SASAGURI Toshiyuki 笹栗俊之

Researcher Number	30261209
Affiliation (based on the past Project Information) *help	2017 – 2019: 九州大学, 医学研究院, 教授 2011 – 2014: 九州大学, 医学(系)研究科(研究院), 教授 2012: 九州大学, 医学研究院, 教授 2008 – 2010: Kyushu University, 大学院・医学研究院, 教授 2002 – 2005: 九州大学, 大学院・医学研究院, 教授 1995 – 1999: 国立循環器病センター研究所, バイオサイエンス部, 室長
Review Section/Research Field	Principal Investigator Applied pharmacology / General pharmacology / Circulatory organs internal medicine / 血管生物学 / General pharmacology / Biological Sciences Except Principal Investigator General pharmacology / Periodontal dentistry
Keywords	Principal Investigator 細胞周期 / がん / STAT / Jak / 遺伝子多型 / サイクリンD1 / 増殖抑制 / 血管内皮細胞 / cell cycle / cyclin D1 … More / cancer / antiproliferation / Cellular hypertrophy / Tyrosine phosphorylation / αィイD21ィエD2 adrenergic receptor / Vascular smooth muscle / α受容体 / アドレナリン / 交感神経 / 細胞肥大 / チロシンリン酸化 / α_1アドレナリン受容体 / 血管平滑筋 / Cell cycle / Cell proliferation / Vascular smooth muscle cells / Vascular endothelial cells / Protein kinase C / 細胞増殖 / 血管平滑筋細胞 / プロテインキナーゼC / トランスポーター / ファーマコゲノミクス / 副作用 / 高血圧 / 薬物トランスポーター / 薬理ゲノム学 / ABCG2 / BCRP / ABCC4 / MRP4 / 尿酸 / 利尿薬 / チアジド / 炎症 / 抗炎症薬 / mPGES-1 / 新規抗炎症薬 / 硝酸イソソルビド / 薬理遺伝学 / ゲノム薬理学 / 2型アルデヒド脱水素酵素 / 血管拡張 / 狭心症 / 二硝酸イソソルビド / ニトログリセリン / 硝酸薬 / プロスタグランジン / p21 / Cdk阻害蛋白 / シェアストレス / アポトーシス … More Except Principal Investigator Porphyromonas gingivalis / G1期特異的 / YAP / GSK-3 / 抗腫瘍薬 / 分子標的薬 / 細胞内シグナル調節 / 抗がん薬 / intima-media wall thickness of carotid artery / periodontopathic bacteria / atherosclerosis / Periodontal disease / 障害反応説 / 血管内皮細胞 / 歯周病関連細菌 / 総頸動脈内膜中膜複合体 / 歯周病原細菌 / 動脈硬化症 / 歯周病 Less

Identification of the tareget molecule for GSK-3 activator DIF towards clinical usage
- Principal Investigator
  
  Takahashi Fumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Occupational and Environmental Health, Japan
The relationship between trichlormethiazide-induced hyperuricemia and the genotypes of uric acid transportersPrincipal Investigator
- Principal Investigator
  
  TOSHIYUKI Sasaguri
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
Identification of an inhibitor of mPGES-1 expression and its target moleculePrincipal Investigator
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitratesPrincipal Investigator
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
The clinical study on relationship between periodontal disease and atherosclerosis
- Principal Investigator
  
  HAMACHI Takafumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  KYUSHU UNIVERSITY
微生物由来細胞分化誘導因子の作用機構解明とG_1早期選択的抗腫瘍薬開発への応用Principal Investigator
- Principal Investigator
  
  笹栗俊之
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Studies on the signal transduction of difrentiation inducing factor and an application for the development of anti-cancer drug for early G_1 phase.Principal Investigator
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
血管内皮細胞の増殖・分化・死の制御におけるサイクリン依存性キナーゼ阻害蛋白の役割Principal Investigator
- Principal Investigator
  
  笹栗俊之
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Cardiovascular Center Research Institute
Linkage between G protein-coupled receptors and the Jak/STAT pathway in cardiovascular cellsPrincipal Investigator
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Regulation of proliferatin in vascular endothelial and smooth muscle cells by the protein kinase C pathwayPrincipal Investigator
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  National Cardiovascular Center Research Institute

