development of Hepatitis?

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Sakuma Tsutomu 佐久間勉

佐久間勉サクマツトム

SAKUMA Tsutomu 佐久間勉