All 2020 2019 2017 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Other

[Book] NEW薬理学(改訂第6版)(抗狭心症薬)2011
- Author(s)
  笹栗俊之
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20390160
[Book] 抗狭心症薬(分担執筆部分):田中千賀子・加藤隆一編『NEW薬理学』(改訂第6版)2011
- Author(s)
  笹栗俊之(分担執筆部分)
- Total Pages
  662
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20390160
[Book] 降圧薬のコンビネーションセラピー2009
- Author(s)
  笹栗俊之
- Total Pages
  170
- Publisher
  時間薬理学的観点からみた降圧薬の使い方
- Data Source
  KAKENHI-PROJECT-20390160
[Journal Article] 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.2019
- Author(s)
  Morishige S, Takahashi-Yanaga F, Ishikane S, Arioka M, Igawa K, Kuroo A, Tomooka K, Shiose A, Sasaguri T.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 168 Pages: 82-90
- DOI
  10.1016/j.bcp.2019.06.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06907, KAKENHI-PROJECT-17K08598
[Journal Article] Differentiation‐inducing factor‐1 suppresses cyclin D1‐induced cell proliferation of MCF‐7 breast cancer cells by inhibiting S6K‐mediated signal transducer and activator of transcription 3 synthesis2019
- Author(s)
  Tetsuo Fumi、Arioka Masaki、Miura Koichi、Kai Misato、Kubo Momoko、Igawa Kazunobu、Tomooka Katsuhiko、Takahashi‐Yanaga Fumi、Nishimura Fusanori、Sasaguri Toshiyuki
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 12 Pages: 3761-3772
- DOI
  10.1111/cas.14204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08598
[Journal Article] Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.2017
- Author(s)
  Arioka M, Takahashi-Yanaga F, Kubo M, Igawa K, Sasaguri T.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 138 Pages: 31-48
- DOI
  10.1016/j.bcp.2017.05.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08598, KAKENHI-PROJECT-17K15581
[Journal Article] Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study.2013
- Author(s)
  Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T,; The Comfort Investigators
- Journal Title
  
  QJM
  
  Volume: 106 Issue: 10 Pages: 909-914
- DOI
  10.1093/qjmed/hct121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390140
[Journal Article] Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure2012
- Author(s)
  Li L, Morimoto S, Take S, Zhan DY, Du CK Wang YY, Fan XL. Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T
- Journal Title
  
  J MoI Cell Cardiol
  
  Volume: 53 Pages: 760-767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390140
[Journal Article] – A Randomized Controlled Trial –2012
- Author(s)
  Matsunura K, Arima H. Toninaga M, Ohtsubo T. Sasaguri T, Fujii K. Fukuhara M, Uezono K, Morinaga Y, Ohta Y Otonari T. Kavasaki J, Kato I, Tsuchihashi T for the COMFORT invest igators
- Journal Title
  
  Circ J
  
  Volume: 76 Issue: 6 Pages: 1415-1422
- DOI
  10.1253/circj.CJ-11-1481
- NAID
  10030316225
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390140
[Journal Article] Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes : randomised crossover trial.2011
- Author(s)
  Sakata S, Yoshihara T, Arima H, Shiraishi F, Oniki H, Takahashi-Yanaga F, Matsumura K, Sasaguri T.
- Journal Title
  
  BMJ Open in press.
- Data Source
  KAKENHI-PROJECT-20390160
[Journal Article] β_1-adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects.2011
- Author(s)
  Sasaguri T, et al
- Journal Title
  
  J Pharmacol Sci
  
  Volume: (in press)
- NAID
  10029893413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Differentiation-inducing factor-1 suppresses breast cancer cell proliferation by reducing STAT3-mediated cyclin D1 expression2020
- Author(s)
  哲翁ふみ, 有岡将基, 高橋富美, 西村英紀, 笹栗俊之
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] Differentiation-inducing factor-1によるトリプルネガティブ乳癌の抑制機序2019
- Author(s)
  哲翁ふみ, 有岡将基, 高橋富美, 西村英紀, 笹栗俊之
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] Anti-tumor effect of DIF-1 in malignant melanoma2017
- Author(s)
  高橋　富美、有岡　将基、久保　桃子、笹栗　俊之
- Organizer
  第７６回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] Influence of ALDH2 genotype on vascular endothelial function after a long-term treatment with glyceryl trinitrate2014
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Anti-Tumor Effect of Differentiation-Inducing Factors on a Colon Cancer Cell Line HCT-116 <大腸癌細胞株 HCT-116 に対するDifferentiation-Inducing Factor の抗腫瘍効果>(口演)2013
- Author(s)
  久保倉尚哉、高橋富美、松本主之、笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] ロサルタン/ヒドロクロロチアジド合剤とロサルタン以外のアンジオテンシン受容体拮抗薬およびサイアザイド系利尿薬併用との比較：COMFORT試験2013
- Author(s)
  有馬久富、松村潔、冨永光裕、大坪俊夫、笹栗俊之、藤井弘二、福原正代、上園慶子、守永友希、大田祐子、土橋卓也、COMFORT試験グループ
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] ALDH2遺伝子多型がニトログリセリンの単回および長期投与効果に及ぼす影響に関する日本人健康成人を対象としたランダム化クロスオーバー試験2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第32回臨床薬理阿蘇九重カンファレンス
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Tumor suppression by GSK-3ss activator DIF-1 in colorectal and xenografted cancer model mice <GSK-3ss活性化物質 DIF-1の大腸がんおよび担がんモデルマウスにおける抗腫瘍効果>(ポスター)2013
- Author(s)
  高橋富美、笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] ALDH2遺伝子多型がニトログリセリン長期投与効果に及ぼす影響2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] ALDH2遺伝子多型がニトログリセリンの単回および長期投与効果に及ぼす影響2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Inhibition of GSK-3ss accelerates bone formation via the activation of the Wnt/β-catenin signaling pathway <GSK-3β阻害はWnt/ss -catenin シグナル活性化を介して骨形成を促進する>(口演)2013
- Author(s)
  有岡将基、高橋富美、佐々木匡理、笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 水中歩行の妊娠高血圧症候群予防効果に関する臨床研究2013
- Author(s)
  吉原達也、久保田史郎、笹栗俊之
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] ALDH2遺伝子多型がニトログリセリンの単回および長期投与効果に及ぼす影響に関する日本人健康成人を対象としたランダム化クロスオーバー試験2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] MRP4遺伝子多型がトリクロルメチアジド単回投与後の血清尿酸値および尿酸クリアランスに及ぼす影響:パイロットスタディ2013
- Author(s)
  吉原達也、早水憲吾, 永野晃弘, 有岡将基, 北村悠, 高橋富美, 池松秀之, 有馬久富, 笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Does a combination pill of antihypertensive drugs improve medication adherence in Japanese? : the COMFORT study2012
- Author(s)
  Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y Otonari T, Kawasaki J, Kato I, Tsuchihashi T for the COMFORT investigators
- Organizer
  24th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  シドニー
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] The inhibition of DUSP-1 expression enhances anti-tumor effects of differentiation-inducing factor-1 in HeLa cells<DUSP-1 発現抑制によるdifferentiation-inducing factor-1 の抗腫瘍活性の増強効果>2012
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] リチウムの Wnt シグナル活性化作用による新生骨形成の促進(口演)2012
- Author(s)
  有岡将基、高橋富美、佐々木匡理、笹栗俊之
- Organizer
  第31回臨床薬理阿蘇九重カンファレンス
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Differentiation-inducing factor-1 のモデルマウスを用いた抗腫瘍作用の検討(ポスター)2012
- Author(s)
  高橋富美、吉原達也、笹栗俊之
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] MRP4遺伝子多型がトリクロルメチアジド単回投与後の血清尿酸値および尿酸クリアランスに及ぼす影響 : パイロットスタディ2012
- Author(s)
  吉原達也, 早水憲吾, 永野晃弘, 有岡将基, 北村悠, 高橋富美, 池松秀之, 有馬久富, 笹栗俊之
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Wnt/ss-catenin シグナル活性化によるリチウムの骨形成促進作用(口演)(優秀発表賞受賞)2012
- Author(s)
  有岡将基、高橋富美、佐々木匡理、笹栗俊之
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] セレコキシブによる Wnt シグナル伝達経路阻害を介した骨芽細胞の分化抑制(ポスター)2012
- Author(s)
  永野晃弘、高橋富美、笹栗俊之
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 大腸癌細胞株 HCT-116 に対する differentiation-inducing Factor の抗腫瘍効果(ポスター)2012
- Author(s)
  久保倉尚哉、高橋富美、松本主之、笹栗俊之
- Organizer
  第71回日本癌学会学術総
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Impact of antihypertensive Dedication adherence on blood pressure control in hypertension : the COMFORT study2012
- Author(s)
  Matsuiura K, Anna H, Toninaga M, Ohtsubo T, Sasaguri T, Fujii K Fukuhara M, Dezono K, Norinaga Y, Ohta Y Otonari T, Kawasaki J, Kato I. Tsuchihashi T for the COMFORT investigators
- Organizer
  24 th Scientific Meeting 01 tne International Society of Hyoertension
- Place of Presentation
  シドニー
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Wnt シグナル阻害剤 DIF-1 の経口投与による抗腫瘍効果(ポスター)2012
- Author(s)
  高橋富美、笹栗俊之
- Organizer
  第71回日本癌学会学術総
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 細胞性粘菌由来分化誘導因子 DIF-1 はヒト大腸癌由来 HCT-116 細胞においてc-Myc の発現を低下させる2012
- Author(s)
  神宮司健太郎、高橋富美、中村俊央、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 細胞性粘菌由来分化誘導因子DIFによるmPGES-1の発現抑制機序の解明2011
- Author(s)
  高橋富美、笹栗俊之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Wnt シグナル阻害剤Differentiation-inducing factor-1 の抗腫瘍活性の検討2011
- Author(s)
  高橋富美、吉原達也、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] DUSP-1 の抑制によりdifferentiation-inducing factor-1 の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Differentiation-inducing factor-1 inhibits the Wnt signaling pathway by reducing TCF7L2 expression in colon cancer cells2011
- Author(s)
  Jingushi, K., Takahashi, F., Sasaguri, T
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] DUSP-1 の抑制によりdifferentiation-inducing factor-1 の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型ガニトログリセリンおとび二硝酸イソソルビドの血管拡張作用に印ぼす効果2010
- Author(s)
  吉原達也, 坂田智子, 白石富美恵, 鬼木秀幸, 市島久仁彦, 大坪俊夫, 三輪宜一, 高橋富美, 有馬久富, 松村潔, 笹栗俊之
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Effect of aldehyde dehydrogenase-2 gene polymorphism on vasodilatory response of brachial artery induced by nitroglycerin.2010
- Author(s)
  Sakata S, Matsumura K, Miwa Y, Oniki H, Ichishima K, Arima H, Takahashi-Yanaga F, Yoshihara T, Shiraishi F, Iida M, Sasaguri T
- Organizer
  23rd Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  バンクーバー
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] ALDH2の遺伝子多型がニトログリセリンの薬効に印ぼす影響2010
- Author(s)
  笹栗俊之, 坂田智子, 吉原達也, 白石富美恵, 松村潔
- Organizer
  第20回日本循環薬理学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] ALDH2の遺伝子多型がニトログリセリンの薬効に及ぼす影響2010
- Author(s)
  笹栗俊之, 他
- Organizer
  第20回日本循環薬理学会
- Place of Presentation
  札幌市教育文化会館(札幌市)
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型がニトログリセリンおよび二硝酸イソソルビドの血管拡張作用に及ぼす影響2010
- Author(s)
  坂田智子, 松村潔, 三輪宜一, 鬼木秀幸, 市島久仁彦, 吉原達也, 高橋富美, 白石富美恵, 大坪俊夫, 笹栗俊之
- Organizer
  第33回日本高血圧学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Influence of aldehyde dehydrogenase-2 gene polymorphism on vasodilatation induced by organic nitrates in healthy human subjects.2010
- Author(s)
  Sakata S, Ichijima K, Oniki H, Miwa Y, Arima H, Matsumura K, Yoshihara T, Takahashi-Yanaga F, Shiraishi F, Sasaguri T
- Organizer
  WorldPharma 2010
- Place of Presentation
  コペンハーゲン
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] The relationship between trichlormethiazide-induced hyperuricemia and the genotypes of uric acid transporters.
- Author(s)
  Yoshihara T, Imai H, Shiraishi F, Sasaguri T
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2015-03-18 – 2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] MRP4の遺伝子多型がトリクロルメチアジド投与後の血清尿酸値および尿酸クリアランスに及ぼす影響に関する臨床試験
- Author(s)
  吉原達也、有馬久富、笹栗俊之
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  横浜市
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] MRP4の遺伝子多型がトリクロルメチアジド投与後の血清尿酸値と尿酸クリアランスに及ぼす影響
- Author(s)
  吉原達也、今井浩光、白石富美恵、有馬久富、高橋富美、池松秀之、小手川勤、笹栗俊之
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  松山市
- Year and Date
  2014-12-04 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Influence of a loss-of-function polymorphism of MRP4 on serum uric acid concentration and uric acid clearance after the administration of trichlormethiazide
- Author(s)
  Tatsuya Yoshihara, Hiromitsu Imai, Fumie Shiraishi, Hisatomi Arima, Fumi Takahashi-Yanaga, Hideyuki Ikematsu, Tsutomu Kotegawa, Toshiyuki Sasaguri
- Organizer
  17th World Congress of Basic and Clinical Pharmacology
- Place of Presentation
  ケープタウン（南アフリカ共和国）
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24390140
[]

1. TAKAHASHI Fumi (50274436)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MATSUMURA Kiyoshi (70285469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. MATSUMURA Kiyoshi (70285409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YOSHIHARA Tatsuya (80419613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. OHTSUBO Toshio (30423974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. ARIMA Hisatomi (20437784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. HAMACHI Takafumi (80198811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJISE Osamu (40315099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MAEDA Katsumasa (00117243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIURA Mayumi (00404054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUJII Kouji (40209002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三輪宜一 (60346773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. IKEMATU Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
14. SHIRAISHI Fumie

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. 弥永富美

# of Collaborated Projects: 0 results

# of Collaborated Products: 36 results
16. 石兼真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAGURI Toshiyuki 笹栗 俊之

Research Projects

Research Products

Co-Researchers

Identification of the tareget molecule for GSK-3 activator DIF towards clinical usage

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The relationship between trichlormethiazide-induced hyperuricemia and the genotypes of uric acid transportersPrincipal Investigator

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Identification of an inhibitor of mPGES-1 expression and its target moleculePrincipal Investigator

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Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitratesPrincipal Investigator

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The clinical study on relationship between periodontal disease and atherosclerosis

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微生物由来細胞分化誘導因子の作用機構解明とG_1早期選択的抗腫瘍薬開発への応用Principal Investigator

Principal Investigator

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Review Section

Research Institution

Studies on the signal transduction of difrentiation inducing factor and an application for the development of anti-cancer drug for early G_1 phase.Principal Investigator

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血管内皮細胞の増殖・分化・死の制御におけるサイクリン依存性キナーゼ阻害蛋白の役割Principal Investigator

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Linkage between G protein-coupled receptors and the Jak/STAT pathway in cardiovascular cellsPrincipal Investigator

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Regulation of proliferatin in vascular endothelial and smooth muscle cells by the protein kinase C pathwayPrincipal Investigator

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[Book] NEW薬理学(改訂第6版)(抗狭心症薬)2011

Author(s)

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Data Source

[Book] 抗狭心症薬(分担執筆部分):田中千賀子・加藤隆一編『NEW薬理学』(改訂第6版)2011

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[Book] 降圧薬のコンビネーションセラピー2009

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[Journal Article] 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.2019

Author(s)

Journal Title

SASAGURI Toshiyuki 笹栗俊之

[Journal Article] – A Randomized Controlled Trial –2012